检索结果-南通市图书馆

Apoptosis and non-alcoholic fatty liver diseases

World Journal of Gastroenterology 2018年第25期24卷 2661-2672页

作者： Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki toshikatsu shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine

The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice.

关键词： Apoptosis Autophagy c-Jun N-terminal kinase Nonalcoholic fatty liver diseases Nonalcoholic steatohepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A dispersed vegetative cover contributes to urban biodiversity:plant diversity across land use types and scale in an Asian city

引用

Journal of Forestry Research 2023年第2期34卷 539-551页

作者： Jiefeng Kang Shozo shibata Laboratory of Landscape Ecology and Planning Graduate School of Global Environmental StudiesKyoto UniversityKyotoJapan

Urbanization provides both challenges and opportunities for biodiversity conservation,but patterns of urban plant diversity across land uses,especially in Asian countries,remains *** determine these patterns of diversity,woody plants in 174 sample quadrats across various land use types in Kyoto City were ***,abundance,and evenness were evaluated at city,land use,and quadrat scales,and biodiversity of different land use types was *** the city level,223 species in 77 families were *** the land use level,residential areas had the highest total biological richness,with moderate to low evenness,while commercial areas exhibited low *** the quadrat level,the low-rise residential area had higher species richness than the other land *** abundance and evenness in quadrats were significantly different across land use types for the canopy layer but not for the *** results provide insights into urban biodiversity design and management by identifying prior land uses for biodiversity improvement and by highlighting the contribution of residential private *** heterogeneity,scale,and multidimensionality should be considered when measuring urban biodiversity.

关键词： Urban biodiversity Woody plants Land uses Residential areas Japan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology

引用

Neuroscience Bulletin 2021年第1期37卷 103-116页

作者： Mamoru shibata Chunhua Tang Department of Neurology Keio University School of MedicineTokyo 160-8582Japan Department of Neurology Tokyo Dental College Ichikawa General HospitalChiba 272-8513Japan Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing 400042China

Migraine is a common and debilitating headache disorder. Although its pathogenesis remains elusive,abnormal trigeminal and central nervous system activity is likely to play an important role. Transient receptor potential(TRP) channels, which transduce noxious stimuli into pain signals, are expressed in trigeminal ganglion neurons and brain regions closely associated with the pathophysiology of migraine. In the trigeminal ganglion,TRP channels co-localize with calcitonin gene-related peptide, a neuropeptide crucially implicated in migraine pathophysiology. Many preclinical and clinical data support the roles of TRP channels in migraine. In particular,activation of TRP cation channel V1 has been shown to regulate calcitonin gene-related peptide release from trigeminal nerves. Intriguingly, several effective antimigraine therapies, including botulinum neurotoxin type A, affect the functions of TRP cation channels. Here, we discuss currently available data regarding the roles of major TRP cation channels in the pathophysiology of migraine and the therapeutic applicability thereof.

关键词： Migraine TRPV1 TRPM8 TRPA1 TRPV4 Calcitonin gene-related peptide Trigeminal ganglion Neurogenic inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three-dimensional crystal defect imaging by STEM depth sectioning

引用

Chinese Physics B 2024年第8期33卷 2-7页

作者： Ryo Ishikawa Naoya shibata Yuichi Ikuhara Institute of Engineering Innovation The University of TokyoBunkyoTokyo 113-8656Japan

One of the major innovations awaiting in electron microscopy is full three-dimensional imaging at atomic *** the success of aberration correction to deep sub-angstrom lateral resolution,spatial resolution in depth is still far from atomic *** scanning transmission electron microscopy(STEM),this poor depth resolution is due to the limitation of the illumination *** overcome this physical limitation,it is essential to implement a next-generation aberration corrector in STEM that can significantly improve the depth *** review discusses the capability of depth sectioning for three-dimensional imaging combined with large-angle illumination ***,the statistical analysis approach remarkably improves the depth resolution,making it possible to achieve three-dimensional atomic resolution imaging at oxide *** will also discuss the future prospects of three-dimensional imaging at atomic resolution by STEM depth sectioning.

关键词： atomic-resolution STEM STEM depth sectioning depth resolution dopants surface topography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial distributions of the leafminer Ophiomyia maura （Diptera： Agromyzidae） in host plant Aster ageratoides

引用

Insect Science 2008年第4期15卷 343-348页

作者： Yoshiko Ayabe Ei'ichi shibata Laboratory of Forest Protection Graduate School of Bioagricultural Sciences Nagoya University Nagoya 464-8601 Japan

The seasonal occurrence and among-plant and within-plant spatial distribution of the multivoltine leafminer Ophiomyia maura Meigen （Diptera： Agromyzidae） on the herbaceous plant Aster ageratoides Turcz. subsp, ovatus （Asteraceae） were investigated in the field. O. maura has at least four generations a year and mines per leaf fluctuate with a mean of 0.007 throughout the occurrence period. Seasonal occurrence is associated with abundance of new host leaves, suggesting O. maura females prefer to oviposit in newly emerged leaves. The among-plant distribution of O. maura is described by a Poisson distribution early in the season but tends to be weakly clumped later. The within-plant vertical distribution of larval mines increased from middle to upper leaves during plant development, because mined leaves in the middle position early in the season move downward with the emergence of new leaves, shifting mined leaves from the position where O. maura oviposits eggs. Later in the season, mined leaves remain where they are deposited because few new leaves emerge. The spatial distribution of O. maura, resource utilization patterns, and host plant characteristics are discussed.

关键词： host-plant interactions resource utilization seasonal occurrence spatialdistribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fukuititan nipponensis,A New Titanosauriform Sauropod from the Early Cretaceous Tetori Group of Fukui Prefecture,Japan

引用

Acta Geologica Sinica(English Edition) 2010年第3期84卷 454-462页

作者： Yoichi AZUMA Masateru shibata Fukui Prefectural Dinosaur Museum 51-11 TeraoMurokoKatsuyamaFukui 911-8601Japan

A titanosauriform dinosaur： Fukuititan nipponensis gen. et sp. nov. is erected based on the incomplete skeleton. It is characterized by elongated asymmetric tooth crown with a weak or absent labial groove and without lingual concavity; stalk-like epipophysis of cervical vertebra; the transverse width of the proximal end of the humerus approximately 32% of the humerus length; metacarpal longer, approximately 48 % of the radius and the distal end of the ischia slightly expanded. It represents the first relatively complete titanosauriform skeleton found from Japan. The discovery of Fukuititan indicates that the diversity and geographical distribution of Titanosauriformes are much higher than the previous thought.

关键词： Fukuititan Titanosauriformes Early Cretaceous Japan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Iguanodontian Dinosaur from the Lower Cretaceous Khok Kruat Formation,Nakhon Ratchasima in Northeastern Thailand

引用

Acta Geologica Sinica(English Edition) 2011年第5期85卷 969-976页

作者： Masateru shibata Pratueng JINTASAKUL Yoichi AZUMA Fukui Prefectural Dinosaur Museum 51-11 TeraoMurokoKatsuyamaFukui 911-8601Japan Northeastern Research Institute of Petrified Wood and Mineral Resources Nakhon Ratchasima Rajabhat University184 Moo 7 Suranaree SubdistictMuangNakhon Ratchasima 30000Thailand

Here we report a new iguanodontian dentary found from the Lower Cretaceous Khok Kruat Formation,Nakhon Ratchasima,northeast Thailand.A unique character,which is an elongated and flat shape of the dentary ramus,makes it possible to assign the specimen to the new genus of non-hadrosaurid iguanodontian,Ratchasimasaurus suranareae *** *** shows both primitive and derived characters,such as a caudally inclined coronoid process and alveolar trough with a primitive crown impression,and a derived buccal shelf between tooth row and coronoid *** discovery of a new iguanodontian from the Indochina Terrene,considering that the previously reported 'Probactrosaurus-like' iguanodontian,points out a great diversity of this group in the late Early Cretaceous in Thailand,and corresponds to the Asian iguanodontian diversity at that time.

关键词： Ratchasimasaurus iguanodontia dentary Early Cretaceous Thailand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A NOTE ON THE UNIQUENESS AND THE NON-DEGENERACY OF POSITIVE RADIAL SOLUTIONS FOR SEMILINEAR ELLIPTIC PROBLEMS AND ITS APPLICATION

引用

Acta Mathematica Scientia 2018年第4期38卷 1121-1142页

作者： Shinji ADACHI Masataka shibata Tatsuya WATANABE Department of Mathematical and Systems Engineering Faculty of Engineering Shizuoka University 3-5-1 Johoku Naka-ku Hamarnatsu 432-8551 Japan Department of Mathematics Tokyo Institute of Technology 2-12-1 Oh-okayama Meguro-ku Tokyo 15248551 Japan Department of Mathematics Faculty of Science Kyoto Sangyo University Motoyama Kamigamo Kita-ku Kyoto 603-8555 Japan

In this paper, we are concerned with the uniqueness and the non-degeneracy of positive radial solutions for a class of semilinear elliptic equations. Using detailed ODE anal- ysis, we extend previous results to cases where nonlinear terms may have sublinear growth. As an application, we obtain the uniqueness and the non-degeneracy of ground states for modified SchrSdinger equations.

关键词： positive radial solution uniqueness non-degeneracy shooting method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tegafur-uracil-induced rapid development of advanced hepatic fibrosis

引用

World Journal of Gastroenterology 2017年第31期23卷 5823-5828页

作者： shuya honda koji sawada takumu hasebe shunsuke nakajima mikihiro fujiya toshikatsu okumura division of gastroenterology and hematology/oncology department of medicine asahikawa medical university

Tegafur-uracil has been reported to have only minor adverse effects and is associated with liver injury in 1.79% of Japanese patients. The development of tegafur-uracil-induced hepatic fibrosis with portal hypertension is rare. Here, we report a case of a 74-year-old woman with rapidly developing tegafururacil-induced hepatic fibrosis. The patient had no history of liver disease and had been treated with tegafur-uracil for 8 mo after breast cancer surgery. The patient was admitted to our hospital for abdominal distension and leg edema associated with liver dysfunction. Computed tomography imaging revealed massive ascites and splenomegaly, and a non-invasive assessment of liver fibrosis indicated advanced fibrosis. The histopathological findings revealed periportal fibrosis and bridging fibrosis with septation. The massive ascites resolved after discontinuing tegafururacil. These findings suggest that advanced hepatic fibrosis can develop from a relatively short-term administration of tegafur-uracil and that non-invasive assessment is useful for predicting hepatic fibrosis.

关键词： Tegafur-uracil Drug-induced liver injury Hepatic fibrosis Portal hypertension Non-invasive assessment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deformation mechanism of bimodal microstructure in Ti-6Al-4V alloy:The effects of intercritical annealing temperature and constituent hardness

引用

Journal of Materials Science & Technology 2021年第12期71卷 138-151页

作者： Yan Chong Tilak Bhattacharjee Yanzhong Tian Akinobu shibata Nobuhiro Tsuji Department of Materials Science and Engineering Kyoto UniversityKyotoJapan Department of Materials Science and Engineering University of CaliforniaBerkeleyCAUSA Elements Strategy Initiative for Structural Materials(ESISM) Kyoto UniversityKyotoJapan Key Laboratory for Anisotropy and Texture of Materials School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

The so-called bimodal microstructure of Ti-6 Al-4 V alloy,composed of primaryαgrains(α_(p))and transformed β areas(β_(trans)),can be regarded as a"dual-phase"structure to some extent,the mechanical properties of which are closely related to the sizes,volume fractions,distributions as well as nanohardness of the two *** this study,the volume fractions of primaryαgrains(vol.%(α_(p)))were systematically modified in three series of bimodal microstructures with fixed primaryαgrain sizes(0.8μm,2.4μm and 5.0μm),by changing the intercritical annealing temperature(T_(int)).By evaluating the tensile properties at room temperature,it was found that with increasing T_(int)(decreasing vol.%(α_(p))),the yield strength of bimodal microstructures monotonically increased,while the uniform elongation firstly increased with T_(int)until 910°C and then drastically decreased afterwards,thereby dividing the T_(int)into two regions,namely region I(830-910°C)and region II(910-970℃).The detailed deformation behaviors within the two regions were studied and compared,from the perspectives of strain distribution analysis,slip system analysis as well as dislocation *** bimodal microstructures in region I,due to the much lower nano-hardness ofβ_(trans)thanα_(p),there was a clear strain partitioning between the two constituents as well as a strain gradient from theα_(p)/β_(trans)interface to the grain interior ofα_(p).This activated a large number of geometrically necessary dislocations(GNDs)near the interface,mostly with components,which contributed greatly to the extraordinary work-hardening abilities of bimodal microstructures in region *** increasing T_(int),theα_(p)/β_(trans)interface length density gradually increased and so was the density of GNDs with components,which explained the continuous increase of uniform elongation with T_(int)in this *** bimodal microstructures in region II,where the nano-hardness ofβ_(trans)andα_(p)were comparable,neither a clear s

关键词： Ti-6Al-4V Bimodal microstructure Intercritical annealing temperature Strain distribution dislocation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：