Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology
在周期性偏头痛 Pathophysiology 的短暂受体潜在的阳离子隧道的含意作者机构:Department of NeurologyKeio University School of MedicineTokyo 160-8582Japan Department of NeurologyTokyo Dental College Ichikawa General HospitalChiba 272-8513Japan Department of Neurology and Center for Clinical NeuroscienceDaping HospitalThird Military Medical UniversityChongqing 400042China
出 版 物:《Neuroscience Bulletin》 (神经科学通报(英文版))
年 卷 期:2021年第37卷第1期
页 面:103-116页
核心收录:
学科分类:1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金:supported by the Japan Society for the Promotion of Science KAKENHI(26460706 and 19K07849) a Japan-China Sasakawa Medical Fellowship(2017816) a State Scholarship Fund of the China Scholarship Council(201908500072)
主 题:Migraine TRPV1 TRPM8 TRPA1 TRPV4 Calcitonin gene-related peptide Trigeminal ganglion Neurogenic inflammation
摘 要:Migraine is a common and debilitating headache disorder. Although its pathogenesis remains elusive,abnormal trigeminal and central nervous system activity is likely to play an important role. Transient receptor potential(TRP) channels, which transduce noxious stimuli into pain signals, are expressed in trigeminal ganglion neurons and brain regions closely associated with the pathophysiology of migraine. In the trigeminal ganglion,TRP channels co-localize with calcitonin gene-related peptide, a neuropeptide crucially implicated in migraine pathophysiology. Many preclinical and clinical data support the roles of TRP channels in migraine. In particular,activation of TRP cation channel V1 has been shown to regulate calcitonin gene-related peptide release from trigeminal nerves. Intriguingly, several effective antimigraine therapies, including botulinum neurotoxin type A, affect the functions of TRP cation channels. Here, we discuss currently available data regarding the roles of major TRP cation channels in the pathophysiology of migraine and the therapeutic applicability thereof.