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Differences in clinicopathological characteristics between lipohypertrophy and localized insulin-derived amyloidosis:A scoping review

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Chronic Diseases and Translational Medicine 2024年第1期10卷 22-30页

作者： Kanae Mukai Hiromasa Tanno Junko Sugama toshihiko Yanagita emi Kanno Department of Clinical Nursing Faculty ofHealth SciencesInstitute of MedicalPharmaceutical and Health SciencesKanazawa UniversityKanazawaJapan Department of Translational Science forNursing Tohoku University Graduate School ofMedicineSendaiJapan Research Center for Implementation NursingScience Initiative School of Health SciencesFujita Health UniversityToyoakeJapan Department of Clinical Pharmacology Schoolof NursingUniversity of MiyazakiMiyazakiJapan

Insulin is used as a therapeutic agent in patients with diabetes,and cutaneous lipohypertrophy(LH)and localized insulin-derived amyloidosis(LIDA)are well-known adverse effects associated with insulin *** clinical implications,management,assessment methods,and pathological differentiation of LH and LIDA have been recently *** review was to update our knowledge of the pathological differentiation,effects of insulin absorption,hypoglycemic events,and recent assessment methods for LH and LIDA.A scoping review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses extension for Scoping Reviews *** studies and case reports in English were also *** and Scopus databases were searched for keywords to identify papers published up to January 2022.A total of 113 studies were identified through a database search,and 31 were eligible for inclusion in this scoping *** the 31 studies included in this review,patients with type 2 diabetes had high frequencies of LH and *** outcome parameters were assessed using pathological findings and *** is mainly determined by pathological methods,such as hematoxylin and eosin and Congo red *** in vitro and in vivo LIDA models of LIDA have been *** results suggest that pathological analysis is required to identify LH and *** is important to consider LIDA,as it likely influences insulin adsorption and glycemic *** several studies have evaluated the LIDA process,little is known about the mechanisms underlying the development of adverse effects associated with insulin injections.

关键词： diabetes mellitus insulin injection lipohypertrophy localized insulin-derived amyloidosis

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转炉炼钢的复合吹炼技术

钢铁 1985年第10期 68-71页

作者： Takuo IMAI Kanji EMOTO toshihiko emi 张荣生川崎制铁·株川崎制铁·株川崎制铁·株

1.引言 1977年千叶厂引入了纯氧底吹转炉(Q-BOP),在冶金和操作两方面都有了成效。钢液搅拌良好、吹炼平稳这两个特点给人以深刻印象。与此同时,在日本开展了对复合吹炼法

关键词：吹炼冶金日本熔炼脱磷炼钢方法铁水预处理脱碳化工单元操作底吹气钢液 BOP 热补偿技术 LD 转炉高碳钢碳素钢

在Q-BOP法,底吹LD法,氩气搅拌LD法和LD法中的冶金反应

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钢铁 1982年第3期17卷 46-52页

作者：江见俊彦古隆建唐仲和川崎钢铁公司

1. 引言纯氧和熔剂从转炉底部吹入熔池产生了许多优于顶吹的特点,最突出的是更接近平衡态,增强了气相-金属和炉渣-金属间的传质并改善了熔池温度和化学成分的均匀性.这是因底吹过程中强烈的熔池搅拌和在金属-O2,金属-熔剂之间形成了相... 详细信息

1. 引言纯氧和熔剂从转炉底部吹入熔池产生了许多优于顶吹的特点,最突出的是更接近平衡态,增强了气相-金属和炉渣-金属间的传质并改善了熔池温度和化学成分的均匀性.这是因底吹过程中强烈的熔池搅拌和在金属-O2,金属-熔剂之间形成了相当大的界面所致.Q-BOP法的成功已使底吹技术应用于改变现有的LD法为顶-底复合吹,产生了如图1所示的三种类型.其中两种现已用于工业规模（LD-KG:千叶150t,水岛200t;K-BOP:千叶80t,水岛250t）.

关键词： Q-BOP LD 底吹吹炼

Clinical Features of Giant Cell Tumor of Bone in Elderly Patients

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Open Journal of Orthopedics 2021年第9期11卷 257-268页

作者： Hiroyuki Tsuchie Makoto Emori Hiroyuki Nagasawa Yasutaka Murahashi emi Mizushima Junya Shimizu toshihiko Yamashita Naohisa Miyakoshi Department of Orthopedic Surgery Akita University Graduate School of Medicine Hondo Japan Department of Orthopedic Surgery Sapporo Medical University School of Medicine Chūō-ku Japan

Background: Giant cell tumor of the bone (GCTB) occurs most often in younger individuals aged between 20 and 40 years. However, it also occurs in a small proportion of elderly people. Therefore, it is necessary to determine the clinical characteristics of GCTB in elderly people, as only few reports have completely examined the characteristics of GCTB in elderly patients. Methods: This retrospective study enrolled 69 patients with benign GCTB. Patients’ information on age, sex, anatomical location and size, Campanacci grade, pathological fracture, treatment for primary tumors, local and distant relapse, and outcome was collected. We compared these clinical courses between the younger and older groups. We divided the age groups into three subgroups: ≤54 years and ≥55 years, ≤59 years and ≥60 years, and ≤64 years and ≥65 years. We compared the two groups in each subgroup. In addition, we examined factors affecting local recurrence and distant metastasis. Results: Tumor size was significantly larger in the older group between the two subgroups of 55 and 60 years. Kaplan-Meier curves for local recurrence-free survival and distant metastasis-free survival between the two subgroups of 65 years showed significant differences (p = 0.0183 and p

关键词： Giant Cell Tumor Bone Elderly Local Recurrence

Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

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World Journal of Gastroenterology 2015年第16期21卷 4933-4945页

作者： Makoto Meguro Toru Mizuguchi toshihiko Nishidate Kenji Okita Masayuki Ishii Shigenori Ota Tomomi Ueki emi Akizuki Koichi Hirata Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of Medicine

AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)***:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled *** AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were *** in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between *** survival curves were compared by logrank test using the Kaplan-Meier *** analysis using a Cox forward stepwise logistic regression model was conducted for a ***:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV *** HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical *** differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volu

关键词： Hepatocellular carcinoma Hepatitis B Hepatitis C Des-γ-carboxy prothrombin α-fetoprotein