Clinical Features of Giant Cell Tumor of Bone in Elderly Patients

作     者：Hiroyuki Tsuchie Makoto Emori Hiroyuki Nagasawa Yasutaka Murahashi Emi Mizushima Junya Shimizu Toshihiko Yamashita Naohisa Miyakoshi Hiroyuki Tsuchie;Makoto Emori;Hiroyuki Nagasawa;Yasutaka Murahashi;Emi Mizushima;Junya Shimizu;Toshihiko Yamashita;Naohisa Miyakoshi

作者机构：Department of Orthopedic Surgery Akita University Graduate School of Medicine Hondo Japan Department of Orthopedic Surgery Sapporo Medical University School of Medicine Chūō-ku Japan 

出 版 物：《Open Journal of Orthopedics》 (矫形学期刊（英文）)

年 卷 期：2021年第11卷第9期

页      面：257-268页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Giant Cell Tumor Bone Elderly Local Recurrence 

摘      要：Background: Giant cell tumor of the bone (GCTB) occurs most often in younger individuals aged between 20 and 40 years. However, it also occurs in a small proportion of elderly people. Therefore, it is necessary to determine the clinical characteristics of GCTB in elderly people, as only few reports have completely examined the characteristics of GCTB in elderly patients. Methods: This retrospective study enrolled 69 patients with benign GCTB. Patients’ information on age, sex, anatomical location and size, Campanacci grade, pathological fracture, treatment for primary tumors, local and distant relapse, and outcome was collected. We compared these clinical courses between the younger and older groups. We divided the age groups into three subgroups: ≤54 years and ≥55 years, ≤59 years and ≥60 years, and ≤64 years and ≥65 years. We compared the two groups in each subgroup. In addition, we examined factors affecting local recurrence and distant metastasis. Results: Tumor size was significantly larger in the older group between the two subgroups of 55 and 60 years. Kaplan-Meier curves for local recurrence-free survival and distant metastasis-free survival between the two subgroups of 65 years showed significant differences (p=0.0183 and p /s