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Effect of zeta potentials on bovine serum albumin adsorption on crown composite resin surfaces <i>in vitro</i>

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Journal of Biomedical Science and Engineering 2013年第3期6卷 273-276页

作者： Nahoko Miyake Tadashi Miura toru sato Masao Yoshinari Department of Crown & Bridge Prosthodontics Tokyo Dental College Chiba Japan Division of Oral Implants Research Oral Health Science Center Tokyo Dental College Chiba Japan Division of Prosthodontics Department of Clinical Oral Health Science Tokyo Dental College Tokyo Japan

We previously studied the mechanism underlying the adsorption of oral bacteria on the surfaces of dental prosthetic materials such as ceramics and resins in vitro. The aim of the present study was to examine bovine serum albumin (BSA) adsorption on crown composite resin surfaces by means of zeta potential. We measured the zeta potentials of resins alone, BSA alone, and resins after BSA adsorption. Eight resins were pulverized into powders (300 - 1000 nm). All experiments were conducted in 10 mM sodium chloride solution (pH 6.5). BSA was dissolved in 10 mM NaCl with a concentration of 2.0 × 10-5 mol/l. An adsorption assay was performed for one hour at 37°C under continuous rotation (6 rpm). The zeta potentials of both resins and BSA were negative, with BSA itself less negative than the resins themselves as an absolute value (p < 0.0001). The zeta potentials of seven resin surfaces after BSA adsorption were significantly less negative than were those of the resins without BSA adsorption (p < 0.0001). Eight resins were divided into two classes based on the size of the surface potential difference between each resin and the BSA. The difference in surface potential between the resins and the BSA were small, leading to the theory that particles with identical charges repulse each other, and the amounts of adsorbed BSA on these resins might be less. On the other, when the differences between the other resins and BSA are large, so that the repulsive force between two nonidentical particles becomes zero and an attractive force might be generated, then more BSA might be adsorbed on those resins. Therefore, the zeta potentials were affected by BSA adsorption and became less negative. These results suggested that electrostatic interactions play an important role in the adsorption of BSA on resin surfaces.

关键词： Zeta Potential Crown Composite Resins Bovine Serum Albumin Adsorption Electrostatic Interactions

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MU雷达观测到的台风

气象科技 1992年第4期20卷 36-43,F003页

作者： toru sato Naoki Ao Mamoru Yamamoto 封娟兰

8719号台风途经日本期间,用MU(中、高层大气)雷达对对流层和平流层低层进行了60小时的连续观测.以150m的高度分辨率每隔2.5分钟测量风速矢量的高度廓线.1987年10月17日,8719号台风袭击了日本,并在距MU雷达100km的范围内通过.18km以下都... 详细信息

8719号台风途经日本期间,用MU(中、高层大气)雷达对对流层和平流层低层进行了60小时的连续观测.以150m的高度分辨率每隔2.5分钟测量风速矢量的高度廓线.1987年10月17日,8719号台风袭击了日本,并在距MU雷达100km的范围内通过.18km以下都能观测到清晰的台风旋转结构,往上直到24km,风有短时的振动,表明受台风的强烈影响.整个观测期间,都发现有垂直波长为2-4km,周期为10小时的主波.高空风分析图显示,这些波从一个逆温层附近向上和向下传播,这意味着波动是在逆温层上生成的.

关键词：台风 MU雷达观测对流层平流层

Structural study of receptor recognition mechanism of a mouse pheromone ESPl

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Structural study of receptor recognition mechanism of a mous...

Effect of Application of Pipe Roof Method by Using Pipe Jacking on Behavior of Surrounding Soil

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Makoto Hirakane Sosuke Yoshinaga toru sato Yumi Soejima Sachiko Haga Ichio Shimada Kazushige Touhara Hiroaki Terasawa Faculty of Life Sciences Kumamoto UniversityKumamotoJapan Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Graduate School of Pharmaceutical Sciences The University of TokyoTokyoJapan

Pheromones are species-specific chemical signals that regulate a wide range of social and sexual behaviours in many *** vomeronasal organ(VNO) detects the pheromonal information via vomeronasal sensory neurons(VSNs) in *** have identified a male-specific peptide ESPl(exocrine-gland-secreting peptide 1) secreted into tear fluids that stimulates female *** ESPl signal is received,the vomeronasal type 2

关键词： mouse pheromone ESP1 GPCR molecular recognition NMR

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Journal of Physical Science and Application 2013年第6期3卷 353-358页

作者： Hideki Shimada Akihiro Hamanakal Takashi Sasaoka Kikuo Matsui toru sato Department of Earth Resources Engineering Kyushu University Fukuoka 819-0395 Japan Iseki Poly-tech Inc Tokyo 107-0051 Japan

Tunnels in an urban area, in many cases, are constructed in soft ground which contains underground water, near existing facilities and structures. Structural stability for the tunnel and also the nearby structures and facilities is vital in this kind of work. Slurry pipe jacking was firmly established as a special method for the non-disruptive construction of underground pipelines of sewage systems. This method utilizes mud slurry that is formed around the pipes in order to stabilize the surrounding soil. In the pipe roof method the tubing elements that are constructed by slurry pipe jacking are near each other longitudinally, and create a rigid and stable lining before the excavation of the main tunnel. This paper discusses the application of a slurry pipe jacking system on the pipe roof method by means of numerical analysis. Because of the rigid behavior of the lining, the results show little subsidence, making this method a reliable method of constructing large tunnels with small cover in an urban area.

关键词：管棚法顶管行为应用污水处理系统结构稳定邻近建筑物破坏性建设

Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina

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Neural Regeneration Research 2023年第5期18卷 1004-1008页

作者： Yukitoshi Izumi Makoto Ishikawa toru Nakazawa Hiroshi Kunikata Kota sato Douglas F.Covey Charles F.Zorumski Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA Department of Ophthalmic Imaging and Information Analytics Tohoku University Graduate School of MedicineSendaiJapan Department of Ophthalmology Tohoku University Graduate School of MedicineSendaiJapan Department of Retinal Disease Control Tohoku University Graduate School of MedicineSendaiJapan Department of Advanced Ophthalmic Medicine Tohoku University Graduate School of MedicineSendaiJapan Department of Developmental Biology Washington University School of MedicineSt.LouisMOUSA

Neurosteroids are rapidly emerging as important new therapies in neuropsychiatry, with one such agent, brexanolone, already approved for treatment of postpartum depression, and others on the horizon. These steroids have unique properties, including neuroprotective effects that could benefit a wide range of brain illnesses including depression, anxiety, epilepsy, and neurodegeneration. Over the past 25 years, our group has developed ex vivo rodent models to examine factors contributing to several forms of neurodegeneration in the retina. In the course of this work, we have developed a model of acute closed angle glaucoma that involves incubation of ex vivo retinas under hyperbaric conditions and results in neuronal and axonal changes that mimic glaucoma. We have used this model to determine neuroprotective mechanisms that could have therapeutic implications. In particular, we have focused on the role of both endogenous and exogenous neurosteroids in modulating the effects of acute high pressure. Endogenous allopregnanolone, a major stress-activated neurosteroid in the brain and retina, helps to prevent severe pressure-induced retinal excitotoxicity but is unable to protect against degenerative changes in ganglion cells and their axons under hyperbaric conditions. However, exogenous allopregnanolone, at a pharmacological concentration, completely preserves retinal structure and does so by combined effects on gamma-aminobutyric acid type A receptors and stimulation of the cellular process of macroautophagy. Surprisingly, the enantiomer of allopregnanolone, which is inactive at gamma-aminobutyric acid type A receptors, is equally retinoprotective and acts primarily via autophagy. Both enantiomers are also equally effective in preserving retinal structure and function in an in vivo glaucoma model. These studies in the retina have important implications for the ongoing development of allopregnanolone and other neurosteroids as therapeutics for neuropsychiatric illnesses.

关键词： allopregnanolone autophagy enantiomers excitotoxicity gamma-aminobutyric acid type A receptors glaucoma optic nerve oxysterols

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微细颗粒在岩床中运移沉积过程的显微模拟

海洋地质 2013年第1期29卷 26-26页

作者： Shinichiro HIRABAYASHI toru sato Yoshitaka YAMAMOTO

为了解可移动微细颗粒在压实砂岩中运移和沉积过程其渗透率降低的程度，在预期的显微区域内进行了数值模拟。模拟方法为用玻尔兹曼格子方法表示流体相，用特定的元素方法求解每一个运移颗粒的运动过程，并用模拟结果直接计算了视渗透率。

关键词：微细颗粒数值模拟沉积过程运移岩床视渗透率模拟方法运动过程

Recent Progress of Thioester Method

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Chemical Research in Chinese Universities 2006年第2期22卷 253-257页

作者： Saburo Aimoto Kenta Teruya Koki Hasegawa Takeshi sato Kenichi Akaji toru Kawakami Institute for Protein Research Osaka University Suita Osaka 565-0871 Japan

Introduction The availability of site-specifically modified peptides is of vital importance for biochemical and biophysical studies. Biological methods, such as expression using bacteria, are useful. They are, however, not always applicable to the synthesis of peptides with sitespecific modifications. Chemical methods can be viable alternatives to those biological approaches. Peptides obtained by chemical and biological means,

关键词： Thioester method Thiol linker Peptide

Role of circulating tumor cell clusters in patients with metastatic hormone-sensitive prostate cancer receiving a gonadotropin-releasing hormone antagonist: A pilot study

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Asian Journal of Urology 2023年第2期10卷 210-212页

作者： Yuki Kohada Hiroki Kusumoto Takashi Kukimoto Jotaro Mikami Jun Ito Katsutoshi Asano toru Yaegashi Kanichi Nakagawara Jun Teishima Yasuhiro Kaiho Nobuyuki Hinata Yasuhiro Nakamura Makoto sato Division of Urology Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan Department of Urology Hiroshima University Graduate School of Biomedical SciencesHiroshimaJapan Nihon Gene Research Laboratories Inc SendaiJapan Division of Pathology Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan

Dear Editor,Prostate cancer is the most common cancer among men[1].Androgen deprivation therapy(ADT)has remained the primary treatment of metastatic-hormone-sensitive prostate cancer(mHSPC),providing a temporary disease control in the majority of *** initial ADT response,castration-resistance prostate cancer(CRPC)still *** study have attempted to determine possible biomarkers for poor prognosis in patients with CRPC[2].

关键词： patients metastatic cancer

Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 657-660页

作者： Shinichi Akahoshi toru Beppu Yasuhisa Mori Koichi Kinoshita Nobutaka sato Ken Kikuchi Department of Surgery Yamaga City Medical CenterKumamotoJapan Department of Surgery and Oncology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Adviser Sakurajuji HospitalKumamotoJapan

The recent Southampton consensus guideline and two previous international consensus meetings held in Louisville and Morioka in 2008 and 2014,respectively have recommended laparoscopic liver resection(LLR)as a standard procedure for selected patients with colorectal liver metastases(CRLM)(1-3).The Oslo-CoMet and LapOpHuva studies are the only two randomized controlled trials(RCTs)that have provided solid evidence showing that LLR is a safer,less invasive,and more cost-effective approach with higher health-related quality of life and oncological outcomes equivalent to those of open liver resection(OLR)for patients with CRLM(4-6).

关键词： resection colorectal metastases