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World Journal of Gastroenterology 2010年第20期16卷 2484-2495页

作者： Mitsuro chiba toru Abe Hidehiko Tsuda Takeshi Sugawara Satoko Tsuda Haruhiko Tozawa Katsuhiko Fujiwara Hideo Imai Division of Gastroenterology Nakadori General HospitalAkita 010-8577Japan

AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for ***: A prospective,single center,2-year clinical trial was ***-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel *** primary endpoint was clinical relapse defi ned as the appearance of active symptoms of ***-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse.A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was ***: SVD was continued by 16 patients (compliance 73%).Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%)in the omnivorous *** rate with SVD was 100% at 1 year and 92% at 2 *** showed signif icant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003,log rank test).The concentration of C-reactive protein was normal at the f inal visit in more than half of the patients in remission who were taking an SVD,who maintained remission during the study (9/15;60%),who terminated follow-up (8/12;67%),and who completed 2 years follow-up (7/10;70%).There was no untoward effect of ***: SVD was highly effective in preventing relapse in CD.

关键词： Crohn’s disease Inflammatory bowel disease Vegetarian diet Recurrence Lifestyle

Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis

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World Journal of Gastroenterology 2009年第17期15卷 2166-2169页

作者： Mitsuro chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda toru Abe Takuo Tokairin Iwao Ono Eriko Ushiyama Division of Gastroenterology Nakadori General Hospital Akita 010-8577 Japan Department of Pathology Nakadori General Hospital Akita 010-8577 Japan Department of Internal Medicine Nakadori Rehabilitation Hospital Akita 010-8577 Japan

There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis.

关键词： Collagenous colitis Microscopic colitis,Lansoprazole Ulcerative colitis Sulfasalazine

Multi-disciplinary Conceptual Design Knowledge of Multi-stage Hybrid Rocket Using Data Mining Technique

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Journal of Mechanics Engineering and Automation 2015年第1期5卷 1-9页

作者： Masahiro Kanazaki Kazuhisa chiba Koki Kitagawa toru Shimada Masashi Nakamiya Department of Aerospace Engineering Graduate School of System Design Tokyo Metropolitan University Tokyo 191-0065Japan Graduate School of Engineering Hokkaido University of Science Sapporo 006-8585 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Sagamihara 252-5210 Japan Research Institute for Sustainable Humanosphere Kyoto University Kyoto 606-8501 Japan

This paper deals with the application of data mining techniques to the conceptual design knowledge for a LV （launch vehicle） with a HRE （hybrid rocket engine）. This LV is a concept of the space transportation, which can deliver micro-satellite to the SSO （sun-synchronous orbit）. To design the higher performance LV with HRE, the optimum size of each component, such as an oxidizer tank containing liquid oxidizer, a combustion chamber containing solid fuel, a pressurizing tank and a nozzle, should be acquired. The Kriging based ANOVA （analysis of variance） and SOM （self-organizing map） are employed as data mining techniques for knowledge discovery. In this study, the paraffin （FT-0070） is used as a propellant of HRE. Then, the relationship among LV performances and design variables are investigated through the analysis and the visualization. To calculate the engine performance, the regression rate is computed based on an empirical expression. The design knowledge is extracted for the design knowledge of the multi-stage LV with HRE by analysis using ANOVA and SOM. As a result, the useful design knowledge on the present design problem is obtained to design HRE for space transportation.

关键词： Hybrid rocket data mining techniques multidisciplinary design

Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease

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Cell Research 2007年第2期17卷 184-186页

作者： toru Hosoi Kanae Hyoda Yasunobu Okuma Yasuyuki Nomura Koichiro Ozawa Department of Pharmacotherapy Graduate School of Biomedical SciencesHiroshima University1-2-3 KasumiMinami-kuHiroshima 734-8551Japan Department of Pharmacology Graduate School of Pharmaceutical SciencesHokkaido UniversitySapporo 060-0812Japan Department of Pharmacology Faculty of Pharmaceutical SciencesChiba Institute of SciencesChoshiChiba 288-0025Japan

Dear Editor:Geldanamycin is a benzoquinone ansamycin,which wasoriginally described as a tyrosine kinase ***-ever,subsequent studies have revealed that geldanamycinbinds to and inhibits heat-shock protein 90(Hsp90)activity[1].Hsp90 is a molecular chaperone involved in the con-formational maturation of proteins such as mutated p53,Raf-1,Akt,Bcr-Ab1,and *** is suggested that agentsinhibiting Hsp90 have anti-cancer properties,although theprecise molecular mechanisms underlying the anti-cancereffects of geldanamycin are not well *** evidence has suggested that diabetes andneurodegenerative disorders such as Parkinson's andAlzheimer's diseases are related to the disruption ofendoplasmic reticulum(ER)*** response to ERstress,unfolded proteins accumulate and aggregate in theER,which will trigger many rescuer responses,includingthe unfolded protein response(UPR)and ***,geldanamycin has been shownto upregulate ER chaperones and the expression of CHOP[2].Moreover,Hsp90 associates with PERK and IRE1α,ER-resident trans-membrane protein kinases involved inER stress response[3].These observations suggest that

关键词： CHOP benzenesulfonyl fluoride-responsive serine protease ER aminoethyl Geldanamycin induces CHOP expression through a 4

Scoring criteria for determining the safety of liver resection for malignant liver tumors

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World Journal of Meta-Analysis 2019年第5期7卷 234-248页

作者： Kohei Harada Minoru Nagayama Yoshiya Ohashi Ayaka chiba Kanako Numasawa Makoto Meguro Yasutoshi Kimura Hiroshi Yamaguchi Masahiro Kobayashi Koji Miyanishi Junji Kato toru Mizuguchi Departments of Surgery Surgical Scienceand OncologySapporo Medical UniversitySapporoHokkaido 060-8556Japan Division of Radiology Sapporo Medical University HospitalSapporoHokkaido 060-8556Japan Sapporo Medical University Postgraduate School of Health Science and Medicine Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Research and Education Center for Clinical Pharmacy Kitasato University School of PharmacyTokyo 108-8641Japan Department of Internal Medicine IV Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Department of Nursing and Surgical Science Sapporo Medical UniversitySapporo 0608543Japan

BACKGROUND Liver resection has become safer as it has become less ***,the minimum residual liver volume(RLV)required to maintain homeostasis is ***,the formulae used to calculate standard liver volume(SLV)are *** To review previously reported SLV formulae and the methods used to evaluate the minimum RLV,and explore the association between liver volume and *** A systematic review of Medline,PubMed,and grey literature was *** in the retrieved articles were cross-checked manually to obtain further *** last search was conducted on January 20,*** developed an SLV formula using data for 86 consecutive patients who underwent hepatectomy at our institution between July 2009 and August *** Linear regression analysis revealed the following formula:SLV(mL)=822.7×body surface area(BSA)?183.2(R2=0.419 and R=0.644,P<0.001).We retrieved 25 studies relating to SLV formulae and 12 studies about the RLV required for safe liver *** the previously reported formulae included various coefficient and constant values,a simplified version of the SLV,the common SLV(cSLV),can be calculated as follows:cSLV(mL)=710 or 770×*** minimum RLV for normal and damaged livers ranged from 20%-40%and 30%-50%,*** Sapporo score indicated that the minimum RLV ranges from 35%-95%depending on liver *** We reviewed SLV formulae and the minimum RLV required for safe liver *** Sapporo score is the only liver function-based method for determining the minimum RLV.

关键词： Standard liver volume Residual liver volume Hepatectomy Mortality Liver failure Liver function

Laparoscopy in the management of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2014年第41期20卷 15153-15157页

作者： Akihiro Cho Hiroshi Yamamoto Osamu Kainuma Yorihiko Muto Hiroo Yanagibashi toru Tonooka Takahito Masuda Division of Gastroenterological Surgery Chiba Cancer Center Hospital

The use of minimally invasive surgery has become widely accepted in many gastrointestinal fields,even in patients with ***,performing laparoscopic resection for the treatment of hilar cholangiocarcinoma is still not universally accepted as an alternative approach to open surgery,and only a limited number of such procedures have been reporteddue to the difficulty of performing oncologic resection and the lack of consensus regarding the adequacy of this *** was initially limited to staging,biopsy and *** technological developments and improvements in endoscopic procedures have greatly expanded the applications of laparoscopic liver resection and lymphadenectomy,and some reports have described the use of laparoscopic or robot-assisted laparoscopic resection for hilar cholangiocarcinoma as being feasible and safe in highly selected cases,with the ability to obtain an adequate surgical ***,the benefits of major laparoscopic surgery have yet to be conclusively proven,and carefully selecting patients is essential for successfully performing this procedure.

关键词： Hilar cholangiocarcinoma Laparoscopy Minimally invasive surgery

Imaging biomarkers for the treatment of esophageal cancer

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World Journal of Gastroenterology 2019年第24期25卷 3021-3029页

作者： Koichi Hayano Gaku Ohira Atsushi Hirata Tomoyoshi Aoyagi Shunsuke Imanishi toru Tochigi Toshiharu Hanaoka Kiyohiko Shuto Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of MedicineChiba 260-8677Japan Department of Surgery Teikyo University Medical CenterChiba 299-0111Japan

Esophageal cancer is known as one of the malignant cancers with poor *** improve the outcome,combined multimodality treatment is *** the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”*** advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer *** this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer.

关键词： Esophageal cancer Computed tomography perfusion Dynamic-contrastenhanced magnetic resonance imaging Texture analysis Diffusion-weighted imaging Positron emission tomography

Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer

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World Journal of Gastroenterology 2014年第46期20卷 17345-17351页

作者： Koichi Hayano Takeshi Fujishiro Dushyant V Sahani Asami Satoh Tomoyoshi Aoyagi Gaku Ohira toru Tochigi Hisahiro Matsubara Kiyohiko Shuto Division of Abdominal Imaging and Intervention Department of RadiologyMassachusetts General HospitalBostonMA 02114United States Department of Frontier surgery Chiba university Graduate School of MedicineChiba 260-8677Japan Department of Surgery Teikyo University Medical CenterIchiharaChiba 299-0111Japan

Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer(CRC),and the importance of angiogenesis in cancer progression has been *** tomography(CT)perfusion(CTP)based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer *** has been reported to characterize tumor angiogenesis,and to be a sensitive marker for predicting recurrence or survival in *** this review,we will discuss the biomarker value of CTP in the management of CRC patients.

关键词： Colorectal cancer Angiogenesis Computed tomography perfusion Antiangiogenic therapy Chemoradiation therapy

Brown slits for colorectal adenoma crypts on conventional magnifying endoscopy with narrow band imaging using the X1 system

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World Journal of Gastroenterology 2022年第24期28卷 2748-2757页

作者： Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Hidenobu Watanabe Nariaki Odawara Kosuke Sakitani toru Arano Hirotoshi Takiyama Hideyuki Kobayashi Hirofumi Kogure Mitsuhiro Fujishiro Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalChiba 286-8520Japan Department of Pathology Pathology and Cytology Laboratory JapanTokyo 166-0003Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Sakitani Endoscopy ClinicChiba 275-0026Japan Department of Gastroenterology The Fraternity Memorial HospitalTokyo 130-8587Japan Department of Surgical Oncology The University of TokyoTokyo 113-8655Japan Department of Internal Medicine Umegaoka Ekimae ClinicTokyo 154-0022Japan

BACKGROUND Accurate diagnosis of colorectal premalignant polyps,including adenomas,is vital in clinical *** To investigate the diagnostic yields of novel findings of brown slits for *** Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic were *** sized≥5 mm suspected of adenomas or clinically significant serrated polyps were included in the *** defined the surface structures of colorectal polyps,which were brown curves inside and along the tubular glands identified using a combination of a new X1 system(Olympus Corporation)and a conventional magnifying colonoscope with non-staining narrow band imaging(NBI),as brown *** brown slits corresponded to slit-like lumens on endocytoscopy and histological crypt openings of an *** evaluated the diagnostic performance of brown slits for *** A total of 108 Lesions from 62 patients were *** average age was 60.4 years and 41.9%were *** mean polyp size was 7.45±2.83 ***-seven lesions were positive for brown *** diagnosis comprised 59 low-grade tubular adenomas,16 sessile serrated lesions,and 33 hyperplastic *** 59 adenomas,56(94.9%)were positive for brown *** 16 sessile serrated lesions,0(0%)was positive for brown *** 33 hyperplastic polyps,1(3.0%)was positive for brown *** sensitivity,specificity,and accuracy of brown slits for adenoma were 94.9%,98.0%,and 96.3%,*** positive predictive value and negative predictive value of brown slits for adenoma were also excellent for 98.2%,and 94.1%,*** Brown slits on conventional magnifying endoscopy with non-staining NBI using the X1 system were useful for diagnosing colorectal *** new endoscopy system could be examined using new standards.

关键词： Adenoma Colonoscopy Narrow band imaging Magnifying endoscopy X1 Serrated polyp Colorectal neoplasm Endocytoscopy