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高血压患者血钾水平与短期死亡风险:丹麦全国登记数据的回顾性分析

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中华高血压杂志 2016年第10期24卷 982-984页

作者： Krogager ML torp-pedersen c Mortensen RN Kober L Gislason G Sogaard P Aasbjerg K

欧洲高血压发病率为30%~45%,治疗率为11%~66%。多种降压药,包括利尿剂、β受体阻滞剂、血管紧张素转换酶抑制剂（angiotensin-converting enzyme inhibitor,AcEI）和血管紧张素受体拮抗剂（angiotensin receptor blocker,ARB）均会引起... 详细信息

关键词：高血压患者血钾水平登记数据死亡风险血管紧张素转换酶抑制剂血管紧张素受体拮抗剂 receptor 丹麦

年龄对充血性心力衰竭住院患者短期和长期死亡率的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 31-32页

作者： Gustafsson F. torp pedersen c. Seibk M 丁倩

To describe the association between age and risk factors in patients hospitali sed with congestive heart failure(cHF) and to determine the effect of age on mor tality. consecutive patients admitted to 34 hospitals with cHF during a period o f 2 years were registered. Mean age was 71.7±10.2 years, 60%were male and 63% were in NYHA class III IV. Moderate to severe left ventricular(LV) systolic dysfunction was present in 41%. Short and long term survival status was obta ined after 30 days and 5-8 years, respectively. Older patients less frequently had LV systolic dysfunction, were under treated with AcE inhibitors and were mo re often female. The prevalence of hypertension, diabetes and ischaemic heart di sease increased with age, until the oldest age group (>80 years). Age was an ind ependent predictor of short term mortality (risk ratio (RR) per 10-year increa se was 1.23(95%cI 1.04-1.47)). Advancing age significantly increased long ter m mortality (RR 1.55 (1.50-1.61)). Age interacted with the LV ejection fraction (P=0.003). In patients with LV systolic dysfunction, the RR per 10-year increa se was 1.29(1.19-1.39) whereas in patients with preserved systolic function the RR was 1.57(1.43-1.72, multivariate analyses). The clinical characteristics of cHF patients vary considerably with age. Elderly patients hospitalised with cHF face a very grave prognosis, particularly if their heart failure symptoms are c aused by LV systolic dysfunction.

关键词：充血性心力衰竭收缩功能障碍左室收缩功能射血分数缺血性心脏病功能代偿多元分析

植入式除颤器与再同步治疗对左室功能障碍患者临床结局的影响:一项荟萃分析

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 16-17页

作者： Abdulla J. Haarbo J. Kφber L. torp-pedersen c. 罗亮 Lyφvej 18 3.TVDK-2000 Copenhagen FDenmark

背景:左心室收缩功能障碍(LVSD)患者从心脏再同步治疗(cRT)以及以预防为主的植入式除颤器(IcD)中临床获益的问题仍有争议。

关键词：再同步左室功能障碍临床结局植入式左心室收缩功能荟萃分析住院率心功能临床获益全因死亡

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抗高血压药物可推迟青光眼的发作

中华高血压杂志 2016年第12期24卷 1178-1178页

作者：刘莉叶鹏 Horwitz A Klemp M Jeppesen J Tsai Jc torp-pedersen c Kolko M

该研究旨在调查抗高血压药物对青光眼发病的影响。方法：纳入1996-2012年间年龄40~95岁完整丹麦人口数据,共覆盖〉260万人。应用丹麦国家医药产品统计登记表确定所有用青光眼药物和抗高血压药物的处方。首先,研究人员调查了数据中的基... 详细信息

该研究旨在调查抗高血压药物对青光眼发病的影响。方法：纳入1996-2012年间年龄40~95岁完整丹麦人口数据,共覆盖〉260万人。应用丹麦国家医药产品统计登记表确定所有用青光眼药物和抗高血压药物的处方。首先,研究人员调查了数据中的基本相关性,发现在研究期间的任何时间,即使控制了年龄和性别因素，高血压患者青光眼总体相对危险度（RR）显著增高（RR=1．31，P＜0．01）。

关键词：抗高血压药物青光眼治疗产品统计人口数据国家医药抗高血压治疗不连续性性别因素文中

Risk of pacemaker implantation after femur fracture in patients with and without a history syncope: a Danish nationwide registry-based follow-up study

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Journal of Geriatric cardiology 2022年第9期19卷 712-718页

作者： Sara LK clemmensen Kristian Kragholm Bhupendar Tayal christian torp-pedersen Søren Kold Peter Søgaard Sam Riahi Department of cardiology Aalborg University HospitalAalborgDenmark Unit of clinical Biostatistics and Epi-demiology Aalborg University HospitalAalborgDenmark Department of clinical Epidemiology Aalborg University HospitalAalborgDenmark Department of Orthopedics Aalborg University HospitalAalborgDenmark Depart-ment of clinical Institute Aalborg University HospitalAalborgDenmark

BAcKGROUND It has previously been described that fall-associated injuries including fractures are commonly observed among patients with ***,knowledge on the risk of pacemaker implantation after admission due to femur fracture from large population-based epidemiologic data is ***,we investigated the risk of pacemaker implanta-tion following femur fracture in patients with and without a history of previous *** All patients with femur fracture between 2005-2017 were identified using the Danish Nationwide Patient *** these,patients already having a pacemaker were *** outcome was one-year risk of pacemaker implanta-tion and secondary outcome was one-year all-cause *** logistic regression was used to obtain absolute and relative risks of the study endpoint in relation to patients with versus without history of syncope and standardized to the age,sex,selected comorbidity and pharmacotherapy distribution of all *** Of 93,093 patients with femur fracture,5508(5.9%)had a history of syncope within five *** with prior syn-cope were slightly older(84 vs.83 years),more often male(33.6%vs.29.4%),and had more often comorbidities relative to those without history of ***-cause mortality was significantly higher among those with previous history of syncope com-pared to those without previous syncope(29.9%vs.28.6%,P=0.021).The relative mortality risk was 1.05(95%cI:1.01−1.09,P=0.021).A total of 695(0.8%)patients underwent pacemaker implantation within 5 years following femur fracture,and a signific-antly higher proportion of patients with syncope had a pacemaker implanted within one year(1.6%vs.0.7%,PcI:1.55−2.46]).cONcLUSIONS In patients with femur fracture,a history of syncope was significantly associated with a higher one-year risk of pacemaker implantation.

关键词： patients syncope injuries

心电图预激表现与心血管病和死亡风险的关系:哥本哈根心电图研究结果

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中华高血压杂志 2017年第10期25卷 989-989页

作者：刘莉叶鹏 Skov MW Rasmussen PV Ghouse J Hansen SM Graff c Olesen MS Pietersen A torp-pedersen c HaunsS Kφber L Svendsen JH Holst AG Nielsen JB

大部分心室预激患者临床发病过程中的心电图资料来源于三级医疗中心。为了调查患有心电图预激的初级保健人群的长期预后，来自丹麦哥本哈根Rigshospitalet心脏中心分子心脏病学实验室的研究人员在2001—2011年收集了328638例初级保健患... 详细信息

大部分心室预激患者临床发病过程中的心电图资料来源于三级医疗中心。为了调查患有心电图预激的初级保健人群的长期预后，来自丹麦哥本哈根Rigshospitalet心脏中心分子心脏病学实验室的研究人员在2001—2011年收集了328638例初级保健患者的电子心电图数据，确定了310例心电图显示预激（年龄8～85岁）的个体。并从丹麦全国注册管理机构获取关于患者药物、合并症和临床结局的资料。随访中位数为7．4（四分位间距4．6～10．3）年。

关键词：心电图数据心室预激哥本哈根死亡风险心血管病三级医疗中心临床发病过程初级保健

因新型冠状病毒肺炎封锁前、中、后已确诊心血管病患者的全因死亡率:一项丹麦全国范围的队列研究

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中华高血压杂志 2021年第6期29卷 518-518页

作者：刘青(摘译) 郑武洪(审校) Butt JH FosbΦl EL Gerds TA Andersson c Kragholm K Biering-SΦrensen T Andersen J Phelps M Andersen MP Gislason G torp-pedersen c KΦber L Schou M 不详

2020年3月13日,丹麦当局在全国范围内实施了广泛的封锁措施,以防止冠状病毒疾病2019(coronavirus disease 2019,cOVID-19)的传播,并重新分配有限的医疗资源。研究者调查了在采取这些封锁措施之前、期间和之后,已确诊的心血管病患者的死... 详细信息

2020年3月13日,丹麦当局在全国范围内实施了广泛的封锁措施,以防止冠状病毒疾病2019(coronavirus disease 2019,cOVID-19)的传播,并重新分配有限的医疗资源。研究者调查了在采取这些封锁措施之前、期间和之后,已确诊的心血管病患者的死亡率和不同地点的死亡率。

关键词：心血管病患者冠状病毒队列研究医疗资源封锁肺炎丹麦

美托洛尔和卡维地洛对慢性心衰患者病因特异性死亡率和发病率的影响:cOMET研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 29-29页

作者： torp-pedersen c. Poole-Wilson P.A. Swedberg K. et al. 武敏 Dr. Department of cardiology Bispebjerg University Hospital 2400 Copenhagen NV Denmark

Background: β-Blockers with different receptor bindings reduce mortality in patients with chronic heart failure. We compared the effects of the β1-blocker metoprolol tartrate and the β1-, β2-, and α1-blocker carvedilol. Methods: In a randomized double-blind design, 3029 patients with chronic congestive heart failure requiring diuretic therapy and with left ventricular dysfunction were randomized to treatment with carvedilol(n=1511) or metoprolol tartrate(n=1518) and titrated to target doses of 25 mg of carvedilol twice daily or 50 mg of metoprolol tartrate twice daily. The main outcome measures were total mortality and the combination of mortality or hospitalization for any cause. Secondary end points were cardiovascular death, combinations of morbidity and mortality, New York Heart Association class, worsening of heart failure, hospitalizations, and discontinuation of study therapy. Results: A total of 512 and 600 patients in the carvedilol group and metoprolol group, respectively, died(hazard ratio[HR] 0.83, 95%cI 0.74-0.93, P=.0017). cardiovascular death was reduced by carvedilol(HR 0.80, 95%cI 0.70-0.90, P=.0004). There were fewer sudden deaths and deaths caused by circulatory failure or by stroke in the carvedilol group. There was no difference in all-cause hospitalizations or in worsening heart failure between treatment groups. The incidence of fatal or nonfatal acute myocardial infarction was significantly lower in the carvedilol group(HR 0.71, 95%cI 0.52-0.97, P=.03). Discontinuations of study therapy were similar in the 2 groups. conclusion: compared with metoprolol tartrate, carvedilol reduced cardiovascular mortality, sudden death, death caused by circulatory failure, death caused by stroke, as well as fatal and nonfatal myocardial infarctions.

关键词： cOMET 慢性心衰利尿治疗受体阻断剂慢性充血性心衰左心室功能不全特异性全因死亡住院率随机双盲

Understanding the mechanism of capacity increase during early cycling of commercial NMc/graphite lithium-ion batteries

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Journal of Energy chemistry 2022年第11期31卷 34-44,I0003页

作者： Jia Guo Yaqi Li Jinhao Meng Kjeld pedersen Leonid Gurevich Daniel-Ioan Stroe AAU Energy Aalborg UniversityAalborg9220Denmark Department of Materials and Production Aalborg UniversityAalborg 9220Denmark college of Electrical Engineering Sichuan UniversityChengdu 610065SichuanChina

A capacity increase is often observed in the early stage of Li-ion battery *** study explores the phenomena involved in the capacity increase from the full cell,electrodes,and materials perspective through a combination of non-destructive diagnostic methods in a full cell and post-mortem analysis in a coin *** results show an increase of 1%initial capacity for the battery aged at 100%depth of discharge(DOD)and 45℃.Furthermore,large DODs or high temperatures accelerate the capacity *** the incremental capacity and differential voltage(Ic-DV)analysis,we concluded that the increased capacity in a full cell originates from the graphite ***,graphite/Li coin cells show an increased capacity for larger DODs and a decreased capacity for lower DODs,thus in agreement with the full cell ***-mortem analysis results show that a larger DOD enlarges the graphite dspace and separates the graphite layer structure,facilitating the Li+diffusion,hence increasing the battery capacity.

关键词： capacity increasing Lithium-ion battery Full cell coin cell Graphite anode