年龄对充血性心力衰竭住院患者短期和长期死亡率的影响

作     者：Gustafsson F. Torp Pedersen C. Seibk M 丁倩 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2005年第1卷第2期

页      面：31-32页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：充血性心力衰竭 收缩功能障碍 左室收缩功能 射血分数 缺血性心脏病 功能代偿 多元分析 

摘      要：To describe the association between age and risk factors in patients hospitali sed with congestive heart failure(CHF) and to determine the effect of age on mor tality. Consecutive patients admitted to 34 hospitals with CHF during a period o f 2 years were registered. Mean age was 71.7±10.2 years, 60%were male and 63% were in NYHA class III IV. Moderate to severe left ventricular(LV) systolic dysfunction was present in 41%. Short and long term survival status was obta ined after 30 days and 5-8 years, respectively. Older patients less frequently had LV systolic dysfunction, were under treated with ACE inhibitors and were mo re often female. The prevalence of hypertension, diabetes and ischaemic heart di sease increased with age, until the oldest age group (80 years). Age was an ind ependent predictor of short term mortality (risk ratio (RR) per 10-year increa se was 1.23(95%CI 1.04-1.47)). Advancing age significantly increased long ter m mortality (RR 1.55 (1.50-1.61)). Age interacted with the LV ejection fraction (P=0.003). In patients with LV systolic dysfunction, the RR per 10-year increa se was 1.29(1.19-1.39) whereas in patients with preserved systolic function the RR was 1.57(1.43-1.72, multivariate analyses). The clinical characteristics of CHF patients vary considerably with age. Elderly patients hospitalised with CHF face a very grave prognosis, particularly if their heart failure symptoms are c aused by LV systolic dysfunction.