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Biomimetic Hydroxyapatite Coated Titanium Screws Demonstrate Rapid Implant Stabilization and Safe Removal In-Vivo

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 20-35页

作者： Jan Henrik Sorensen Lutz Durselen Ken Welch torben Christian Sorensen Philip Procter Hakan Engqvist maria Stromme Anita Ignatius Hartwig Steckel Department of Pharmaceutics and Biopharmaceutics Christian-Albrechts UniversityKielGermany Institute of Orthopaedic Research and Biomechanics Centre of Musculoskeletal ResearchUlmGermany Division for Nanotechnology and Functional materials The Angstrom LaboratoryUppsala UniversityUppsalaSweden Stryker Trauma GmbH SchonkirchenGermany Stryker Trauma AG SelzachSwitzerland Division for Applied materials Sciences The Angstrom LaboratoryUppsala UniversityUppsalaSweden

The early fixation of bone screws after surgical implantation still remains a challenge in the field of traumatology. Whilst hydroxyapatite (HA) coatings are known to enhance the fixation of implants;their removal at a later time-point may be problematic. An HA coating has been developed to demonstrate that both implant fixation and safe removal are feasible in the same design. Accordingly the aim of this study was to compare the In-Vivo performance of thin biomimetic HA coated titanium screws to uncoated counterparts used as control after bilateral implantation in the femoral condyle of 36 New Zealand White Rabbits. The screws were analysed macroscopically, by histology, micro-CT and biomechanically at both two and six weeks post-implantation. The HA coated screws demonstrated excellent biocompatibility. At two weeks the HA coated screws demonstrated a significant increase in removal torque values as well as a strong trend towards higher pull-out forces. In addition histology confirmed a higher degree of osseointegration and direct bone to implant contact. At six weeks no difference in pull-out force and removal torque could be detected. SEm images confirmed the absence of any residual HA coating indicating a fast coating degradation In-Vivo. The low level of removal torque after full osseointegration at 6 weeks supports the feasibility of safe and easy removal of the implant. The HA coating under study appears to offer a unique characteristic of enhanced fixation with a minimal increase in removal torque after full osseointegration. This may be of value in clinical applications where it is necessary to assure both screw fixation and later removal.

关键词： Biomimetic Hydroxyapatite In-Vivo Screw Implant Removal Pull-Out Force Removal Torque

A Novel Rodent model modifying Perioperative Temperature and Humidity during Bowel Surgery and mimicking Laparoscopic Conditions

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Surgical Science 2012年第7期3卷 353-357页

作者： torben Glatz Gabriel Seifert Philipp AHolzner SChikhladze Birte Kulemann Olivia Sick Jens Hoppner Ulrich Theodor Hopt Goran marjanovic Department of General and Visceral Surgery Albert Ludwigs UniversityFreiburgGermany

Laparoscopic surgery seems to have a general physiological benefit compared to conventional procedures in several clincal studies especially regarding intestinal anastomotic healing. Reliable experimental data concerning the particular mode of beneficial action are lacking. Clinical studies will not be able to identify the variables responsible for this effect. To establish a feasible, standardized experimental model to investigate variables such as humidity and perioperative room temperature, we employed an incubator designed for neonatal care. This allows individual manipulation and observation of above mentioned variables. Our initial results show that creating intestinal anastomoses in the incubator is safe and easy to perform, creating a valuable possibility to influence perioperative conditions for experimental and clinical research.

关键词： Intestinal Anastomosis Anastomotic Leak Laparoscopy Incubator Rat

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旧水塔,新宿舍水塔的改造

城市环境设计 2009年第5期 96-103页

作者： Jens markus Lindhe torben Eskerod 孙莹莹 Dorte mandrup Architects ApS (DmA) 北京航空航天大学外国语学院

工业改造新思路这个项目突破了一般工业改造思路,将废弃水塔改造成了一个学生公寓。设计充分保留了原有建筑特点,形成了独特的具有雕塑感的外形和舒适的室内空间,在设计思路和改造方式上都有独到之处,很有借鉴价值。

关键词：水塔娱乐中心住宅透明窗室内空间雕塑感宿舍原有建筑平面图图(数学) 水箱户型

Ropinirole Implants Reverse mPTP-Induced Parkinsonism in Rhesus monkeys

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Pharmacology & Pharmacy 2013年第3期4卷 1-8页

作者： Steven J. Siegel Lauren Nagy torben Skarsfeldt mark Pierce Carol O’ Neill Robert Lin Lori Langhamer Jeffery H. Kordower Department of Psychiatry University of Pennsylvania Philadelphia USA NuPathe Inc. Conshohocken USA Rush medical Center Chicago USA

Purpose: We compared efficacy and side effects of ropinirole implants with oral ropinirole in parkinsonian monkeys. methods: Twenty monkeys received injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloride (mPTP) to render them parkinsonian. monkeys were then placed into 3 groups based upon clinical rating scores (CRS). Group 1 received oral ropinirole and placebo implants. Group 2 receivedropinirole implants that released 1/9th of the animals’ optimal daily oral dose and oral placebo. Group 3 received placebo implants and oral placebo. monkeys were assessed for pharmacokinetic data, CRS, Global Dyskinesia Rating Scale, and skin irritation. Results: For the ropinirole implant group, the activity pattern was similar to that seen pre-mPTP;which extended through the weekends and was greater than control treated parkinsonian monkeys. Oral ropinirole yielded a high degree of variability for activity, with values following oral dosing being higher than the pre-mPTP periodbut levels similar to placebo treated parkinsonian animals during weekends, which were excluded from oral dosing. Implants and oral treatment achieved significant improvement in CRS between 11 - 60 days and 4 - 60 days respectively. Conclusion: Low dose ropinirole implants have the potential to provide continuous clinical improvement in bradykinesia with fewer “off periods” and lower risk for medication-induced psychosis than oral medication.

关键词： Ropinirole Implant Parkinson’s Disease mPTP Pharmacokinetic Dyskinesia

3D-printed facet-attached microlenses for advanced photonic system assembly

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Light(Advanced manufacturing) 2023年第2期4卷 1-17页

作者： Yilin Xu Pascal maier mareike Trappen Philipp-Immanuel Dietrich matthias Blaicher Rokas Jutas Achim Weber torben Kind Colin Dankwart Jens Stephan Andreas Steffan Amin Abbasi Padraic morrissey Kamil Gradkowski Brian Kelly Peter O’Brien Wolfgang Freude Christian Koos Institute of Photonics and Quantum Electronics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstr.576131 KarlsruheGermany Institute of microstructure Technology(ImT) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Vanguard Automation GmbH Gablonzer Strasse.1076185 KarlsruheGermany ficon TEC Service GmbH Im Finigen 328832 AchimGermany II-VI Inc. Reuchlinstraße 10/1110553 BerlinGermany Photonics Research Group Ghent University-imecTechnologiepark-Zwijnaarde 126B-9052 GentBelgium Tyndall National Institute T12 R5CP CorkIreland Eblana Photonics Ltd. West Pier Business Campus3 Old Dunleary RdDún LaoghaireDublinA96 A621Ireland

Wafer-level mass production of photonic integrated circuits(PIC)has become a technological mainstay in the field of optics and photonics,enabling many novel and disrupting a wide range of existing ***,scalable photonic packaging and system assembly still represents a major challenge that often hinders commercial adoption of PIC-based ***,chip-to-chip and fiber-to-chip connections often rely on so-called active alignment techniques,where the coupling efficiency is continuously measured and optimized during the assembly *** unavoidably leads to technically complex assembly processes and high cost,thereby eliminating most of the inherent scalability advantages of PIC-based *** this paper,we demonstrate that 3D-printed facet-attached microlenses(FamL)can overcome this problem by opening an attractive path towards highly scalable photonic system assembly,relying entirely on passive assembly techniques based on industry-standard machine vision and/or simple mechanical *** can be printed with high precision to the facets of optical components using multi-photon lithography,thereby offering the possibility to shape the emitted beams by freely designed refractive or reflective ***,the emitted beams can be collimated to a comparatively large diameter that is independent of the device-specific mode fields,thereby relaxing both axial and lateral alignment ***,the FamL concept allows to insert discrete optical elements such as optical isolators into the free-space beam paths between PIC *** show the viability and the versatility of the scheme in a series of selected experiments of high technical relevance,comprising pluggable fiber-chip interfaces,the combination of PIC with discrete micro-optical elements such as polarization beam splitters,as well as coupling with ultra-low back-reflection based on non-planar beam paths that only comprise tilted optical *** on our re

关键词： Photonic integration Photonic assembly Photonic packaging Additive laser manufacturing multi-photon lithography Facet-attached microlenses Optical alignment tolerances Fiber-chip coupling Hybrid multi-chip modules

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儿童文化之家

住区 2013年第5期 72-75页

作者： Dorte mandrup torben Eskerod Courtesy of Dorte mandrup Jens Lindhe

儿童文化之家通过插入和切割周边建筑的形体，达到了调和它们之间关系的目的。建筑的核心是现状建筑几何延长线的交点，形体被压低以允许阳光最大程度地投射到相邻的院子。儿童文化之家是令人惊奇也是充满想象力的：屋顶和立面被等同处... 详细信息

儿童文化之家通过插入和切割周边建筑的形体，达到了调和它们之间关系的目的。建筑的核心是现状建筑几何延长线的交点，形体被压低以允许阳光最大程度地投射到相邻的院子。儿童文化之家是令人惊奇也是充满想象力的：屋顶和立面被等同处理，建筑也没有通常所谓的“起点”和“结束”。

关键词：儿童文化建筑延长线想象力形体几何

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一种满足欧盟铁路防火标准EN45545的高流动性共聚PC材料

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一种满足欧盟铁路防火标准EN45545的高流动性共聚PC材料

轨道客车安全防火及阻燃技术学术研讨会

作者： mark van der mee torben Kempers Paul Sybert SABIC Plasticslann 14612PXBergen op Zoomthe Netherlands SABIC 1 Lexan LaneMount VernonINUnite States.

一种新型的共聚聚碳酸酯树脂已经被研发出来,它能够满足新的欧盟铁路防火标准EN45545并达到危险等级（HL3）,这个欧盟防火标准包括热释放,烟密度,烟毒性的测试。这种新材料具有高流动性同时保持优秀的抗冲击特性,因此它是一种理想的对EN... 详细信息

一种新型的共聚聚碳酸酯树脂已经被研发出来,它能够满足新的欧盟铁路防火标准EN45545并达到危险等级（HL3）,这个欧盟防火标准包括热释放,烟密度,烟毒性的测试。这种新材料具有高流动性同时保持优秀的抗冲击特性,因此它是一种理想的对EN45545法规有要求的车辆座椅背板的候选材料。最重要的是这是一种完全不含卤素的阻燃技术。

关键词： SABICTm EN45545 LexanTmFST3403 高流动性物理性能

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氨制冷系统在工业领域的成功应用

制冷与空调 2019年第1期19卷 61-66页

作者： Niels P Vestergaard torben Funder-Kristensen 肖伦黄志华丹佛斯自动控制管理(上海)有限公司

在冷链规模不断扩大、制冷剂环保要求不断上升的趋势下,氨以其独特的制冷特性和高效能,不仅是大型工业制冷的主流制冷剂,近年来更是广泛应用于小型制冷系统中。氨是优质的天然工质,制冷效率高,但同时氨也是有毒气体,本文就如何更安全更... 详细信息

在冷链规模不断扩大、制冷剂环保要求不断上升的趋势下,氨以其独特的制冷特性和高效能,不仅是大型工业制冷的主流制冷剂,近年来更是广泛应用于小型制冷系统中。氨是优质的天然工质,制冷效率高,但同时氨也是有毒气体,本文就如何更安全更有效地使用氨展开了论述。理想情况下是所有制冷系统的设计都应该遵循"四标准三能力"。在计划设计一个新的氨制冷系统时,工艺、安全和对环境产生的影响等要求都必须要考虑进去。系统设计方法和原则是决定整个系统安全的关键。要确保制冷系统安全运行,就要对风险和危害进行细节分析,包括对在系统投运前和投运后的"近似事故"进行研究调查。不仅如此,还要关注所有安全项,对所有的安全因素逐个评估,并确保最佳实践得以实施,确保整个系统处于低风险等级。

关键词：氨天然工质制冷高效能安全低风险

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三块区域,三种色彩,同一个社区——哥本哈根Superkilen公园

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设计家 2013年第2期 56-61页

作者： Iwan Baan Hasse Ferrold Jens Lindhe maria da Schio torben Eskerod mike magnussen Topotek 1 BIG Architects Superflex

Superkilen是一个一公里长的城市空间,是BIG,Topotek 1和Superflex三家合作单位创造力的结晶。从早期的概念到建设阶段,它把建筑、景观和艺术罕见地融合在一起,其中包含了60多个不同文化背景城市的展览,在丹麦哥本哈根市中心掀起了一项... 详细信息

Superkilen是一个一公里长的城市空间,是BIG,Topotek 1和Superflex三家合作单位创造力的结晶。从早期的概念到建设阶段,它把建筑、景观和艺术罕见地融合在一起,其中包含了60多个不同文化背景城市的展览,在丹麦哥本哈根市中心掀起了一项别开生面的挑战和展示。三个色彩鲜明的区域分别有着自己独特的氛围和功能。

关键词：哥本哈根色彩公园社区城市空间文化体育文化背景活动空间

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