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Luminal oxidants selectively modulate electrogenic ion transport in rat colon

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World Journal of Gastroenterology 2006年第34期12卷 5523-5527页

作者： Julio m mayol Yolanda Adame-Navarrete Pilar Alarma-Estrany Elena molina-Roldan Fernando Huete-toral Jesus A Fernandez-Represa Servicio De Cirugia I Hospital Clinico San Carlos Universidad Complutense De Madrid Madrid 28040 Spain

AIm： To investigate the effects of luminal exposure to H2O2 and two related thiol oxidizing agents on basal and stimulated chloride secretion in native colon using electrophysiological and pharmacological approaches. mETHODS： Unstripped rat distal colon segments were mounted in Ussing chambers. Potential difference, calculated resistance and short-circuit current across unstripped colon segments were monitored with a dual voltage/current clamp. Paracellular permeability was assessed by measuring the mucosa-to-serosa flux of a fluorescent probe （FITC）. RESULTS： Luminal exposure to hydrogen peroxide transitorily stimulated chloride secretion without altering barrier function. This stimulatory effect could be blocked by basolateral atropine but not indomethacin. The cysteine and methionine oxidizing compounds, phenylarsine oxide and chloramine T respectively, mimicked the effect of H2O2, except for a drop in transcolonic resistance after 30 min. In contrast to the observed stimulatory effect on basal secretion, cAmP-stimulated electrogenic ion transport was blunted by luminal H2O2. However, the Ca^2＋- activated response remained unchanged. CONCLUSION： H2O2 may be an important selective modulator of intestinal ion and water secretion in certain pathologic conditions such as inflammation or ischemiareperfusion by multiple mechanisms.

关键词： Chloride secretion Ion transport Rat distal colon Hydrogen peroxide Acetylcholine Atropine

Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5296-5303页

作者： Jaime toral-Lopez Luz maría González Huerta Olga messina-Baas Sergio A Cuevas-Covarrubias Departamento de Genética medica Centro Medico EcatepecISSEMYMEcatepec 55000México Programa de maestría y Doctorado en Ciencias médicas Odontológicas y de la Salud/Hospital Infantil de MéxicoUniversidad Nacional Autónoma de MéxicoMéxico 06720México Departamento de Biología molecular Hospital General de MéxicoCuauhtémoc 06720México Departamento de Oftalmología Hospital General de MéxicoCuauhtémoc 06720México Genetica Hospital General de MéxicoCuauhtémoc 06726Mexico Sergio A Cuevas-CovarrubiasPrograma de Maestría y Doctorado en Ciencias MédicasOdontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoMéxico 06720Mexico

BACKGROUND We described the main features of an infant diagnosed with facial dysmorphic,language failure,intellectual disability and congenital malformations to strengthen our understanding of the ***,treatment is only rehabilitation and surgery for cleft lip and *** SUmmARY The proband was a 2-years-8-months-old *** history was negative for congenital malformations or intellectual *** patient had microcephaly,upward-slanting palpebral fissures,depressed nasal bridge,bulbous nose and bilateral cleft lip and *** magnetic resonance imaging showed cortical atrophy and band *** motor and intellectual development is delayed.A submicroscopic deletion in 11p13 involving the elongator acetyltransferase complex subunit 4 gene(ELP4)and a loss of heterozygosity in Xq25-q26.3 were *** There is no treatment for the ELP4 deletion caused by a submicroscopic 11p3 *** describe a second case of deletion of the ELP4 gene without aniridia,which confirms the association between ELP4 gene with several defects and absence of this ocular *** clinical data in the deletion of the ELP4 gene as cleft palate,facial dysmorphism,and changes at level brain could be associated to this gene or be part of the effect of the recessives genes involved in the loss of heterozygosity region of Xq25-26.3.

关键词： Submicroscopic 11p13 deletion Elongator acetyltransferase complex subunit 4 gene Language failure Intellectual disability Congenital malformations Case report

Insects as alternative feed for ruminants:comparison of protein evaluation methods

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1143-1150页

作者： Pablo G.toral Gonzalo Hervás mariana Gabriela González-Rosales Alejandro G.mendoza Lizbeth E.Robles-Jiménez Pilar Frutos Instituto de Ganadería de montaña(CSIC-University of León) Finca Marzanas s/n24346 GrullerosLeónSpain Facultad de medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de MéxicoNo.100 Instituto Literario 100Col.Centro50000 TolucaEstado de MéxicoMexico.

Background:The high dependence of intensive ruminant production on soybean meal and the environmental impact of this crop encourage the search for alternative protein-rich *** use of insects seems promising,but the extent of their ruminal protein degradation is largely *** parameter has major influence not only on N utilization efficiency but also on the environmental burden of ruminant *** addition,although assessing ruminal N degradation represents a key first step to examine the potential of new feeds,it is a challenging task due to the lack of a reference *** study was conducted to investigate the potential of 4 insects(Tenebrio molitor,Zophobas morio,Alphitobius diaperinus and Acheta domesticus)as alternative protein sources for ruminants,using 3 methodologies:1)a regression technique based on the in vitro relationship between gas production and ammonia-N concentration;2)a conventional in vitro technique of batch cultures of ruminal microorganisms,based on filtering the incubation residue through sintered glass crucibles;and 3)the in situ nylon bag *** in vitro intestinal digestibility of the non-degraded protein in the rumen was also *** meal was used as a reference ***:Comparison of evaluation methods(regression,in vitro and in situ)did not allow to reliably select a single value of ruminal N degradation for the studied substrates,but all techniques seem to establish a similar ranking,with good correlations between methods,particularly between regression and in situ *** of the methodology,nitrogen from the 4 insects(with contents ranging from 81 to 112 g/kg of dry matter)did not show high ruminal degradation(41–76%),this value being always lower than that of soybean ***,the in vitro intestinal digestibility of non-degraded N was relatively high in all feeds(≥64%).Conclusion:Overall,these results support the potential of the 4 studied insects as alternative feedstu

关键词： In situ In vitro Livestock Nitrogen degradation Sheep

Inexpensive and flexible nanographene-based electrodes for ubiquitous electrocardiogram monitoring

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npj Flexible Electronics 2019年第1期3卷 100-105页

作者： Francisco J.Romero Encarnacion Castillo Almudena Rivadeneyra Alejandro toral-Lopez markus Becherer Francisco G.Ruiz Noel Rodriguez Diego P.morales Pervasive Electronics Advanced Research Laboratory University of Granada18071 GranadaSpain Department of Electronics and Computer Technology University of Granada18071 GranadaSpain Institute for Nanoelectronics Technische Universität München80333 MunichGermany Biochemistry and Electronics as Sensing Technologies Group University of Granada18071 GranadaSpain

Flexible electronics is one of the fundamental technologies for the development of electronic skin,implant wearables,or ubiquitous *** this context,graphene-derived materials have attracted great interest due to their unique properties to fulfill the demands of these *** we report a simple one-step method for the fabrication of electrophysical electrodes based on the photothermal production of porous nanographene structures on the surface of flexible polyimide *** approach constitutes an inexpensive alternative to the commercial medical electrodes,leading to a lower and much more stable skin–electrode contact resistance and providing comparable signal *** technology has been framed inside the IoT paradigm through the development of a denoising and signal classification clustering algorithm suitable for its implementation in wearable *** experiments have shown promising achievements regarding noise reduction,increasing the crest factor~3.7 dB,as well as for the over 90%heart rate-monitoring accuracy.

关键词： ubiquitous IoT electrodes

THE SCENERY FLOW FOR GEOmETRIC STRUCTURES ON THE TORUS: THE LINEAR SETTING

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Chinese Annals of mathematics,Series B 2001年第4期22卷 427-470页

作者： P.ARNOUX A.m.FISHER InstitutdemathematiquesdeLuminy（UPR9016） 163AvenuedeLuminycase90713288MarseilleCedex9France. DeptmatImE-USP CaixaPostal66281CEP05315-970SaoPauloBrazil.

The authOrs define the scenery flow of the torus. The flow space is the union of all flat 2- dimensional tori of area 1 with a marked direction (or equivalently the union of all tori with a quadratic differential of norm 1). This is a 5-dimensional space, and the flow acts by following individual points under an extremal deformation of the quadratic differential. The authors define associated horocycle and translation flows; the latter preserve each torus and are the horizontal and vertical flows of the corresponding quadratic differential. The scenery flow projects to the geodesic flow on the modular surface, and admits, for each orientation preserving hyperbolic toral automorphism, an invariant 3-dimensional subset on which it is the suspension flow of that map. The authors first give a simple algebraic definition in terms of the group of affine maps of the plane, and prove that the flow is Anosov. They give an explicit formula for the first-return map of the flow on convenient cross-sections. Then, in the main part of the paper, the authors give several different models for the flow and its cross-sections, in terms of : stacking and rescaling periodic tilings of the plane; symbolic dynamics: the natural extension of the recoding of Sturmian sequences, or the S-adic system generated by two substitutions; zooming and subdividing quasi-periodic tilings of the real line, or aperiodic quasicrystals of minimal complexity; the natural extension of two-dimensional continued fractions; induction on exchanges of three intervals; rescaling on pairs of transverse measure foliations on the torus, or the Teichmuller flow on the twice-punctured torus.

关键词： modular surface Continued fractions Sturmian sequences Plane tilings Teichmuller flow Substitution dynamical system

X linked recessive ichthyosis: Current concepts

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World Journal of Dermatology 2015年第3期4卷 129-134页

作者： Jaime toral-López Luz maría González-Huerta Sergio A Cuevas-Covarrubias Departamento de Genética médica Centro Médico Ecatepec Instituto de Seguridad Social del Estado de México y Municipios Ecatepec Estado de México CP 55000 México Departamento de Genética médica Hospital General de México/Facultad de Medicina Universidad Nacional Autónoma de México Ciudad de México CP 06726 México

In the present review, we describe the most importantaspects of the X-linked ichthyosis(XLI) and make a compilation of the some historic details of the disease. The aim of the present study is an update of the XLI. Historical, clinical, epidemiological, and molecular aspects are described through the text. Recessive XLI is a relatively common genodermatosis affecting different ethnic groups. With a high spectrum of the clinical manifestations due to environmental factors, the disease has a genetic heterogeneity that goes from a point mutation to a large deletion involving several genes to produce a contiguous gene syndrome. most XLI patients harbor complete STS gene deletion and flanked sequences; seven intragenic deletions and 14 point mutations with a complete loss of the steroid sulfatase activity have been reported worldwide. In this study, we review current knowledge about the disease.

关键词： STS gene X-linked ichthyosis Steroid sulfatase Gene deletion Contiguous gene syndrome Genodermatosis

Study on mechanism of mercury oxidation by fly ash from coal combustion

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Chinese Science Bulletin 2010年第2期55卷 163-167页

作者： ZHAO YongChun ZHANG JunYing LIU Jing DIAZ-SOmOANO mercedes mARTINEZ-TARAZONA m. Rosa ZHENG ChuGuang State Key Laboratory of Coal Combustion Huazhong University of Science & Technology Wuhan 430074 China Instituto Nacional del Carbon ( CSIC) Francisco Pintado Fe 26 33011 Oviedo Spain

To understand the interaction of fly ash and mercury, systematic experiments on mercury oxidation in single flue gas composition are conducted on a fixed bed reactor system, the desorption rate and speciation of mercury are valuated. The results indicate that fly ash itself can significantly promote elemental mercury oxidation. A classification of fly ash activated sites is developed according to the speciation of mercury during adsorption-desorption tests, the reaction mechanism of mercury oxidation by fly ash is proposed. Acid gas can promote mercury oxidation and improve the stability of oxidation product. Lattice oxygen is an important oxidant of mercury oxidation.

关键词：氧化机制粉煤灰煤炭燃烧汞反应器系统氧化反应机理相互作用烟气成分

A visible light-mediated three-component strategy based on the ring-opening of cyclic ethers with aryldiazoacetates and nucleophiles

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Organic Chemistry Frontiers 2022年第5期9卷 1321-1326页

作者： mateus L.Stivanin Rafael D.C.Gallo Joao Paulo m.Spadeto Rodrigo A.Cormanich Igor D.Jurberg State University of Campinas Institute of ChemistryRua Monteiro Lobato 27013083-862 CampinasSPBrazil

A blue light-promoted reaction between aryldiazoacetates and different nucleophiles has been developed in the presence of THF(and other cyclic ethers)as the solvent,allowing the incorporation of these three elements into a single ***,this transformation represents an O–H insertion strategy of more complex alcohols into aryldiazoesters,without the need of pre-assembling *** method is mild and efficient and proceeds in the absence of metals,generally at room temperature.

关键词： temperature visible light

博士生教育去向何方?——全球变化背景下欧洲的新举措

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北京大学教育评论 2007年第4期5卷 66-74页

作者：芭芭拉·m·科姆朱知翔（译）德国卡塞尔大学高等教育与职业研究中心卡塞尔34109 不详

本文第一部分概括了欧洲和北美的博士生教育与训练正在变化中的政策背景,并指出目前这两大地区关于博士生教育的争论和关注点的异同。第二部分分析了博士生教育动机与目的之间的区别,正是这些区别导致了基于研究型博士学位和专业博士学... 详细信息

本文第一部分概括了欧洲和北美的博士生教育与训练正在变化中的政策背景,并指出目前这两大地区关于博士生教育的争论和关注点的异同。第二部分分析了博士生教育动机与目的之间的区别,正是这些区别导致了基于研究型博士学位和专业博士学位显著差异之上的博士生教育模式的不同。第三部分介绍了大量关于博士生教育改革的合作、项目及提议,以此说明目前变化的趋势。最后一部分得出了若干结论,特别强调知识生产已经成为逐渐兴起的知识经济中的一项战略资源,因此也成为政策制定和制度安排的目标。这一进展将导致一些教育机构中对研究和研究训练的关注。

关键词：博洛尼亚进程博士生教育合作