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Coarse to Fine: The Role of Severe Plastic Deformation in Advancing Titanium-Based Medical implants - A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan i Međo ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča institute of Nuclear Sci-ences-National institute of the Republic of Serbia University of Belgrade11001BeogradSerbia innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico i.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Apolipoprotein A-i binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury i.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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动态坐具的舒适度评价及使用动作分析

家具 2025年第1期 82-86+104页

作者：魏佳丽林珈好 Onder tor 齐蔚王郑兴胡玲玲浙江农林大学化学与材料工程学院卡斯塔莫努大学森林工程系恒林家居股份有限公司

在办公场景中，为减少久坐中身体活动缺乏所带来的不良影响，“坐具的动态支撑”作为新型技术备受关注。从坐具的结构差异和人的使用2个角度出发，采用语义差异法对3种动态坐具和1种非动态坐具作为对照组的就坐体验进行主观舒适度评价... 详细信息

在办公场景中，为减少久坐中身体活动缺乏所带来的不良影响，“坐具的动态支撑”作为新型技术备受关注。从坐具的结构差异和人的使用2个角度出发，采用语义差异法对3种动态坐具和1种非动态坐具作为对照组的就坐体验进行主观舒适度评价，探究动态坐具的结构与功能对人体舒适度的影响；通过观察记录使用动态坐具时的身体动作，采用聚类分析法分析了身体动作的方向、幅度、频率等关键要素，最终为动态坐具产品的研发和使用指南提供科学依据。结果显示椅类动态坐具比凳类动态坐具和瑜伽球的坐姿舒适度更高；动态坐具的座面前倾和不稳定显著降低坐姿舒适度；使用动态坐具时，64.7%的实验对象选择身体动作的方向为前后摆动。建议当使用者处于办公状态时，上半身保持相对稳定，下半身可进行小幅度、高频率的前后摆动，并在动态坐具研发中提高椅脚与地板接触面之间的摩擦力，增加脚轮锁定功能，从而加强坐具抓地力以便于高频活动。

关键词：动态坐具结构与功能舒适度动作要素

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Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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Neural Regeneration Research 2023年第8期18卷 1719-1720页

作者： Vítor Costa Vitor Teixeira i3S-instituto de investigação e inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal iCBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

Hormonal Regulation of Tissue-type Plasminogen Activator and Plasminogen Activator inhibitor Type-1 Gene Expression in Cultured Mouse Sertoli Cells

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Science China Chemistry 1993年第3期36卷 319-328页

作者：刘以训杜群胡召元 Ny tor Department of Endocrinology Institute of Zoology Academia Sinica Beijing 100080 PRC State Key Laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing 100080 PRC Unit for Applied Cell and Molecular Biology Umea University S90187 Umea Sweden

We have demonstrated for the first time that (ⅰ) mouse Sertoli cells predominantly secrete tPA under the action of FSH and cAMP-generating agents, whereas Leydig cells mainly produce uPA; (ⅱ) Sertoli cells are also capable of secreting PAi-1, as well as FSH, growth factors and GnRH increase PAi-1 gene expression; (ⅲ) the increases in tPA and PAi-1 activities by different hormones in the conditioned media of Sertoli cells correspond to the increases in the levels of tPA and PAi-1 mRNA in the cultured cells, suggesting that the synthesis of the activator-inhibitor in mouse Sertoli cells is regulated at a transcriptional level and the tPA secreted by Sertoli cells may be involved in the spermatogenesis.

关键词： Sertoli cells tPA PAl-1 spermiation spermatogenesis.

CVaR-based stochastic wind-thermal generation coordination for Turkish electricity market

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1307-1318页

作者： Aycan AYDOGDU Osman Bulent tor Ali Nezih GUVEN Department of Electrical and Electronics Engineering Middle East Technical UniversityAnkara 06800Turkey The Bucharest University of Economic Studies BucharestRomania

Uncertainties in wind power forecasting,dayahead and imbalance prices for the next day possess a great deal of risks for the profit of generation companies participating in a day-ahead electricity *** companies are exposed to imbalance penalties in the balancing market for unordered mismatches between associated day-ahead power schedule and real-time *** of wind and thermal power plants alleviates the risks raised from wind *** paper proposes a novel optimal coordination strategy by balancing wind power forecasting deviations with thermal units in the Turkish day-ahead electricity *** main focus of this study is to provide an optimal trade-off between the expected profit and the risk under wind uncertainty through conditional value at risk(CVa R)*** problem is formulated as a two-stage mixed-integer stochastic programming problem,where scenario-based wind power approach is used to handle the stochasticity of the wind *** programming approach is utilized to attain the commitment status of thermal *** of the coordination with different day-ahead bidding strategies and trade-off between expected profit and CVa R are examined with comparative scenario studies.

关键词： Conditional value at risk(CVaR) Windthermal coordination Electricity market Wind power Thermal power

Nano-Enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

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Journal of Thermal Science 2025年第1期34卷 283-302页

作者： Veeranna MODi Prasad B.RAMPURE Sunil Kumar SHETTY Madeva NAGARAL Channa Keshava NAiK N Johar MGM Muhammad irsyad ABDULLAH Abdullah i.AL-MANSOUR Shamshad ALAM KLE College of Engineering and Technology ChikodiVisvesvaraya Technological University Nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester Biodiesel 20%+Neat Diesel 80%（in volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon,and increased NOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20NP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal Efficiency（BTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME B20 and other DSME B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTE,BSFC）,and emissions（CO,CO2,NOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTE and BSFC shows that CatBoost-based BTE models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

关键词： Al2O3 concentration Ci engine Dairy Scum Methyl Ester Biodiesel

The Euclidean Distance Spectra of FDMA-CPM: Algorithms and Applications

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Chinese Journal of Electronics 2014年第4期23卷 821-826页

作者： Li Bing BAi Baoming tor Aulin iSN State Key Laboratory of Xidian University TCT Computer Science and Engineering Chalmers University of Technology

The performance of multiuser Continuous phase modulation(CPM) over the additive white Gaussian noise channel with coherent maximum likelihood detection is considered. Algorithms are developed to calculate the Euclidean distance spectra employing tree-search and Astar algorithm. The complexity of proposed algorithms are further reduced using trellis minimization. The distance spectrum is then used to evaluate the performance of multiuser CPM systems, which reveals that the performance of multiuser CPM can be significantly improved by using optimized parameters. Both equally-powered and non-equally powered systems are considered. Numerical and simulated results confirm that the proposed algorithms can generate the distance spectra of all systems with lower complexity relative to previous methods and are particularly suited for multi user CPM systems.

关键词： Continuous phase modulation Minimum achievable Euclidean distance Achievable spectral efficiency Frequency division multiple acc