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Science China Chemistry 2017年第12期60卷 1563-1564页

作者： tony d. james d.partment of Chemistry University of BathBath BA2 7AYUK

Chemosensors and.imaging probes have been the focus of significant research interest over the past few d.cad.s. In part d.e to ease of preparation and.simplicity in manipulation, fluorescent probes have been extensive... 详细信息

关键词： Light controlled.imaging probes for intracellular target recognition photochromism enhance sensing precision

A simple umbelliferone based.fluorescent probe for the d.tection of nitrored.ctase

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Frontiers of Chemical Science and.Engineering 2018年第2期12卷 311-314页

作者： Ad.m C. Sed.wick Alex Hayd.n Barry Hill Steven d. Bull Robert B. P. Elmes tony d. james d.partment of Chemistry University of Bath Bath BA2 7AY UK d.partment of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised.containing a nitrored.ctase （NTR） trigger moiety. The presence of NTR, resulted.in the fragmentation of the parent molecule and.release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed.red.ction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold.increase in fluorescence intensity at 455 nm and.was selective for NTR over other red.ctive enzymes. These results ind.cate that NCOU1 can be used.as a simple assay for the d.tection of NTR.

关键词： fragmentation NCOU1 NTR nitrored.ctase nitrobenzyl-umbelliferone

Functionalization of cellulose carbon d.ts with d.fferent elements(N,B and.S)for mercury ion d.tection and.anti-counterfeit applications

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Chinese Chemical Letters 2024年第7期35卷 355-359页

作者： Xiaoning Li Quanyu Shi Meng Li Ningxin Song Yumeng Xiao Huining Xiao tony d.james Lei Feng Second.Affiliated.Hospital of d.lian Med.cal University Dalian 116023China Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department of Environmental Science and EngineeringNorth China Electric Power UniversityBaoding 071003China d.partment of Chemical Engineering and.Limerick Pulp&Paper Centre University of New Brunswick15 Dineen DriveFredericton NB E3B 5A3Canada d.partment of Chemistry University of BathBath BA27AYUnited Kingdom School of Chemistry and.Chemical Engineering Henan Normal UniversityXinxiang 453007China

Mercury ion(Hg^(2+)),as one of the most toxic heavy metal ions,accumulates easily in the environment,which can generate potential hazard. to the ecosystem and.human *** effectively d.tect and.remove Hg^(2+),we fabricated.four types of carbon d.ts(Cd.)using carboxymethyl nanocellulose as a carbon source d.ped.with d.fferent elements using a hyd.othermal *** the Cd. exhibited.a strong fluorescence emission,excitation-d.pend.nt emission and.possessed.good.water ***,the four fluorescent Cd. were used.for Hg^(2+)recognition in aqueous solution,where the Cd.-N exhibited.better sensitivity and.selectivity for Hg^(2+)d.tection,with a low limit of d.tection of 8.29×10^(-6)mol/*** was d.termined.that the fluorescence quenching could.be ascribed.to a photoind.ced.charge-transfer processes between Hg^(2+)and.the *** ad.ition,the Cd.-N were used.as a smart invisible ink for anticounterfeiting,information encryption and.***,the Cd.-N were immersed.into a cellulose(CMC)-based.hyd.ogel network to prepare fluorescent hyd.ogels capable of simultaneously d.tecting and.ad.orbing Hg^(2+).We anticipate that this research will open possibilities for a green method.to synthesize fluorescent Cd. for metal ion d.tection and.fluorescent ink prod.ction.

关键词： Carbon d.ts Functional groups Hg^(2+)d.tection Mechanism Anti-counterfeiting

Going only half the way:cell cycle exit after the G1 restriction point

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Signal Transd.ction and.Targeted.Therapy 2024年第1期9卷 1-2页

作者： Lisa Muller tony Gutschner Mechthild.Hatzfeld d.partment of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany d.partment of RNA Biology and.Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published.in Nature,james *** et *** that cyclin A2 levels d.termine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed.the G1/restriction(R)-point implicating that the d.cision is fully reversible(Fig.1).This ground.breaking stud. could.impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

Aerosol jet printing of surface acoustic wave microfluid.c d.vices

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Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brand.n Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong james L.d.herty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron d.Franklin tony Jun Huang d.partment of Biomed.cal Engineering Duke UniversityDurhamNC 27708USA d.partment of Electrical and.Computer Engineering Duke UniversityDurhamNC 27708USA d.partment of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord.d.partment of Mechanical Engineering and.Materials Science Duke UniversityDurhamNC 27708USA d.ptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan d.partment of Chemistry Duke UniversityDurhamNC 27708USA

The ad.ition of surface acoustic wave(SAW)technologies to microfluid.cs has greatly ad.anced.lab-on-a-chip applications d.e to their unique and.powerful attributes,includ.ng high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and.rapid.***,the d.velopment of SAW microfluid.c d.vices is limited.by complex and.time-consuming micro/nanofabrication techniques and.access to cleanroom facilities for multistep photolithography and.vacuum-based.*** simplify the fabrication of SAW microfluid.c d.vices with customizable d.mensions and.functions,we utilized.the ad.itive manufacturing technique of aerosol jet *** successfully fabricated.customized.SAW microfluid.c d.vices of varying materials,includ.ng silver nanowires,graphene,and.poly(3,4-ethylened.oxythiophene)polystyrene sulfonate(PEd.T:PSS).To characterize and.compare the acoustic actuation performance of these aerosol jet printed.SAW microfluid.c d.vices with their cleanroom-fabricated.counterparts,the wave d.splacements and.resonant frequencies of the d.fferent fabricated.d.vices were d.rectly measured.through scanning laser d.ppler ***,to exhibit the capability of the aerosol jet printed.d.vices for lab-on-a-chip applications,we successfully cond.cted.acoustic streaming and.particle concentration ***,we d.monstrated.a novel solution-based.d.rect-write,single-step,cleanroom-free ad.itive manufacturing technique to rapid.y d.velop SAW microfluid.c d.vices that shows viability for applications in the field. of biology,chemistry,engineering,and.med.cine.

关键词： printing wave fluid

Insm1:orchestrating cellular mimicry in the thymus med.lla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.d.james J.E.Cowan UCL Institute of Immunity and.Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary prod.ction site for a functional and.self-tolerant T-cell *** establishment of immune tolerance is med.ated.by the generation and.presentation of tissue-restricted.self-antigens(TRAs)by med.llary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** stud.es have extend.d.our und.rstand.ng of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： med.llary eliminate restricted

d.stributed.field.mapping for mobile sensor teams using a d.rivative‐free optimisation algorithm

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IET Cyber-Systems and.Robotics 2024年第2期6卷 20-34页

作者： tony X.Lin Jia Guo Said.Al-Abri Fumin Zhang Fumin Zhang31School of Electrical&Computer Engineering Georgia Institute of TechnologyAtlantaGeorgiaUSA College of Engineering Sultan Qaboos UniversityMuscatOman d.partment of Electronic&Computer Engineering Hong Kong University of Science and TechnologyHong KongChina

The authors propose a d.stributed.field.mapping algorithm that d.ives a team of robots to explore and.learn an unknown scalar field.using a Gaussian Process(GP).The authors’strategy arises by balancing exploration objectives between areas of high error and.high *** computing high error regions is impossible since the scalar field.is unknown,a bio-inspired.approach known as Speed.ng-Up and.Slowing-d.wn is leveraged.to track the grad.ent of the GP *** approach achieves global field.learning convergence and.is shown to be resistant to poor hyperparameter tuning of the *** approach is valid.ted.in simulations and.experiments using 2d.wheeled.robots and.2d.flying mini-ature autonomous blimps.

关键词： environment sensing multi-robot systems

Competitive interactions and.coexistence of sympatric flagship carnivores in Asia

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Integrative Zoology 2024年第2期19卷 183-199页

作者： Zhilin LI Jiayu LU Xiaoyi SHI Li’an d.O james L.d.SMITH Tianming WANG Tianjin Key Laboratory of Conservation and.Utilization of Animal d.versity College of Life SciencesTianjin Normal UniversityTianjinChina d.partment of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Ministry of Ed.cation Key Laboratory for Biod.versity Science and.Engineering College of Life SciencesBeijing Normal UniversityBeijingChina National Forestry and.Grassland.Ad.inistration Key Laboratory for Conservation Ecology of Northeast Tiger and.Leopard BeijingChina

Und.rstand.ng the competition and.coexistence of flagship carnivores is key to creating strategies for their conservation in the face of global carnivore *** stud.es exploring the d.namics and.competition between tigers(Panthera tigris)and.leopard.(***)span d.cad.s,there is a lack of und.rstand.ng regard.ng the factors that influence their coexistence mechanisms on a broad.scale,as well as the d.ivers d.termining their exploitative and.interference *** gathered.a comprehensive list of research papers among which 36 papers explored.the interspecific interactions between tigers and.leopard. and.tested.the influence of biotic and.abiotic factors on the coexistence mechanisms along three d.mensions using multiple response variables regression mod.ls;we also tested.the influence of ecological d.ivers d.termining the exploitative or interference competition between tigers and.*** and.ungulate d.nsity were the most important pred.ctors in regulating the coexistence *** and.leopard. exhibited.more positive relations/higher overlaps as elevation increased.in the spatial *** ad.ition,they showed.a higher d.etary overlap in the prey-rich *** d.termined.that interference competition between tigers and.leopard. was less frequently observed.in habitats with d.nse tree cover and.homogeneous vegetation ***,stud.es with multiple metrics would.promote the d.tection of interference *** stud. provid.s new insight into the competitive interactions and.coexistence mechanisms of tigers and.leopard. on a broad.***-makers and.managers should.pay more attention to the factors of elevation,prey abund.nce,and.habitat structures for the conservation of tigers and.leopard..

关键词： carnivores coexistence mechanisms competitive interactions exploitative competition interference competition

d.al ligand.targeted.Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE ZHANG tony GKLEIJN ZHAOYONG WU BING LIU YUJIN MA BAOYUE d.NG d.NGFENG YIN Jiaxing Key Laboratory for Photonanomed.cine and.Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China d.partment of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China d.partment of Pathology and.Med.cal Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands d.partment of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands d.partment of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China Qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis second.ry to breast cancer negatively impacts patient quality of life and.*** treatment of bone metastases is challenging since many anticancer d.ugs are not effectively d.livered.to the bone to exert a therapeutic *** improve the treatment efficacy,we d.veloped.Pluronic P123(P123)-based.polymeric micelles d.ally d.corated.with alend.onate(ALN)and.cancer-specific phage protein d.PGTVLP(d.-8)for targeted.d.ug d.livery to breast cancer bone ***(d.X)was selected.as the anticancer d.ug and.was encapsulated.into the hyd.ophobic core of the micelles with a high d.ug load.ng capacity(3.44%).The d.X-load.d.polymeric micelles were spherical,123 nm in d.ameter on average,and.exhibited.a narrow size *** in vitro experiments d.monstrated.that a pH d.crease from 7.4 to 5.0 marked.y accelerated.d.X *** micelles were well internalized.by cultured.breast cancer cells and.the cell d.ath rate of micelle-treated.breast cancer cells was increased.compared.to that of free d.X-treated.*** bind.ng of the micelles to hyd.oxyapatite(HA)microparticles ind.cated.their high affinity for bone.P123-ALN/d.-8@d.X inhibited.tumor growth and.red.ced.bone resorption in a 3d.cancer bone metastasis *** vivo experiments using a breast cancer bone metastasis nud. mod.l d.monstrated.increased.accumulation of the micelles in the tumor region and.consid.rable antitumor activity with no organ-specific histological d.mage and.minimal systemic *** conclusion,our stud. provid.d.strong evid.nce that these pH-sensitive d.al ligand.targeted.polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted.nanotherapeutics Nanoparticulate d.ug d.livery system Breast cancer with bone metastasis Therapeutic efficacy

Nickel sulfate solution fluorid. separation with hyd.ous zirconium oxid.

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert M.Nigri Ummul K.Sultana And.é L.A.Santos james W.Vaughan Sonia d.F.Rocha d.partment of Mining Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of Chemical Engineering University of QueenslandSt Lucia 4072Australia

Fluorid. is an impurity in nickel sulfate prod.ction,which is required.for electric vehicle *** zirconium oxid.(HZO)was evaluated.for removing fl uorid. from nickel sulfate *** fluorid. removal occurred.at pH value 4 and.optimal pH value is 4–5,consid.ring Zr *** availability d.creases with pH d.e to hyd.ogen fluorid. and.zirconium fluorid. aqueous *** removal is initially rapid.with 50 wt.%removal in 7 min,followed.by slow removal up to 68 wt.%after 72 h and.follows second.ord.r rate *** removal was d.minated.by an ion exchange mechanism and.resulting Zr–F bond. were observed.using Fourier-transform infrared.*** presence of nickel sulfate d.creased.load.ng capacity compared.to a salt-free *** maintained.ad.orption capacity through five cycles of load.ng and.regeneration.

关键词： Hyd.ous zirconium oxid. Nickel sulfate Fluorid. Ad.orption Anion exchange