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Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： Lisa Muller tony Gutschner Mechthild Hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,James *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

The cautionary tale of Peirce’s logical interpretant

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Language and Semiotic Studies 2024年第1期10卷 1-16页

作者： tony Jappy University of Perpignan Via Domitia PerpignanFrance27074

In 1904,Peirce described to Lady welby a six-division typology composed of the sign,two objects,and a trio of interpretants for which he subsequently proposed numerous *** the three,the final interpretant was particularly problematic,and over the years Peirce experimented with at least eight different identifying terms such as“final,”“rational,”“normal,”“eventual,”*** group of interpretants is especially interesting as it only occurs in a single manuscript but has attracted considerable critical attention,namely the emotional,energetic,and logical interpretant series in a projected article of *** paper examines the description of these,paying particular attention to the logical interpretant,and suggests how important aspects of the logic determining how Peirce defined them may have been neglected or ignored by *** first shows how the group was presented,how the logical interpretant related to Peirce’s purpose in the article,how it related to a restricted conception of the dynamic object in the manuscript,and explains through an analysis of its logical complications why Peirce was led to abandon *** considerations suggest that much of the critical attention that the logical interpretant in particular has generated might be incomplete or,more seriously,nonsense.

关键词： pragmatism meaning interpretation logical interpretants MS318

Unveiling the shadows: a qualitative exploration of barriers to rooftop solar photovoltaic adoption in residential sectors

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Clean Energy 2024年第5期8卷 218-228页

作者： tony C.Mathew Sridevi Nagaraja Pandian School of Commerce Kumaraguru College of Liberal Arts and ScienceCoimbatore 641035Tamil NaduIndia

In the face of global climate change,the urgent shift towards renewable energy sources such as solar power is vital for reducing greenhouse gas emissions and fostering a sustainable future,presenting a universal challenge and opportunity for energy policy ***’s adoption of rooftop solar photovoltaic is pivotal due to its vast solar potential,which aligns with national goals to increase renewable energy capacity,reduce carbon emissions,and achieve energy ***’s geographical location offers abundant solar potential,making it a prime candidate for the adoption of rooftop solar photovoltaic *** with the state’s strong commitment to renewable energy initiatives such as the ambitious“SOURA”(solar subsidy program by the Kerala State Electricity Board)project and various incentives for solar adoption,Kerala stands at the forefront of India’s transition towards sustainable energy *** the barriers to rooftop solar photovoltaic adoption in Kerala is crucial for tailoring ef-fective policies and strategies that address specific hindrances from economic constraints to informational *** study employs a qualitative research method to identify the barriers to rooftop solar photovoltaic adoption among households in *** face-to-face interviews with a purposively selected sample of 52 households,the research aims to gain in-depth insights into the multifaceted challenges hindering the widespread adoption of solar energy in residential *** findings reveal several key barriers:financial barriers,informational barriers,technical barriers,regulatory barriers,social barriers,and psychological *** analysis indicates that while there is a predominantly positive attitude towards solar photovoltaic adoption,there are sig-nificant concerns that still need to be *** these barriers with targeted policy interventions and public awareness campaigns could significantly enhance the adoptio

关键词： rooftop solar photovoltaic adoption barriers to solar energy residential solar systems Kerala solar initiatives qualitative analysis in renewable energy

Enhanced High-Temperature Cycling Stability of Garnet-Based All Solid-State Lithium Battery Using a Multi-Functional Catholyte Buffer Layer

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Nano-Micro Letters 2024年第7期16卷 59-73页

作者： Leqi Zhao yijun Zhong Chencheng Cao tony Tang Zongping Shao wA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWA 6102Australia

The pursuit of safer and high-performance lithium-ion batteries(LIBs)has triggered extensive research activities on solid-state batteries,while challenges related to the unstable electrode-electrolyte interface hinder their practical *** has been used extensively to improve the cathode-electrolyte interface in garnet-based all-solid-state LIBs(ASSLBs),while it introduces new concerns about thermal *** this study,we propose the incorporation of a multi-functional flame-retardant triphenyl phos-phate additive into poly(ethylene oxide),acting as a thin buffer layer between LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cathode and garnet *** electrochemical stability tests,cycling performance evaluations,interfacial thermal stability analysis and flammability tests,improved thermal stability(capacity retention of 98.5%after 100 cycles at 60℃,and 89.6%after 50 cycles at 80℃)and safety characteristics(safe and stable cycling up to 100℃)are *** on various materials characterizations,the mechanism for the improved thermal stability of the interface is *** results highlight the potential of multi-functional flame-retardant additives to address the challenges associated with the electrode-electrolyte interface in ASSLBs at high *** thermal modification in ASSLBs operating at elevated temperatures is also essential for enabling large-scale energy storage with safety being the primary concern.

关键词： Solid-state battery Cathode electrolyte interlayer Flame-retardant additive Cycling stability Interfacial stability

Recent advances to address challenges in extracellular vesicle-based applications for lung cancer

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3855-3875页

作者： Gaigai Huang wenshu Zheng yu Zhou Meihua wan tony Hu Department of Clinical Laboratory the First People’s Hospital of Shuangliu District(West China Airport Hospital of Sichuan University)Chengdu 610200China Center for Cellular and Molecular Diagnostics Tulane University School of MedicineNew OrleansLA 70112USA Department of Integrated Traditional Chinese and western Medicine West China Hospital of Sichuan UniversityChengdu 610200China The First People’s Hospital of Shuangliu District(west China Airport Hospital of Sichuan University) Chengdu 610200China

Lung cancer,highly prevalent and the leading cause of cancer-related death globally,persists as a significant challenge due to the lack of definitive tumor markers for early diagnosis and personalized therapeutic ***,extracellular vesicles(EVs),functioning as natural carriers for intercellular communication,have received increasing attention due to their ability to traverse biological barriers and deliver diverse biological cargoes,including cytosolic proteins,cell surface proteins,microRNA,lncRNA,circRNA,DNA,and *** are increasingly recognized as a valuable resource for non-invasive liquid biopsy,as well as drug delivery platforms,and anticancer vaccines for precision medicine in lung ***,given the diagnostic and therapeutic potential of tumor-associated EVs for lung cancer,we discuss this topic from a translational *** delve into the specific roles that EVs play in lung cancer carcinogenesis and offer a particular perspective on how advanced engineering technologies can overcome the current challenges and expedite and/or enhance the translation of EVs from laboratory research to clinical settings.

关键词： Lung cancer Extracellular vesicles Therapy resistance Delivery Diagnostics Therapeutics Nanotechnology Engineering

Acoustofluidic scanning fluorescence nanoscopy with a large field of view

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Microsystems & Nanoengineering 2024年第3期10卷 159-167页

作者： Geonsoo Jin Neil Upreti Joseph Rich Jianping Xia Chenglong Zhao tony Jun Huang Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA The MITRE Corporation McLeanVA 22102USA

Large-field nanoscale fluorescence imaging is invaluable for many applications,such as imaging subcellular structures,visualizing protein interactions,and high-resolution tissue ***,conventional fluorescence microscopy requires a trade-off between resolution and field of view due to the nature of the optics used to form the *** overcome this barrier,we developed an acoustofluidic scanning fluorescence nanoscope that simultaneously achieves superior resolution,a large field of view,and strong fluorescent *** acoustofluidic scanning fluorescence nanoscope utilizes the superresolution capabilities of microspheres that are controlled by a programmable acoustofluidic device for rapid fluorescence enhancement and *** acoustofluidic scanning fluorescence nanoscope resolves structures that cannot be resolved with conventional fluorescence microscopes with the same objective lens and enhances the fluorescent signal by a factor of~5 without altering the field of view of the *** improved resolution realized with enhanced fluorescent signals and the large field of view achieved via acoustofluidic scanning fluorescence nanoscopy provides a powerful tool for versatile nanoscale fluorescence imaging for researchers in the fields of medicine,biology,biophysics,and biomedical engineering.

关键词： field resolution utilize

Distributed field mapping for mobile sensor teams using a derivative‐free optimisation algorithm

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IET Cyber-Systems and Robotics 2024年第2期6卷 20-34页

作者： tony X.Lin Jia Guo Said Al-Abri Fumin Zhang Fumin Zhang31School of Electrical&Computer Engineering Georgia Institute of TechnologyAtlantaGeorgiaUSA College of Engineering Sultan Qaboos UniversityMuscatOman Department of Electronic&Computer Engineering Hong Kong University of Science and TechnologyHong KongChina

The authors propose a distributed field mapping algorithm that drives a team of robots to explore and learn an unknown scalar field using a Gaussian Process(GP).The authors’strategy arises by balancing exploration objectives between areas of high error and high *** computing high error regions is impossible since the scalar field is unknown,a bio-inspired approach known as Speeding-Up and Slowing-Down is leveraged to track the gradient of the GP *** approach achieves global field-learning convergence and is shown to be resistant to poor hyperparameter tuning of the *** approach is validated in simulations and experiments using 2D wheeled robots and 2D flying mini-ature autonomous blimps.

关键词： environment sensing multi-robot systems

Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE ZHANG tony GKLEIJN ZHAOyONG wU BING LIU yUJIN MA BAOyUE DING DONGFENG yIN Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China Department of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands Department of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands Department of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China Qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and *** treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic *** improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone ***(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size *** in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX *** micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated *** binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis *** vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic *** conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted nanotherapeutics Nanoparticulate drug delivery system Breast cancer with bone metastasis Therapeutic efficacy

Functionalization of cellulose carbon dots with different elements(N,B and S)for mercury ion detection and anti-counterfeit applications

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Chinese Chemical Letters 2024年第7期35卷 355-359页

作者： Xiaoning Li Quanyu Shi Meng Li Ningxin Song yumeng Xiao Huining Xiao tony D.James Lei Feng Second Affiliated Hospital of Dalian Medical University Dalian 116023China Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department of Environmental Science and EngineeringNorth China Electric Power UniversityBaoding 071003China Department of Chemical Engineering and Limerick Pulp&Paper Centre University of New Brunswick15 Dineen DriveFredericton NB E3B 5A3Canada Department of Chemistry University of BathBath BA27AYUnited Kingdom School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Mercury ion(Hg^(2+)),as one of the most toxic heavy metal ions,accumulates easily in the environment,which can generate potential hazards to the ecosystem and human *** effectively detect and remove Hg^(2+),we fabricated four types of carbon dots(CDs)using carboxymethyl nanocellulose as a carbon source doped with different elements using a hydrothermal *** the CDs exhibited a strong fluorescence emission,excitation-dependent emission and possessed good water ***,the four fluorescent CDs were used for Hg^(2+)recognition in aqueous solution,where the CDs-N exhibited better sensitivity and selectivity for Hg^(2+)detection,with a low limit of detection of 8.29×10^(-6)mol/*** was determined that the fluorescence quenching could be ascribed to a photoinduced charge-transfer processes between Hg^(2+)and the *** addition,the CDs-N were used as a smart invisible ink for anticounterfeiting,information encryption and ***,the CDs-N were immersed into a cellulose(CMC)-based hydrogel network to prepare fluorescent hydrogels capable of simultaneously detecting and adsorbing Hg^(2+).we anticipate that this research will open possibilities for a green method to synthesize fluorescent CDs for metal ion detection and fluorescent ink production.

关键词： Carbon dots Functional groups Hg^(2+)detection Mechanism Anti-counterfeiting