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Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones

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Chinese Chemical Letters 2020年第2期31卷 377-380页

作者： Chuncheng Zou Yuanyuan Han Chuikun Zeng tony YZhang Jinxing Ye Gonghua Song Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Chemistry Biology East China University of Science and TechnologyShanghai 200237China

An organocatalytic asymmetric [3+2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was *** process enables efficient incorporation of CF3 groups into functionalized spiro [pyrro... 详细信息

关键词： Organocatalysis Spiro oxindole skeleton [3+2]cycloaddition Cyclic 2,4-dienones CF3 group

Pyogenic liver abscess:An audit of 10 years’experience

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World Journal of Gastroenterology 2011年第12期17卷 1622-1630页

作者： tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt Leonards NSW 2065Australia

AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous ***:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were *** and hydatid abscesses were ***,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were ***:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) *** 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was *** function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) *** organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial *** initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their *** hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate ***:PLA is a diagnostic challenge,because the presentation of this condition is *** antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage.

关键词： Pyogenic liver abscess Image guided drainage Surgical drainage C-reactive protein Hypoalbuminaemia

Distributed field mapping for mobile sensor teams using a derivative‐free optimisation algorithm

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IET Cyber-Systems and Robotics 2024年第2期6卷 20-34页

作者： tony X.Lin Jia Guo Said Al-Abri Fumin Zhang School of Electrical&Computer Engineering Georgia Institute of TechnologyAtlantaGeorgiaUSA College of Engineering Sultan Qaboos UniversityMuscatOman Department of Electronic&Computer Engineering Hong Kong University of Science and TechnologyHong KongChina

The authors propose a distributed field mapping algorithm that drives a team of robots to explore and learn an unknown scalar field using a Gaussian Process(GP).The authors’strategy arises by balancing exploration objectives between areas of high error and high *** computing high error regions is impossible since the scalar field is unknown,a bio-inspired approach known as Speeding-Up and Slowing-Down is leveraged to track the gradient of the GP *** approach achieves global field-learning convergence and is shown to be resistant to poor hyperparameter tuning of the *** approach is validated in simulations and experiments using 2D wheeled robots and 2D flying mini-ature autonomous blimps.

关键词： environment sensing multi-robot systems

On generation source sites of internal waves in the Luzon Strait

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Acta Oceanologica Sinica 2008年第3期27卷 38-50页

作者： ZHENG Quanan SONG Y tony LIN Hui HU Xiaomin MENG Junmin WANG Dan Department of Atmospheric and Oceanic Science University of Maryland College Park Maryland USA Jet Propulsion Laboratory California Institute of Technology Pasadena California USA Institute of Space and Earth Information Sciences The Chinese University of Hong Kong Hong Kong China First Institute of Oceanography. State Oceanic Administration. Oingdao 266061. China

This effort aims to determine the generation source sites in the Luzon Strait for energetic, long-crest, transbasin internal waves （IW） observed in the northern South China Sea （NSCS）. The roles of islands distributed on eastern side of the strait, Kuroshio, submarine ridges, shoaling thennocline, and strait configuration played in the IW generation are examined using the cruise data analysis, satellite data interpretation, and dynamical analysis. The islands and channels on eastern side of the strait are excluded from a list of possible IW source sites owing to their unmatched horizontal dimensions to the scale of IW crest line length, and the relative low Reynolds number. The Kuroshio has a potential to be a radiator for the long-crest IW disturbances, meanwhile, the Kurosbio west （east） wing absorbs the eastward （westward） propagating IW disturbance. Namely, the Kuroshio blockades the outside west-east propagating IW disturbances. The 3-D configuration of the Luzon Strait is characterized by a sudden, more than one order widening of the cross-section areas at the outlets on both sides, providing a favorable condition for IW type initial disturbance formation. In the Luzon Strait, the thermocline is featured by a westward shoaling all the year around, providing the dynamical conditions for the amplitude growth （declination） to the westward （eastward） propagating IW type disturbance. Thus, the west slope of western submarine ridge at the western outlet of the Luzon Strait is a high possibility source sites for energetic, long-crest, transbasin IWs in the NSCS. The interpretation results of satellite SAR images during a 13 a period from 1995 to 2007 provide the convincing evidence for the conclusions.

关键词： ocean internal waves solitary waves Luzon Strait satellite SAR image

Acoustofluidic separation of cells andparticles

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Microsystems & Nanoengineering 2019年第1期5卷 436-453页

作者： Mengxi Wu Adem Ozcelik Joseph Rufo Zeyu Wang Rui Fang tony Jun Huang Department of Mechanical Engineering and Material Science Duke UniversityDurhamNC 27708USA Mechanical Engineering Department Aydin Adnan Menderes University09010 AydinTurkey Department of Molecular and Cellular Biology Harvard UniversityCambridgeMA 02138USA

Acoustofluidics,the integration of acoustics and microfluidics,is a rapidly growing research field that is addressing challenges in biology,medicine,chemistry,engineering,and *** particular,acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free,biocompatible,and contact-free nature of the *** carefully designing and tuning the applied acoustic field,cells and other bioparticles can be isolated with high yield,purity,and *** advances in acoustofluidics,such as the development of automated,point-of-care devices for isolating sub-micron bioparticles,address many of the limitations of conventional separation *** importantly,advances in the research lab are quickly being adopted to solve clinical *** this review article,we discuss working principles of acoustofluidic separation,compare different approaches of acoustofluidic separation,and provide a synopsis of how it is being applied in both traditional applications,such as blood component separation,cell washing,and fluorescence activated cell sorting,as well as emerging applications,including circulating tumor cell and exosome isolation.

关键词： fluid separation acoustics

Benign vs malignant pancreatic lesions: Molecular insights to an ongoing debate

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 406-418页

作者： Mahmoud Aldyab tony El Jabbour Megan Parilla Hwajeong Lee Department of Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States Department of Pathology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065United States

Several benign conditions such as chronic pancreatitis, autoimmune pancreatitis,and paraduodenal pancreatitis can present as mass lesions and may mimicpancreatic ductal adenocarcinoma (PDAC) clinically and radiologically. Thoroughhistologic examination with attention to certain morphologic features can assist indeciphering neoplastic from reactive, however small biopsies often remain achallenge. Variable histologic patterns in conventional PDAC may also confoundthe diagnosis of PDAC. Uncommon subtypes of pancreatic carcinoma such asadenosquamous and squamous cell carcinoma, colloid carcinoma, medullarycarcinoma, hepatoid carcinoma and signet ring cell carcinoma necessitateexcluding metastasis from other sites prior to rendering the diagnosis ofpancreatic carcinoma. The use of immunohistochemical staining and molecularmarkers can aid in separating benign from malignant and PDAC from *** expresses a few non-specific epithelial and mucin immunomarkers such asCK7, CK19, MUC1, MUC4 and MUC5AC. However, the only immunohistochemicalmarker that is specific for PDAC in the right clinical context is *** of SMAD4 within atypical glands and ducts supports the diagnosis of PDACin a limited sample. Unfortunately, this finding is seen only in 50% of PDACcases. The identification of certain mutations can help support a diagnosis ofPDAC when benign conditions are in the differential. At the molecular level,KRAS oncogene mutations are seen in approximately 93% of PDACs. Subsequentneoplastic progression is driven by additional mutations of tumor suppressorgenes, such as CDKN2A, TP53, and SMAD4. Molecular markers can also providean insight to the prognosis. For instance, the loss of SMAD4 is associated with apoor outcome whereas mutations in MLL, MLL2, MLL3, and ARID1A are associatedwith improved survival.

关键词： Pancreas Pancreatitis Autoimmune SMAD4 Molecular

A new place for psychiatry among the forensic sciences

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Forensic Sciences Research 2021年第2期6卷 95-96页

作者： tony Godet Gérard Niveau Geneva University Hospitals GenevaSwitzerland

Forensic psychiatry occupies a special place among the forensic *** has not always been recognized as a forensic science,and,even today,is not always inte-grated in forensic medicine centres in all *** may be because forensic psychiatry has not always demonstrated the rigour and robustness expected of a discipline that must be legally useful,and has thus faced criticism in the context of criminal trials.

关键词： forensic legal centre

Role of myelin auto-antigens in pain:a female connection

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Neural Regeneration Research 2016年第6期11卷 890-891页

作者： Veronica I.Shubayev Alex Y.Strongin tony L.Yaksh Department of Anesthesiology University of CaliforniaSan DiegoLa JollaCAUSA VA San Diego Healthcare System La JollaCAUSA Sanford-Burnham-Prebys Medical Discovery Institute La jollaCAUSA

Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly *** origins are poorly understood and the pain is often refractory to common analgesic *** past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain（pain arising from damage or disease of the somatosensory system）.

关键词： myelin understood stimulation poorly refractory analgesic microglia immunity signaling likely

Time-dependent reliability analysis for repairable consecutive-k-out-of-n:F system

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Statistical Theory and Related Fields 2022年第2期6卷 139-147页

作者： Gökhan Gökdere Hon Keung tony Ng Department of Statistics Faculty of ScienceFırat UniversityElazıgTurkey Department of Statistical Science Southern Methodist UniversityDallasTXUSA

In a repairable consecutive C(k,n:F)system,after the system operates for a certain time,some components may fail,some failed components may be repaired and the state of the system may *** models developed in the existing literature usually assume that the state of the sys-tem varies over time depending on the values of n and k and the state of the system is *** the system reliability will vary over time,it is of great interest to analyse the time-dependent system *** this paper,we develop a novel and simple method that utilizes the eigen-values of the transition rate matrix of the system for the computation of time-dependent system reliability when the system state is *** addition,the transition performance probabilities of the system from a known state to the possible states are also *** results are presented to illustrate the applicability and accuracy of the proposed method.

关键词： Repairable consecutive-k-out-of-n:F system transition rate matrix time-dependent reliability time-dependent transition performance probability