Acoustofluidic separation of cells andparticles
作者机构：Department of Mechanical Engineering and Material ScienceDuke UniversityDurhamNC 27708USA Mechanical Engineering DepartmentAydin Adnan Menderes University09010 AydinTurkey Department of Molecular and Cellular BiologyHarvard UniversityCambridgeMA 02138USA
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2019年第5卷第1期
页 面：436-453页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：We acknowledge support from the National Institutes of Health(R01HD086325,R44GM125439,R43HL140800,and R01GM127714) the United States Army Medical Research Acquisition Activity(W81XWH-18-1-0242)
主 题：fluid separation acoustics
摘 要：Acoustofluidics,the integration of acoustics and microfluidics,is a rapidly growing research field that is addressing challenges in biology,medicine,chemistry,engineering,and *** particular,acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free,biocompatible,and contact-free nature of the *** carefully designing and tuning the applied acoustic field,cells and other bioparticles can be isolated with high yield,purity,and *** advances in acoustofluidics,such as the development of automated,point-of-care devices for isolating sub-micron bioparticles,address many of the limitations of conventional separation *** importantly,advances in the research lab are quickly being adopted to solve clinical *** this review article,we discuss working principles of acoustofluidic separation,compare different approaches of acoustofluidic separation,and provide a synopsis of how it is being applied in both traditional applications,such as blood component separation,cell washing,and fluorescence activated cell sorting,as well as emerging applications,including circulating tumor cell and exosome isolation.
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