检索结果-南通市图书馆

Ulcerative colitis and bullous pemphigoid:Direct association or a medication side effect:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第9期13卷 47-52页

作者： Gaelle-Christie Haddad Anthony El Dada Sergio Sbeih tony Kazzi Karam Karam Louis A Chaptini Department of Internal Medicine University of BalamandBeirut 100Lebanon Department of Medicine GastroenterologyUniversity of BalamandBalamand 100Lebanon Department of Medicine Digestive DiseasesYale School of MedicineNew HavenCT 06510United States

BACKGROUND Bullous pemphigoid(BP)is an autoimmune blistering skin *** is associated with other autoimmune disorders and the use of certain *** describe a case of BP in a patient with ulcerative colitis(UC)treated with *** SUMMARY A 38-year-old male patient with UC and a history of multiple flares was maintained on mesalamine with good clinical *** year after starting mesalamine,he sought medical care following the onset of a severe itchy rash of several weeks’duration with a recent appearance of skin bullae.A biopsy of the skin revealed subepidermal blistering dermatitis with focal eosinophilic *** immunofluorescence studies revealed linear IgG and C3 immune reactant deposits at the dermoepidermal junction,consistent with the diagnosis of *** therapy alleviated his ***,tapering prednisone led to re-eruption of the *** BP should be considered when patients with UC develop skin *** BP is not one of the extraintestinal manifestations of UC,there may be an association between these two *** treatment with mesalamine or other therapeutic agents plays a role in the development of BP remains unclear.

关键词： Bullous pemphigoid Ulcerative colitis Autoimmune disorders Skin manifestations in inflammatory bowel diseases Mesalamine Case report

On recommendation-aware content caching for 6G:An artificial intelligence and optimization empowered paradigm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2020年第3期6卷 304-311页

作者： Yaru Fu Khai Nguyen Doan tony Q.S.Quek The School of Science and Technology The Open University of Hong Kong(OUHK)KowloonHong KongChina Information Systems Technology and Design Singapore University of Technology and Design487372Singapore

Recommendation-aware Content Caching(RCC)at the edge enables a significant reduction of the network latency and the backhaul load,thereby invigorating ubiquitous latency-sensitive innovative ***,the effectiveness of RCC strategies is highly dependent on explicit information as regards subscribers’content request patterns,the sophisticated caching placement policy,and the personalized recommendation *** this article,we investigate how the potentials of Artificial Intelligence(AI)and optimization techniques can be harnessed to address those core issues and facilitate the full implementation of RCC for the upcoming intelligent 6G *** this end,we first elaborate on the hierarchical RCC network ***,the devised AI and optimization empowered paradigm is introduced,whereas AI and optimization techniques are leveraged to predict the users’content preferences in real-time situations with the assistance of their historical behavior data and determine the cache pushing and recommendation decision,*** extensive case studies,we validate the effectiveness of AI-based predictors in estimating users’content preference and the superiority of optimized RCC policies over the conventional *** last,we shed light on the opportunities and challenges in the future.

关键词： Artificial intelligence Content caching Optimization techniques Recommendation 6G

Underpinning the molecular programming attributing heat stress associated thermotoleranee in tea (Camellia sinensis (L.) O. Kuntze)

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2021年第1期8卷 1333-1351页

作者： Romit Seth tony Kipkoech Maritim Rajni Parmar Ram Kumar Sharma Biotechnology Department CSIR-I nstitute of Himalayan Bioresource Technology(CSIR-IHBT)PalampurHimachal Pradesh 176061India Academy of Scientific and Innovative Research(AcSIR) CSIR-HRDC CampusGhaziabadUttar Pradesh 201002India Teabreeding and genetic improvement division KALRO-Tea Research InstituteBox 82020200 KerichoKenya

The most daunting issue of global climate change is the deleterious impact of extreme temperatures on tea productivity and quality,which has resulted in a quest among researchers and *** current study aims to unravel molecular programming underpinning thermotolerance by characterizing heat tolerance and sensitivity response in 20 tea *** signi fi cantly higher negative in fl uence of heat stress was recorded in a sensitive cultivar with reduced water retention(47%),chlorophyll content(33.79%),oxidation potential(32.48%),and increase in membrane damage(76.4%).Transcriptional pro fi ling of most tolerant and sensitive cultivars identi fi ed 78 differentially expressed unigenes with chaperon domains,including low and high molecular weight heat shock protein(HSP)and heat shock transcription factors(HSFs)involved in heat shock response(HSR).Further,predicted transcriptional interactome network revealed their key role in thermotolerance via well-co-ordinated transcriptional regulation of aquaporins,starch metabolism,chlorophyll biosynthesis,calcium,and ethylene mediated plant signaling *** study identi fi ed the key role of HSPs(CsHSP90)in regulating HSR in tea,wherein,structure-based molecular docking revealed the inhibitory role of geldanamycin(GDA)on CsHSP90 by blocking ATP binding site at N-terminal domain of predicted ***,GDA mediated leaf disc inhibitor assay further af fi rmed enhanced HSR with higher expression of CsHSP17.6,CsHSP70,HSP101,and CsHSFA2 genes in *** the current study,efforts were made to extrapolate a deeper understanding of chaperons mediated regulation of HSR attributing thermotolerance in tea.

关键词： metabolism programming stress

Exploring the Case for Monetary Integration between the Chinese Mainland and Hong Kong

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China & World Economy 2007年第4期15卷 17-34页

作者： tony Cavoli Ramkishen S. Rajan Lecturer School of Economics and Finance Queensland University of TechnologyAustralia. Associate Professor School of Public PolicyGeorge Mason University Arlington VA USA.

This paper presents an empirical investigation on an important policy issue, namely, whether there is any evidence supporting monetary integration between the Chinese mainland and Hong Kong. We follow two lines of inquiry. First, we present a series of simple tests to find the extent to which trade and/or financial linkages exist between the two regions. Second, we use simple inflation and output differentials and structural VAR techniques to test for the degree of business cycle synchronization between the two regions. The results indicate that there is evidence supporting the existence of trade linkages and that there is also support for the possible synchronization of business cycles. We discuss the implications of this for monetary integration between Hong Kong and the mainland

关键词： Hong Kong the Chinese mainland monetary integration optimum currency area renminbi

Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第11期22卷 3275-3284页

作者： Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach tony Bruns Department of Internal Medicine IV (Gastroenterology Hepatologyand Infectious Diseases)Jena University Hospital Center for Sepsis Control and Care Jena University Hospital

AIM: To prospectively analyze the impact of increased intestinal permeability (IP) on mortality and the occurrence of infections in patients with ***: IP was quantified using the lactulose/mannitol (L/M) test in 46 hospitalized patients with cirrhosis (25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPS-binding protein, Interleukin-6 (IL-6)] and enterocyte death [intestinal fatty-acid binding protein (I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol ***: Thirty-nine (85%) patients with cirrhosis had a pathologically increased IP index (L/M ratio > 0.07) compared to 4 (25%) healthy controls (P < 0.0001). The IP index correlated with the Child-Pugh score (r = 0.484, P = 0.001) and with serum IL-6 (r = 0.342, P = 0.02). Within one year, nineteen (41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis (SBP) (n = 7) had a higher IP index than patients who did not (0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free ***: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective coho

关键词： Intestinal permeability Liver cirrhosis Lactulose/mannitol ratio Spontaneous bacterial peritonitis Bacterial translocation

Strategies for advanced personalized tuberculosis diagnosis:Current technologies and clinical approaches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2021年第1期4卷 35-44页

作者： Xuerong Chen tony Y.Hu Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China Center for Cellular and Molecular Diagnostics School of MedicineTulane UniversityNew OrleansLA 70112USA

Diagnosis of tuberculosis can be difficult as advances in molecular diagnosis approaches(especially nanoparticles combined with high-throughput mass spectrometry for detecting mycobacteria peptide)and personalized medicine result in many changes to the diagnostic *** review will address issues concerning novel technologies from bench to bed and new strategies for personalized tuberculosis diagnosis.

关键词： tuberculosis molecular diagnosis personalized medicine

The mechanical properties of plastic evidence bags used for collection and storage of drug chemicals relevant to clandestine laboratory investigations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forensic Sciences Research 2017年第4期2卷 198-202页

作者： Harmonie Michelot Barbara Stuart Shanlin Fu Ronald Shimmon tony Raymond tony Crandell Claude Roux Centre for Forensic Science University of Technology SydneyUltimoNSWAustralia Strategic Forensic Support Branch NSW Police ForceParramattaNSWAustralia Surry Hills Local Area Command NSW Police ForceSurry HillsNSWAustralia

The effectiveness of three types of plastic bags used by the New South Wales Police Force for the storage of clandestine drug evidence has been investigated through a comparison of mechanical *** tensile and tear properties of“as received”low-density polyethylene(LDPE)and poly(vinyl chloride)(PVC)bags do not show major differences such that one type would be favoured over the ***,the mechanical properties of the bags once exposed to a range of chemicals routinely collected as drug evidence have been shown to be influenced as a result of different chemical *** an interaction of reagents/solvents with an additive within the LDPE bags is proposed to influence the mechanical properties of the bags,the change in properties has been shown to be less severe than that observed for the PVC bag,where softening and damage of the bags results due to absorption of reagents.

关键词： Forensic science plastic evidence bags drug seizures tensile tests tear tests

Development and validation of a rapid UPLC/MS method for the simultaneous determination of I3C, DIM, and related metabolites and its application to pharmacokinetics studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2016年第7期25卷 477-488页

作者： Yury Gomez Hu Wang Ah-Ng tony Kong Graduate Program in Pharmaceutical Science Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey

Indole-3-carbinol(I3C) and diindolylmethane(DIM) are naturally derived dietary phytochemicals with promising anti-cancer properties that have been demonstrated both in vitro and in vivo. Using reversed-phase ultra-performance liquid chromatography(UPLC) coupled with mass spectrometry(MS), a rapid, specific, and high throughput method was developed and validated for the quantification and identification of I3 C, DIM, and other I3 C metabolites in plasma. Samples containing I3 C or DIM and the internal standard 4-methoxy indole(IS) were extracted using a liquid-liquid extraction technique. The mean recovery was 96.21% for I3 C and 108.5% for DIM. Separation was achieved using a Waters Acquity UPLC HSS T3, 1.8 μm, 2.1 mm×150 mm column and acetonitrile–water gradient elution. The flow rate was 0.3 m L/min and the run time was 9 min. The limits of detection and quantification for I3 C and DIM were 15 ng/m L and 25 ng/m L, respectively. Calibration curves for I3 C and DIM were linear(r2>0.99) over a concentration range of 0.025–20 μg/m L. Precision, accuracy, and stability analysis fulfilled the CDER guidelines criteria. The method was successfully applied to the determination of the pharmacokinetic parameters of I3 C or DIM after oral, intravenous, or intraperitoneal administration to Sprague Dawley rats. The method described here is superior over existing analytical methods for I3 C and its metabolites in terms of sensitivity, speed, and separation.

关键词： UPLC/MS Indole-3-Carbinol Diindolylmethane Pharmacokinetics Single-dose administration Sprague-Dawley Rats

Matching while Learning: Wireless Scheduling for Age of Information Optimization at the Edge

在线全文

学校读者我要写书评

暂无评论

China Communications 2023年第3期20卷 347-360页

作者： Kun Guo Hao Yang Peng Yang Wei Feng tony Q.S.Quek School of Communications and Electronics Engineering East China Normal UniversityShanghai 200241China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401120China Zhejiang University/University of Illinois at Urbana-Champaign Institute Zhejiang UniversityHaining 314400China School of Electronic and Information Engineering Beihang UniversityBeijing 100083China Beijing National Research Center for Information Science and Technology Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Information Systems Technology and Design(ISTD)Pillar Singapore University of Technology and DesignSingapore 487372

In this paper,we investigate the minimization of age of information(AoI),a metric that measures the information freshness,at the network edge with unreliable wireless ***,we consider a set of users transmitting status updates,which are collected by the user randomly over time,to an edge server through unreliable orthogonal *** begs a natural question:with random status update arrivals and obscure channel conditions,can we devise an intelligent scheduling policy that matches the users and channels to stabilize the queues of all users while minimizing the average AoI?To give an adequate answer,we define a bipartite graph and formulate a dynamic edge activation problem with stability ***,we propose an online matching while learning algorithm(MatL)and discuss its implementation for wireless ***,simulation results demonstrate that the MatL is reliable to learn the channel states and manage the users’buffers for fresher information at the edge.

关键词： information freshness Lyapunov opti-mization multi-armed bandit wireless scheduling