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Natural dietary anti-cancer chemopreventive compounds:redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells

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Acta Pharmacologica Sinica 2007年第4期28卷 459-472页

作者： Sujit NAIR Ah-Ng tony KONG Graduate Program in Pharmaceutical Sciences Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe StateUniversity of New JerseyPiscatawayNew Jersey 08854USA

Many dietary phytochemicals exhibit health-beneficial effects including preven-tion of diseases such as cancer,as well as neurological,cardiovascular,inflam-matory,and metabolic ***,herbivorous and omnivorousanimals have been ingesting *** interaction between"animal-plant"ecosystems has resulted in an elaborate system of detoxification and defensemechanisms evolved by animals including *** cells,includinghuman cells,respond to these dietary phytochemicals by"non-classical receptorsensing"mechanisms of electrophilic chemical-stress typified by"thiol-modu-lated"cellular signaling events primarily leading to the gene expression of phar-macologically beneficial effects,but sometimes unwanted cytotoxicity *** has been studying two groups of dietary phytochemical cancer-chemopreventive compounds (isothiocyanates and polyphenols),which areeffective in chemical-induced,as well as genetically-induced,animal carcinogen-esis *** compounds typically generate"cellular stress"and modulategene expression of phase Ⅱ detoxifying/antioxidant ***,reac-tive oxygen species,and reactive nitrogen species are known to act as secondmessengers in the modulation of many cellular signaling pathways leading togene expression changes and pharmacological ***-sensitive tran-scription factors such as nuclear factor-E2-related factor 2 (Nrf2),AP-1,NF-κB,tocite a few examples,sense and transduce changes in the cellular redox status andmodulate gene expression responses to oxidative and electrophilic stresses,pre-sumably via sulfhydryl modification of critical cysteine residues found on theseproteins and/or other upstream redox-sensitive molecular *** the currentreview,we will explore dietary cancer chemopreventive phytochemicals,discussthe link between oxidative/electrophilic stresses and the redox circuitry,and con-sider different redox-sensitive transcription *** will also discuss thekelch-l

关键词： redox Nrf2 Keapl NES NLS gene expression profiles

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Going only half the way:cell cycle exit after the G1 restriction point

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Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： Lisa Muller tony Gutschner Mechthild Hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,James *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

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Receptance Coupling for Tool Point Dynamics Prediction on Machine Tools

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Chinese Journal of Mechanical Engineering 2011年第3期24卷 340-345页

作者： ZHANG Jun SCHMITZ tony ZHAO Wanhua LU Bingheng State Key Laboratory for Manufacturing System Engineering Xi＇an Jiaotong University Xi＇an 710049 China Department of Mechanical andAerospaee Engineering University of Florida Gainesville FL 32611 United States

Chatter has been a primary obstacle to the successful implementation of high speed *** frequency response function（FRF） of the tool point is crucial for identification of chatter free cutting *** order to quickly acquire the FRF of the different components combinations of machine tool,the assembly of machine tool was always decomposed into several parts,where the fluted portion of tool,however,was always treated as a uniform beam,and the associated discrepancy was *** paper presents a new method to predict the dynamic response of the machine-spindle-holder-tool assembly using the receptance coupling substructure analysis technique,where the assembly is divided into three parts：machine-spindle,holder and tool shank,and tool＇s fluted *** testing is used to measure the receptance of machine-spindle,the Timoshenko beam model is employed to analyze the dynamics of holder and tool shank,and the finite element method（FEM） is used to calculate the receptance of the tool＇s fluted *** approximation of the fluted portion cross section using an equivalent diameter is also *** the individual receptances are coupled by using substructure *** predicted assembly receptance is experimentally verified for three different tool overhang *** results also show that the equivalent diameter beam model reaches an acceptable *** proposed approach is helpful to predict the tool point dynamics rapidly in industry.

关键词： receptance coupling dynamics endmill chatter

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The Clean Energy Research Centre (CERC)

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Clean Energy 2022年第2期6卷 238-246页

作者： Xiaotao(tony)Bi Junnan Chao Clean Energy Research Centre University of British Columbia2360 East MallVancouverCanadaV6T 1Z3

Introduction The Clean Energy Research Centre(CERC)is a multidisciplinary re-search hub dedicated to undertaking world-class clean-energy re-search,training,development and ***‘future today’research adds to the outstanding research endeavours and sterling reputation of the University of British Columbia(UBC)within Canada and *** goal is to become a world leader and a research-de-velopment-demonstration powerhouse for innovative clean-energy solutions to climate change and sustainability problems.

关键词： problems globally Clean

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A new horizon of targeted therapy in management of lung cancer

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中国肺癌杂志 2004年第4期7卷 276-283页

作者： tony Mok Department of Clinical Oncology the Chinese University of Hong Kong Hong Kong P.R.China BMSc MD FRCPC FHKAM FHKCP

1 IntroductionCisplatin-based combination chemotherapy using one of the novel cytotoxic agents, such as gemcitabine or taxane, prolongs survival of patients with advanced non-small cell lung cancer (NSCLC). The recent published phase Ⅲ study that compared paclitaxel/cisplatin to gemcitabine/cisplatin, docetaxel/cisplatin or paclitaxel/carboplatin has shown equal efficacy with the exception of longer progression-free survival from the gemcitabine/cisplatin combination[1]. Overall tumor response rates of 1 155 eligible patients was 19% with median survival of 7. 9months only. Findings from other major randomized comparative studies were similar. Table 1 summarized the tumor response rate and survival of these studies[1-4]. Hundreds of patients received platinumbased new drug doublets and the overall response rate was persistently reported at only about 20% to 30%. Survivals were better than the first generation of combination chemotherapy but the best median survival was less than 10 months and 1-year survival rate was persistently less than 45 %.

关键词：靶向治疗肺癌肿瘤 NSCLC 化学疗法

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Biosemiotics and Peirce

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Language and Semiotic Studies 2023年第2期9卷 143-162页

作者： tony Jappy University of Perpignan Via Domitia PerpignanFrance

Peirce's final statements on the sign were consigned in various ways over a hundred years ago as a form of logic,a branch of the science of enquiry based upon *** means inevitably that some parts of the theory will have been contested or considered superseded by more recent pronouncements on cognitive activity in general,both within and without the field of *** such areas that have been host to innovative developments concern central preoccupations of the entire Peircean edifice:the basic unit of semiotics and its function,and ways of ***,following Thomas Sebeok's pioneering integration of semiotics and the biological theories of Jakob von Uexkull,biosemiotics,it is claimed,has espoused a Peircean approach to the definitions of sign and ***,observation involves the relation between the observer and the object observed,and,as a theoretical consequence,the relation between an organism and its environment,von Uexkill's *** view of the importance accorded Peircean semiotic theory in this more recent science,the paper compares and contrasts aspects of the later theory with the earlier,and concludes that there are significant theoretical differences between the two conceptions of the sign and its theoretical implications.

关键词： biosemiotics observation Peirce perception semiosis sign

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Reflections on Black Visual Artist Doug Redd

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Journal of Foreign Languages and Cultures 2020年第2期4卷 134-143页

作者： tony Bolden University of Kansas

This essay was inspired by the death and devastation related to the pandemic of Covid-19 which intensified the ways that preexisting sociopolitical contradictions affected black *** the pandemic it was commonplace for thinkers to describe themselves as ***,in the moment of crisis,their voices were often silent or they offered superficial *** the magnitude of their lim itations-conflating moral protestations with political analyses,for instance-evoked memories of perceptive thinkers that I knew as a young man,such as visual artist Doug Redd whose worldview and aesthetics exemplify our need for alternative sensibilities,perspectives,and centers of thought in African American culture.

关键词： Blues Neo-Confederacy Doug Redd Black Art

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Hypoiconicity, Semiosis and Peirce’s Immediate Object

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Language and Semiotic Studies 2019年第2期5卷 1-36页

作者： tony Jappy University of Perpignan Via Domitia

Between 1865 and 1909 Peirce established over a dozen different sign taxonomies, most of which were established using his system of universal categories, Firstness, Secondness and Thirdness. Of these various systems, that of late 1903 with its universally-known iconindex-symbol division is the one most employed in the analysis of verbal and pictorial signs, as within this division the icon constitutes the sign’s purely formal, qualitative mode of representation showing how a sign might resemble its object. Now, Peirce further analyzed the icon into three more basic modes of qualitative representation, namely the hypoicons, thus enabling 'finer-grained' structural analyses of signs. However, in 1908 his conception of the way signs functioned developed into a very different, universebased, six-stage system, namely semiosis, from which the icon-index-symbol division,together with the hypoicons, was absent. Since, in view of the theoretical foundations distinguishing the three-division system of 1903 from the intention-based hexadic system of 1908, it might be thought that Peirce had introduced an unresolvable inconsistency into the two conceptions of the sign, the paper discusses ways for Peircean semiotics to accommodate, in examples of principally figurative pictorial representation, both the potential for structural analysis offered by hypoiconicity and the intentionality of semiosis. In this latter case, the role of the sign’s immediate object will be shown to be of considerable theoretical interest.

关键词： mode of representation image diagram metaphor category universe intentionality

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Peirce’s Other Ten-Class Typology

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Language and Semiotic Studies 2021年第1期7卷 1-33页

作者： tony Jappy University of Perpignan Via Domitia France

In the manuscript of the 1903 Syllabus intended to accompany his lowell lectures on logic,Peirce developed what is one of his best-known semiotic constructions,namely a ten-class,three-division typology of *** nine subdivisions in the typology define,amongst others,the icon-index-symbol division much used in visual semiotics and even in competing theories of the sign,and were based upon the three phenomenological categories as Peirce conceived them at the ***,within five years he had developed a different ten-class typology left as a scrap of information in a post-scriptum to a draft letter intended for,but never sent to,Lady ***,this new typology was established following a period in which Peirce’s thinking on signs had undergone considerable developments;it was underwritten by a different set of theoretical choices from which it was impossible to construct the earlier icon-index-symbol *** paper seeks to tease out the differences between the two typologies,the interpretation of the latter presenting Peirce scholars with an interesting theoretical *** summarising the 1903 system for purposes of comparison,the paper examines the theoretical developments leading to the 1908 post-scriptum typology,establishes the ten classes it yields and attempts to illustrate some of *** two ten-class taxonomies show in a striking manner how significantly Peirce’s criteria for the classification of signs developed in the five years between the Syllabus and the draft *** is to be hoped that this will contribute to our understanding of how Peirce came later to conceive the sign and the way it functions.

关键词： phenomenology category pragmaticism universe semiosis intentionality post-scriptum

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Intentional Signs From a Peircean Perspective

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Language and Semiotic Studies 2018年第1期4卷 1-21页

作者： tony Jappy University of Perpignan Via Domitia France

It can safely be assumed that with its well-known icon-index-symbol trichotomy, Peirce's 1903 ten-class typology can adequately analyze still images, photographs and ***, given the implication principle whereby a symbol can involve an index and an index an icon, it follows that any symbolic element can, by transitivity, involve iconic elements, making it possible within this system to accommodate complex forms of *** phenomenological basis, however, and the nature of the divisions composing it make it less amenable to the analysis of intentionality in ***, in 1908 Peirce introduced two far more complex *** first, formed of six divisions from which the icon-indexsymbol trichotomy is absent, generates twenty-eight classes of signs; the second, ten-division system, theoretically generates *** exact order of the ten divisions forming the latter system is disputed, rendering the typology's semiotic viability uncertain, whereas the 28-class typology, which classifies signs not on how they represent their object but, amongst other things, according to the sorts of objects they represent, is fully *** is therefore of considerable semiotic interest to investigate the way this typology without icons, indices or symbols, might contribute to the analysis of image-based expressions of *** paper sets out the basic features of the ten-and 28-class systems, explores the semiotic potential of the latter for the analysis of image-based signs by examining the transmodal iconoclasm characteristic of the photomontages of Barbara Kruger and the films of Guy-Ernest Debord, and attempts in this way to establish the logical basis of their transgressive ideological motivation and commitment.

关键词： Peirce intentionality anti-ocularcentrism iconoclasm transmodality

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