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Influence of Hot-Rolling Deformation on Microstructure,Crystalline Orientation,and Texture Evolution of the Ti6Al4V-5Cu Alloy

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Acta Metallurgica Sinica(English Letters) 2023年第8期36卷 1261-1280页

作者： Solomon Kerealme Yeshanew Chunguang Bai Qing Jia tong Xi Zhiqiang Zhang Diaofeng Li Zhizhou Xia rui yang Ke yang Shi-Changxu Innovation Center for Advanced Materials Institute of Metal Research(IMR)Chinese Academy of Sciences(CAS)Shenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

The influence of hot-deformation on the microstructure,crystalline orientation,and texture evolution of Ti6Al4V-5Cu,an antibacterial(α+β)titanium alloy,was *** alloy was deformed using a hot rolling process in 15%,58%,and 73%thickness reduction *** was found that the basaland pyramidaltype slip planes could be activated in theαphase,which dominated the deformation behavior of Ti6Al4V-5Cu *** various deformation conditions,the alloy revealed different microstructure *** the 15%hot rolled alloy,the deformation was performed by the breakdown of priorβgrain boundaries(GBβ),which was attributed to the formation of coarseαgrains,rotated nearly 45°with respect to the transversal and rolling *** presence of different sub-structure geometries made the interior grain size distribution *** the 58%hot rolled alloy,Ti2Cu intermetallic compound was found at theα/β***-resolution transmission electron microscopy investigation showed the occurrence of grain rotation in different crystallographic *** room temperature,the percentage elongation(El)of the alloy reached 23.15%on the 58%hot rolled *** the 73%deformed alloy,refined and randomly oriented characteristics of grains were obtained due to higher thickness reduction,which resulted from the segregation of very fine *** influence of grain rotation during a hot rolling process revealed that theα/βtexture fiber separation angle to maintain the Burger orientation relationship of{0001}α//{110}βplanes decreased with increase of the thickness reduction ratio when Ti6Al4V-5Cu alloy was deformed by a hot rolling *** of tensile{1012}and compressive{1122}twins on the deformation of the alloy was also studied.

关键词： Ti6Al4V-5Cu Hot rolling Microstructure Texture evolution Twining

Real-time detection network for tiny traffic sign using multi-scale attention module

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维普期刊数据库

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Science China(Technological Sciences) 2022年第2期65卷 396-406页

作者： yang TingTing tong Chao School of Computer Science&Engineering Beihang UniversityBeijing 100191China

As one of the key technologies of intelligent vehicles, traffic sign detection is still a challenging task because of the tiny size of its target object. To address the challenge, we present a novel detection network improved from yolo-v3 for the tiny traffic sign with high precision in real-time. First, a visual multi-scale attention module(MSAM), a light-weight yet effective module, is devised to fuse the multi-scale feature maps with channel weights and spatial masks. It increases the representation power of the network by emphasizing useful features and suppressing unnecessary ones. Second, we exploit effectively fine-grained features about tiny objects from the shallower layers through modifying backbone Darknet-53 and adding one prediction head to yolo-v3. Finally, a receptive field block is added into the neck of the network to broaden the receptive field. Experiments prove the effectiveness of our network in both quantitative and qualitative aspects. The m AP@0.5 of our network reaches 0.965 and its detection speed is55.56 FPS for 512 × 512 images on the challenging Tsinghua-Tencent 100 k(TT100 k) dataset.

关键词： tiny object detection traffic sign detection multi-scale attention module real-time

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie yang Ganggang Zhang Chen Wang Yanlian yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

Optimizing Culture System of Ri T-DNA Transformed Roots for Citrus grandis cv. Changshou Shatian You

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Agricultural Sciences in China 2006年第2期5卷 90-97页

作者： yang Xiao-hong SUN Zhong-hai tong rui-jian Institute of Citrus Huazhong Agricultural University Wuhan 430007 P.R.China College of Horticulture and Landscape Architecture Southwest University Chongqing 400716 P.R. China

Genetic transformation experiments of the different explants from Citrus grandis cv. Changshou Shatian You infected with Agrobacterium rhizogenes were carried out in darkness or in light. The optimizing culture system of Ri T-DNA transformed roots for C. grandis cv. Changshou Shatian You was constructed as follows： After the ventral wounded striations on the single activation cotyledon were inoculated by A. rhizogenes A4 （logarithmic period）, they were cocultured at （25 ±2）℃ in darkness for 25-30 days; some transformed roots were generated from wounded striations of most cotyledons. The genetically transformed ratio is （83 ± 11）%. Axenic Ri T-DNA transformed roots （hairy roots） were harvested after five subcultures. Explants were activated on MT medium. The MS medium was used for subculture of transformed roots. Mass Ri T-DNA transformed roots in which the hormone was produced independently were harvested from this optimizing culture system. White, fresh Ri T-DNA transformed roots were （1.14 ±0.07） cm long, （0.73 ±0.04） mm wide, and the growth direction of transformed roots was negative geotropism.

关键词： Citrus grandis cv. Changshou Shatian You Agrobacterium rhizogenes Ri T-DNA transformed root optimizingculture system

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Whole-lifetime Coordinated Service Strategy for Battery Energy Storage System Considering Multi-stage Battery Aging Characteristics

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Journal of Modern Power Systems and Clean Energy 2022年第3期10卷 689-699页

作者： Feilong Fan Yan Xu rui Zhang tong Wan IEEE Energy Research Institute@NTU Nanyang Technological UniversitySingapore College of Smart Energy Shanghai Jiao Tong UniversityShanghaiChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore The University of New South Wales SydneyAustralia University of Sydney SydneyAustralia

One battery energy storage system(BESS)can be used to provide different services,such as energy arbitrage(EA)and frequency regulation(FR)support,etc.,which have different revenues and lead to different battery degradation *** paper proposes a whole-lifetime coordinated service strategy to maximize the total operation profit of BESS.A multi-stage battery aging model is developed to characterize the battery aging rates during the whole *** the uncertainty of electricity price in EA service and frequency deviation in FR service,the whole problem is formulated as a twostage stochastic programming *** the first stage,the optimal service switching scheme between the EA and FR services are formulated to maximize the expected value of the whole-lifetime operation *** the second stage,the output power of BESS in EA service is optimized according to the electricity price in the hourly timescale,whereas the output power of BESS in FR service is directly determined according to the frequency deviation in the second *** above optimization problem is then converted as a deterministic mixed-integer nonlinear programming(MINLP)model with bilinear *** Cormick envelopes and a bound tightening algorithm are used to solve *** simulation is carried out to validate the effectiveness and advantages of the proposed strategy.

关键词： Battery energy storage system(BESS) wholelifetime coordinated service multi-stage battery aging model two-stage stochastic programming mixed-integer nonlinear programming(MINLP)

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu Yifei yang Yike Jing Zhen Zeng Xuesong Yi Wei Sun Fei yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed