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In vitro evaluation of inorganic and methyl mercury mediated cytotoxic effect on neural cells derived from different animal species

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Journal of Environmental Sciences 2016年第3期28卷 138-145页

作者： jing tong Youwei Wang Yuanan Lu Institute of TCM & Natural Products School of Pharmaceutical SciencesWuhan University Department of Public Health Sciences University of Hawaii at Manoa Global Health Center School of Public HealthWuhan University

To extend the current understanding of the mercury-mediated cytotoxic effect,five neural cell lines established from different animal species were comparatively analyzed using three different endpoint bioassays：thiazolyl blue tetrazolium bromide,3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay（MTT）,neutral red uptake assay（NRU）,and Coomassie blue assay（CB）.Following a 24-hr exposure to selected concentrations of mercury chloride（HgCl_2） and methylmercury（Ⅱ） chloride（MeHgCl）,the cytotoxic effect on test cells was characterized by comparing their 50%inhibition concentration（IC_（50）） *** results indicated that both these forms of mercury were toxic to all the neural cells,but at very different *** IC_（50）values of MeHgCl among these cell lines ranged from 1.15±0.22 to 10.31 ± 0.70 μmol/L while the IC_（50） values for HgCl_2 were much higher,ranging from 6.44 ± 0.36 to 160.97±19.63 μmol/L,indicating the more toxic nature of *** IC_（50） ratio between HgCl_2and MeHgCl ranged from 1.75 to 96.0,which confirms that organic mercury is much more toxic to these neural cells than inorganic *** these cell lines,HGST-BR and TriG44 derived from marine sea turtles showed a significantly high tolerance to HgCl_2 as compared to the three mammalian neural *** these neural cells,SK-N-SH represented the most sensitive cells to both chemical forms of mercury.

关键词： In vitro cytotoxicity Neural cell lines HgCl_2 MeHgCl

Steiner Minimal Trees in Rectilinear and Octilinear Planes

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1577-1586页

作者： Song Pu SHANG tong jing College of Mathematics and Information Sciences North China University of Water Conservancy and Electric Power Zhengzhou 450011 P. R. China Department of Computer Science and Technology Tsinghua University Beijing 100084 P. R. China

This paper considers the Steiner Minimal Tree （SMT） problem in the rectilinear and octilinear planes. The study is motivated by the physical design of VLSI： The rectilinear case corresponds to the currently used M-architecture, which uses either horizontal or vertical routing, while the octilinear case corresponds to a new routing technique, X-architecture, that is based on the pervasive use of diagonal directions. The experimental studies show that the X-architecture demonstrates a length reduction of more than 10-20%. In this paper, we make a theoretical study on the lengths of SMTs in these two planes. Our mathematical analysis confirms that the length reduction is significant as the previous experimental studies claimed, but the reduction for three points is not as significant as for two points. We also obtain the lower and upper bounds on the expected lengths of SMTs in these two planes for arbitrary number of points.

关键词： Steiner minimal tree minimum spanning tree rectilinear plane octilinear plane

Observability and estimability of passive radar with unknown illuminator states using different observations

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1193-1205页

作者： jing tong TIAN Wei HUANG Gaoming PENG Huafu College of Electronic Engineering Naval University of EngineeringWuhan 430033China

Most existing studies about passive radar systems are based on the already known illuminator of opportunity(IO)***,in practice,the receiver generally has little knowledge about the IO *** research has studied this *** paper analyzes the observability and estimability for passive radar systems with unknown IO states under three typical ***,the directions of high and low estimability with respect to various states are ***,two types of observations are taken into *** effects of different observations on both observability and estimability are well *** the observability test,linear and nonlinear methods are considered,which proves that both tests are applicable to the *** simulations confirm the correctness of the theoretical analysis.

关键词： passive radar passive coherent location(PCL) observability estimability unknown illuminator states

Analysis of energy saving optimization of campus buildings based on energy simulation

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Frontiers in Energy 2013年第3期7卷 388-398页

作者： Dingding tong jing ZHAO School of Environmental Science and Engineering Tianjin UniversityTianjin 300072 China

The energy consumption of campus buildings has specific characteristics, because of the concentrated distribution of people＇s working time and locations that change in line with distinct seasonal features. The traditional energy system design and operation for campus buildings is only based on the constant room temperature, such as 25~C in summer and 18~C in winter in China, not taking into consideration the real heating or cooling load characteristics of campus buildings with different func- tions during the whole day and whole year, which usually results in a lot of energy waste. This paper proposes to set different set-point temperatures in different operation stages of public and residential campus buildings to reduce the heating and cooling design load for energy station and total campus energy consumption for annual operation. Taking a campus under construction in Tianjin, China as an example, two kinds of single building models were established as the typical public building and residential building models on the campus. Besides, the models were simulated at both set-point room temperature and constant room temperature respectively. The comparison of the simulation results showed that the single building energy saving method of the peak load clipping could be used for further analysis of the annual energy consumption of campus building groups. The results proved that the strategy of set-point temperature optimization could efficiently reduce the design load and energy consumption of campus building groups.

关键词： campus buildings set-point temperature energy simulation energy saving optimization

PGT or ICSI?The impression of NGS-based PGT outcomes in nonmosaic Klinefelter syndrome

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Asian Journal of Andrology 2021年第6期23卷 621-626页

作者： jing tong Xiao-Ming Zhao An-Ran Wan Ting Zhang Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200135China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200135China

This retrospective study demonstrates the clinical outcomes of patients with nonmosaic Klinefelter's syndrome(KS)who underwent preimplantation genetic testing(PGT)with frozen-thawed testicular *** testicular sperm extraction(micro-TESE)was performed for sperm ***-generation sequencing(NGS)was conducted for embryo analysis.A total of 18 couples aged≤35 years were included,and 22 oocyte retrieval cycles were *** was detected in 29 of 45(64.4%)***,the numbers of aneuploid and mosaic embryos detected were 8(17.8%)and 8(17.8%),respectively,regardless of a lack of sex chromosome ***,13 couples with euploid embryos completed 14 frozen embryo transfer(FET)*** couples had clinical pregnancies,and 6 of them had already delivered 5 healthy babies and 1 monozygotic *** were also 4 ongoing pregnancies and 2 biochemical pregnancies,but no early pregnancy loss was *** on our results,we speculate that for KS patients,when sperm can be obtained by micro-TESE,the cryopreservation strategy makes the ovarian stimulation procedure more favorable for female *** paternal genetic risk of sex chromosome abnormalities in their offspring is extremely low in men with *** addition to PGT,the intracytoplasmic sperm injection(ICSI)procedure is comparably effective but more economical for young nonmosaic KS *** should be offered as an option for such couples,but monitoring by prenatal genetic diagnosis is recommended.

关键词： microdissection testicular sperm extraction next-generation sequencing nonmosaic Klinefelter's syndrome preimplantation genetic testing

Molar Surface Gibbs Energy of the Aqueous Solution of Ionic Liquid [C4mim][OAc]

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Chemical Research in Chinese Universities 2017年第5期33卷 828-832页

作者： tong jing ZHENG Xu tong Jian QU Ye LIU Lu LI Hui College of Chemistry Liaoning University Shenyang 110036 P. R. China

The values of density and surface tension for aqueous solution of ionic liquid（IL） 1-butyl-3-methylimi- dazolium acetate（[C4nim][OAc]） with various molalities were measured in the range of 288.15--318.15 K at intervals of 5 K. On the basis of thermodynamics, a semi-empirical model-molar surface Gibbs energy model of the ionic liquid solution that could be used to predict the surface tension or molar volume of solutions was put forward. The predicted values of the surface tension for aqueous [C4mim][OAc] and the corresponding experimental ones were highly correlated and extremely similar. In terms of the concept of the molar Gibbs energy, a new Eotvos equation was obtained and each parameter of the new equation has a clear physical meaning.

关键词： Ionic liquid Aqueous solution Molar surface Gibbs energy Density Surface tension

A Generalized Equation of State for High-Pressure Liquids

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Journal of China University of Mining and Technology 2005年第4期15卷 376-378页

作者： LIANG Yan-bo tong jing-shan Department of Chemistry Xuzhou Normal University Xuzhou Jiangsu 221009 China Department of Chemical Engineering Tsinghua University Beijing 100084 China

An equation of state （EOS） for high-pressure liquids, i.e., Tait EOS, is deduced according to isothermal 1 3V compressibility KT= -1/V· （2V/2p）T·.Based on the equation, a generalized EOS for high pressure-liquids is established by using the reduced state principle and introducing a characteristic parameter-configuration factor ξ. Reasonably satisfactory P-V-T data for many organic compounds, including some polar components, were calculated by using the equation.

关键词： equation of state for high-pressure liquids organic compounds P-V-T data

Gender Classification Based on Multi-Scale and Run-Length Features

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Journal of Electronic Science and Technology 2017年第3期15卷 251-257页

作者： Sheng-Hung Wang Chih-Yang Lin jing-tong Fu Department of Computer Science and Information Engineering Asia University Taichung 41354 Department of Bioinformatics and Medical Engineering Asia University Taichung 41354

Human faces can convey substantial information about a person,such as his or her age,race,identity,gender,and *** facial information can be obtained through techniques like human facial tracking and detection,facial recognition,gender classification,emotion recognition,as well as age *** these,gender classification is particularly important due to its diverse applications in the fields such as video surveillance and commercial *** this thesis,we propose a method of gender classification based on run-length *** proposed method uses a run-length histogram to record the position information of pixels,thereby efficiently improves the recognition rate and makes the technique suitable for a big-data multimedia *** experimental results show that the proposed method can achieve better accuracy than a multi-scale based method can.

关键词： Index Terms--Gender classification run-length,texture feature.

Oncolytic virus-based hepatocellular carcinoma treatment:Current status,intravenous delivery strategies,and emerging combination therapeutic solutions

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Asian Journal of Pharmaceutical Sciences 2023年第1期18卷 4-26页

作者： Xinguo Li Xiaonan Sun BingyuanWang Yiling Li jing tong The First Hospital of China Medical University Shenyang 110001China The 4th People’s Hospital of Shenyang Shenyang 110031China

Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life *** clinical need for more efficient and safe therapies has contributed to the exploration of emerging ***,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for *** undergo selective replication in cancerous tissues and kill tumor ***,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the *** and Drug Administration(FDA)in ***,dozens of OVs are being tested in HCC-directed clinical and preclinical *** this review,the pathogenesis and current therapies of HCC are ***,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and *** carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are *** addition,we highlight the combination treatments between oncolytic virotherapy and other ***,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.

关键词： Oncolytic viruses(OVs) OV intravenous delivery systems Combination treatments Advanced hepatocellular carcinoma (HCC) Pexa-Vec