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Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

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World Journal of Gastroenterology 2008年第20期14卷 3212-3217页

作者： Ken Ariizumi tomoyuki koike Shuichi Ohara Yoshifumi Inomata Yasuhiko Abe Katsunori Iijima Akira Imatani Tomoyoshi Oka Tooru Shimosegawa Division of Gastroenterology TohokuUniversity Graduate School of Medicine Sendai Miyagi9808574 Japan Division of Diabetes and Metabolic Diseases Tohoku University Graduate School of Medicine Sendai Miyagi 9808574 Japan

AIM: To investigate the incidence of reflux esophagitis (RE) and H pylori infection in the diabetic patient. METHODS: The incidence of RE and H pylori infection were investigated in 85 patients with diabetes mellitus and the results were compared with controls. RESULTS: The incidence of RE in diabetic patients was 17.6%. Although this tended to be higher in diabetic patients, there were no statistically significant differences between diabetic patients and controls. The incidence of H pylori infection in diabetic patients was 53.7% but no statistically significant difference was seen between diabetic patients and controls in the incidence of H pylori infection. CONCLUSION: No significant differences could be seen between diabetic patients and controls in the incidence of RE and H pylori infection.

关键词：糖尿病食管炎幽门螺杆菌细菌感染

Identification of the layered morphology of the esophageal wall by optical coherence tomography

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World Journal of Gastroenterology 2009年第35期15卷 4402-4409页

作者： Satoshi Yokosawa tomoyuki koike Yasushi Kitagawa Waku Hatta Kaname Uno Yasuhiko Abe Katsunori Iijima Akira Imatani Shuichi Ohara Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine1-1Seiryo-machiAoba-kuSendai Miyagi 980-8574Japan

AIM:To assess each layer of the optical coherence tomography(OCT)image of the esophageal wall with reference to the histological structure. METHODS:Resected specimens of fresh pig esophagus was used as a model for the esophageal *** injected cyanoacrylate adhesive into the specimens to create a marker,and scanned them using a miniature OCT *** localization of these markers was assessed in the OCT *** we compared the OCT-imaged morphology with the corresponding histological section,guided by the cyanoacrylate adhesive *** prepared a second set of experiments using nylon sutures as markers. RESULTS:The OCT image of the esophageal specimen has a clear five-layered morphology. First,it consisted of a relatively less reflective layer; second,a more reflective layer;third,a less reflective layer;fourth,a more reflective layer;and fifth,a less reflective *** the OCT images with marked histological sections showed that the first layer corresponded to stratified squamous epithelium; the second to lamina propria;the third to muscularis mucosa;fourth,submucosa;and fifth,muscularispropria with deeper structures of the esophageal ***:We demonstrated that the OCT image of the normal esophageal wall showed a five- layered morphology,which corresponds to histological esophageal wall components.

关键词：形态鉴定断层扫描光学相干氰基丙烯酸酯胶粘剂食道标记定位组织结构组织切片

Brain activity following esophageal acid infusion using positron emission tomography

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World Journal of Gastroenterology 2010年第43期16卷 5481-5489页

作者： Shigeyuki Kobayashi Yasuhiko Abe Manabu Tashiro tomoyuki koike Katsunori Iijima Akira Imatani Shuichi Ohara Satoshi Watanabe Shin Fukudo Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Division of Cyclotron Nuclear Medicine Cyclotron and Radioisotope Center Tohoku University Division of Behavioral Medicine Tohoku University Graduate School of Medicine

AIM: To investigate symptoms and brain activity following esophageal acid infusion. METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of ***: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/ posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms. CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

关键词： Esophageal acid infusion Brain imaging Positron emission tomography

Role of T-box transcription factor 3 in gastric cancers

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World Journal of Gastrointestinal Pathophysiology 2023年第2期14卷 12-20页

作者： Naoki Asano Akira Imatani Akio Takeuchi Masashi Saito Xiao-Yi Jin Waku Hatta Kaname Uno tomoyuki koike Atsushi Masamune Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

The expression of T-box transcription factor 3(TBX3)has been identified in various cancers,including gastric *** role in breast cancers and melanomas has been intensively studied,and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been *** reports on the role of TBX3 in gastric cancers have implied its involvement in gastric *** its pivotal role in the initiation and progression of cancers,TBX3 could be a promising therapeutic target for gastric cancers.

关键词： Aging Wnt β-catenin Transforming growth factor-β Stomach Carcinogenesis

Assessing efficacy of standard impregnation techniques on die-cast aluminum alloys using X-ray micro-CT

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China Foundry 2024年第3期21卷 276-286页

作者： Ajith Bandara Koichi Kan Katanaga Yusuke Natsuto Soga Akifumi koike Toru Aoki Hamamatsu TSC Chuo Hatsumei Institute322 lida-choMinami-kuHamamatsu435-0028Japan Graduate School of Medical Photonics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan ANSeeN Inc Johoku 3-5-1HamamatsuShizuoka432-8561Japan Research Institute of Electronics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan

Utilizing lightweight Al alloys in various industrial applications requires achieving precise pressure tightness and leak *** pressure impregnation(VPI)with thermosetting polymers is commonly used to address leakage defects in die-cast Al *** this study,the efficacy of the VPI technique in sealing alloy parts was investigated using a combination of nondestructive micro X-ray computed tomography(micro XCT)and a standard leak *** results demonstrate that the commonly used water leak test is insufficient for determining the sealing ***,micro XCT shows distinct advantages by enabling more comprehensive *** reveals the presence of a low atomic number impregnates sealant within casting defects,which has low grey contrast and allows for visualizing primary leakage paths in *** effective atomic number of impregnated resin is 6.75 and that of Al alloy is 13.69 by dual-energy X-ray *** research findings will contribute to enhancing the standard VPI process parameters and the properties of impregnating sealants to improve quality assurance for impregnation in industrial metals.

关键词： nondestructive testing Al alloy die-casting vacuum pressure impregnation micro X-ray computed tomography duel-energy X-ray CT

Helicobacter pylori-negative,non-steroidal anti-inflammatory drug:Negative idiopathic ulcers in Asia

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World Journal of Gastroenterology 2014年第3期20卷 706-713页

作者： Katsunori Iijima Takeshi Kanno tomoyuki koike Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine

Since the discovery of Helicobacter pylori(***)infection in the stomach,the bacteria infection and non-steroidal anti-inflammatory drugs(NSAIDs)use had been considered to be the 2 main causes of peptic ***,there have been recent reports of an increase in the proportion of peptic ulcers without these known risk factors;these are termed idiopathic peptic *** trend was firstly indicated in 1990s from some reports in North *** Asia,numerous studies reported that idiopathic ulcers accounted for a small percentage of all ulcers in the 1990s,but in the2000s,multiple studies reported that the proportion of idiopathic ulcers had reached 10%-30%,indicating that the incidence of idiopathic ulcers in Asia has also been rising in recent *** a decline in *** infection rates of general population in Asia is seen as the main reason for the increased incidence of idiopathic ulcers,it is also possible that the absolute number of idiopathic ulcer cases has *** age,serious systemic complication,and psychological stress are considered to be the potential risk factors for idiopathic *** of idiopathic ulcers is challenging,at present,because there is no effective preventative measure against recurrence in contrast with cases of ***-positive ulcers and NSAIDs-induced *** it is expected that *** infection rates in Asia will decline further in the future,measures to treat idiopathic ulcers will also likely become more important.

关键词： Helicobacter pylori Non-steroidal antiinflammatory

Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm

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World Journal of Gastroenterology 2015年第23期21卷 7120-7133页

作者： Kaname Uno Katsunori Iijima tomoyuki koike Tooru Shimosegawa Division of Gastroenterology Tohoku University Hospital

The minimal invasiveness of endoscopic submucosal dissection(ESD) prompted us to apply this technique to large-size early esophageal squamous cell carcinoma and Barrett's adenocarcinoma, despite the limitationsin the study population and surveillance duration. A post-ESD ulceration of greater than three-fourths of esophageal circumference was advocated as an important risk factor for refractory strictures that require several sessions of dilation therapy. Most of the preoperative conditions are asymptomatic, but dilatation treatment for dysphagia associated with the stricture has potential risks of severe complications and a worsening of quality of life. Possible mechanisms of dysphasia were demonstrated based on dysmotility and pathological abnormalities at the site:(1) delayed mucosal healing;(2) severe inflammation and disorganized fibrosis with abundant extracellular matrices in the submucosa; and(3) atrophy in the muscularis proper. However, reports on the administration of anti-scarring agents, preventive dilation therapies, and regenerative medicine demonstrated limited success in stricture prevention, and there were discrepancies in the study designs and protocols of these reports. The development and consequent long-term assessments of new prophylactic technologies on the promotion of wound healing and control of the inflammatory/tumor microenvironment will require collaboration among various research fields because of the limited accuracy of preoperative staging and high-risk of local recurrence.

关键词： Esophageal stricture Dysphasia Endoscopicsubmucosal dissection

Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review

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World Journal of Gastroenterology 2015年第26期21卷 8014-8020页

作者： Naoki Asano Katsunori Iijima tomoyuki koike Akira Imatani Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine

Since Isaacson and Wright first reported on the extranodal marginal zone B-cell lymphoma of the stomach in 1983,following studies have clarified many aspects of this *** now know that the stomach is the most affected organ by this disease,and approximately90% of gastric mucosa-associated lymphoid tissue(MALT) lymphomas are related to Helicobacter pylori(***) *** implies that approximately 10% of gastric MALT lymphomas occur independent of *** *** pathogenesis of these ***-negative gastric MALT lymphomas remains *** date,there have been several *** possibility is that genetic alterations result in nuclear factor-kappa B(NF-κB) *** these alterations,t(11;18)(q21;q21) is more frequently observed in ***-negative gastric MALT lymphomas,and such translocation results in the synthesis of fusion protein API2-MALT1,which causes canonical and noncanonical NF-κB *** possibility is infection with bacteria other than *** could explain why *** eradication therapy can cure some proportions of ***-negative gastric MALT lymphoma patients,although the bacteria responsible for MALT lymphomagenesis are yet to be *** advances in endoscopy suggest magnifying endoscopy with narrow band imaging as a useful tool for both detecting gastric MALT lymphoma lesions and judging the response to treatment.A certain proportion of ***-negative gastric MALT lymphoma patients respond to eradication therapy; hence,*** eradication therapy could be considered as a first-line treatment for gastric MALT lymphomas regardless of their *** infection status.

关键词： Helicobacter pylori Mucosa-associatedlymphoid tissue lymphoma API2-MALT1 Antibiotics Endoscopy

The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner Michał Kowalczyk Julian Srebrny Leszek Próchniak Chrystian Droste Jan Kownacki Maciej Kisieliński Krzysztof Starosta Takeshi koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. Our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes