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Meta-analysis of lymph node metastasis in Siewert type Ⅰ and Ⅱ T1 adenocarcinomas

World Journal of Meta-Analysis 2016年第6期4卷 118-123页

作者： Hiroki Osumi Junko Fujisaki Masami Omae tomoki shimizu Toshiyuki Yoshio Akiyoshi Ishiyama Toshiaki Hirasawa Tomohiro Tsuchida Yorimasa Yamamoto Hiroshi Kawachi Noriko Yamamoto Masahiro Igarashi Departments of Gastroenterology and Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research Departments of Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research

AIM To evaluate the incidence of lymph node metastasis （LNM） and its risk factors in patients with Siewert type Ⅰ and type Ⅱ pT1 *** We enrolled 85 patients [69 men, 16 women; median age （range）, 67 （38-84） years] who had undergone esophagectomy or proximal gastrectomy for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas. Predictive risk factors of LNM included age, sex, location of the tumor center, confirmed Barrett’s esophageal adenocarcinoma, tumor size, macroscopic tumor type, pathology, invasion depth, presence of ulceration, and lymphovascular invasion. Multivariate logistic regression analysis was used to identify factors predicting LNM. We also evaluated the frequencies of LNM for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas in meta-data *** were found in 11 out of 85 patients （12.9%, 95%CI： 5.8-20.0）. Only 1 of the 15 patients （6.6%, 95%CI： 0.0-19.2） who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 10 of the 70 patients （14.2%, 95%CI： 6.0-22.4） with a final diagnosis of pT1b adenocarcinoma had positive LNM. Furthermore, only one of the 30 patients （3.3%, 95%CI： 0.0-9.7） with a tumor invasion depth within 500 μm from muscularis mucosae had positive LNM. Poor differentiation and lymphovascular invasion were independently associated with a risk of LNM. In meta-data analysis, 12 of the 355 patients （3.3%, 95%CI： 1.5-5.2） who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 91 of the 438 patients （20.7%, 95%CI： 16.9-24.5） with a fnal diagnosis of pT1b adenocarcinoma had positive *** consider endoscopic submucosal dissection （ESD） is suitable for patients with Siewert type Ⅰ and type Ⅱ T1a adenocarcinomas. For patients with T1b adenocarcinoma, especially invasion depth is within 500 μm from muscularis mucosae with no other risk factor for LNM, diagnostic ESD could be a treatment option according to the overall status of patients and the presence of comorbiditi

关键词： Siewert type Ⅰ and type Ⅱ adenocarcinomas Lymph node metastasis

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Seismic response reduction of a three-story building by an MR grease damper

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Frontiers of Mechanical Engineering 2017年第2期12卷 224-233页

作者： tomoki SAKURAI Shin MORISHITA Graduate School of Environment and Information Sciences YokohamaNational University Yokohama 240-8501 Japan Environment and Information Sciences Yokohama National UniversityYokohama 240-8501 Japan

This paper describes an application of mag- neto-rheological （MR） grease dampers as seismic dampers for a three-story steel structure. MR fluid is widely known as a smart material with rheological properties that can be varied by magnetic field strength. This material has been applied to various types of devices, such as dampers, clutches, and engine mounts. However, the ferromagnetic particles dispersed in MR fluid settle out of the suspension after a certain interval because of the density difference between the particles and their carrier fluid. To overcome this defect, we developed a new type of controllable working fluid using grease as the carrier of magnetic particles. MR grease was introduced into a cylindrical damper, and the seismic performance of the damper was subsequently studied via numerical analysis. The analysis results of the MR grease damper were compared with those of other seismic dampers. We confirmed that the MR grease damper is an effective seismic damper.

关键词： MR grease damper seismic damper vibration control structural response FEM analysis

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Formation and Annealing of BaTiO_3 and SrTiO_3 Nanoparticles in KOH Solution

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Journal of Materials Science & Technology 2010年第1期26卷 33-38页

作者： tomoki Tsumura Keiichi Matsuoka Masahiro Toyoda Department of Applied Chemistry Faculty of EngineeringOita University

Barium titanate （BaTiO3） and strontium titanate （SrTiO3） nanoparticles were synthesized separately through hydrothermal reaction of crystalline TiO2 particles and corresponding alkaline earth hydroxides, Ba（OH）2 and St（OH）2 respectively, in 50 mol·dm^-3 KOH solution at 150℃. Each structural evolution of BaTiO3 and SrTiO3 during the hydrothermal treatment was investigated by X-ray diffraction （XRD）, field emission scanning electron microscopy （FE-SEM）, field emission transmission electron microscopy （FE-TEM） and thermogravimetry- differential analysis （TG-DTA）. In the BaTiO3 system, round particles with cubic perovskite-type structure were obtained within 1 h. However, these particles were gradually dissolved and then were re-precipitated in the form of cube-shape BaTiO3 particles with a smaller lattice constant ac than that of the former phase. After the BaTiO3 particles formed firstly have disappeared completely, or the two phases coexistence stage with different lattice constant ac passed, lattice constant ac of BaTiO3 phase re-precipitated continuously decreased with annealing time. In contrast, once SrTiO3 particles are formed, the lattice constant ac decreased continuously throughout the reaction. The result indicates that SrTiO3 particles were annealed without dissolution and precipitation process under the present condition.

关键词： BaTiO3 SrTiO3 Nanoparticle Hydrothermal reaction

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Numerical analysis of a projecting wall type oscillating water column(PW-OWC)wave energy converter in regular waves

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Journal of Hydrodynamics 2024年第3期36卷 479-491页

作者： Lei Tan Ruiyuan Chang tomoki Ikoma Department of Oceanic Architecture and Engineering College of Science and TechnologyNihon UniversityChibaJapan

Oscillating water column(OWC)based wave energy absorption devices are classic which have been widely used for harnessing ocean wave *** paper presents a numerical study on a projecting wall(PW)type OWC wave energy converter in regular *** computational fluid dynamics(CFD)modelling of a stationary floating PW-OWC model in a three-dimensional wave flume is achieved by the software *** analyses are carried out based on CFD simulations and the linear potential flow solutions with modifications to account for turbine-induced *** present numerical solutions are validated against our previous experimental *** is found that both the CFD and modified linear potential flow predictions are in reasonably good agreements with the experimental data in the first order results of OWC and air pressure *** the nonlinear responses are included in the result,the modified linear potential flow solution is found to slightly under-estimate the wave energy conversion performance at long *** the airflows above and below the chamber orifice,the CFD results suggest that they are almost unidirectional,oscillating in not only the base frequency but also subharmonic and ultraharmonic *** evolution of the OWC responses during an entire period and the phase analysis based on CFD simulations are *** phase results provide the crucial evidence to the reasonability of the physics-based modification of the potential flow model in modelling of *** present results and analysis are expected to be beneficial to the understanding on the physical mechanism of OWCs and the design of phase control strategies.

关键词： Computational fluid dynamics(CFD)simulation hydrodynamic analysis oscillating water column(OWC)damping orifice airflow phase difference

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Generating Nanodot Structures on Stainless-Steel Surfaces by Cross Scanning of a Picosecond Pulsed Laser

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Nanomanufacturing and Metrology 2020年第2期3卷 105-111页

作者： tomoki Kobayashi Jiwang Yan Department of Mechanical Engineering Faculty of Science and TechnologyKeio UniversityHiyoshi 3-14-1 KohokuYokohamaKanagawa 223-8522Japan

Ultrashort pulsed laser-induced periodic surface structures(LIPSS)can be generated on difFerent kinds of materials,which are widely utilized for modifying surface properties such as wettability,adhesion,and tribological,as well as optical *** studies have focused mainly on one-dimensional LIPSS(i.e.,line structure)*** this study,a picosecond pulsed laser was used to irradiate stainless-steel surfaces for generating two-dimensional LIPSS,namely nanodot structures,by cross-scanning the laser beam for a different number of *** obtained nanodot structures were found to be super hydrophilic just after laser irradiation,but turned to be hydrophobic after exposure in air for a few *** cross・scanning the laser beam for the same number of times,local LIPSS rewriting was *** study showed the possibility of improving the homogeneity of the surface properties of steel materials through laser-induced nanodot structuring.

关键词： Nanodot structure Surface patterning Picosecond pulsed laser LIPSS Tool steel Wettability control

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Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR： simultaneous removal of nitrogen and antibiotics

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 123-131页

作者： Xiaoyan Song Rui Liu Lujun Chen tomoki Kawagishi Zhejiang Provincial Key Laboratory of Water Science and Technology Department of Environment in Yangtze Delta Region Institute of Tsinghua University-Zhejiang Jiaxing 314006 China School of Environment Tsinghua University Beijing 100084 China Aqua Development Center Mitsubishi Rayon Co. Ltd. Toyohashi 4408601 Japan

A biofilm membrane bioreactor （BF-MBR） and a conventional membrane bioreactor （MBR） were parallelly operated for treating digested piggery wastewater. The removal performance of COD, TN, NH4＋-N, TP as well as antibiotics were simultaneously studied when the hydraulic retention time （HRT） was gradually shortened from 9 d to 1 d and when the ratio ofinfluent COD to TN was changed. The results showed that the effluent quality in both reactors was poor and unstable at an influent COD/ TN ratio of 1.0±0.2. The effluent quality was signifcantly improved as the influent COD/TN ratio was increased to 2.3±0.5. The averaged removal rates of COD, NH4＋-N, TN and TP were 92.1%, 97.1%, 35.6% and 54.2%, respectively, in the BF-MBR, significantly higher than the corresponding values of 91.7%, 90.9%, 17.4% and 31.9% in the MBR. Analysis of 11 typical veterinary antibiotics （from the tetracycline, sulfonamide, quinolone, and macrolide families） revealed that the BF-MBR removed more antibiotics than the MBR. Although the antibiotics removal decreased with a shortened HRT, high antibiotics removals of 86.8%, 80.2% and 45.3% were observed in the BF-MBR at HRT of 5~4 d, 3-2 d and 1 d, respectively, while the corresponding values were only 83.8%, 57.0% and 25.5% in the MBR. Moreover, the BF-MBR showed a 15% higher retention rate of antibiotics and consumed 40% less alkalinity than the MBR. Results above suggest that the BF-MBR was more suitable for digested piggery wastewater treatment.

关键词： AlkalinityAntibioticsBiofilmDigested piggery wastewater (DPW)Membrane bioreactor

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Picosecond burst pulse machining with temporal energy modulation

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Chinese Optics Letters 2020年第12期18卷 87-91页

作者： Akinao Nakamura tomoki Mizuta Yasuhiko Shimotsuma Masaaki Sakakura Tomohito Otobe Masahiro shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of Engineering Kyoto University National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science Institute

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy modulation. The origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the focus. To reveal the effectiveness of the temporal energy modulation for smooth machining, such plasma motion was simulated by the finite-difference time-domain method. Furthermore, photoinduced birefringence was observed using a high-speed polarization camera.

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Picosecond burst pulse machining with temporal energy modulation [Invited]

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Chinese Optics Letters 2020年第12期18卷 83-87页

作者： Akinao Nakamura tomoki Mizuta Yasuhiko Shimotsuma Masaaki Sakakura Tomohito Otobe Masahiro shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of EngineeringKyoto UniversityKyoto 615-8510Japan National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science InstituteKyoto 619-0215Japan

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy *** origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the *** reveal the effectiveness of the temporal energy modulation for smootli machining,such plasma motion was simulated by the fiidtc-d ifference time-domain method.F urt her more,photoinduced birefringence was observed using a high-speed polarization camera.

关键词： picosecond laser energy modulation burst pulse material processing stress distribution

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Drive Train Cooling Options for Electric Vehicles

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Frontiers in Heat and Mass Transfer 2024年第3期22卷 703-717页

作者： Randeep Singh tomoki Oridate Tien Nguyen Fujikura Automotive Europe GmbH Manchinger Strasse 114IngolstadtD-85053Germany Fujikura Ltd. 1-5-1 KibaKoto-KuTokyo135-8512Japan

Electrification of vehicles intensifies their cooling demands due to the requirements of maintaining electronics/electrical systems below their maximum temperature *** this paper,passive cooling approaches based on heat pipes have been considered for the thermal management of electric vehicle(EV)traction systems including battery,inverter,and *** the battery,a heat pipe base plate is used to provide high heat removal(180 W per module)and better thermal uniformity(<5°C)for the battery modules in a pack while downsizing the liquid cold plate *** the case of Inverter,two phase cooling system based on heat pipes was designed to handle hot spots arising from high heat flux(∼100 W/cm2)–for liquid cooling and provide location independence and a dedicated cooling approach-for air *** EV motors,heat pipebased systems are explored for stator and rotor *** paper also provides a glimpse of development on high-performance microchannel-based cold plate technologies based on parallel fins and multi-layer 3D stacked ***,this work extends the concept of hybridization of two-phase technology based on heat pipes with single-phase technology,predominately based on liquid cooling,to extend performance,functionalities,and operational regime of cooling solutions for components of EV drive *** summary,heat pipes will help to improve and extend the overall reliability,performance,and safety of air and liquid cooling systems in electric vehicles.

关键词： Li-ion battery inverter motor electric vehicle heat pipe two-phase cooling high performance cold plate

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Fine-grained optimization method for crystal structure prediction

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npj Computational Materials 2018年第1期4卷 379-386页

作者： Kei Terayama tomoki Yamashita Tamio Oguchi Koji Tsuda Graduate school of Frontier Sciences the University of Tokyo5-1-5Kashiwa-no-haKashiwaChibaJapan RIKEN Center for Advanced Intelligence Project 1-4-1 NihonbashiChuo-kuTokyo 103-0027Japan Graduate school of Medicine Kyoto UniversityYoshida-Konoe-choSakyo-kuKyoto 606-8507Japan Center for Materials research by Information Integration Research and ServicesDivision of Materials Data and Integrated SystemNational Institute for MaterialsScience1-2-1 SengenTsukubaIbaraki 305-0047Japan Institute of Scientific and Industrial Research Osaka University8-1 MihogaokaIbarakiOsaka 567-0047Japan

Crystal structure prediction based on first-principles calculations is often achieved by applying relaxation to randomly generated initial *** a structure requires multiple optimization *** is time consuming to fully relax all the initial structures,but it is difficult to figure out which initial structure leads to the optimal solution in *** this paper,we propose a optimization method for crystal structure prediction,called Look Ahead based on Quadratic Approximation,that optimally assigns optimization steps to each candidate *** allows us to identify the most stable structure with a minimum number of total local optimization *** simulations using known systems Si,NaCl,Y_(2)Co_(17),Al_(2)O_(3),and GaAs showed that the computational cost can be reduced significantly compared to random *** method can be applied for controlling all kinds of local optimizations based on first-principles calculations to obtain best results under restricted computational resources.

关键词： structure grain optimization

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