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Nutritional supplement drink reduces inflammation and postoperative depression in patients after off-pump coronary artery bypass surgery

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World Journal of Cardiology 2021年第8期13卷 348-360页

作者： Satoshi Matsushita Akie Shimada Taira Yamamoto Kazuo Minematsu Hirotaka inaba Kenji Kuwaki Atsushi Amano Department of Cardiovascular Surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of School Health Graduate School of EducationNagasaki UniversityNagasaki 852-8521Japan Department of Cardiovascular Surgery Juntendo University Urayasu HospitalChiba 279-0021Japan Department of Cardiovascular Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

BACKGROUND Coronary artery bypass grafting is a surgical treatment for ischemic heart *** development in surgical technique and improvement of perioperative management reduced the postoperative complications,some patients still delayed in progress of postoperative *** this study,we aimed to investigate the effect of daily intake of an herbal medicine-containing drink for rehabilitation after surgery in patients with ischemic heart *** To investigate the effect of taking an herbal medicine-containing,commercially available drink for postoperative rehabilitation in those *** Patients who underwent isolated off-pump coronary artery bypass(OPCAB)surgery were divided into two groups depend on the timing of the admission to the hospital:the Yunker(YKR)group,that consumed one bottle of a caffeine-free nutritional supplement drink on a daily basis and the control group(CTL)that underwent regular *** A total of 229 patients(CTL=130,YKR=99)were *** significant differences were observed in the baseline characteristics between the two *** YKR group had a significantly increased number of daily steps postoperatively(P<0.05)and had significantly lower postoperative serum tumor necrosis factor-alpha levels(P<0.01),while no significant differences were observed in the levels of other inflammatory or stress-related cytokines(interleukin-6,adiponectin,superoxide dismutase,and urine 8-hydroxy-2′-deoxyguanosine)between the two ***,the YKR group showed a significant improvement in the Hospital Anxiety and Depression Score(P<0.05).Moreover,there were no differences in postoperative complications and the duration of postoperative hospital stay between the two *** Our results demonstrated that the daily intake of an herbal medicine-containing drink after OPCAB surgery may have beneficial effects on cardiac rehabilitation by reducing inflammation markers and depression.

关键词： Herbal medicine Inflammation Cardiac rehabilitation Moderate-to-vigorous intensity physical activity Off-pump coronary artery bypass

Laparoscopic repair of hiatal hernia with mesenterioaxial volvulus of the stomach

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World Journal of Gastroenterology 2011年第15期17卷 2054-2057页

作者： Kazuki inaba Yoichi Sakurai Jun Isogaki Yoshiyuki Komori Ichiro Uyama Department of Surgery Fujita Health University School of Medicine 1-98 Dengakugakubo Kutsukake-cho Toyoake Aichi 470-1192 Japan

Although mesenterioaxial gastric volvulus is an uncommon entity characterized by rotation at the transverse axis of the stomach, laparoscopic repair procedures have still been controversial. We reported a case of mesenterioaxial intrathoracic gastric volvulus, which was successfully treated with laparoscopic repair of the diaphragmatic hiatal defect using a polytetrafluoroethylene mesh associated with Toupet fundoplication. A 70-year-old Japanese woman was admitted to our hospital because of sudden onset of upper abdominal pain. An upper gastrointestinal series revealed an incarcerated intrathoracic mesenterioaxial volvulus of the distal portion of the stomach and the duodenum. The complete laparoscopic approach was used to repair the volvulus. The laparoscopic procedures involved the repair of the hiatal hernia using polytetrafluoroethylene mesh and Toupet fundoplication. This case highlights the feasibility and effectiveness of the laparoscopic procedure, and laparoscopic repair of the hiatal defect using a polytetrafluoroethylene mesh associated with Toupet fundoplication may be useful for preventing postoperative recurrence of hiatal her-nia, volvulus, and gastroesophageal reflux.

关键词： Gastric volvulus Mesenterioaxial form Hiatal hernia Mesh repair Laparoscopic procedure

Differences between diffuse and focal autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第17期18卷 2099-2104页

作者： Taku Tabata Terumi Kamisawa Kensuke Takuma Seiichi Hara Sawako Kuruma Yoshihiko inaba Department of Internal Medicine Tokyo Metropolitan Komagome Hospital3-18-22 HonkomagomeBunkyo-kuTokyo 113-8677Japan

AIM:To investigate differences in clinical features between diffuse-and focal-type autoimmune pancreatitis(AIP).METHODS:Based on radiological findings by computed tomography and/or magnetic resonance imaging,we divided 67 AIP patients into diffuse type(D type) and focal type(F type).We further divided F type into head type(H type) and body and/or tail type(B/T type) according to the location of ***,we classified the 67 AIP patients into three groups:D type,H type and B/T *** compared the three types of AIP in terms of clinical,laboratory,radiological,functional and histological findings and clinical ***:There were 34 patients with D-type,19 with H-type and 14 with B/T-type *** obstructive jaundice was frequently detected in D-typepatients(88%) and H-type patients(68%),no B/T-type patients showed jaundice as an initial symptom(P < 0.001).There were no differences in frequency of abdominal pain,but acute pancreatitis was associated more frequently in B/T-type patients(36%) than in D-type patients(3%)(P = 0.017).Serum immunoglobulin G(IgG)4 levels were significantly higher in D-type patients(median 309 mg/dL) than in B/T-type patients(133.5 mg/dL)(P = 0.042).Serum amylase levels in B/T-type patients(median:114 IU/L) were significantly greater than in H-type patients(72 IU/L)(P = 0.049).Lymphoplasmacytic sclerosing pancreatitis(LPSP) was histologically confirmed in 6 D-type,7 H-type and 4 B/T-type patients;idiopathic duct-centric pancreatitis was observed in no *** fibrosis and abundant infiltration of CD20-positive B lymphocytes with few IgG4-positive plasma cells were detected in 2 B/T-type *** therapy was effective in all 50 patients(31 D type,13 H type and 6 B/T type).Although AIP relapsed during tapering or after stopping steroids in 3 D-type and 3 H-type patients,no patients relapsed in B/T *** follow-up,radiological features of 6 B/T-type patients were not changed and 1 B/T-type patient impr

关键词： Autoimmune pancreatitis Immunoglobulin G 4 Lymphoplasmacytic sclerosing pancreatitis

Utility of pancreatography for diagnosing autoimmune pancreatitis

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World Journal of Gastroenterology 2011年第18期17卷 2332-2337页

作者： Kensuke Takuma Terumi Kamisawa Taku Tabata Yoshihiko inaba Naoto Egawa Yoshinori Igarashi Department of Internal Medicine Tokyo Metropolitan Komagome Hospital Department of Gastroenterology and Hepatology Omori Medical Center Toho University School of Medicine

AIM: To identify pancreatographic findings that facilitate differentiating between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) on endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP). METHODS: ERCP findings of 48 AIP and 143 PC patients were compared. Diagnostic accuracies for AIP by ERCP and MRCP were compared in 30 AIP patients. RESULTS: The following ERCP findings suggested a diagnosis of AIP rather than PC. Obstruction of the main pancreatic duct (MPD) was more frequently detected in PC (P < 0.001). Skipped MPD lesions were detected only in AIP (P < 0.001). Side branch derivation from the narrowed MPD was more frequent in AIP (P < 0.001). The narrowed MPD was longer in AIP (P < 0.001), and a narrowed MPD longer than 3 cm was more frequent in AIP (P < 0.001). Maximal diameter of the upstream MPD was smaller in AIP (P < 0.001), and upstream dilatation of the MPD less than 5 mm was more frequent in AIP (P < 0.001). Stenosis of the lower bile duct was smooth in 87% of AIP and irregular in 65% of PC patients (P < 0.001). Stenosis of the intrahepatic or hilar bile duct was detected only in AIP (P = 0.001). On MRCP, diffuse narrowing of the MPD on ERCP was shown as a skipped non-visualized lesion in 50% and faint visualization in 19%, but segmental narrowing of the MPD was visualized faintly in only 14%. CONCLUSION: Several ERCP findings are useful for differentiating AIP from PC. Although MRCP cannot replace ERCP for the diagnostic evaluation of AIP, some MRCP findings support the diagnosis of AIP.

关键词： Autoimmune pancreatitis Pancreatic cancer Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography

Evaluation of Thermal Strain on Cylindrical Adhesive Bonded Joints

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Evaluation of Thermal Strain on Cylindrical Adhesive Bonded ...

Au Nanoparticle Formation from Amorphous Au/Si Multilayer

第三届世界粘接及相关现象大会暨北京粘接学会第十五届学术年会

作者： Yoshitsugu inaba Kosuke HARAGA Masatoshi KONDO Materials & Processing Technology Department Advanced Technology R&D CenterMITSUBISHI ELECTRIC CORPORATION 8-1-1Tsukaguchi-HonmachiAmagasakiHyogo661-8661Japan

In bonding a cylinder and a column,it is difficult to observe the destructive state of a bonded *** adhesive failure and the material destruction by thermal strain occur,depending on materials and adherents. Then,by the strain gauge bonded outside of the cylinder,we evaluated the adhesive failure and the material destruction at the heat cycle. As a result,it was found that the distortion of the circumferential direction was larger than the lengthwise direction and it was found that the thermal strain changed from the kind of the adhesive,the bonding lap length,the bonding layer thickness and so ***,change of the distortion in curing process was able to be measured.

关键词： thermal strain cylindrical adhesive bonded joints distortion curing process circumferential direction lengthwise direction

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Journal of Crystallization Process and Technology 2014年第4期4卷 193-205页

作者： Masami Aono Takashi Ueda Hiroshi Abe Shintaro Kobayashi Katsuhiko inaba Department of Materials Science and Engineering National Defense Academy Yokosuka Japan Application Laboratory Rigaku Co. Akishima Tokyo Japan

By direct observations of transmission electron microscopy (TEM), irreversible morphological transformations of as-deposited amorphous Au/Si multilayer (a-Au/a-Si) were observed on heating. The well arrayed sequence of the multilayer changed to zigzag layered structure at 478 K (=Tzig). Finally, the zigzag structure transformed to Au nanoparticles at 508 K. The distribution of the Au nanoparticles was random within the thin film. In situ X-ray diffraction during heating can clarify partial crystallization Si (c-Si) in the multilayer at 450 K (= ), which corresponds to metal induced crystallization (MIC) from amorphous Si (a-Si) accompanying by Au diffusion. On further heating, a-Au started to crystallize at around 480 K (=Tc) and gradually grew up to 3.2 nm in radius, although the volume of c-Si was almost constant. Continuous heating caused crystal Au (c-Au) melting into liquid AuSi (l-AuSi) at 600 K (= ), which was lower than bulk eutectic temperature ( ). Due to the AuSi eutectic effect, reversible phase transition between liquid and solid occurred once temperature is larger than . Proportionally to the maximum temperatures at each cycles (673, 873 and 1073 K), both and Au crystallization temperature approaches to . Using a thermodynamic theory of the nanoparticle formation in the eutectic system, the relationship between and the nanoparticle size is explained.

关键词： Amorphous Au/Si Multilayer Au Nanoparticle Low Eutectic Point Metal Induced Crystallization Irreversible Morphological Transformation Reversible l-AuSi-c-Au Nanoparticle Phase Transition

Hepatocellular adenoma associated with familial adenomatous polyposis coli

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World Journal of Hepatology 2012年第11期4卷 322-326页

作者： Keisuke inaba Takanori Sakaguchi Kiyotaka Kurachi Hiroki Mori Toshio Nakamura Yasuo Takehara Satoshi Baba Masato Maekawa Haruhiko Sugimura Hiroyuki Konno Second Department of Surgery Hamamatsu University School of Medicine Hama-matsu 431-3192 Japan Department of Surgery Iwata City Hospital Iwata 438-8500 Japan Department of Pathology Hamamatsu University School of Medicine Hamamatsu 431-3192 Japan Department of Radiology Hamamatsu University School of Medicine Hamamatsu 431-3192 Japan Department of Laboratory Medicine Hamamatsu University School of Medicine Hamamatsu 431-3192 Japan

Hepatocellular adenoma (HCA) is a benign liver tumor that most frequently occurs in young women using oral contraceptives. We report a rare case of HCA in a 29 years old female with familial adenomatous polyposis (FAP). The first proband was her sister, who under-went a total colectomy and was genetically diagnosed as FAP. A tumor, 3.0 cm in diameter, was detected in the right lobe of the liver during a screening study for FAP. A colonoscopy and gastroendoscopy revealed numerous adenomatous polyps without carcinoma. The patient underwent a total colectomy and ileoanal anastomosis and hepatic posterior sectoriectomy. The pathological findings of the liver tumor were compatible with HCA. The resected specimen of the colon revealed multiple colonic adenomatous polyps. Examination of genetic alteration revealed a germ-line mutation of the adenomatous polyposis coli (APC) gene. Inactivation of the second APC allele was not found. Other genetic alterations in the hepatocyte nuclear factor 1 alpha and β-catenin gene, which are reported to be associated with HCA, were not detected. Although FAP is reported to be complicated with various neoplasias in extracolic organs, only six cases of HCA associated with FAP, including the present case, have been reported. Additional reports will establish the precise mechanisms of HCA development in FAP patients.

关键词： Hepatic adenoma Familial adenomatous polyposis coli Extrahepatic manifestation Adenomatous polyposis coli gene Hepatocyte nuclear factor 1 alpha

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创伤急救评估与治疗手册

创伤急救评估与治疗手册

Hot snare polypectomy vs endoscopic mucosal resection using bipolar snare for intermediate size colorectal lesions:Propensity score matching

作者： Demetrios Demetriades，Kenji inaba原

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World Journal of Gastroenterology 2023年第23期29卷 3668-3677页

作者： Nobuhisa Minakata Tatsuro Murano Masashi Wakabayashi Maasa Sasabe Takashi Watanabe Tomohiro Mitsui Hiroki Yamashita Atsushi inaba Hironori Sunakawa Keiichiro Nakajo Tomohiro Kadota Kensuke Shinmura Hiroaki Ikematsu Tomonori Yano Department of Gastroenterology and Endoscopy National Cancer Center Hospital EastKashiwa 2778577ChibaJapan Department of Biostatistics Division Center for Research Administration and SupportNational Cancer CenterKashiwa 2778577ChibaJapan

BACKGROUND Endoscopic resection(ER)with bipolar snare,in which the electric current only passes through the tissue between the device’s two electrodes,is a prominent method used to prevent perforation due to electricity *** using bipolar snare with or without submucosal injection enabled safe resection of colorectal lesions measuring 10-15 mm in an ex vivo porcine *** with bipolar snare is expected to have good treatment outcomes in 10-15 mm colorectal lesions,with high safety even without submucosal ***,no clinical reports have compared treatment outcomes with and without submucosal *** To compare the treatment outcomes of bipolar polypectomy with hot snare polypectomy(HSP)to those with endoscopic mucosal resection(EMR).METHODS In this single-centre retrospective study,we enrolled 10-15 mm nonpedunculated colorectal lesions(565 Lesions in 463 patients)diagnosed as type 2A based on the Japan Narrow-band Imaging Expert Team classification,resected by either HSP or EMR between January 2018 and June 2021 at the National Cancer Center Hospital *** were divided into HSP and EMR groups,and propensity score matching was *** the matched cohort,en bloc and R0 resection rates and adverse events were compared between the two *** Of the 565 lesions in 463 patients,117 lesions each in the HSP and EMR groups were selected after propensity score *** the original cohort,there was a significant difference in antithrombotic drug use(P<0.05),lesion size(P<0.01),location(P<0.01),and macroscopic type(P<0.05)between the HSP and EMR *** the matched cohort,the en bloc resection rates were comparable between both groups[93.2%(109/117)vs 92.3%(108/117),P=0.81],and there was no significant difference in the R0 resection rate[77.8%(91/117)vs 80.3%(94/117),P=0.64].The incidence of delayed bleeding was similar in both groups[1.7%(2/117)].Perforation occurred in the EMR group[0.9%(1/117)]but not in the HSP ***

关键词： Adenoma Cohort studies Colonoscopy Colorectal cancer Endoscopic mucosal resection Treatment outcome