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Patterns of Recurrence and Their Significance in Patients with Endometrial Carcinoma<br>—For Improved Follow-Up after Initial Treatment<br>

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Surgical Science 2013年第2期4卷 154-159页

作者： Fumi Utsumi Hiroaki Kajiyama Kiyosumi Shibata Hiroko Mitsui Ryuichiro Sekiya Mika Mizuno Shiro Suzuki tomokazu umezu Eiko Yamamoto Fumitaka Kikkawa Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Objectives: The aim of this study was to identify the patterns of recurrence and their significance in patients with endometrial carcinoma (EMCA). Patients and Methods: After a search of the medical records from single institutions, a total of 49 patients with relapsed endometrial carcinoma were retrospectively evaluated. Various clinical information was examined, including the site of recurrence, detection procedure, and presence or absence of any symptom at the time of recurrence. Furthermore, the postrecurrence survival analysis was based on the Kaplan-Meier method. Results: The median follow-up period of all patients was 39.4 months (5.8 - 293.1). In all, twenty-five (51.0%) patients experienced recurrence within 12 months after the final treatment. At the time of recurrence, 15 (30.6%) and 34 (69.4%) patients were symptomatic and asymptomatic, respectively. Among the 34 asymptomatic patients, recurrence was detected by CT scan in 14 (28.6%), tumor markers alone in 14 (28.6%), and pelvic examination/ultrasound scan in 5 (10.2%). There was no relapsed case detected by vaginal vault cytology alone. The 5-year postrecurrence survival rates in symptomatic and asymptomatic patients were 57.5 and 36.6 months, respectively (P = 0.2973). After recurrence, 12 patients underwent debulking surgery, and 37 received salvage chemotherapy or radiotherapy. The postrecurrence survival of patients receiving surgery did not differ from that of those with chemotherapy/radiotherapy (P = 0.9198). Conclusion: Although imaging studies and tumor marker measurement contributed to the early detection of recurrence, they did not necessarily improve the prognosis postrecurrence.

关键词： Endometrial Carcinoma Recurrence Site Postrecurrence Survival Symptomatic Vaginal Vault Cytology

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Grain refining in weld metal using short-pulsed laser ablation during CW laser welding of 2024-T3 aluminum alloy

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International Journal of Extreme Manufacturing 2019年第4期1卷 34-41页

作者： Masaki Kasuga tomokazu Sano Akio Hirose Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan

The 2024 aluminum alloy is used extensively in the aircraft and aerospace industries because of its excellent mechanical ***,the weldability of 2024 aluminum alloy is generally low because it contains a high number of solutes,such as copper(Cu),magnesium(Mg),and manganese(Mn),causing solidification *** high speed welding of 2024 aluminum alloy without the use of filler is achieved,the applicability of 2024 aluminum alloys will *** refining is one of the methods used to prevent solidification cracking in weld metal,although it has never been achieved for high-speed laser welding of 2024 aluminum alloy without ***,we propose a short-pulsed,laser-induced,grain-refining method during continuous wave laser welding without ***-on-plate welding was performed on a 2024-T3 aluminum alloy at a welding speed of 1 m min−1 with a single mode fiber laser at a wavelength of 1070 nm and power of 1 *** in and around the molten pool were irradiated with nanosecond laser pulses at a wavelength of 1064 nm,pulse width of 10 ns,and pulse energy of 430 *** grain-refinement effect was confirmed when laser pulses were irradiated on the molten *** grain-refinement region was formed in a semicircular shape along the solid–liquid *** of the vertical section indicate that the grain-refinement region reached a depth of 1 mm along the solid–liquid *** Vickers hardness test results demonstrated that the hardness increased as a result of grain refinement and that the progress of solidification cracking was suppressed in the grain refinement region.

关键词： 2024 aluminum alloy hot cracking laser welding grain refinement dendrite fragmentation short pulsed laser laser ablation

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Formation of Low Aspect Ratio Torus Equilibria by ECH in the LATE Device

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Plasma Science and Technology 2006年第1期8卷 95-98页

作者： Takashi MAEKAWA Hitoshi TANAKA Masaki UCHIDA tomokazu YOSHINAGA Graduate School of Energy Science Kyoto UniversityKyoto 606-8502Japan

By ECH under a steady By field, a closed field equilibrium of a low aspect ratio as low as R/a = 1.4 is spontaneously formed in the LATE device. After the spontaneous formation, the plasma current has increased further up to Ip = 7.2 kA by 2.45 GHz, 30 kW and Ip = 11 kA by 5 GHz, 120 kW, by increasing the microwave power with a slow ramp of By for the equilibrium of the plasma loop at larger currents. Both amount to 12% of the total toroidai coil current. ECH/ECCD at 2nd harmonic resonance of EBW supports the plasma. An outline of the theoretical considerations for the formation process is presented.

关键词： ECH spherical tokamaks non-inductive start-up

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Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

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World Journal of Gastroenterology 2014年第10期20卷 2641-2652页

作者： Atsuki Yamamoto tomokazu Itoh Reishi Nasu Ryuichi Nishida Pharmaceutical research laboratories Sakai Chemical Industry Co. Ltd. Kawachinagano Osaka 586-0006 Japan KATAYAMA SEIYAKUSYO Co. Ltd.Hirakata Osaka 573-1132 Japan Kaigen Pharma Co. Ltd.Doshomachi Chuo-ku Osaka 541-0045 Japan

AIM: To investigate the effects of sodium alginate (AL-Na) on indomethacin-induced small intestinal lesions in rats.

关键词： Sodium alginate Non-steroidal anti-inflammatory drugs Gastrointestinal mucosal injury Mucin Bacterial translocation

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Study of Electron Orbits for Formation of Toroidal Closed Flux Surface by ECH

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Plasma Science and Technology 2011年第3期13卷 342-346页

作者： Tak,ushi MAEKAWA tomokazu YOSHINAGA Hitoshi TANAKA Masaki UCHIDA Fumitake WATANABE Graduate School of Energy Science Kyoto University Kyoto 606-8502 Japan National Institute for Fusion Science Toki 509-5292 Japan

Electron orbits under the external vertical field （Bv） and the self poloidal field of the toroidal plasma current in a toroidal geometry are investigated by using analytic model fields in order to search for the conditions of occurence of appropriate confinement asymmetry of fast electrons along the field lines. This asymmetry efficiently and quickly generates a toroidal current, which may close the field lines in ECH-started plasmas. It is analytically shown that the characteristics of confinement asymmetry depend on the product of the major radius and the strength of the external vertical field. The results suggest that in large devices By should be lowered and also some artificial means to speed up the pitch angle scattering for the fast electrons at a higher energy range are beneficial to generate the toroidal current in order to close the filed

关键词： ECH closed flux surface electron orbit

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Evaluation of Central Nervous System Acting Effects of Plant-Derived Essential Oils Using Ambulatory Activity in Mice

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Pharmacology & Pharmacy 2013年第2期4卷 160-170页

作者： Toyoshi umezu Biological Imaging and Analysis Section Center for Environmental Measurement and Analysis National Institute for Environmental Studies Ibaraki Japan

Although plant-derived essential oils (EOs) have traditionally been used for treating various kinds of mental disorders, their Central Nervous System (CNS) acting effects have not yet been clarified well. The present study examined effects of 30 kinds of EOs on ambulatory activity, a kind of spontaneous motor activity, in ICR mice. Nineteen kinds of them did not produce any significant effects on the ambulatory activity of mice. Although effects of EOs of lavender, jasmine and neroli on the activity were statistically significant, their CNS acting properties remained unclear. EOs of peppermint, chamomile, thyme, tea tree, rosemary and basil significantly increased the ambulatory activity of mice as well as CNS stimulants, suggesting that they possess CNS stimulant-like effects. In contrast, an EO of myrtle significantly decreased the activity as well as CNS depressants, suggesting that it possesses a CNS depressant-like effect. An EO of palmarosa significantly increased the activity at a lower dose and decreased at a higher dose as well as some kinds of CNS depressants such as ethanol, suggesting that it also possesses a CNS depressant-like effect. These 8 kinds of EOs might be useful for treating some kinds of mental troubles and/or symptoms through their CNS acting effects.

关键词： Essential Oil Pharmacology Psychoactive Effect Behavior Locomotion Mouse

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Evaluation method of dam behavior during construction and reservoir filling and application to real dams

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Frontiers of Structural and Civil Engineering 2010年第1期4卷 92-101页

作者： Yuji KOHGO Akira TAKAHASHI tomokazu SUZUKI Tokyo University of Agriculture and Technology TokyoJapan Tokyo Electric Power Company Limited TokyoJapan Tokyo Electric Power Services Company Limited TokyoJapan

In this paper we analyzed a real fill-type dam,named the Minami-Aiki Dam,to verify a numerical consolidation method with an elastoplastic model for unsaturated *** validities were conducted by comparing the analyzed and measured values during construction and *** settlements calculated showed good agreement to those *** the changing patterns of the measured and calculated pore water pressures were similar,the amounts of pore water pressures induced by the self-weights of embankment and the dissipation speeds were *** earth pressures measured at the bottom of the core zone showed good agreement with those *** method is valid for estimating behavior of fill-type dams during construction and impounding.

关键词： fill dam consolidation analysis unsaturated geo-materials impounding construction

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Methylation-mediated gene silencing as biomarkers of gastric cancer:a review

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World Journal of Gastroenterology 2014年第34期20卷 11991-12006页

作者： Jun Nakamura tomokazu Tanaka Yoshihiko Kitajima Hirokazu Noshiro Kohji Miyazaki Department of Surgery Saga University Faculty of MedicineSaga 849-8501Japan Department of Surgery National Hospital Organization Higashi-Saga Hospital7324 HarakogaMiyaki TownSaga 849-0101Japan

Despite a decline in the overall incidence of gastric cancer(GC),the disease remains the second most common cause of cancer-related death worldwide and is thus a significant global health *** best means of improving the survival of GC patients is to screen for and treat early ***,GC is often diagnosed at an advanced stage and is associated with a poor *** diagnostic and therapeutic strategies have not been successful in decreasing the global burden of the disease;therefore,the identification of reliable biomarkers for an early diagnosis,predictive markers of recurrence and survival and markers of drug sensitivity and/or resistance is urgently *** initiation and progression of GC depends not only on genetic alterations but also epigenetic changes,such as DNA methylation and histone *** DNA methylation is the most well-defined epigenetic change in human cancers and is associated with inappropriate gene ***,an increasing number of genes methylated at the promoter region have been targeted as possible biomarkers for different purposes,including early detection,classification,the assessment of the tumor prognosis,the development of therapeutic strategies and patient *** review article summarizes the current understanding and recent evidence regarding DNA methylation markers in GC with a focus on the clinical potential of these markers.

关键词： Gastric cancer Methylation Biomarker Early detection Drug sensitivity

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Enzymatic treatment of estrogens and estrogen glucuronide

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Journal of Environmental Sciences 2009年第6期21卷 731-735页

作者： Takaaki Tanaka Toshiyuki Tamura Yuuichi Ishizaki Akito Kawasaki tomokazu Kawase Masahiro Teraguchi Masayuki Taniguchi Department of Materials Science and Technology Niigata University Venture Business Laboratory Niigata University Department of Chemistry and Chemical Engineering Niigata University

Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estrogens （estrone, 17β-estradiol, and 17α-ethynyletstradiol） by a fungal laccase which oxidize phenolic compounds with dissolved oxygen. The elimination of the estrogenic activities by enzymatic oxidation was demonstrated by medaka vitellogenin assay. In addition, we developed an enzymatic treatment system comprised of β-D-glucuronidase and the laccase for 17β-estradiol 3-（β-D-glucuronide） degradation. The two enzymes eliminated 17β-estradiol 3-（β- D-glucuronide） and the intermediate, 17β-estradiol, efficiently.

关键词： enzymatic treatment laccase estrone estradiol ethynylestradiol glucuronidase glucuronide

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A high quality surface finish grinding process to produce total reflection mirror for x-ray fluorescence analysis

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International Journal of Extreme Manufacturing 2020年第1期2卷 156-162页

作者： Hitoshi Ohmori Shinjiro umezu Yunji Kim Yoshihiro Uehara Hiroshi Kasuga Teruko Kato Nobuhide Itoh Syuhei Kurokawa Takayuki Kusumi Yugo Sugawara Shinsuke Kunimura Materials Fabrication Laboratory RIKENSaitama 351-0198Japan Department of Modern Mechanical Engineering Waseda UniversityTokyo 169-8555Japan Department of Mechanical Systems Engineering Ibaraki UniversityIbaraki 316-8511Japan Department of Mechanical Engineering Kyushu UniversityFukuoka 819-0395Japan New technology developments Akita Industrial Technology CentreAkita 010-1623Japan Department of Industrial Chemistry Tokyo University of ScienceTokyo 162-8601Japan

Total reflection x-ray fluorescence analysis is applied to trace element detection in liquid for effective environmental *** analytical approach requires x-ray total reflection *** order to achieve high sensitivity element detection,the mirrors require high surface quality for high x-ray *** finishing for x-ray mirrors is typically conducted through a series of abrasive processes,such as grinding and polishing,and is thus time *** purpose of this study is to streamline and enhance the surface finishing process based on unique high quality grinding techniques for the production of x-ray total reflection mirrors.

关键词： grinding finishing x-ray mirror

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