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Enzymatic treatment of estrogens and estrogen glucuronide

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Journal of Environmental Sciences 2009年第6期21卷 731-735页

作者： Takaaki Tanaka Toshiyuki Tamura Yuuichi Ishizaki Akito Kawasaki tomokazu Kawase Masahiro Teraguchi Masayuki Taniguchi Department of Materials Science and Technology Niigata University Venture Business Laboratory Niigata University Department of Chemistry and Chemical Engineering Niigata University

Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estrogens （estrone, 17β-estradiol, and 17α-ethynyletstradiol） by a fungal laccase which oxidize phenolic compounds with dissolved oxygen. The elimination of the estrogenic activities by enzymatic oxidation was demonstrated by medaka vitellogenin assay. In addition, we developed an enzymatic treatment system comprised of β-D-glucuronidase and the laccase for 17β-estradiol 3-（β-D-glucuronide） degradation. The two enzymes eliminated 17β-estradiol 3-（β- D-glucuronide） and the intermediate, 17β-estradiol, efficiently.

关键词： enzymatic treatment laccase estrone estradiol ethynylestradiol glucuronidase glucuronide

Photodimerization and photooxygenation of 9-vinylcarbazole catalyzed by titanium dioxide and magnesium perchlorate

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Chinese Chemical Letters 2010年第3期21卷 365-368页

作者： Hajime Maeda Mio Yamamoto Hideyuki Nakagawa Kazuhiko mizuno Division of Material Sciences Graduate School of Natural Science and TechnologyKanazawa University Department of Applied Chemistry Graduate School of EngineeringOsaka Prefecture University

Photoreaction of 9-vinylcarbazole in acetonitrile in the presence of titanium dioxide and a catalytic amount of magnesium perchlorate gave 3,6-di(9-carbazolyl)-1,2-dioxane as a photooxygenated product via photodimerization of *** photoreaction proceeds via an electron transfer mechanism,where magnesium perchlorate accelerated formation of the photo-oxygenated product.

关键词： Titanium dioxide Magnesium perchlorate 9-Vinylcarbazole Photooxygenation Photodimerization

Semisupervised Deep State-Space Model for Plant Growth Modeling

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Plant Phenomics 2020年第1期2卷 122-137页

作者： S.Shibata R.mizuno H.Mineno Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka 432-8011Japan College of Informatics Academic InstituteShizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka 432-8011Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan

The optimal control of sugar content and its associated technology is important for producing high-quality crops more stably and ***-based reinforcement learning(RL)indicates a desirable action depending on the type of situation based on trialand-error calculations conducted by an environmental *** this paper,we address plant growth modeling as an environmental model for the optimal control of sugar *** the growth process,fruiting plants generate sugar depending on their state and evolve via various external stimuli;however,sugar content data are sparse because appropriate remote sensing technology is yet to be developed,and thus,sugar content is measured *** propose a semisupervised deep state-space model(SDSSM)where semisupervised learning is introduced into a sequential deep generative *** achieves a high generalization performance by optimizing the parameters while inferring unobserved data and using training data efficiently,even if some categories of training data are *** designed an appropriate model combined with model-based RL for the optimal control of sugar content using SDSSM for plant growth *** evaluated the performance of SDSSM using tomato greenhouse cultivation data and applied cross-validation to the comparative evaluation *** SDSSM was trained using approximately 500 sugar content data of appropriately inferred plant states and reduced the mean absolute error by approximately 38%compared with other supervised learning *** results demonstrate that SDSSM has good potential to estimate time-series sugar content variation and validate uncertainty for the optimal control of high-quality fruit cultivation using model-based RL.

关键词： Deep sugar optimal

Vulnerable atherosclerotic plaque features:findings from coronary imaging

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Journal of Geriatric Cardiology 2021年第7期18卷 577-584页

作者： Osamu Kurihara Masamichi Takano Yasushi Miyauchi Kyoichi mizuno Wataru Shimizu Cardiovascular Center Chiba Hokusoh HospitalNippon Medical SchoolChibaJapan Mitsukoshi Health and Welfare Foundation TokyoJapan Division of Cardiology Nippon Medical SchoolTokyoJapan

Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific *** the progress of intravascular coronary imaging technology,some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging ***,the rate of cardiovascular events,such as acute coronary syndrome,has been found to be considerably reduced in the limited follow-up period available in the statin ***,not all disrupted plaques lead to thrombus formation with clinical *** sub-occlusive or occlusive thrombus formation does not occur,a thrombus on a disrupted plaque will organize without any symptoms,forming a"healed plaque".Although vulnerable plaque detection using intracoronary imaging is focused on"thin-cap fibroatheroma"leading to plaque rupture,superficial plaque erosion is increasingly recognized;however,the underlying mechanism of thrombus formation on eroded plaques is not well *** of intravascular imaging,optical coherence tomography(OCT)has the highest image resolution and has enabled detailed characterization of the plaque in ***,we reviewed the status and limitations of intravascular imaging in terms of detecting vulnerable plaque through mainly OCT *** suggested that vulnerable plaque should be reconsidered in terms of eroded plaque and healed plaque and that both plaque and circulating blood should be assessed in greater detail accordingly.

关键词： coronary acute superficial

Surpassing 1,000,000 resolving points in chaotic Brillouin sensing

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Advanced Photonics 2023年第3期5卷 25-26页

作者： Yosuke mizuno Yokohama National University YokohamaJapan

Optical fiber sensors have played a pivotal role in structural health monitoring for over half a century,owing to their inherent advantages such as lightweight design,compactness,immunity to electromagnetic interference,and their ability to enable distributed sensing.1 Within this diverse range of sensors,Brillouin scattering has emerged as a widely adopted principle for distributed measurements of strain and temperature.

关键词： scattering Brillouin chaotic

Myringoplasty: A comparison of inlay and underlay techniques

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Journal of Otology 2024年第2期19卷 72-76页

作者： Hisashi Sugimoto Akiko Tamori Miyako Hatano Hiroki Hasegawa tomokazu Yoshizaki Department of Otolaryngology-Head and Neck Surgery Kanazawa University Graduate School of Medical ScienceKanazawaJapan

Purpose:Myringoplasty aims to improve hearing and prevent otorrhea,making graft uptake rates and hearing crucial *** study analyzed the factors associated with unsuccessful graft uptake and hearing improvement to guide the selection of optimal surgical approaches for ***:We retrospectively reviewed 56 ears with chronic otitis *** patients were followed up for>6 months after tympanic membrane closure *** compared the underlay method using the transcanal approach with the inlay method using the retroauricular approach for myringoplasty in patients with chronic otitis *** underlay and inlay methods were used for 23 and 33 ears,*** primary outcomes were graft uptake rate and hearing ***,factors such as the location of tympanic membrane perforation,patient age,and the degree of mastoid development were ***:The perforation rate was high when the transcanal underlay method was employed to repair perforations in the anterior inferior *** the underlay and inlay methods significantly improved ***,the success rate of the inlay method was *** the cases performed using the inlay method,outcomes tended to be poorer in older age *** were no significant differences in surgical success rates related to mastoid ***:The inlay method using the retroauricular approach is a favorable option for repairing perforations involving the anterior inferior ***,older patients presented lower rates of hearing improvement when the inlay method was used.

关键词： Myringoplasty Chronic otitis media Underlay method Inlay method

Mesenchymal stem cells for cartilage regeneration in dogs

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World Journal of Stem Cells 2019年第5期11卷 254-269页

作者： Akari Sasaki Mitsuru mizuno Manabu Mochizuki Ichiro Sekiya Laboratory of Veterinary Emergency Medicine Graduate School of Agricultural and Life Sciences the University of Tokyo Bunkyo-ku Tokyo 113- 8657 Japan Center for Stem Cell and Regenerative Medicine Tokyo Medical and Dental University Bunkyo-ku Tokyo 113-8519 Japan

Articular cartilage damage and osteoarthritis (OA) are common orthopedic diseases in both humans and dogs. Once damaged, the articular cartilage seldom undergoes spontaneous repair because of its avascular, aneural, and alymphatic state, and the damage progresses to a chronic and painful situation. Dogs have distinctive characteristics compared to other laboratory animal species in that they share an OA pathology with humans. Dogs can also require treatment for naturally developed OA;therefore, effective treatment methods for OA are desired in veterinary medicine as well as in human medicine. Recently, interest has grown in regenerative medicine that includes the use of mesenchymal stem cells (MSCs). In cartilage repair, MSCs are a promising therapeutic tool due to their self-renewal capacity, ability to differentiate into cartilage, potential for trophic factor production, and capacity for immunomodulation. The MSCs from dogs (canine MSCs;cMSCs) share various characteristics with MSCs from other animal species, but they show some deviations, particularly in their differentiation ability and surface epitope expression. In vivo studies of cMSCs have demonstrated that intraarticular cMSC injection into cartilage lesions results in excellent hyaline cartilage regeneration. In clinical situations, cMSCs have shown great therapeutic effects, including amelioration of pain and lameness in dogs suffering from OA. However, some issues remain, such as a lack of regulations or guidelines and a need for unified methods for the use of cMSCs. This review summarizes what is known about cMSCs, including their in vitro characteristics, their therapeutic effects in cartilage lesion treatment in preclinical in vivo studies, their clinical efficacy for treatment of naturally developed OA in dogs, and the current limitations of cMSC studies.

关键词： Mesenchymal stem cell Dog Cartilage Osteoarthritis Regenerative medicine Veterinary medicine

Function of shoulder muscles of driver in vehicle steering maneuver

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Science China(Technological Sciences) 2012年第12期55卷 3445-3454页

作者： LIU YaHui JI XueWu RYOUHEI Hayama TAKAHIRO mizuno LOU LiMing State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Research and Development Center JTEKT Co.Ltd.Nara 634-8555Japan

In order to study the function of muscles of driver shoulder during vehicle steering, identification of relations between electromyograph (EMG) activity of 10 shoulder muscles and steering force was performed. The procedure was to perform controlled steering maneuver by right hand in a driving simulator, and based on analyzing the EMG data with steering force in the steering wheel plane, the function was identified. It was found that muscle function depends strongly on both steering rotation and steering torque directions. In clockwise steering, the long head of triceps brachii was the prime mover and an important contributor to clockwise moment, while the sternocostal portion of the pectoralis major, the lateral head of triceps brachii, biceps brachii and teres major were the important stabilizers or fixators. In contrast, in counterclockwise steering, the anterior, middle and posterior deltoid, the clavicular portion of the pectoralis major and infraspinatus were the prime movers and also the important contributors to counterclockwise moment, while the sternocostal portion of the pectoralis major, the lateral head of triceps brachii, biceps brachii and teres major were the important stabilizers or fixators. We conclude that the prime movers are primarily a consequence of steering direction, while the stabilizers or fixators are primarily constant. These results can be used to improve the neuromuscular model and estimate the steering comfort of driver.

关键词： electromyograph muscle function steering maneuver

Fatigue Behavior of HDPE Composite Reinforced with Silane Modified TiO_2

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Journal of Materials Science & Technology 2011年第7期27卷 659-667页

作者： C.X. Dong S.J. Zhu Mineo mizuno Masami Hashimoto Department of Intelligent Mechanical Engineering Fukuoka Institute of Technology Fukuoka 811-0295 Japan Nanomaterials Laboratory Beihua University Jilin 132013 China Japan Fine Ceramics Center Nagoya 456-8587 Japan

The composite of high density polyethylene reinforced with silane-modified TiO2 particles （silane-TiO2/HDPE） is a potential bone substitute biomaterial. The structure, bioactivity, and mechanical properties of silane-TiO2/HDPE are analogous to those of natural bone, correspondingly. In order to investigate the effect of silane connection and saline solution on fatigue behaviors, flexural fatigue tests with this composite were carried out in both air and saline solution. Saline solution was found to have different effect on fatigue life. In saline solution, the fatigue life could be improved at stress levels lower than 30 MPa, while the fatigue life could be reduced at stress levels higher than 30 MPa. After analyzing the fracture morphologies, different failure mechanisms were proposed, and the important role of silane connection in the composite during the fatigue process was discussed. Silane connection cannot only support the loading stress but also hinder the failure process under loading effectively. For dry specimens, no interfacial failure between the filler and matrix was found. For wet specimens, it is inferred that the synergetic effect of saline solution and high concentrated stress at high stress level could easily destroy the silane connection, which accelerated the fracture process, whereas the synergetic effect of saline solution and silane connection at low stress level could promote the formation of more microcracks on sample surface, which hindered the final fracture.

关键词： Fatigue Composites Polymers Fracture Interfaces