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Spontaneous pneumothorax in a 17-year-old male patient with multiple exostoses:A case report and review of the literature

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World Journal of Orthopedics 2021年第11期12卷 945-953页

作者： Koichi Nakamura Kunihiro Asanuma Akira Shimamoto Shinji Kaneda Keisuke Yoshida Yumi Matsuyama tomohito Hagi Tomoki Nakamura Motoshi Takao Akihiro Sudo Department of Orthopedic Surgery Mie University Graduate School of MedicineTsu 514-8507Mie PrefectureJapan Department of Thoracic and Cardiovascular Surgery Mie University Graduate School of MedicineTsu 514-8507Mie PrefectureJapan

BACKGROUND Multiple exostoses generally develop in the first decade of *** most frequently arise from the distal femur,proximal tibia,fibula,and proximal *** exostoses are rare,contributing to 1%-2% of all exostoses in hereditary multiple exostoses(HME).They are usually asymptomatic,but a few cases have resulted in severe thoracic *** caused by costal exostoses is rare,with only 13 previously reported *** report a new case of pneumothorax caused by costal *** SUMMARY A 17-year-old male with HME underwent surgery for removal of exostoses around his right *** months following the operation,he felt chest pain when he was playing the trumpet;however,he did not stop playing for a *** was referred to our hospital with a chief complaint of chest *** computed tomography(CT)scan revealed right pneumothorax and multiple exostoses in his right *** CT scan also revealed visceral pleura thickness and damaged lung tissues facing the exostosis of the seventh *** diagnosed that exostosis of the seventh rib induced *** exostosis resection was performed by video-assisted thoracoscopic surgery(VATS)2 wk after the *** patient’s postoperative course was uneventful,and there was no recurrence of pneumothorax for 2 *** Costal exostoses causing thoracic injuries should be resected regardless of *** must be considered in cases with apparently benign and relatively small exostoses or HME.

关键词： Costal exostosis Pneumothorax Video-assisted thoracoscopic surgery Hereditary multiple exostoses Case report Treatment

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Complete withdrawal of glucocorticoids after dupilumab therapy in allergic bronchopulmonary aspergillosis:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6922-6928页

作者： Tadashi Nishimura tomohito Okano Masahiro Naito Chikashi Tsuji Soichi Iwanaka Yasumasa Sakakura Taro Yasuma Hajime Fujimoto Corina N D'Alessandro-Gabazza Yasuhiro Oomoto Tetsu Kobayashi Esteban C Gabazza Hidenori Ibata Department of Pulmonary Medicine Mie Chuo Medical CenterTsu 514-1101MieJapan Department of Pulmonary and Critical Care Medicine Mie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan Department of Pulmonary and Critical Care Medicine Graduate School of Medicine MieMie UniversityTsu 514-8507MieJapan

BACKGROUND Allergic bronchopulmonary aspergillosis(ABPA)is an allergic reaction to Aspergillus species that aggravates bronchial *** studies demonstrated the glucocorticoid-sparing effect of dupilumab in patients with *** is no report of complete withdrawal of glucocorticoids after *** SUMMARY The patient was a 54-year-old woman with bronchial asthma treated with inhaled corticosteroids and a long-acting beta-2 *** consulted our institution for productive cough and fever in March *** computed tomography scan revealed mucoid impaction,and the bronchial lavage fluid culture was positive for Aspergillus *** diagnosis was *** patient was treated with oral glucocorticoids from April 2017 to November *** January 2019,she had bronchial asthma exacerbation,and a chest computed tomography scan showed recurrent mucoid *** was treated with oral glucocorticoids and *** February 2020,during tapering of oral glucocorticoid,she had the third episode of bronchial asthma exacerbation and a mucoid *** patient was treated with dupilumab in addition to oral glucocorticoid and *** clinical response improved,and oral glucocorticoid was discontinued in June *** This is the first case of ABPA in which complete withdrawal of glucocorticoid was possible after treatment with dupilumab.

关键词： Allergic bronchopulmonary aspergillosis Dupilumab Asthma Interleukin-13 Interleukin-4 Case report

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Podocyte loss and albuminuria of KK-Ay mouse: A spontaneous animal model for human type 2 diabetic nephropathy

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Journal of Diabetes Mellitus 2012年第3期2卷 346-352页

作者： Yuji Ishikawa Takamichi Ito Mitsuo Tanimoto Shinji Hagiwara Masako Furukawa Saori Yamaguchi Keisuke Omote Katsuhiko Asanuma tomohito Gohda Yoshio Shimizu Kazuhiko Funabiki Satoshi Horikoshi Yasuhiko Tomino Division of Nephrology Department of Internal Medicine Faculty of Medicine Juntendo University Tokyo Japan

Podocyte loss was well known in type 2 diabetic nephropathy patients. The objective of the present study was to determine the number of podocytes and the degree of albuminuria in diabetic KK-Ay/Ta (KK-Ay) mice which had been reported as diabetic nephropathy model. Diabetic KK-Ay mice, diabetic KK/Ta mice and non-diabetic BALB/cA Jcl (BALB/cA) mice were studied. We analyzed glomerular lesions in all mice by morphometric analysis and immunofluorescence to determine the number of podocytes. Level of urinary albumin was also measured. Glomerular enlargement and mesangial expansion were observed in KK-Ay mice. Mean number of podocytes per glomerulus (NG pod) in diabetic KK-Ay mice was significantly lower than that in non-diabetic BALB/cA mice. Mean NG pod/glomerular area (GA) per glomerulus was also significantly decreased in diabetic KK-Ay mice. The level of urinary albumin/creatinine ratio (ACR) in diabetic KK-Ay mice was significantly higher than that in non-diabetic BALB/cA mice. These data suggest that podocyte loss might induce albuminuria in KK-Ay mice. This finding confirmed our previous report that KK-Ay mice, especially in terms of histological findings, are a suitable animal model for glomerular injury in type 2 diabetic nephropathy.

关键词： Podocyte Loss Albuminuria Diabetic Rodent Model Diabetes Type 2 DiabeticNephropathy

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New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury

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World Journal of Gastroenterology 2015年第45期21卷 12778-12786页

作者： Naoki Sano Takafumi Tamura Naoyuki Toriyabe Takeshi Nowatari Ken Nakayama tomohito Tanoi Soichiro Murata Yu Sakurai Mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi Department of Surgery Doctoral Program in Clinical Science Graduate School of Comprehensive Human Sciences University of Tsukuba Faculty of Pharmaceutical Sciences Hokkaido University

AIM: To investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine ***: We divided Sprague-Dawley rats into 4 groups: control, HA, sphingosine 1-phosphate(S1P), and HA-S1 P. After the administration of each agent, we subjected the rat livers to total ischemia followed by reperfusion. After reperfusion, we performed the following investigations: alanine aminotransferase(ALT), histological findings, Td T-mediated d UTP-biotin nick end labeling(TUNEL) staining, and transmission electron microscopy(TEM). We also investigated the expressionof proteins associated with apoptosis, hepatoprotection, and S1 P accumulation. RESULTS: S1 P accumulated in the HA-S1 P group livers more than S1 P group livers. Serum ALT levels, TUNEL-positive hepatocytes, and expression of cleaved caspase-3 expression, were significantly decreased in the HA-S1 P group. TEM revealed that the liver sinusoidal endothelial cell(LSEC) lining was preserved in the HA-S1 P group. Moreover, the HA-S1 P group showed a greater increase in the HO-1 protein levels compared to the S1 P ***: Our results suggest that HA-S1 P exhibits cytoprotective effects in the liver through the inhibition of LSEC apoptosis. HA-S1 P is an effective agent for hepatic ischemia/reperfusion injury.

关键词： Hyaluronic acid Sphingosine 1-phosphate Liver sinu

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An inter-laboratory study of DNA-based identity,parentage and species testing in animal forensic genetics

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Forensic Sciences Research 2022年第4期7卷 708-713页

作者： Sreetharan Kanthaswamy Torsten Brendel Luis Cancela Denise A.Andrade de Oliveira Bertram Brenig Carmen Cons Julian A.Crespi Markéta Dajbychová Andreas Feldl tomohito Itoh Vincenzo Landi Amparo Martinez Malgorzata Natonek-Wisniewska Robert F.Oldt Anna Radko Oscar Ramírez Clementina Rodellar Manuel Ruiz-Girón David Schikorski María Elena Turba Guillermo Giovambatista School of Mathematics and Natural Sciences Arizona State University(ASU)at the West CampusGlendaleAZUSA California National Primate Research Center University of CaliforniaDavisCAUSA Evolutionary Biology Graduate Program School of Life SciencesArizona State UniversityTempeAZUSA Eurofins Genomics Europe Applied Genomics GmbH EbersbergGermany IDENTITAS MontevideoUruguay Laboratório de Genética Escola de Veterinária da UFMGBelo HorizonteBrazil Institute of Veterinary Medicine University of GoettingenGoettingenGermany Facultad de Veterinaria Laboratorio de Genética Bioquímica(LAGENBIO)Instituto Agroalimentario de Aragón-IA2(Universidad de Zaragoza-CITA)ZaragozaSpain Facultad de Ciencias Veterinarias UNLP IGEVET-Instituto de Genética Veterinaria(UNLP-CONICET LAPLATA)La PlataArgentina Genomia s.r.o. PlzeňCzech Republic Maebashi Institute of Animal Science Livestock Improvement Association of Japan(LIAJ)MaebashiJapan Department of Veterinary Medicine Animal Breeding and GeneticsUniversity of Bari“Aldo Moro”ValenzanoItaly Department of Genetics Faculty of Veterinary SciencesUniversity of CórdobaCórdobaSpain Department of Animal Molecular Biology National Research Institute of Animal ProductionBalicePoland Vetgenomics SL BarcelonaSpain Laboratorio de Biología Molecular y Genómica Hispalis Biolab S.L.U.SevilleSpain Laboratoire LABOFARM-GENINDEXE LOUDEACCedexFrance Genefast SRL ForlìItaly

The probative value of animal forensic genetic evidence relies on laboratory accuracy and ***-laboratory comparisons allow laboratories to evaluate their performance on specific tests and analyses and to continue to monitor their *** International Society for Animal Genetics(ISAG)administered animal forensic comparison tests(AFCTs)in 2016 and 2018 to assess the limitations and capabilities of laboratories offering forensic identification,parentage and species determination *** AFCTs revealed that analyses of low DNA template concentrations(≤300 pg/μL)constitute a significant challenge that has prevented many laboratories from reporting correct identification and parentage ***,a lack of familiarity with species testing protocols,interpretation guidelines and representative databases prevented over a quarter of the participating laboratories from submitting correct species determination *** laboratories showed improvement in their genotyping accuracy over ***,the use of forensically validated standards,such as a standard forensic short tandem repeat(STR)kit,preferably with an allelic ladder,and stricter guidelines for STR typing,may have prevented some common issues from occurring,such as genotyping inaccuracies,missing data,elevated stutter products and loading *** AFCTs underscore the importance of conducting routine forensic comparison tests to allow laboratories to compare results from each *** should keep improving their scientific and technical capabilities and continuously evaluate their personnel’s proficiency in critical techniques such as low copy number(LCN)analysis and species *** this is the first time that the ISAG has conducted comparison tests for forensic testing,findings from these AFCTs may serve as the foundation for continuous improvements of the overall quality of animal forensic genetic testing.

关键词： Forensic sciences forensic genetics comparison test forensic DNA analysis individual identification parentage test species test

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日本机构伦理委员会关于研究规程的审议要点

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中国医学伦理学 2011年第5期24卷 670-672页

作者：毛敬洁沈永新池田博昭龟田美保粟屋智一川上由育福建中医药大学中西医结合研究院福建福州350108 广岛大学病院临床研究部

随着临床试验国际化进程的加快,在中国进行的国际合作临床试验逐渐增多。保证临床试验的科学性和维护受试者的权益,需要伦理委员会的审查和监督管理。介绍日本伦理委员会审查研究规程的视点,旨在使我国广大临床工作者了解国外的伦理审... 详细信息

随着临床试验国际化进程的加快,在中国进行的国际合作临床试验逐渐增多。保证临床试验的科学性和维护受试者的权益,需要伦理委员会的审查和监督管理。介绍日本伦理委员会审查研究规程的视点,旨在使我国广大临床工作者了解国外的伦理审查工作,以期对提高国内的临床试验水平和质量控制提供参考。

关键词：伦理委员会伦理审查临床试验临床研究规程医学伦理学

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QT间期延长综合征病人ankyrin-B基因突变的解析(英文)

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南方医科大学学报 2006年第7期26卷 901-903,909页

作者：周翔清水贤巳今野哲雄井野秀一藤野阳内山胜晴马渊智仁金田朋也藤田崇志舜田英一加藤大雅舟田晃马渊宏南方医科大学病理生理学教研室广东广州510515 金泽大学医学部附属医院心内科

目的确定ankyrin-B基因突变在日本人群QT间期延长综合征中的发病率以及ankyrin-B基因突变与QT间期延长综合征之间的关系。方法我们对相互之间无血缘关系的日本人群已确诊的QT间期延长综合征患者78例(男28例,女50例)进行了研究。在征得... 详细信息

目的确定ankyrin-B基因突变在日本人群QT间期延长综合征中的发病率以及ankyrin-B基因突变与QT间期延长综合征之间的关系。方法我们对相互之间无血缘关系的日本人群已确诊的QT间期延长综合征患者78例(男28例,女50例)进行了研究。在征得患者的同意之后,从其白细胞中提取纯化基因组DNA并行多聚酶链式反应(PCR)扩增。随即对扩增的DNA行单链构像多态性(SSCP)分析。而后将突变或异常的SSCP产物分离后,采用自动荧光测序仪检测DNA序列。最后再用150例正常健康人的DNA作为对照,对上述经测序确认的误义点突变进行PCR-限制性片段长度多态性分析,以进一步证实误义点突变的真实性和可靠性。结果我们在一例确诊的QT间期延长综合征患者的ankyrin-B基因的4603碱基位点上发现了从T到A的突变(T4603A)。出现于基因的第40号外显子上的该误义点突变,导致了氨基酸序列第1535位点上的色氨酸残基被精氨酸残基所取代(W1535R)。而该氨基酸序列正位于ankyrin-B基因高度保守的调节区域。结论新发现的位于ankyrin-B基因调节区域的误义点突变可能是导致4型QT间期延长综合征的原因之一,而该突变似乎并不是导致日本人群4型QT间期延长综合征的主要病因。

关键词：基因突变 QT间期延长综合征 ankyrin-B基因

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Podocyte loss and albuminuria of KK-Ay mouse: A spontaneous animal model for human type 2 diabetic nephropathy

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Journal of Diabetes Mellitus（糖尿病） 2012年第3期

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