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Optimal Design of TMD Under Long-Term Nonstationary Wave Loading

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China Ocean Engineering 2000年第1期15卷 25-32页

作者：李华军蒋济同曹宏生稽春艳 Tomotsuka takayama Professor Disaster Prevention Res. Inst. Kyoto Univ. Gokasho Uji

Traditionally, the use of a tuned mass damper (TMD) is to improve the surviability of the primary structure under extraordinary loading environment while the design loading condition is described by either a harmonic function or a stationary random process that can be fully characterized by a power spectral density (PSD) function. Aiming at prolonging the fatigue life of an offshore platform, this study considers an optimal design of TMD for the platform under long-term nonstationary loading due to long-term random sea waves characterized by a probabilistic power spectral density (PPSD) function In principle, a PPSD could be derived based on numerous ordinary PSD functions; and each of them is treated as realization of the corresponding PPSD. This study provides a theoretical development for the optimal TMD design by minimizing the cost function to be the mean square value of the expected long term response. A numerical example is presented to illustrate the developed design procedure.

关键词： optimal design tuned mass damper power spectral density fatigue life offshore platform

Patient blinding with blunt tip placebo acupuncture needles:comparison between 1 mm and 2 mm skin press

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Journal of Integrative Medicine 2018年第3期16卷 164-171页

作者： Nobuari Takakura Miho takayama Morihiro Nasu Masako Nishiwaki Akiko Kawase Hiroyoshi Yajima Department of Acupuncture and Moxibustion Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Physiology Showa University School of Medicine Japan School of Acupuncture Moxibustion and Physiotherapy

Objective： To investigate the influence of the depth of skin press in blunt tip placebo acupuncture needles on patient blinding and its relationship to needle ***： Forty healthy volunteers were enrolled as subjects for patient blinding. Four acupuncturists applied the following needles randomly at three points in each forearm： 0.18 mm and 0.25 mm diameter penetrating needles inserted to a depth of 5 mm, and 0.18 mm and 0.25 mm diameter skin-touch needles depressing the skin at the acupoint to a depth of 1 mm and 2 mm from the skin surface. The subjects reported their guesses at the nature of needles they received, and rated needle pain and de qi. A blinding index was calculated to define the success of blinding for ***： The blinding status of subjects for 1 mm press needles of 0.18 mm diameter was ＂random guess＂,but ＂unblinded＂ for 1 mm press needles of 0.25 mm diameter. For 2 mm press needles of both diameters,the blinding status was ＂opposite guess＂ and the blinding status for penetrating needles of both diameters was ＂unblinded.＂ The percentages of ＂felt pain＂ with 2 mm press needles of both diameters were similar to that with penetrating needles, but those were not similar for 1 mm press needles. The frequency of de qi occurrence with 2 mm press needles of 0.18 mm diameter was similar to that of penetrating needles of both ***： Placebo needles of 2 mm press made more subjects guess that the needles penetrated the skin than 1 mm press needles. The use of small diameter needles increased patient blinding.

关键词： Double-blind method Acupuncture Placebo Sham De qi

Strategies for gastric cancer in the modern era

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 335-341页

作者： Satoru takayama Takehiro Wakasugi Hitoshi Funahashi Hiromitsu Takeyama Department of Gastroenterological Surgery Nagoya City University Graduate School of Medical Sciences

Gastric cancer is one of the most common neoplasms in Japan, and it is also the second leading cause of cancer-related deaths worldwide. Nowadays, infection with Helicobacter pylori (H. pylori) is a known risk factor for the development of gastric cancer. Therefore, gastric cancer should be considered as an infectious disease, and in fact, prophylactic eradication of H. pylori may prevent the development of metachronous gastric carcinoma. Before the role of H. pylori was understood, a different approach was used. Recently even after the cancer has developed, some newer therapeutic approaches have been pursued. These newer treatments have been summarized as "minimally invasive therapies" and use endoscopic or laparoscopic techniques. In addition, robotic approaches are being developed that seem to hold a great potential to change the surgical approach. Since basic understanding and treatment of the disease have both changed signif icantly over the last decade, we present a review of current advances in gastric cancer research and therapy.

关键词： Helicobacter pylori Endoscopic submucosal dissection Laparoscopy-assisted distal gastrectomy Gastric cancer Robot

UNSTEADY INTERACTION OF SHOCK WAVE DIFFRACTING AROUND A CIRCULAR CYLINDER IN AIR

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Acta Mechanica Sinica 1991年第4期7卷 295-299页

作者：黄文生 O.Onodera K.takayama Peking University Beijing 100871China Tohoku University Japan

The reflection and diffraction of a planar shock wave around a circular cylinder are a typical problem of the complex nonlinear shock wave phenomena in *** has long been studied experimentally,analytically as well as *** in 1987 obtained clear experimental pictures ofisopycnics in shock tube under the condi- tion that the impinging shock wave propagates as far as 3 diameters away from the *** know more complete- ly the whole unsteady process,it is desirable to get experimental results in a region which is more than 10 diameters away from the *** is what has been done in this paper by using the pulsed laser holographic interferometry for several shock Mach numbers of the impinging shock. Results for several moments are shown,giving more know- ledge about the whole unsteady flow *** is useful for a reliable and complete understanding of the changing force acting on the cylinder,and provides interesting data to check the performance of many recently developed high resolution numerical methods for unsteady shock wave calculation.

关键词： shock wave diffraction large flow field around a cylinder pulsed laser holographic interferometry isopycnics complex interaction of curved shocks

Overexpression of S-adenosylmethionine decarboxylase(SAMDC)in Xeno-pus embryos activates maternal program of apoptosis as a "fail-safe"mechanism of early embryogenesis

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Cell Research 2003年第3期13卷 147-158页

作者： MASATAKEKAI,CHIKARAKAITO,HIROSHIFUKAMACHI,TAKAYASUHIGO,EIJI takayama,HIROSHI HARA,YOSHIKAZU OHYA,KAZUEI IGARASHI,KOICHIRO SHIOKAWA Laboratory of Molecular Embryology Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan Laboratory of Molecular Embryology Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan Laboratory of Molecular Embryology Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan Laboratory of Molecular Embryology Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan Department of Parasitology National Defense Medical College Namiki 3-2 Tokorozawa Saitama 359-8843 Japan Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd. 1-403 Yoshino-cho Kita-ku Saitama 331-9530 Japan Department of Integrated Biosciences Graduate School of Frontier Sciences University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba 277-8562 Japan Faculty of Pharmaceutical Sciences Chiba University Yayoi-cho 1-33 Inage-ku Chiba 263-8522 Japan Laboratory of Molecular Embryology Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan

In Xenopus, injection of S-adenosylmethionine decarboxylase (SAMDC) mRNA into fertilized eggs or2-cell stage embryos induces massive cell dissociation and embryo-lysis at the early gastrula stage due toactivation of the maternal program of apoptosis. We injected SAMDC mRNA into only one of the animal side blastomeres of embryos at different stages of cleavage, and examined the timing of the onset of theapoptotic reaction. In the injection at 4- and 8-cell stages, a considerable number of embryos developed intotadpoles and in the injection at 16- and 32-cell stages, all the embryos became tadpoles, although tadpolesobtained were sometimes abnormal. However, using GFP as a lineage tracer, we found that descendant cellsof the blastomere injected with SAMDC mRNA at 8- to 32-cell stages are confined within the blastocoel atthe early gastrula stage and undergo apoptotic cell death within the blastocoel, in spite of the continueddevelopment of the injected embryos. These results indicate that cells overexpress

关键词： SAMDC overexpression maternal apoptosis program processing-defective SAMDC mutant MBT fail-safe mechanism.

The difference of Park and Streitberger singleblind needles from Takakura double-blind needle

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Journal of Integrative Medicine 2015年第4期13卷 212-214页

作者： Nobuari Takakura Miho takayama Hiroyoshi Yajima Department of Acupuncture and Moxibustion Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Physiology Showa University School of Medicine

In a recent study aimed at validating the Park sham needle for use as a double-blind control intervention,To and Alexander concluded that the practitioner who was performing acupuncture recognized the type of needle[1].This paper may lead the reader to misunderstand the design and purpose of placebo/sham acupuncture[2–6]which have been developed in recent decades for the purpose of acupuncture research.

关键词： acupuncture single blind double blind sham treatment

Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers

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World Journal of Gastroenterology 2013年第34期19卷 5706-5712页

作者： Masaki takayama Shigenaga Matsui Masanori Kawasaki Yutaka Asakuma Toshiharu Sakurai Hiroshi Kashida Masatoshi Kudo Department of Gastroenterology and Hepatology Kinki University

AIM:To prospectively compare the healing rates of endoscopic submucosal dissection(ESD)-induced ulcers treated with either a proton-pump inhibitor(PPI)or ***:We examined 90 patients with early gastric cancer who had undergone *** patients were administered an intravenous infusion of the PPI lansoprazole(20 mg)every 12 h for 2 d,followed by oral administration of lansoprazole(30 mg/d,5 d).After7-d treatment,the patients were randomly assigned to 2 groups and received either lansoprazole(30 mg/d orally,n=45;PPI group)or rebamipide(300 mg orally,three times a day;n=45;rebamipide group).At 4and 8 wk after ESD,the ulcer outcomes in the 2 groups were ***:No significant differences were noted in patient age,underlying disease,tumor location,Helicobacter pylori infection rate,or ESD-induced ulcersize between the 2 *** both 4 and 8 wk,the healing rates of ESD-induced ulcers were similar in the PPI-treated and the rebamipide-treated patients(4 wk:PPI,27.2%;rebamipide,33.3%;P=0.5341;8 wk:PPI,90.9%;rebamipide,93.3%;P=0.6710).At 8 wk,the rates of granulation lesions following ulcer healing were significantly higher in the PPI-treated group(13.6%)than in the rebamipide-treated group(0.0%;P=0.0103).Ulcer-related symptoms were similar in the2 treatment groups at 8 *** medication cost of 8-wk treatment with the PPI was 10945 yen vs 4889 yen for *** ulcer bleeding or complications due to the drugs were observed in either treatment ***:The healing rate of ESD-induced ulcers was similar with rebamipide or PPI treatment;however,rebamipide treatment is more cost-effective and prevents granulation lesions following ulcer healing.

关键词： Early gastric cancer Rebamipide Endoscopic submucosal dissection Gastric ulcer Protonpump inhibitor

Prospective validation to prevent symptomatic portal vein thrombosis after liver resection

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World Journal of Hepatology 2022年第5期14卷 1016-1024页

作者： Nao Yoshida Shintaro Yamazaki Moriguchi Masamichi Yukiyasu Okamura Tadatoshi takayama Department of Digestive Surgery Nihon University School of MedicineTokyo 1738610Japan

BACKGROUND Portal vein thrombosis(PVT)after liver resection is rare but can lead to lifethreatening liver *** prospective study evaluated patients using contrastenhanced computed tomography(E-CT)on the first day after liver resection for early PVT detection and *** To evaluate patients by E-CT on the first day after liver resection for early PVT detection and immediate *** Patients who underwent liver resection for primary liver cancer from January 2015 were enrolled.E-CT was performed on the first day after surgery in patients undergoing anatomical resection,multiple resections,or with postoperative bile leakage in the high-risk group for *** PVT was detected,anticoagulant therapy including heparin,warfarin,and edoxaban was administered.E-CT was performed monthly until PVT *** The overall incidence of PVT was 1.57%(8/508).E-CT was performed on the first day after surgery in 235 consecutive high-risk patients(165 anatomical resections,74 multiple resections,and 28 bile leakages),with a PVT incidence of 3.4%(8/235).Symptomatic PVT was not observed in the excluded *** analyses revealed that sectionectomy was the only independent predictor of PVT[odds ratio(OR)=12.20;95%confidence interval(CI):2.22-115.97;P=0.003].PVT was found in the umbilical portion of 75.0%(6/8)of patients,and sectionectomy on the left side showed the highest risk of PVT(OR=14.10;95%CI:3.17-62.71;P<0.0001).CONCLUSION Sectionectomy on the left side should be chosen with caution as it showed the highest risk of PVT.E-CT followed by anticoagulant therapy was effective in managing early-phase PVT for 2 mo without adverse events.

关键词： Portal vein thrombosis Liver resection Anatomical resection Anticoagulant therapy Hepatocellular carcinoma Umbilical potion

Current State of the Japanese Roofing Industry

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中国建筑防水 2005年第1期 17-19+25页

作者： Hiroshi takayama President of Japan Roofing Contractors Assoc.