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Compartmentalization of local cAMP signaling in neuronal growth and survival

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Neural Regeneration Research 2020年第3期15卷 453-454页

作者： tomasz Boczek Michael S.Kapiloff Department of Ophthalmology Byers Eye InstituteMary M.and Sash A.Spencer Center for Vision ResearchStanford University School of MedicinePalo AltoCAUSA Department of Molecular Neurochemistry Medical University of LodzPoland

Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and *** highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite *** these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream *** the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in *** complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.

关键词： metabolism specificity integrate

Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability

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World Journal of Gastroenterology 2014年第1期20卷 53-63页

作者： Danuta Owczarek Dorota Cibor Mikolaj K Glowacki tomasz Rodacki tomasz Mach Department of Gastroenterology Hepatology and Infectious DiseasesJagiellonian University Medical College31-531 KrakówPoland

Hypercoagulability observed in patients with inflammatory bowel diseases(IBD)may lead to thromboembolic events(TE),which affect the venous and arterial systems alike and are an important factor in patients’morbidity and *** risk of TE in IBD patients has been demonstrated to be approximately threefold higher as compared to the general *** pathogenesis of thrombosis in IBD patients is multifactorial and not fully *** most commonly listed factors include genetic and immune abnormalities,disequilibrium between procoagulant and anticoagulant factors,although recently,the role of endothelial damage as an IBD-triggering factor is *** studies report that the levels of some coagulation enzymes,including fibrinogen,factorsⅤ,Ⅶ,Ⅷ,active factorⅪ,tissue factor,prothrombin fragment 1+2and the thrombin-antithrombin complex,are altered in IBD *** has been demonstrated that there is a significant decrease of tissue plasminogen activator level,a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor,a significantly lower level of antithrombinⅢand tissue factor pathway *** patients have been also observed to produce an increased amount of various anticoagulant ***,which is a potential risk factor for TE was also observed in some IBD *** studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE.

关键词： Crohn’s disease Hypercoagulation Risk factors Thro

Diet and nutritional factors in inflammatory bowel diseases

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World Journal of Gastroenterology 2016年第3期22卷 895-905页

作者： Danuta Owczarek tomasz Rodacki Renata Domagała-Rodacka Dorota Cibor tomasz Mach Department of Gastroenterology Hepatology and Infectious DiseasesJagiellonian University Medical College31-531 CracowPoland Department of Food Chemistry and Nutrition Jagiellonian University Medical College30-688 CracowPoland

Inflammatory bowel disease(IBD) development is affected by complex interactions between environmental factors, changes in intestinal flora, various predisposing genetic properties and changes in the immune system. Dietary factors seem to play an underestimated role in the etiopathogenesis and course of the disease. However, research about food and IBD is conflicting. An excessive consumption of sugar, animal fat and linoleic acid is considered a risk factor for IBD development, whereas a high fiber diet and citrus fruit consumption may play a protective role. Also, appropriate nutrition in particular periods of the disease may facilitate achieving or prolonging remissions and most of all, improve the quality of life for patients. During disease exacerbation, a low fiber diet is recommended for most patients. In the remission time, an excessive consumption of alcohol and sulfur products may have a negative effect on the disease course. Attempts are also made at employing diets composed in detail in order to supplement IBD therapy. A diet with a modified carbohydrate composition, a semi-vegetarian diet and a diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols are under investigation. Due to chronic inflammation as well as side effects of chronically used medications, patients with IBD are also at increased risk of nutritional factor deficiencies, including iron, calcium, vitamin D, vitamin B12, folic acid, zinc, magnesium and vitamin A. It should also be remembered that there is no single common diet suitable for all IBD patients; each of them is unique and dietary recommendations must be individually developed for each patient, depending on the course of the disease, past surgical procedures and type of pharmacotherapy.

关键词： Crohn's disease Diet Nutrition Supplementation Ulcerative colitis

Micromorphological features of soils formed on calcium carbonate–rich slope deposits in the Polish Carpathians

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Journal of Mountain Science 2020年第6期17卷 1310-1332页

作者： Joanna Beata KOWALSKA tomasz ZALESKI Ryszard MAZUREK Department of Soil Science and Agrophysics University of AgricultureAl.Mickiewicza 2131-120 KrakowPoland

Seven soil profiles developed on calcium carbonate–rich slope deposits in the Polish Carpathians were studied in order to:i)determine the micromorphological features of heterogeneous soils formed in a carbonate depositional environment,and ii)track primary and secondary calcium carbonate forms and their distribution in such stratified *** cases of soils with different arrangements of calcium carbonate were distinguished,controlled mostly by slope *** instance,the increasing content and random distribution of angular and subangular rock fragments found in the overall soil matrix and the irregular coarse:fine size limit suggested different intensities of accumulation and mixing of soil material transported along the *** processes,together with the calcium carbonate content,mineralogical characteristics and texture influenced the type and arrangement of the bfabric *** calcium carbonate distribution within the soils,besides the obvious inheritance from parent material,was governed by the translocation and mixing of deposits on *** climatic conditions prevailing in the area favour the development of secondary forms of calcium ***,only three of the seven studied profiles contained pedogenic forms of calcium carbonate,yet they were distributed *** occurrence,distribution and preservation of secondary carbonates depended on the content of primary calcium carbonate and soil features such as *** transported material down the slope may indicate a very low content of primary calcium or lack thereof,hence its pedogenic forms could not be created.

关键词： Heterogeneous soils Microfacies Secondary calcium carbonate Pedofeatures Soil profile

Application of long-reach directional drilling boreholes for gas drainage of adjacent seams in coal mines with severe geological conditions

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International Journal of Coal Science & Technology 2022年第6期9卷 75-88页

作者： Grzegorz Lesniak Daniel JBrunner tomasz Topòr Malgorzata Slota-Valim Renata Cicha-Szot Bartlomiej Jura Jacek Skiba Arnold Przystolik Ben Lyddall Grzegorz Plonka Oil and Gas Institute-National Research Institute Lubicz 25A31-503 KrakówPoland REI Drilling INC.250 West Berger Lane84107 Salt Lake CityUTUSA Central Mining Institute 40-166 KatowicePoland Polish Mining Group(PGG) Powstańców 3040-039 KatowicePoland

This study aimed to demonstrate the application of Long Reach Directionally Drilled Boreholes(LRDD)for gas drainage of adjacent seams before and during the longwall face operations of low permeability-high gas content coals Staszic-Wujek Hard Coal Mine in the Upper Silesia Coal Basin(Poland).Five LRDD Boreholes(TM1a-TM5)with a length of 300 and 400 m were located over coal seam 501 in the fractured zone and monitored over six months of longwall face *** Boreholes were combined with Cross-Measured *** characterization and geological modeling supported the results obtained from gas *** drainage efficiency of LRDD Boreholes was the approxi-mately 70%level,while conventional Cross-Measured Boreholes were only 30%.The highest goaf gas quality(94%methane concentration)was reported for TM4,placed at an average elevation of 41 m above coal seam *** highest goaf gas production(average 6.2 m^(3)/min)was reported for LRDD Borehole *** borehole was placed within the fracture zone(average elevation of 24.4 m)and drilled through the sandstone lithotype with the best reservoir properties,enhancing drainage *** Boreholes TM2 and TM4 achieved similar *** three LRDD Boreholes were drilled close to the maximum principal horizontal stress direction,providing borehole stability during *** lowest goaf gas production was reported for LRDD Boreholes TM1a and *** Boreholes were placed in the rubble zone.

关键词： Coal Mine methane Methane control strategy In-seam horizontal boreholes Long reach directionally

Supplementation of a lacto-fermented rapeseed-seaweed blend promotes gut microbial-and gut immune-modulation in weaner piglets

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Journal of Animal Science and Biotechnology 2022年第1期13卷 138-151页

作者： Yan Hui Paulina Tamez-Hidalgo tomasz Cieplak Gizaw Dabessa Satessa Witold Kot Søren Kjærulff Mette Olaf Nielsen Dennis Sandris Nielsen Lukasz Krych Department of Food Science Faculty of ScienceUniversity of CopenhagenRolighedsvej 26DK-1958 Frederiksberg CDenmark Fermentationexperts A/S.Vorbassevej 12 DK-6622 BaekkeDenmark Department of Veterinary and Animal Sciences Faculty of Health and Medical SciencesUniversity of CopenhagenGrønnegårdsvej 3DK-1870 Frederiksberg CDenmark Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenRolighedsvej 26DK-1958 Frederiksberg CDenmark Department of Animal Science Faculty of Technical SciencesAarhus UniversityBlichers Alle 20DK-8830 TjeleDenmark

Background:The direct use of medical zinc oxide in feed will be abandoned after 2022 in Europe,leaving an urgent need for substitutes to prevent post-weaning ***:This study investigated the effect of using rapeseed-seaweed blend(rapeseed meal added two brown macroalgae species Ascophylum nodosum and Saccharina latissima)fermented by lactobacilli(FRS)as feed ingredients in piglet *** d 28 of life to d 85,the piglets were fed one of three different feeding regimens(n=230 each)with inclusion of 0%,2.5% and 5% *** this period,no significant difference of piglet performance was found among the three *** a subset of piglets(n=10 from each treatment),blood samples for hematology,biochemistry and immunoglobulin analysis,colon digesta for microbiome analysis,and jejunum and colon tissues for histopathological analyses were *** piglets fed with 2.5% FRS manifested alleviated intraepithelial and stromal lymphocytes infiltration in the gut,enhanced colon mucosa barrier relative to the 0% FRS *** colon microbiota composition was determined using V3 and V1-V8 region 16S rRNA gene amplicon sequencing by Illumina NextSeq and Oxford Nanopore MinION,*** two amplicon sequencing strategies showed high consistency between the detected *** sequencing strategies indicated that inclusion of FRS reshaped the colon microbiome of weaned piglets with increased Shannon *** stercorea was verified by both methods to be more abundant in the piglets supplied with FRS feed,and its abundance was positively correlated with colonic mucosa thickness but negatively correlated with blood concentrations of leucocytes and ***:FRS supplementation relieved the gut lymphocyte infiltration of the weaned piglets,improved the colon mucosa barrier with altered microbiota *** the dietary inclusion of FRS from 2.5% to 5% did not lead to further improvements.

关键词： Amplicon sequencing Colon microbiota Fermented feed Gut barrier

The visual analytics of big,open public transport data-a framework and pipeline for monitoring system performance in Greater Sydney

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Big Earth Data 2021年第1期5卷 134-159页

作者： Oliver Lock tomasz Bednarz Christopher Pettit City Analytics Lab Faculty of Built EnvironmentUniversity of New South WalesSydneyAustralia Expanded Perception and Interaction Centre Faculty of Art&DesignUniversity of New South WalesSydneyAustralia

Many cities,countries and transport operators around the world are striving to design intelligent transport *** systems capture the value of multisource and multiform data related to the functionality and use of transportation infrastructure to better support human mobility,interests,economic activity and *** aim to provide services that can enable transportation customers and managers to be better informed and make safer and more efficient use of *** developing principles,guidelines,methods and tools to enable synergistic work between humans and computer-generated information,the science of visual analytics continues to expand our understanding of data through effective and interactive visual *** this paper,we describe an application of visual analytics related to the study of movement and transportation *** application documents the use of rapid,2D and 3D web visualisation and data analytics libraries and explores their potential added value to the analysis of big public transport performance data.A novel approach to displaying such data through a generalisable framework visualisation system is *** framework recalls over a year’sworth of public transport performance data at a highly granular level in a fast,interactive browser-based *** Sydney,Australia forms a case study to highlight potential uses of the visualisation of such large,passively-collected data sets as an applied research *** this paper,we argue that such highly visual systems can add data-driven rigour to service planning and longer-term transport ***,they enable the sharing of quality of service statistics with various stakeholders and citizens and can showcase improvements in services before and after policy *** paper concludes by making recommendations on the value of this approach in embedding these or similar web-based systems in transport planning practice,performance

关键词： WebGL visual analytics public transportation transport performance visualisation open data big data

Lithological indicators of discontinuities in mountain soils rich in calcium carbonate in the Polish Carpathians

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Journal of Mountain Science 2020年第5期17卷 1058-1083页

作者： Joanna Beata KOWALSKA Bartlomiej KAJDAS tomasz ZALESKI Depatment of Soil Science and Agrophysics University of AgricultureAl.Mickiewicza 2131-120 KrakowPoland Natural Science Education Centre Jagiellonian UniversityGronostajowa 530-387 KrakowPoland

Six soils located within the Polish Carpathians,developed on calcium carbonate–rich sedimentary parent materials and representing various reference groups,were investigated in order to detect the lithic *** propose using a multidirectional approach to assess the lithic discontinuity in these soils,one that includes grain size distribution,geochemical composition,heavy mineral content and micromorphology,supported by a traditional soil survey.A further aim of this process was to identify the possible admixture of allochthonous material of aeolian *** studied soils presented lithic discontinuities mostly at the contact of underlying calcium carbonate–rich coarsegrained slope deposits with the overlaying colluvium layer having a lower content of rock *** significant changes in grain size distribution,especially in the silt and sand content,as well as high Uniformity Values and partially,high Lithological Discontinuity Index values,confirmed the occurrence of a lithic discontinuity in all studied *** heterogeneity in the soil profiles was also confirmed by the distribution of the major oxides;however,their distribution did not clearly indicate the lithic *** most visible distinctions were noted from CaO content,which resulted from the deposition of carbonate-free materials(aeolian silts)and their mixing with the calcium carbonate–rich parent ***,the analysis of heavy mineral content confirmed the allochthonous origin of the upper(and in some cases also the middle)parts of all profiles,which was manifested by the presence of highly weathering-resistant minerals such as zircon,epidote and various types of *** micromorphological features of some of the studied soils showed distinctiveness within the soil profile,manifested by changes in b-fabric pattern,the occurrence and distribution of secondary carbonate and the coarse and fine coarse and fine *** on the high content of silt within the u

关键词： Lithic discontinuities Heavy minerals Geochemistry Slope processes Micromorphology Uniformity Values

On Problems of Multicomponent System Maintenance Modelling

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International Journal of Automation and computing 2009年第4期6卷 364-378页

作者： tomasz Nowakowski Sylwia Werbin'ka Department of Logistics and Transportation Systems Wroclaw University of Technology

We present an overview of some recent developments in the area of mathematical modeling of maintenance decisions for multi-unit systems. The emphasis is on three main groups of multicomponent maintenance optimization models： the block replacement models, group maintenance models, and opportunistic maintenance models. Moreover, an example of a two-unit system maintenance process is provided in order to compare various maintenance policies.

关键词： Multicomponent systems corrective and preventive maintenance maintenance free operating periods (MFOP) concepts.