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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

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Journal of Pharmaceutical Analysis 2021年第3期11卷 364-373页

作者： Monika Zielinska Ewa Chmielewska tomasz buchwald Adam Voelkel PawełKafarski Poznan University of Technology Institute of Chemical Technology and EngineeringUl.Berdychowo 460-965PoznanPoland Wrocław University of Science and Technology Faculty of ChemistryDepartment of Bioorganic ChemistryWybrzeze Wyspia_nskiego 2750-370WrocławPoland Poznan University of Technology Institute of Materials Research and Quantum EngineeringPiotrowo 360-965PoznanPoland

There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.

关键词： Monolithic column Polymer composites Bisphosphonates Hydroxyapatite coatings Hydroxyapatite composite

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Therapeutics administered during ex vivo liver machine perfusion:An overview

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World Journal of Transplantation 2020年第1期10卷 1-I0001页

作者： Julianna E buchwald Jing Xu Adel Bozorgzadeh Paulo N Martins Division of Transplantation Department of Surgery University of Massachusetts Medical School

Although the use of extended criteria donors has increased the pool of available livers for transplant,it has also introduced the need to develop improved methods of protection against ischemia-reperfusion injury(IRI),as these"marginal"organs are particularly vulnerable to IRI during the process of procurement,preservation,surgery,and *** this review,we explore the current basic science research investigating therapeutics administered during ex vivo liver machine perfusion aimed at mitigating the effects of IRI in the liver transplantation *** various categories of therapeutics are utilized during the perfusion process and include invoking the RNA interference pathway,utilizing defatting cocktails,and administering classes of agents such as vasodilators,anti-inflammatory drugs,human liver stem cell-derived extracellular vesicles,and δ-opioid agonists in order to reduce the damage of *** vivo machine perfusion is an attractive alternative to static cold storage due to its ability to continuously perfuse the organ,effectively deliver substrates and oxygen required for cellular metabolism,therapeutically administer pharmacological or cytoprotective agents,and continuously monitor organ viability during *** use of administered therapeutics during machine liver perfusion has demonstrated promising results in basic science *** novel therapeutic approaches to combat IRI are being developed through basic science research,their use in clinical medicine and treatment in patients for liver transplantation has yet to be explored.

关键词： Therapeutics Liver transplantation Ex vivo machine perfusion Ischemia reperfusion injury Organ preservation Extended criteria donors

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The Shock of Recognition

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英语学习 1994年第4期 52-53页

作者： Art buchwald

电视出现之后,人们不必走出家门,就能了解外界发生的大事,也可观看各类文艺演出和体育比赛。不仅儿童迷电视,成年人也迷电视。电视给家庭成员之间的关系带来了很大的影响。但是许多人并未察觉。美国幽默作家 Art buchwald(1925—1982)... 详细信息

电视出现之后,人们不必走出家门,就能了解外界发生的大事,也可观看各类文艺演出和体育比赛。不仅儿童迷电视,成年人也迷电视。电视给家庭成员之间的关系带来了很大的影响。但是许多人并未察觉。美国幽默作家 Art buchwald(1925—1982)的这篇讽刺小品震撼了许多美国家庭。电视已大步地进入了中国的千家万户,读一读这篇短文对我们不无启迪。

关键词： TV The Shock of Recognition

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The Einstein Papers Project 1955～2005

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自然科学史研究 2005年第B7期24卷 111-114页

作者： Diana Kormos buchwald California Institute of Technology Pasadena USA

The publication of the Collected Papers of Albert Einstein has been a long-standing editorial project. So far, nine volumes of Einstein’s collected writings and correspondence have been published since 1987 (with one double volume). They cover Einstein’s life and work from 1879 to 1921. The tenth volume of correspondence is due to appear in fall 2006. Albert Einstein (1879～1955), whose 125 th birthday we are celebrating March 14, lived in Germany, Switzerland, and eventually the United States, through six major epochs of modern history: the Wilhelmine Empire, World War I, the Weimar Republic, Fascism, World War II, and the post-war period. He had been the prime mover of the transformation of modern physics, starting with the publication of his revolutionary papers on the photoelectric effect and on the special theory of relativity in what we call “the miraculous year 1905”, and became the most important scientist after Isaac *** never wished for a memorial, and insisted that his ashes be scattered at an undisclosed location. The Einstein Papers Project is our intellectual memorial to his life and work.

关键词：爱因斯坦相对论物理学学术研究

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Clean Your Room

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大学英语 1986年第6期 31-34页

作者： Art buchwald 田之秋

You don’t really feel the generation gap in this country until ason or daughter comes home from college for *** itstrikes you how out of it you really *** dialogue probably took place all over America last Christmasw... 详细信息

关键词： Clean Your Room

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Successful treatment of complete traumatic transection of the suprahepatic inferior vena cava with veno-venous and cardiopulmonary bypass with hypothermic circulatory arrest

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 601-610页

作者： Paulo N.Martins Julianna E.buchwald Babak Movahedi Ulises Torres Timothy Emhoff Jennifer Walker Michael G.DeBusk Adel Bozorgzadeh Department of Surgery Division of TransplantationUniversity of MassachusettsWorcesterMA 01655USA Department of Surgery Division of TraumaUniversity of MassachusettsWorcesterMA 01655USA Department of Surgery Division of Cardiac SurgeryUniversity of MassachusettsWorcesterMA 01655USA

To the Editor:Complete traumatic transection of the suprahepatic inferior vena cava(IVC)has almost invariably a fatal *** are very few cases in the literature of patients that survived this type of *** we presented a case that was approached multidisciplinary(trauma surgeon,liver transplant surgeon,perfusionist,anesthesiologist,and cardiac surgeon)with a successful outcome including early recovery of all body functions and quality of life.

关键词： traumatic hepatic bypass

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Glucose-stimulated insulin secretion in isolated pancreatic islets: Multiphysics FEM model calculations compared to results of perifusion experiments with human islets

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Journal of Biomedical Science and Engineering 2013年第5期6卷 26-35页

作者： Peter buchwald Sirlene R. Cechin Diabetes Research Institute University of Miami Miller School of Medicine Miami USA

Because insulin released by the β-cells of pancreatic islets is the main regulator of glucose levels, the quantitative modeling of their glucose-stimulated insulin secretion is of obvious interest not only to improve our understanding of the processes involved, but also to allow better assessment of β -cell function in diabetic patients or islet transplant recipients as well as the development of improved artificial or bioartificial pancreas devices. We have recently developed a general, local concentrations-based multiphysics computational model of insulin secretion in avascular pancreatic islets that can be used to calculate insulin secretion for arbitrary geometries of cultured, perifused, transplanted, or encapsulated islets in response to various glucose profiles. Here, experimental results obtained from two different dynamic glucose-stimulated insulin release (GSIR) perifusion studies performed by us following standard procedures are compared to those calculated by the model. Such perifusion studies allow the quantitative assessment of insulin release kinetics under fully controllable experimental conditions of varying external concentrations of glucose, oxygen, or other compounds of interest, and can provide an informative assessment of islet quality and function. The time-profile of the insulin secretion calculated by the model was in good agree- ment with the experimental results obtained with isolated human islets. Detailed spatial distributions of glucose, oxygen, and insulin were calculated and are presented to provide a quantitative visualization of various important aspects of the insulin secretion dynamics in perifused islets.

关键词： COMSOL Multiphysics Diabetes Mellitus FEM Model Glucose-Insulin Dynamics Hill Equation Islet Perifusion Islets of Langerhans

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IsThere life on earth?

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英语学习 2001年第1期 20-21页

作者： Art buchwald 王永胜刘晓衡锦州师范学院

本周金星上可谓群情激昂、兴奋异常,因为有史以来金星科学家第一次设法成功地往地球发送了一枚卫星。随后,这枚卫星就不断地传回信号及照片。这枚卫星对准了地球上一个名为"曼哈顿"的地区。这是以金星伟大的天文学家曼哈顿教授来命名的... 详细信息

本周金星上可谓群情激昂、兴奋异常,因为有史以来金星科学家第一次设法成功地往地球发送了一枚卫星。随后,这枚卫星就不断地传回信号及照片。这枚卫星对准了地球上一个名为"曼哈顿"的地区。这是以金星伟大的天文学家曼哈顿教授来命名的,是他首次于20,000光年前使用天文望远镜发现了该地区。由于天气状况极佳,再加上信号特强的原由,金星科学家能够获得有价值的信息,从而

关键词：天文学曼哈顿地球表面 IsThere life on earth 金属颗粒辐射带

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胆固醇抑制、癌症与化疗

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国外医学（肿瘤学分册） 1993年第2期20卷 103-104页

作者： buchwald H 郭其森高顺宗

恶性肿瘤形成的一个重要特征是调节胆固醇合成的反馈抑制机制消失.癌细胞的生长需要高浓度胆固醇及其前身物质.因此一个合理的假说:通过限制摄入胆固醇或抑制胆固醇的合成预防癌细胞的增长.体外及细胞培养实验表明,低血清胆固醇或应用HM... 详细信息

恶性肿瘤形成的一个重要特征是调节胆固醇合成的反馈抑制机制消失.癌细胞的生长需要高浓度胆固醇及其前身物质.因此一个合理的假说:通过限制摄入胆固醇或抑制胆固醇的合成预防癌细胞的增长.体外及细胞培养实验表明,低血清胆固醇或应用HMG-CoA还原酶抑制剂干扰甲羟戊酸途径来减慢肿瘤生长.现在通过口服或通过埋入灌输泵间断地给予HGM-CoA还原酶抑制剂,能够取得这些药物治疗肿瘤的组织浓度.假若胆固醇抑制能够抑制肿瘤细胞的生长,可将其作为肿瘤化疗的辅助治疗,并且可能对癌肿有预防作用.

关键词：胆固醇癌药物疗法

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Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients:a case series and literature update

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Burns & Trauma 2019年第1期7卷 261-268页

作者： Mehran Dadras Johannes M.Wagner Christoph Wallner Julika Huber Dirk buchwald Justus Strauch Kamran Harati Nicolai Kapalschinski Björn Behr Marcus Lehnhardt Department of Plastic Surgery BG University Hospital BergmannsheilBürkle de la Camp-Platz 144789 BochumGermany Department of Cardiothoracic Surgery BG University Hospital BergmannsheilBürkle de la Camp-Platz 144789 BochumGermany

Background:Acute respiratory distress syndrome(ARDS)has a reported incidence of 34–43%in ventilated burn patients and is associated with a mortality of 59%in the severe *** use and experience with extracorporeal membrane oxygenation(ECMO)in burn patients developing ARDS are still *** present our results and discuss the significance of ECMO in treating burn ***:A retrospective analysis of burn patients treated with ECMO for ARDS between January 2017 and January 2019 was ***,clinical,and outcome data were collected and ***:Eight burn patients were treated at our institution with ECMO in the designated time *** these,all but one patient had inhalation injury,burn percentage of TBSA was 37±23%,ABSI score was 8.4±2,and R-Bauxscore was 98±*** patients developed severe ARDS and one patient moderate ARDS according to the Berlin classification with a PaO_(2)/FiO_(2) ratio upon initiation of ECMO therapy of 62±22 *** duration was 388±283 *** patients died from severe sepsis while five patients survived to hospital ***:ECMO is a viable therapy option in burn patients developing severe ARDS and can contribute to survival rates similar to ECMO therapy in non-burn-associated severe ***,patients with severe respiratory insufficiency with unsuccessful conventional treatment and suspected worsening should be transferred to burn units with the possibility of ECMO treatment to improve outcome.

关键词： Extracorporeal membrane oxygenation Acute respiratory distress syndrome Burns Inhalation injury ECMO ARDS

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