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Bone marrow-derived products: A classification proposal – bone marrow aspirate, bone marrow aspirate concentrate or hybrid?

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World Journal of Stem Cells 2020年第4期12卷 241-250页

作者： Joseph Purita JoséFábio Santos Duarte Lana Morey Kolber Bruno Lima Rodrigues tomas mosaner Gabriel Silva Santos Carolina Caliari-Oliveira Stephany Cares Huber Institute of Regenerative Medicine Boca RatonFL 33432United States Institute of Bone and Cartilage IndaiatubaSP 13334-170Brazil Department of Physical Therapy Nova Southeastern UniversityFort LauderdaleFL 33314United States University of Campinas CampinasSP 13083-970Brazil In Situ Cell Therapy Ribeirao PretoSP 14056-680Brazil

Degenerative musculoskeletal disorders are one of the top causes of pain and disability in the adult *** available alternatives to mitigate symptoms include conservative treatments such as the administration of pharmacological agents and an educative approach towards lifestyle *** use of certain analgesics,such as opiates and corticosteroids,delivers short term results but do not address the etiological source of pain and ***,prolonged use of such medications may cause additional ***,the demand for musculoskeletal tissue regeneration has led to an alternative approach referred to as“orthobiologics”.This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** marrow(BM)aspirate(BMA)and concentrate are well-known orthobiologics used to treat musculoskeletal *** derived from the BM have been discussed in the literature;however,the lack of standardization regarding collection and processing protocols presents a challenge for generalization of study outcomes and determination of *** BM-derived orthobiologics have not yet been classified,to our knowledge,this manuscript proposes the ACH classification system,which speaks to BMA(A),BMA and concentrate(C)and hybrid(H),which combines A and *** classification proposes and describes 8 parameters that are relevant for the quality of biological *** more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** ACH classification envisages a necessary contribution to the comprehension of both clinical procedures and research outcomes,ultimately ushering in a standardization of best practice.

关键词： Bone-marrow classification Bone-marrow aspirate concentrate Regenerativemedicine Stem cells Musculoskeletal disorders Orthobiologics

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Platelet-rich plasma vs bone marrow aspirate concentrate:An overview of mechanisms of action and orthobiologic synergistic effects

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World Journal of Stem Cells 2021年第2期13卷 155-167页

作者： JoséFábio Santos Duarte Lana Lucas Furtado da Fonseca Rafael da Rocha Macedo tomas mosaner William Murrell Ashok Kumar Joseph Purita Marco Antonio Percope de Andrade Department of Orthopedics The Bone and Cartilage InstituteIndaiatuba 13334-170SPBrazil Department of Orthopedics The Federal University of São PauloSão Paulo 04023-062SPBrazil Department of Orthopedics Rede D’Or Unit IFOR HospitalSão Bernardo do Campo 09715-021SPBrazil Department of Orthopaedics Healthpoint UAEAbu Dhabi 00000United Arab Emirates Department of Orthopaedics My Doc Specialist Medical CentreDubai 00000United Arab Emirates Department of Orthopedics Institute of Regenerative MedicineBoca RatonFL 33432United States Department of Orthopaedic Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil

The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past ***,there are multiple alternatives available as suitable treatments;however,the use of autologous blood-derived products such as platelet-rich plasma(PRP),bone marrow aspirate(BMA)and BMA concentrate(BMAC),specifically,is *** many investigations attempted to demonstrate the effectiveness of these therapies,even with positive results,the literature lacks standardized protocols and overall accuracy in study designs,which leads to variance and difficulty in reproducibility of *** efficacy of PRP for the treatment of cartilage,bone and muscle tissues is well *** BMAC has generated optimistic results for the same purposes,its applicability in clinical trials is still relatively recent when compared to *** products demonstrate the potential to set forth reparative processes,each in their own distinct *** combination of these biological products has been previously proposed,yet little is known about their *** indicates that growth factor,cytokine,and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal *** products seem to work well without PRP;however,the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow ***,additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy.

关键词： Orthobiologics Platelet-rich plasma Bone-marrow aspirate Regenerative medicine Musculoskeletal diseases Stem cells

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Biofat grafts as an orthobiologic tool in osteoarthritis:An update and classification proposal

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World Journal of Meta-Analysis 2021年第1期9卷 29-39页

作者： Rafael da Rocha Macedo Lucas Furtado da Fonseca JoséFábio Santos Duarte Lana tomas mosaner Joseph Purita MAP de Andrade Luciano Miller Rodrigues Patricio Centurion Department of Orthopedics Rede D’Or unidade IFOR HospitalSão Bernardo do Campo 09715-021São PauloBrazil Department of Orthopedics Escola Paulista de Medicina da Universidade Federal de São PauloSão Paulo 04024-002Brazil Department of Orthopedics The Bone and Cartilage InstituteIndaiatuba 13334-170São PauloBrazil Department of Orthopedics Institute of Regenerative MedicineBoca RatonFL 33432United States Department of Orthopedics Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Orthopedic Department Faculdade de Medicina do ABCSanto André09060-870São PauloBrazil Aesthetic and Reconstructive Plastic Surgery Ricardo Palma UniversityLima 15023Peru

Among degenerative musculoskeletal disorders,osteoarthritis remains one of the main causes of pain and disability in the adult *** available alternatives to alleviate symptoms include conservative treatments such as physical therapy,anti-inflammatory drugs and an educational approach to lifestyle *** use of certain analgesics,such as opiates and corticosteroids offer short-term results but does not address the etiological source of pain and *** addition,prolonged use of such medications can cause additional ***,the demand for regeneration of joint cartilage has led to an alternative approach called"orthobiologics".This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** derived from adipose tissue have been studied as an excellent source of orthobiologics in an attempt to promote joint cartilage ***,the lack of standardization regarding collection and processing protocols presents a challenge for the generalization of study results and determination of *** the best of our knowledge,orthobiologics derived from fat have not yet been ***,this manuscript proposes the HGS classification system which aims to describe certain parameters that are relevant to the quality of organic products regarding harvesting techniques(H),graft type(G),and number of centrifugations(S).The more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** HGS classification may provide a valuable contribution to the understanding of clinical procedures and research results,aiming to ultimately usher in a standardization of optimal practice.

关键词： Orthobiologics Adipose tissue Mesenchymal stem cells Regenerative medicine Musculoskeletal disorders Orthopedics

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Photobiomodulation therapy for osteoarthritis: Mechanisms of action

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World Journal of Translational Medicine 2022年第3期10卷 29-42页

作者： Fábio Pericinoto Giolo Gabriel Silva Santos Victor Fontes Pacheco Stephany Cares Huber Kaue Franco Malange Bruno Lima Rodrigues Fernanda Bassora tomas mosaner Gabriel Azzini Lucas Leite Ribeiro Carlos Amilcar Parada JoséFábio Santos Duarte Lana Department of Physical Therapy Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Biomedical Science Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Department of Orthopedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Neurobiology of Pain and Regenerative Medicine The University of CampinasCampinas 13083-862Brazil Department of Hematology The University of CampinasCampinas 13083-878Brazil

Photobiomodulation(PBM)is a non-invasive therapeutic modality with demonstrated effects in many fields related to regenerative *** the field of orthopedics,in particular,PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal *** articles cited in this review show that devices operating close to or within the near infrared range at low intensities can provoke responses which favor the shift in the predominant catabolic microenvironment typically seen in degenerative joint diseases,especially osteoarthritis(OA).These responses include proliferation,differentiation and expression of proteins associated with stable cell ***,PBM can also modulate oxidative stress,inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers,without adverse ***,these effects are essential in order to control the progression of OA,which is in part attributed to exacerbated inflammation and degradative enzymatic reactions which gradually contribute to the destruction of joint *** may offer medical experts ease of application,financial viability,efficacy and lack of serious adverse ***,it may prove to be a suitable ally in the management of mild to moderate degrees of *** review explores and discusses the principal biological mechanisms of PBM and how the produced effects may contribute to the amelioration of osteoarthritic *** was reviewed using PubMed and Google Scholar in order to find studies describing the mechanisms of *** investigation included a combination of nomenclature such as:“photobiomodulation”,“phototherapy”,“laser therapy”,“PBM”,“osteoarthritis”,low level light therapy”,“inflammation”and“cartilage”.We considered only articles written in English,with access to the full text.

关键词： Photobiomodulation Low-level laser therapy Osteoarthritis Inflammation Regenerative medicine

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Insights from a proteomic atlas of human Alzheimer's disease brain tissue

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Neural Regeneration Research 2025年第3期20卷 799-800页

作者： tomas Kavanagh Eleanor Drummond Brain and Mind Centre and School of Medical Sciences University of SydneyCamperdownNSWAustralia

There is an urgent need to identify new drug targets for Alzheimer's disease(AD). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease mechanisms driving AD is an essential factor that will facilitate the identification of new, effective drug targets.

关键词： Alzheimer clinical driving

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New regulators of systemic iron homeostasis

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2270-2271页

作者： tomas Ganz Center for Iron Disorders Department of MedicineDavid Geffen School of MedicineUCLALos AngelesCAUSA

In a recent study published in Blood,Jiang et al.1 describe two new mechanisms that may contribute to systemic iron *** first identify the methylcytosine dioxygenase Tetl as an iron-dependent epigenetic regulator of multiple downstream target *** through the target genes,they go on to show that one of them,Rnf217,is a long-sought E3 ubiquitin ligase that regulates the degradation of the unique cellular iron exporter ferroportin in response to its ligand,the master iron-regulatory hormone hepcidin.

关键词： Blood homeostasis sought

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DISCONTINUOUS GALERKIN CALCULATIONS FOR A NONLINEAR PDE MODEL OF DNA TRANSCRIPTION WITH SHORT, TRANSIENT AND FREQUENT PAUSING

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Journal of Computational Mathematics 2014年第6期32卷 601-629页

作者： Lisa Davis tomas Gedeon Department of Mathematical Sciences Montana State University P.O. Box 172400 Bozeman MT 59717

A discontinuous Galerkin finite element method is used to approximate solutions to a classical traffic flow PDE. This PDE is used to model the biological process of transcription; the process of transferring genetic information from DNA either to mRNA or to rRNA. The transcription process is punctuated by short, frequent RNAP pauses which are incorporated into the model as traffic lights. These pauses cause a delay in the average transcription process. The DG solution of the nonlinear model is used to calculate the delay and to determine the effect of the pauses on the average transcription time. Numerical error measurements between the DG solution and the true solution （derived by the method of characteristics） are given for a simple model problem. It shows an excellent agreement in a neighborhood away from the shocks as well as C9（Ax） convergence for the delay calculation. Preliminary parameter studies indicate that in a system with multiple pauses both the location and time duration of the pauses can significantly affect the average delay experienced by an RNAP.

关键词： Discontinuous Galerkin finite element method Transcription LWR traffic flowmodel.

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Fast Modification of Microdischarge Emission Bands by Fracture of Sugar

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Chinese Physics Letters 2011年第8期28卷 304-306页

作者： Sergej Aman Juergen tomas AStreletskii Otto-von-Guericke University MagdeburgP.O.Box 412039106 MagdeburgGermany Institute of Chemical Physics RASKosygina 4Moscow 119991Russia

Intensive light pulses with widths of about 10 ns were observed during the crack propagation by cleavage of crystalline sugar at atmospheric *** observed light pulses were caused by a sequence of gas microdischarges(MDs).The pulses were detected in the UV/VIS and NIR wavelength *** the light pulses appear in the UV/VIS wavelength range,and then after a delay of about 0.4–1.2 ns in the NIR wavelength *** characteristic feature of MDs can be used for the characterization of crack propagation.

关键词： delay sugar Fast

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Neutral stochastic delay partial functional integro-differential equations driven by a fractional Brownian motion

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Frontiers of Mathematics in China 2013年第4期8卷 745-760页

作者： tomas CARABALLO Mamadou Abdoul DIOP Dpto. Ecuaciones Diferenciales y Analisis Numerico Universidad de Sevilla Apdo. de Correos 1160 41080-Sevilla Spain Universite Gaston Berger de Saint-Louis UFR SAT Departement de Mathematiques 234 Saint-Louis Senegal

This paper deals with the existence and uniqueness of mild solutions to neutral stochastic delay functional integro-differential equations perturbed by a fractional Brownian motion BH, with Hurst parameter H E （1/2, 1）. We use the theory of resolvent operators developed by R. Grimmer to show the existence of mild solutions. An example is provided to illustrate the results of this work.

关键词： Resolvent operator C0-semigroup Wiener process mild solution fractional Brownian motion

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My Journey to DNA Repair

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Genomics, Proteomics & Bioinformatics 2013年第1期11卷 2-7页

作者： tomas Lindahl Cancer Research UK London Research Institute Clare Hall Laboratories

I completed my medical studies at the Karolinska Institute in Stockholm but have always been devoted to basic research. My longstanding interest is to understand fundamental DNA repair mechanisms in the fields of cancer therapy, inherited human genetic disorders and ancient DNA. I initially measured DNA decay, including rates of base loss and cytosine deamination. I have dis- covered several important DNA repair proteins and determined their mechanisms of action. The discovery of uracil-DNA glycosylase defined a new category of repair enzymes with each specialized for different types of DNA damage. The base excision repair pathway was first reconstituted with human proteins in my group. Cell-free analysis for mammalian nucleotide excision repair of DNA was also developed in my laboratory. I found multiple distinct DNA ligases in mammalian cells, and led the first genetic and biochemical work on DNA ligases I, III and IV. I discovered the mam- malian exonucleases DNase III （TREX1） and IV （FEN1）. Interestingly, expression of TREXI was altered in some human autoimmune diseases. I also showed that the mutagenic DNA adduct O6-methylguanine （O6mG） is repaired without removing the guanine from DNA, identifying a sur- prising mechanism by which the methyl group is transferred to a residue in the repair protein itself. A further novel process of DNA repair discovered by my research group is the action of AlkB as an iron-dependent enzyme carrying out oxidative demethylation.

关键词： DNA repair Base excision repair DNA glycosylase DNA exonuclease AlkB dioxygenase

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