New regulators of systemic iron homeostasis

作     者：Tomas Ganz Tomas Ganz

作者机构：Center for Iron DisordersDepartment of MedicineDavid Geffen School of MedicineUCLALos AngelesCAUSA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第8期

页      面：2270-2271页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：Blood homeostasis sought 

摘      要：In a recent study published in Blood,Jiang et al.1 describe two new mechanisms that may contribute to systemic iron *** first identify the methylcytosine dioxygenase Tetl as an iron-dependent epigenetic regulator of multiple downstream target *** through the target genes,they go on to show that one of them,Rnf217,is a long-sought E3 ubiquitin ligase that regulates the degradation of the unique cellular iron exporter ferroportin in response to its ligand,the master iron-regulatory hormone hepcidin.