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Intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma:A case report

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World Journal of Clinical Cases 2022年第22期10卷 8045-8053页

作者： Hana Zavrtanik Boštjan Luzar Aleštoma.ič Department of Abdominal Surgery University Medical Centre LjubljanaLjubljana 1000Slovenia Institute of Pathology Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Faculty of Medicine University of LjubljanaLjubljana 1000Slovenia

BACKGROUND The ampulla of Vater is an anatomically and histologically complex region giving rise to a heterogenous group of *** is,to the best of our knowledge,the first case of intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma reported in the *** SUMMARY A 61-year-old woman presented to the emergency department for evaluation of painless ***-enhanced computed tomography(CT)of the abdomen and chest showed a periampullary tumor mass measuring 15 mm×12 mm×14 mm,with no evidence of locoregional and distant metastases,for which she underwent *** examination of a resected specimen revealed an intra-ampullary papillary tubular neoplasm with highgrade dysplasia in combination with poorly differentiated grade 3 neuroendocrine carcinoma with a mitotic count of more than 20 mitoses per 10 high power fields and Ki-67 index of 100%.No positive lymph nodes were *** postoperative course was ***,she remained under close *** liver metastases were observed on follow-up CT 8 mo after the surgery,so systemic therapy with cisplatin and etoposide was *** The simultaneous occurrence of neuroendocrine and non-neuroendocrine tumors in the ampulla of Vater is rare and the pathogenesis of such tumors is largely *** to unpredictable clinical behavior and lack of solid evidence on optimal treatment strategy,close patient surveillance is advised after radical resection of the primary tumor.

关键词： Ampulla of Vater Neuroendocrine carcinoma Mixed tumour Pancreaticoduodenectomy Prognosis Case report

Triassic actinopterygian fishes:the recovery after the end-Permian crisis

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Integrative Zoology 2014年第4期9卷 394-411页

作者： Andrea TINTORI toma.HITIJ Dayong JIANG Cristina LOMBARDO Zuoyu SUN Department of Earth Sciences‘A.Desio’ Universitàdegli Studi di MilanoMilanoItaly Dental School Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia Department of Geology and Geological Museum Beijing UniversityBeijingChina

In the last 15 years,the discovery of several new actinopterygian fish faunas from the Early and Middle Triassic of the Tethys,cast new light on the timing,speed and range of their recovery after the end-Permian *** addition to several new taxa having been described,the stratigraphical and geographical record of many others have been greatly *** fact,most of the new fossiliferous sites are in southern China,thus at the Eastern end of the Tethys,and furthermore a few are somewhat older(Chaohu,Panxian,Luoping)than the major classical Western Tethys sites(Monte San Giorgio).Following these new finds,it is possible to have a better definition of the Triassic recovery ***,after a quite short phase till the end of the Smithian(Olenekian,Early Triassic)in which a rather consistent fauna was present all around the Pangea coasts,a major radiation occurred in the Early-Middle Anisian after the new Middle Triassic fish fauna already appeared in the late Early Triassic,thus occuring well before what was previously supposed from the Alps ***,the new assemblages from southern China point to an early broader differentiation among the basal neopterygians rather than in the‘subholosteans’,the group that was then dominant in the Western Tethys since the Late Ani*** stands that during the Norian a new basal neopterygian radiation gave rise to several new branches that dominated the remaining part of the Mesozoic.

关键词： Actinopterygians biodiversity predation stratigraphy Triassic recovery

Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression

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World Journal of Gastroenterology 2009年第48期15卷 6023-6027页

作者： Marko Duvnjak Neven Bari Vedran toma.i Ivan Leroti Division of Gastroenterology and Hepatology Department of Medicine"Sestre milosrdnice" University Hospital

The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and *** the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease *** of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease *** there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD.

关键词： Genetics Liver fibrosis Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Single nucleotide polymorphisms

MADE IN CHINA How the Fidget's Cash and Crash Belies China's Manufacturing Woes

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城市漫步（上海版、英文） 2017年第8期 10-11页

作者： sky Thomas Gidge 不详

If Shenzhen's Huaqiang North Electronics Market had an official noise,it would be the scream of packing tape coming off the *** tape is wrapped around boxes of electronics before they are shipped across the *** things have been quieter recently,with the rise of e-commerce and an influx of retail outlets lining a new pedestrian street in the market.

关键词： packing outlet official

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect

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Science China(Life Sciences) 2016年第8期59卷 802-810页

作者： Oleksandra Tiapko Bernadett Bacsa Gema Guedes de la Cruz toma.Glasnov Klaus Groschner Institute of Biophysics Medical University of GrazBio Tech Med-GrazHarrachgasse 21Graz 8010Austria Institute of Chemistry University of GrazNAWI GrazBio Tech Med-GrazHeinrichstrasse 28Graz 8010Austria

Photouncaging of second messengers has been successfully employed to gain mechanistic insight of cellular signaling path- ways. One of the most enigmatic processes of ion channel regulation is lipid recognition and lipid-gating of TRPC channels, which represents pivotal mechanisms of cellular Ca2＋ homeostasis. Recently, optopharmacological tools including caged lipid mediators became available, enabling an unprecedented level of temporal and spatial control of the activating lipid species within a cellular environment. Here we tested a commonly used caged ligand approach for suitability to investigate TRPC sig- naling at the level of membrane conductance and cellular Ca2＋ handling. We report a specific photouncaging artifact that is triggered by the cage structure coumarin at UV illumination. Electrophysiological characterization identified a light-dependent membrane effect of coumarin. UV light （340 nm） as used for photouncaging, initiated a membrane conductance specifically in the presence of coumarin as low as 30 pmol L-1 concentrations. This conductance masked the TRPC3 conductance evoked by photouncaging, while TRPC-mediated cellular Ca2＋ responses were largely preserved. The observed light-induced membrane effects of the released caging moiety may well interfere with certain cellular functions, and prompt caution in using couma- fin-caged second messengers in cellular studies.

关键词： caged diacylglycerols TRPC channels Ca2+ signaling optopharmacology

CONVENIENCE STORE COCKTAILS

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城市漫步（GBA版） 2017年第11期 60-61页

作者： sky Thomas Gidge 不详

Chinese convenience store booze is a story of extremes:on the mellow end you have the watery slosh of shelf-stuffing lagers,filling out the middle ground is jingjiu,its medicinal undertones an acquired taste and,finally,comes the caustic zip of *** swear off the Middle Kingdoms alcohol afterthe first sip,but this article will change that.

关键词： stuff finally store

MADE IN CHINA:THE FIDGET FAD'S CASH

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城市漫步（GBA版） 2017年第8期 12-15页

作者： sky Thomas Gidge 不详

SHENZHEN-If theHuaqiang Electronics Market had an official noise,it would be the scream of packing tape coming off the *** tape is wrapped around boxes of electronics before they are shipped across the *** things have been quieter recently,with the rise of e-commerce and an influx of retail outlets lining a new pedestrian street in the market.

关键词： packing outlet CASH

DAMA DRAMA Why Do People Hate China's Dancing Grandmas?

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城市漫步（GBA版） 2016年第12期 12-14页

作者： sky Thomas Gidge 不详

Few have less reason to dance than the older women who flood Chinas parks,pavilions and parking lots daily,occupying public spaces with shimmying bodies and ear-ringing music.

关键词： Grand spaces flood

THE ULTIMATE ESCAPE Is Virtual Reality Finally Ready to Get Real?

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城市漫步（GBA版） 2017年第2期 18-19页

作者： sky Thomas Gidge 不详

Virtual reality’s introduction to the world was an amazing *** Sensorama used a 3-D film to simulate a motorcycle ride through Brooklyn,complete with blowing wind and a seat that rumbled with the motion of a mock *** year was *** for arcade-like use,it was an impressive invention,but producing the Sensorama was deemed too expensive and complicated to be commercially viable.

关键词： viable invention producing