Intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma:A case report
作者机构：Department of Abdominal SurgeryUniversity Medical Centre LjubljanaLjubljana 1000Slovenia Institute of PathologyFaculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第22期
页 面：8045-8053页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Ampulla of Vater Neuroendocrine carcinoma Mixed tumour Pancreaticoduodenectomy Prognosis Case report
摘 要：BACKGROUND The ampulla of Vater is an anatomically and histologically complex region giving rise to a heterogenous group of *** is,to the best of our knowledge,the first case of intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma reported in the *** SUMMARY A 61-year-old woman presented to the emergency department for evaluation of painless ***-enhanced computed tomography(CT)of the abdomen and chest showed a periampullary tumor mass measuring 15 mm×12 mm×14 mm,with no evidence of locoregional and distant metastases,for which she underwent *** examination of a resected specimen revealed an intra-ampullary papillary tubular neoplasm with highgrade dysplasia in combination with poorly differentiated grade 3 neuroendocrine carcinoma with a mitotic count of more than 20 mitoses per 10 high power fields and Ki-67 index of 100%.No positive lymph nodes were *** postoperative course was ***,she remained under close *** liver metastases were observed on follow-up CT 8 mo after the surgery,so systemic therapy with cisplatin and etoposide was *** The simultaneous occurrence of neuroendocrine and non-neuroendocrine tumors in the ampulla of Vater is rare and the pathogenesis of such tumors is largely *** to unpredictable clinical behavior and lack of solid evidence on optimal treatment strategy,close patient surveillance is advised after radical resection of the primary tumor.
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