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Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps

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World Journal of Gastroenterology 2012年第39期18卷 5560-5569页

作者： barbara André tom Vercauteren Anna M buchner Murli Krishna Nicholas Ayache Michael b Wallace Image Computing Group Mauna Kea Technologies75010 ParisFrance Asclepios Research Team The National Institute for Research in Computer Science and Control Sophia Antipolis06902 Sophia AntipolisFrance Division of Gastroenterology Hospital of theUniversity of PennsylvaniaPhiladelphiaPA 19104United States Laboratory Medicine and Pathology Mayo Clinic Hospital in JacksonvilleJacksonvilleFL 3224United States Department of Gastroenterology and Hepatology Mayo Clinic Hospital in JacksonvilleJacksonvilleFL 3224United States

AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (bserved differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed i

关键词： Colorectal neoplasia Computer-aided diag-nosis Content-based image retrieval Nearest neigh-bor classification software Probe-based confocal laserendomicroscopy

A Proposal for the Automatic Computation of Envelopes of Families of Plane Curves

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Journal of Systems Science & Complexity 2019年第1期32卷 150-157页

作者： bOTANA Francisco RECIO tomás Depto. de Matemática Aplicada I Universidad de Vigo Campus A Xunqueira Depto. de Matemáticas Estad'?stica y Computación Universidad de Cantabria

The idea of envelope of a family of plane curves is an elementary notion in differential geometry. As such, its implementation in dynamic geometry environments is quite universal(Cabri,The Geometer's Sketchpad, Cinderella, Geo Gebra,...). Nevertheless, most of these programs return,when computing certain envelopes, both some spurious solutions and the curves that truly ?t in the intuitive de?nition of envelope. The precise distinction between spurious and genuine parts has not been made before: This paper proposes such distinction in an algorithmic way, ready for its implementation in interactive geometry systems, allowing a ?ner classi?cation of the different parts resulting from the current, advanced approach to envelope computation and, thus, yielding a more precise output, free from extraneous components.

关键词： Automated deduction in geometry dynamic geometry envelopes parametric polynomial systems symbolic computation

MP-PIC simulation of circulating fluidized beds using an EMMS based drag model for Geldart b particles

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Particuology 2021年第6期19卷 76-90页

作者： Timo Dymala tom Wytrwat Stefan Heinrich Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestr.1521073 HamburgGermany

In this study the multiphase particle-in-cell(MP-PIC)method is used for the simulation of two pilot-scale circulating fluidized beds(CFbs)with quartz sand belonging to Geldart’s group b as bed *** simulations were performed using a homogeneous drag model as well as a structure dependent drag model based on the energy minimization multi-scale method(EMMS).The results are compared with experimental data from literature as well as *** simulations with the EMMS based drag model show a good agreement of the time-averaged axial solids concentration,circulation rate and riser pressure ***,a lower grid sensitivity is observed compared to the homogeneous drag *** contrast to the conventional drag model a dense bottom zone is predicted by the EMMS based drag *** overprediction of the solid concentration in the dense bottom zone is presumably due to an overprediction of the cluster diameter that is calculated using an empirical cluster diameter *** shows the necessity for a new meso-scale cluster correlation for the simulation of Geldart b ***,the results of the time-averaged radial solids concentration differ from the expectations of a core-annulus flow indicating that a mesh refinement at the walls is ***,the importance of using a realistic particle size distribution is identified.

关键词： 3D-CFD simulation Circulating fluidized bed(CFb) Multiphase particle-in-cell method(MP-PIC) Energy minimizing multi-scale theory(EMMS) Validation study

Multispecies coalescent and its applications to infer species phylogenies and cross-species gene flow

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National Science Review 2021年第12期8卷 86-103页

作者： Xiyun Jiao tomá■ Flouri Ziheng Yang Department of Genetics Evolution and EnvironmentUniversity College London Department of Statistics and Data Science Southern University of Science and Technology

Multispecies coalescent(MSC) is the extension of the single-population coalescent model to multiple species. It integrates the phylogenetic process of species divergences and the population genetic process of coalescent, and provides a powerful framework for a number of inference problems using genomic sequence data from multiple species, including estimation of species divergence times and population sizes,estimation of species trees accommodating discordant gene trees, inference of cross-species gene flow and species delimitation. In this review, we introduce the major features of the MSC model, discuss full-likelihood and heuristic methods of species tree estimation and summarize recent methodological advances in inference of cross-species gene flow. We discuss the statistical and computational challenges in the field and research directions where breakthroughs may be likely in the next few years.

关键词： anomaly zone bPP deep coalescence gene flow Markov chain Monte Carlo multispecies coalescent species tree

Hydrogen energy carriers

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Journal of Energy Chemistry 2023年第2期77卷 119-121,I0004页

作者： tom Autrey Ping Chen Pacific Northwest National Laboratories Physical and Computational Science DirectorateRichlandWA99352USA Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina

The versatility of hydrogen will provide opportunities in large scale,long duration energy storage,and the decarbonization of *** energy carriers are molecules and materials that store hydrogen at higher volumetric de... 详细信息

关键词： hydrogen energy Hydrogen

The molecular profile of nerve repair: humans mirror rodents

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Neural Regeneration Research 2021年第7期16卷 1440-1441页

作者： Matthew b.Wilcox Kristjan R.Jessen tom J.Quick James b.Phillips Peripheral Nerve Injury Research Unit Royal National Orthopaedic HospitalStanmoreUK Department of Pharmacology UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK UCL Centre for Nerve Engineering University College LondonLondonUK Department of Cell and Developmental biology University College LondonLondonUK

Peripheral nerve injuries(PNI)are common following blunt or penetrating trauma and can lead to disability and chronic pain in affected individuals,with limited options available to promote regeneration and functional *** animal models,it is known that the regenerative capacity of the peripheral nervous system(PNS)is heavily dependent upon the remarkable ability of Schwann cells to undergo a phenotypic shift from a supportive/myelinating/maintaining phenotype to one that encourages neural regeneration.

关键词： injuries mirror neural

Comments on"Vitamin Pharmacogenomics:New Insight into Individual Differences in Diseases and Drug Responses"

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Genomics, Proteomics & bioinformatics 2017年第6期15卷 405-406页

作者： tom Greenfield International College of Generative Medicine CanterburyKent CTI 1BLUnited Kingdom

Dear Editor, I would like to offer some comments on the excellent article by Hai-Yan He and colleagues published in Genomics, Proteomics ＆ bioinformatics on 1st April 2017 [1]. The authors include, in the list of genetic polymorphisms that have an effect on vita- mins, the low concentrations of cellular and plasma vitamin b12 in GG carriers of SNP rs602662 （772 G 〉 A） in the gene encoding fucosyltransferase 2 （FUT2）.

关键词： Comments on "Vitamin Pharmacogenomics New Insight into Individual Differences Diseases and Drug Responses"

Enhancing the efectiveness of film cooling

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航空动力学报 2007年第4期22卷 531-539页

作者： tom I-P Shih Sangkwon Na Department of Aerospace Engineering Iowa State University Ames Iowa 50011 U. S. A

Advanced gas turbine stages are designed to operate at increasingly higher inlet temperatures to increase thermal efficiency and specific power *** maintain durability and reasonable life,film cooling is needed in addition to internal cooling,especially for the first *** cooling lowers material temperature by forced convection inside film-cooling holes and by forming a layer of coolant about component surfaces to insulate them from the hot ***,each cooling jet forms a pair of counter-rotating vortices that entrains hot gas and causes the film-cooling jet to lift off from the surface that it is intended to *** paper gives an overview of efforts to enhance the effectiveness of *** paper also describes two new design *** design concept seeks to minimize the entrainment of hot gases underneath of film-cooling jets by using flow-aligned *** other design concept shifts the interaction between the approaching hot gas and the cooling jet to occur further above the surface by using an upstream *** both design concepts,computational fluid dynamics results are presented to examine their usefulness in enhancing film-cooling effectivenes

关键词：航空动力推进系统薄雾冷却冷却效率燃气轮机流体动力学

Low-intensity pulsed ultrasound for regenerating peripheral nerves:potential for penile nerve

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Asian Journal of Andrology 2020年第4期22卷 335-341页

作者： Dong-Yi Peng Amanda b Reed-Maldonado Gui-Ting Lin Shu-Jie Xia tom F Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCA 94143U SA departm ent of Urology The Third Xiangya Hospital of Central South UniversityChangsha 410013China departm ent of Urology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200240China.

Peripheral nerve damage,such as that found after surgery or trauma,is a substantial clinical *** research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after *** recent years,low-intensity pulsed ultrasound(LIPUS)has been studied as a potential method of stimulating peripheral nerve *** this review,the physiology of peripheral nerve regeneration is reviewed,and the experiments employing LIPUS to improve peripheral nerve regeneration are *** of LIPUS following nerve surgery may promote nerve regeneration and improve functional outcomes through a variety of proposed *** include an increase of neurotrophic factors,Schwann cell(SC)activation,cellular signaling activations,and induction of *** searched PubMed for articles related to these topics in both in vitro and in vivo animal research *** found numerous studies,suggesting that LIPUS following nerve surgery promotes nerve regeneration and improves functional *** on these findings,LIPUS could be a novel and valuable treatment for nerve injury-induced erectile dysfunction.

关键词： activation cellular signaling low-intensity pulsed ultrasound neurotrophic factors peripheral nerve regeneration Schwann cells