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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang tom yuan Yaozuo yuan Mei Zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

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长白山地区蜜环菌属真菌资源

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菌物研究 2024年第2期22卷 149-157页

作者：朱艳杨非一吕孟洁袁雪艳 HSIANG tom 刘淑艳吉林农业大学植物保护学院长春130118 吉林农业大学菌物学院长春130118 食药用菌教育部工程研究中心长春130118 圭尔夫大学环境科学学院圭尔夫市3227

蜜环菌属Armillaria真菌是长白山地区代表性野生菌,具有重要的食药用价值。本研究采用样方调查和随机踏查相结合的方法对该地区蜜环菌属物种展开资源调查和种类鉴定,结果表明,长白山地区蜜环菌有5种,即北方蜜环菌Armillaira borealis、... 详细信息

蜜环菌属Armillaria真菌是长白山地区代表性野生菌,具有重要的食药用价值。本研究采用样方调查和随机踏查相结合的方法对该地区蜜环菌属物种展开资源调查和种类鉴定,结果表明,长白山地区蜜环菌有5种,即北方蜜环菌Armillaira borealis、法国蜜环菌***、黄小蜜环菌***、芥黄蜜环菌***以及Armillaira sp.,其中北方蜜环菌为吉林省新记录种,法国蜜环菌为该地区的优势物种。多样性分析结果表明,在阔叶林、针阔混交林、针叶林3种林型中,针阔混交林中蜜环菌属α多样性指数相对较高,说明针阔混交林的物种丰富度最高。本研究为蜜环菌属资源的开发和利用提供理论基础和实践依据。

关键词：蜜环菌属物种多样性长白山

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Effects of Extreme Air Temperature and Humidity on the Insecticidal Expression Level of Bt Cotton

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Journal of Integrative Agriculture 2012年第11期11卷 1836-1844页

作者： CHENyuan WEN Yu-jin CHEN yuan John tom Cothren ZHANG Xiang WANG Yong-hui WilliamA Payne CHEN De-hua Ecology and Cultivation in Middle and Lower Reaches of Yangtse River Ministry of Agriculture/Agricultural College Yangzhou University Yangzhou 225009 P.R.China Department of Soil and Crop Sciences Texas A&M University College Station TX77843 USA Key Laboratory of Crops Genetics and Physiology Jiangsu Province/Agricultural College Yangzhou University Yangzhou 225009 P.R. China Norman Borlaug Institute for International Agriculture Texas A&M University College Station TX77843 USA

The higher survival rates of Helicoverpa amigera larvae were usually observed after adverse climate which was related to extreme temperature （T） and relative humidity （RH） stresses in transgenic Bacillus thuringiensis （Bt） cotton. The unstable resistance of Bt cotton to bollworms has been correlated with the reduced expression of CrylAc δ-endotoxin. The objective of this study was to investigate the effects of combined temperature and relative humidity stresses on the leaf CrylAc insecticidal protein expression during critical developmental stages. The study was undertaken on two transgenic cotton cultivars that share same parental background, Sikang 1 （a conventional cultivar） and Sikang 3 （a hybrid cultivar）, during the 2007 and 2008 growing seasons at the Yangzhou University Farm, Yangzhou, China. The study was arranged with two factors that consisted of temperature （two levels） and relative humidity （three levels）. The six T/RH treatments were 37℃/95%, 37℃/70%, 37℃/50%, 18℃/95%, 18℃/70%, and 18℃/50%. In 2007, the six treatments were imposed to the plants at peak flowering stage for 24 h; in 2008, the six treatments were applied to the plants at peak square, peak flowering, and peak boll stages for 48 h. The results of the study indicated that the leaf insecticidal protein expression in CrylAc was significantly affected by extreme temperature only at peak flowering stage, and by both extreme temperature and relative humidity during boll filling stage. The greatest reductions were observed when the stresses were applied at peak boll stage. In 2008, after 48 h stress treatment, the leaf Bt endotoxin expression reduced by 25.9-36.7 and 23.6-40.5% at peak boll stage, but only by 14.9-26.5 and 12.8-24.0% at peak flowering stage for Sikang 1 and Sikang 3, respectively. The greatest reduction was found under the low temperature combined with low relative humidity condition for both years. It is believed that the temperature and relative humidity stresses may be attribut

关键词： Bt cotton high temperature low temperature relative humidity CryIAc protein

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Histological evaluation in ulcerative colitis

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Gastroenterology Report 2014年第3期2卷 178-192页

作者： tom C.DeRoche Shu-yuan Xiao Xiuli Liu Department of Pathology Wake Forest Baptist Medical CenterWinston-SalemNorth CarolinaUSA Department of Pathology University of ChicagoChicagoIllinoisUSA Department of Anatomic Pathology Cleveland ClinicClevelandOhioUSA

This review summarizes diagnostic problems,challenges and advances in ulcerative colitis(UC).It emphasizes that,although histopathological examination plays a major role in the diagnosis and management of UC,it should always be interpreted in the context of clinical,endoscopic,and radiological *** diagnosis requires knowledge of the classic morphological features of UC,as well as a number of atypical pathological presentations that may cause mis-classification of the disease process,either in resection or biopsy *** atypical pathological presentations include rectal sparing and patchiness of disease at initial presentation of UC in pediatric patients or in the setting of medically treated UC,cecal or ascending colon inflammation in left-sided UC,and backwash ileitis in patients with severe ulcerative *** formed microgranulomas,with pale foamy histiocytes adjacent to a damaged crypt or eroded surface,should not be interpreted as evidence of Crohn’s *** colitis should only be used in colectomy specimens as a provisional pathological *** with UC are at risk for the development of dysplasia and carcinoma;optimal outcomes in UC surveillance programs require familiarity with the diagnostic criteria and challenges relating to UC-associated dysplasia and *** biopsy from UC patients should always be evaluated for dysplasia based on cytological and architectural *** interpretation and classification of dysplasia in colon biopsy from UC patients as sporadic adenoma or UC-related dysplasia[flat,adenoma-like,or dysplasia-associated lesion or mass(DALM)]requires clinical and endoscopic *** polypoid dysplastic lesions are considered to be sporadic adenoma if occurring outside areas of histologically proven colitis,or adenoma-like dysplasia if occurring in the diseased *** data suggest that such lesions may be treated adequately by polypectomy in the

关键词： ulcerative colitis histological evaluation dysplasia differential diagnosis

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Applying Neural Network in Classifying Parkinson’s Disease

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Journal of Computer and Communications 2020年第10期8卷 19-23页

作者： yuan-Liang (tom) Liao Fenglinlvzhou F01-10D Beijing China

This project uses knowledge of neural network to analyze if the person under study is analyzed to be Parkinson disease patient or not. Binary classification is constructed based on the multi-feature database. A decision boundary is clearly plotted to separate patient with and without Parkinson disease. Results show that over 80% accuracy could be obtained with the preliminary results. Future efforts could be performed to construct more complicated neural network to improve the accuracy.

关键词： Machine Learning Linear Algebra Error Analysis Neural Network

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Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

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Synthetic and Systems Biotechnology 2021年第4期6卷 446-451页

作者： Wanying Lu Guoliang Zhu Weize yuan Zhaoxi Han Huanqin Dai Mostafa Basiony Lixin Zhang Xueting Liu tom Hsiang Jingyu Zhang State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China The State Key Laboratory of Mycology(SKLM) Institute of MicrobiologyChinese Academy of SciencesBeijing100101China School of Environmental Sciences University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada

Phytopathogenic fungi have attracted great attention as a promising source for new drug *** the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library,a pathogenic fungus,Fusarium proliferatum strain 13294(FP13294),was selected for chemical *** novel aliphatic unsaturated alcohols named fusariumnols A and B(1 and 2),together with one previously characterized sesquiterpenoid lignoren(3)were *** of 1-3 were assigned by mass spectrometry and NMR *** bioactivities were assessed against Staphylococcus epidermidis,***,and Methicillin-resistant ***(MRSA).Compounds 1 and 2 exhibited weak antibacterial activity against ***(MIC=100μM).

关键词： Pathogenic fungus Aliphatic unsaturated alcohols Antibacterial Natural products

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人参皂苷Re通过Nrf2/HO-1/PGC-1α通路调控线粒体生物发生减轻H9c2心肌细胞缺氧/复氧损伤的研究

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中国中药杂志 2024年第4期49卷 1064-1072页

作者：辛高杰陈原原刘子馨胥淑娟张会雨郭帆彭涵李磊韩笑刘建勋付建华中国中医科学院西苑医院基础医学研究所北京100091 国家中医心血管病临床医学研究中心北京100091

该文探讨了人参皂苷Re通过核因子E2相关因子2(nuclear factor-erythroid 2-related factor 2,Nrf2)/血红素氧合酶-1(heme oxidase-1,HO-1)/过氧化物增殖体激活受体γ共激活因子-1α(PGC-1α)调控线粒体生物发生减轻H9c2细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的机制。将H9c2细胞缺氧培养4 h再复氧培养2 h构建心肌细胞H/R损伤模型。Re预给药干预后,首先检测细胞活性、超氧化物歧化酶(superoxide dismutase,SOD)活性、丙二醛(malondialdehyde,MDA)含量、细胞内活性氧(Cyto-ROS)和线粒体内活性氧(Mito-ROS)水平,评估Re通过抗氧化应激对H9c2细胞H/R损伤的保护作用。其次通过荧光探针检测线粒体膜电位(mitochondrial membrane potential,ΔΨ_(m))、线粒体膜通透性开放孔(membrane permeability open pore,mPTP)变化情况,通过免疫荧光检测tom20表达水平,研究Re对线粒体的保护作用。进一步用免疫印迹检测caspase-3、cleaved caspase-3、Cyto C、Nrf2、HO-1、PGC-1α蛋白表达水平,探讨Re抗氧化应激保护线粒体减轻H/R损伤的具体机制。结果显示,与模型组相比,Re有效减轻H9c2细胞H/R损伤氧化应激反应,Re可显著升高细胞中SOD活性,降低MDA含量,降低Cyto-ROS和Mito-ROS水平;Re对线粒体有较好保护作用,升高ΔΨ_(m),降低mPTP开放,升高tom20表达;进一步研究表明Re促进Nrf2、HO-1、PGC-1α蛋白表达,降低凋亡相关调节因子caspase-3向cleaved caspase-3活化、Cyto C蛋白表达。综上所述,人参皂苷Re减轻H9c2细胞H/R损伤的具体机制与通过Nrf2/HO-1/PGC-1α通路促进线粒体生物发生,进而升高线粒体数量、改善线粒体功能,增强细胞抗氧化应激能力,减轻细胞凋亡有关。

关键词：人参皂苷Re 线粒体生物发生 Nrf2/HO-1/PGC-1α 缺氧/复氧损伤氧化应激

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TIME-OPTIMAL INTERPOLATION FOR CNC MACHINING ALONG CURVED TOOL PATHES WITH CONFINED CHORD ERROR

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Journal of Systems Science & Complexity 2013年第5期26卷 836-870页

作者： yuan Chunming ZHANG Ke FAN Wei Key Laboratory of Mathematics Mechanization Institute of Systems ScienceChinese Academy of Sciences

In this paper, two new interpolation algorithms lot CNC machining along curve^l tom pathes are proposed： a time-optimal interpolation algorithm under chord error, feedrate, and tangential acceleration bounds, and a greedy interpolation algorithm under the chord error and tangential jerk bounds. The key idea is to reduce the chord error bound to a centripetal acceleration bound which leads to a velocity limit curve, called the chord error velocity limit curve. Then, the velocity planning is to find the proper velocity curve governed by the acceleration or jerk bounds ＇~under＂ the chord error velocity limit curve. For two types of simple tool pathes, explicit formulas for the velocity curve are given and the methods are implemented in commercial CNC controllers.

关键词： Chord error CNC interpolation cubic PH curve jerk quadratic B-spline time-optimalvelocity planning velocity limit curve.

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Deformation of the Zhangjiazhuang high-speed railway tunnel: an analysis of causal mechanisms using geomorphological surveys and D-InSAR monitoring

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Journal of Mountain Science 2021年第7期18卷 1920-1936页

作者： MENG Xing-min QI Tian-jun ZHAO Yan DIJKSTRA tom SHI Wei LUO Yin-fei WU yuan-zhao SU Xiao-jun ZHAO Fu-meng MA Jin-hui ZHANG Yi CHEN Guan YUE Dong-xia ZHANG Mao-sheng School of Earth Sciences Lanzhou UniversityLanzhou 730000China College of Earth and Environmental Sciences MOE Key Laboratory of Western China's Environmental SystemsLanzhou UniversityLanzhou 730000China Gansu Tech Innovation Centre for Environmental Geology and Geohazard Prevention Lanzhou 730000China School of Architecture Building and Civil EngineeringLoughborough UniversityLoughboroughLE113TUUK Key Laboratory of Qinghai Environmental Geological Survey Xining 810007China Xi’an Centre of China Geological Survey Xi’an 710054China

On 18 January 2016,the Zhangjiazhuang high-speed railway tunnel in Ledu,Qinghai Province,China,underwent serious deformation and structural damage.A crack formed at the top of the tunnel and the concrete on the crown peeled *** a result,the tunnel could not be operated for three *** order to determine the types and spatial distribution of the landslides in the region and the surface deformation characteristics associated with the tunnel deformation,we used field geological and geomorphological surveys,unmanned aerial vehicle image interpretation and differential interferometric synthetic aperture radar(D-In SAR) surface deformation *** ancient and old landslides were identified and analysed in the study *** deformation monitoring and investigation of buildings in several villages on the slope front showed that the tunnel deformation was not related to deep-seated gravitational slope ***,surface deformation monitoring revealed an active NEE–SWW fault in the area intersecting the tunnel at the location of the tunnel *** constitutes a plausible mechanism for the deformation of the *** study highlights the need for detailed engineering geomorphological investigations to better predict the occurrence of tunnel deformation events in the future.

关键词： Gaojiawan Landslide group Zhangjiazhuang tunnel Deformation Fault activity Irrigation infiltration

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红蓝光补光对设施番茄生长发育及荧光特性的影响

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中国农业气象 2024年第5期45卷 506-516页

作者：罗媛叶林郭文忠张馨刘艺涵陈晓丽北京市农林科学院智能装备技术研究中心北京100097 宁夏大学葡萄酒与园艺学院银川750021 农业农村部都市农业(北方)重点实验室北京100097

在全人工光型植物工厂中以番茄品种′Microtom′为试材,采用供光模式可调的LED灯为光源,以LED纯白光为对照,分别采取纯红光、纯蓝光、红蓝混合光、红蓝交替光的不同供光模式的红、蓝光作为补充光,探究不同补光模式对设施番茄生长发育及... 详细信息

在全人工光型植物工厂中以番茄品种′Microtom′为试材,采用供光模式可调的LED灯为光源,以LED纯白光为对照,分别采取纯红光、纯蓝光、红蓝混合光、红蓝交替光的不同供光模式的红、蓝光作为补充光,探究不同补光模式对设施番茄生长发育及荧光特性的影响。结果表明:(1)所有处理下番茄植株生长指标和果实重量均有一定程度提高,补光对叶绿素荧光的动态变化影响显著,纯红光补光对番茄植株的株高、茎粗、叶面积和产量的增加影响最大,红蓝光1h或6h间隔交替补光显著促进了叶绿素含量的增加和PSII光合性能的提高。(2)在番茄营养生长期,纯红光补光处理下番茄株高的相对生长率和绝对生长率分别较对照增加106.8%和60%,茎粗相对生长率和绝对生长率分别较对照增加50%和80%。播种后44d,纯红光补光处理下番茄植株叶面积较对照增加92.1%。(3)在番茄生殖生长期,与对照相比,播种后83d纯红光补光处理下番茄植株坐果数增加73.6%,番茄果实的横、纵径和体积分别增加34.4%、35.3%和129.6%。(4)与对照相比,播种后44d红蓝光以1h或6h间隔交替补光处理下番茄叶片叶绿素含量分别增加30.3%和31.8%。播种后83d红蓝光以1h或6h间隔交替补光处理后番茄植株的性能指数(PIABS)分别较对照提高100%和30%,红蓝光以1h或6h间隔交替补光处理后PSII的电子传递效率(ETo/CS)分别较对照增加16%、23%。综上,纯红光补光可有效促进设施番茄的生长发育,以1h或6h间隔交替红蓝补光显著影响番茄荧光特性。未来可根据不同生产目标,选择最适合的补光模式。

关键词：植物工厂供光模式 LED灯生长期叶绿素

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