Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum
作者机构:State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai200237China The State Key Laboratory of Mycology(SKLM)Institute of MicrobiologyChinese Academy of SciencesBeijing100101China School of Environmental SciencesUniversity of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada
出 版 物:《Synthetic and Systems Biotechnology》 (合成和系统生物技术(英文))
年 卷 期:2021年第6卷第4期
页 面:446-451页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:This work was supported by the National Key Research and Development Program of China(2020YFA0907200,2019YFA0906200,and 2020YFA0907800) the National Natural Science Foundation of China(21877038,21907031,21977029,31720103901,and 81903529) Shanghai Rising-Star Program(20QA1402800) the Open Project Funding of the State Key Laboratory of Bioreactor Engineering,and the 111 Project(B18022)
主 题:Pathogenic fungus Aliphatic unsaturated alcohols Antibacterial Natural products
摘 要:Phytopathogenic fungi have attracted great attention as a promising source for new drug *** the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library,a pathogenic fungus,Fusarium proliferatum strain 13294(FP13294),was selected for chemical *** novel aliphatic unsaturated alcohols named fusariumnols A and B(1 and 2),together with one previously characterized sesquiterpenoid lignoren(3)were *** of 1-3 were assigned by mass spectrometry and NMR *** bioactivities were assessed against Staphylococcus epidermidis,***,and Methicillin-resistant ***(MRSA).Compounds 1 and 2 exhibited weak antibacterial activity against ***(MIC=100μM).