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Comparison of scanning electron microscopy findings regarding biofilm colonization with microbiological results in nasolacrimal stents for external, endoscopic and transcanalicular dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 534-540页

作者： Melike Balikoglu-yilmaz tolga yilmaz Sule Cetinel Umit Taskin Ayse Banu Esen Muhittin Taskapili Timur Kose Department of Ophthalmology Bagcilar Education and Research Hospital Department of Histology & Embryology Marmara UniversityFaculty of Medicine Department of Otorhinolaryngology Bagcilar Education and Research Hospital1Istanbul 34200 Turkey Department of Microbiology and Clinical Microbiology Bagcilar Education and Research Hospital Department of Biostatistics and Medical Informatics Ege University Faculty of Medicine

AIM:To compare bacterial biofilm colonization in lacrimal stents following external dacryocystorhinostomy(EX-DCR),endoscopic dacryocystorhinostomy(EN-DCR),and transcanalicular dacryocystorhinostomy(TC-DCR)with multidiode ***:This prospective study included 30consecutive patients with nasolacrimal duct obstruction who underwent EXT-,EN-,or *** removed lacrimal stent fragments and conjunctival samples were *** lacrimal stent biofilms were examined by scanning electron microscopy(SEM).RESULTS:Eleven(36.7%)of the 30 lacrimal stent cultures were positive for aerobic bacteria(most commonly Staphylococcus epidermidis and Pseudomonas aeruginosa).However anaerobic bacteria and fungi were not identified in the lacrimal stent ***-seven(90%)patients had biofilmpositive lacrimal *** conjunctival culture positivity after the DCR,biofilm positivity on stents,the grade of biofilm colonization,and the presence of mucus and coccoid and rod-shaped organisms did not significantly differ between any of the groups(P>0.05).However,a significant difference was found when the SEM results were compared to the results of the lacrimal stent and conjunctival cultures(P<0.001).CONCLUSION:Type of dacryocystorhinostomy(DCR)surgery did not affect the biofilm colonization of the lacrimal *** also appears to be more precise than microbiological culture for evaluating the presence of biofilms on lacrimal stents.

关键词： biofilms nasolacrimal duct obstruction epiphora dacryocystitis scanning electron microscopy

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Synthesis and thermoluminescence properties of rare earth oxides (Y, Ce-Lu) doped lithium triborate

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Journal of Rare Earths 2011年第6期29卷 618-622页

作者： tolga Depci Gulhan Ozbayoglu Aysen yilmaz Department of Mining Engineering Faculty of Engineering and Architecture Yuzuncu Yil University Faculty of Engineering Atilim University Department of Chemistry Middle East Technical University

Lithium triborate （LiB3O5） was synthesized by high temperature solid-state reaction method, and then rare earth oxides were doped into LiB3O5 to enhance its thermoluminescent （TL） properties. The identification and characteristics of the obtained compounds were determined by X-ray diffraction （XRD）, Fourier transform infrared （FTIR） analyses, differential thermal analyses （DTA） and scanning electron microscopy （SEM）. The glow curves were obtained using a thermoluminescent （TL） reader. The results revealed that all the rare earth oxides were not good activators for lithium triborate and the obtained compounds could not be used for dosimetric applications.

关键词： lithium triborate solid state thermoluminescent rare earth oxides

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COVID-19 pandemic:Its impact on liver disease and liver transplantation

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World Journal of Gastroenterology 2020年第22期26卷 2987-2999页

作者： Tevfik tolga Sahin Sami Akbulut Sezai yilmaz Deaprtment of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 244280Turkey

Severe pulmonary disease caused by the novel coronavirus[severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)],has devastated many countries around the *** has overwhelmed the medical *** priorities of many institutions have changed to manage critically ill corona virus infectious disease-2019(COVID-19)patients,which affected the working style of many *** and transplant surgeons look after a very sensitive patient *** with liver disease need special attention and continuous ***,transplant candidates also need special *** professionals in the field of hepatology face the overwhelming task of taking care of COVID-19 patients with hepatic complications,liver disease or transplant patients who are SARS-CoV-2 positive,and the patients on routine surveillance who do not have *** review will evaluate COVID-19 from the perspective of its effect on the liver and its possible effects on patients with liver ***,the level of care for liver transplant recipients during the pandemic will be discussed.

关键词： SARS-Cov-2 COVID-19 Acute liver injury Chronic liver disease Liver transplantation Risk factors

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Comment on pediatric living donor liver transplantation decade progress in Shanghai: Characteristics and risks factors of mortality

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World Journal of Gastroenterology 2020年第30期26卷 4564-4566页

作者： Sami Akbulut Tevfik tolga Sahin Sezai yilmaz Deaprtment of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey

Since the first successful liver transplantation was performed five decades ago,pediatric liver transplantation has become the gold standard treatment choice for pediatric liver disease,including metabolic diseases,liver tumors,and some acute liver *** improvements in immunosuppression,surgical techniques,and postoperative medical care,long-term outcomes of patients after liver transplantation have markedly improved,especially in pediatric patients.

关键词： Pediatric end stage liver disease Living donor pediatric liver transplantation Survival analysis Risk factors Living donor liver transplantation Outcomes

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Liver transplantation for hepatocellular carcinoma:Historical evolution of transplantation criteria

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World Journal of Clinical Cases 2022年第29期10卷 10413-10427页

作者： Volkan Ince Tevfik tolga Sahin Sami Akbulut Sezai yilmaz Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey

Liver transplantation(LT) for hepatocellular carcinoma is still a hot topic,and the main factor that is associated with the success of treatment is to determine the patients who will benefit from *** criteria have been defined 25 years ago and still is being used for patient selection for ***,in living donor LT,the Milan criteria is being *** criteria for patient selection do not only consider morphologic characteristics such as tumor size and number of tumor nodules but also biologic markers that show tumor aggressiveness is also being *** the present review article,we have summarized all the criteria and scoring systems regarding LT for hepatocellular *** criteria have 5-year overall survival rates that were comparable to the Milan Criteria and ranged between 60%-85%.On the other hand,it was seen that the recurrence rates had increased as the Milan criteria were exceeded;the 5-year recurrence rates ranged between 4.9% to 39.9%.Treatment of hepatocellular carcinoma needs a multidisciplinary *** selection criteria are yet to be *** same is true for treatment *** goal will be achieved by a harmonic interplay between basic science researchers and clinicians.

关键词： Liver transplantation Hepatocellular carcinoma Milan criteria Expanded Malatya criteria

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Impact of COVID-19 pandemic on clinicopathological features of transplant recipients with hepatocellular carcinoma:A case-control study

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World Journal of Clinical Cases 2022年第15期10卷 4785-4798页

作者： Sami Akbulut Tevfik tolga Sahin Volkan Ince Sezai yilmaz Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a significant impact on the management of all *** diseases such as cancer have a higher risk of COVID-19-related *** this fact,any delay or alteration in treatment of cancer may have fatal *** carcinoma(HCC)is an aggressive liver cancer that requires multimodality treatment to improve *** To evaluate the impact of COVID-19 on the management of patients with HCC by determining changes in demographic,clinical and histopathological *** Demographic,clinical and pathological variables of patients with HCC who had undergone liver transplantation between March 2020 and June 2021(Pandemic group,n=48)were retrospectively compared with that of the patients with HCC transplanted between November 2018 and March 2020(Pre-pandemic group,n=61).RESULTS The median age of the patients in the study was 56(interquartile range=15).Ninety-seven patients(89%)were male and 12 were female(11%).The most common etiology of liver disease was hepatitis B virus(n=52,47.7%).According to our results,there was a 21.3% drop in the number of patients transplanted for *** was no difference in the demographic,clinical and pathological characteristics of the patients except blood alkaline phosphatase levels(P=0.029),lymphovascular invasion(P=0.019)and type of the liver graft that was transplanted(P=0.017).CONCLUSION It is important to develop a surveillance strategy for liver transplant *** liver transplantation for HCC is justified and safe provided that strict surveillance protocols are applied.

关键词： COVID-19 pandemic Liver transplantation Hepatocellular carcinoma Biological behavior

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Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis

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World Journal of Clinical Cases 2022年第14期10卷 4348-4356页

作者： Basri Satilmis Gizem Selen Cicek Egemen Cicek Sami Akbulut Tevfik tolga Sahin Sezai yilmaz Hepatology Research Laboratory Liver Transplant InstituteInonu UniversityMalatya 44000BattalgaziTurkey Department of Biochemistry Faculty of PharmacyInonu UniversityMalatya 44000BattalgaziTurkey Department of Anesthesiology and Reanimation Malatya Training and Research HospitalMalatya 44000YesilyurtTurkey Liver Transplant Institute InonuUniversityMalatya 44000BattalgaziTurkey

Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have ***-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and ***-MSC are mesenchymal stem cells that have pluripotent lineage *** are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem *** is also HLA-DR negative and can be transplanted allogenically without the need for *** advantages have popularized its use in many fields including plastic reconstructive ***,in the field of hepatology and liver transplantation,the progress is ***-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract *** are very important for the treatment of various hepatobiliary ***,the anti-inflammatory potential of these cells has paramount importance in the treatment of *** need alternative therapeutic approaches to treat end-stage liver ***-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver *** we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis.

关键词： Adipose-derived stem cells Hepatobiliary diseases Sepsis Mesenchymal stem cells Theoretic application

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Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis:First case report in the literature

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World Journal of Gastrointestinal Surgery 2018年第1期10卷 1-5页

作者： Sami Akbulut Egemen Cicek Mehmet Kolu Tevfik tolga Sahin Sezai yilmaz Department of Surgery and Liver Transplant Institute Inonu University Faculty of Medicine Department of Radiology Inonu University Faculty of Medicine

Alveolar echinococcosis(AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins(R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for marginnegative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery.

关键词： Alveolar echinococcosis Extensive disease Associating liver partition portal vein ligation Curative management

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Adipokines and ghrelin in gastric cancer cachexia

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World Journal of Gastroenterology 2008年第23期14卷 3633-3641页

作者： Mustafa Kerem Zafer Ferahkose Utku Tonguc yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik tolga Sahin Murat Akin Department of General Surgery Medical FacultyGazi UniversityBesevler 06510AnkaraTurkey Department of Biochemistry Medical FacultyGazi UniversityBesevler 06510AnkaraTurkey

AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor.

关键词： Gastric cancer Cachexia Resistin Ghrelin Leptin Adiponectin Insuline

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