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Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019

Infectious Microbes & Diseases 2020年第4期2卷 160-166页

作者： Yujiro Hirose Masaya Yamaguchi Norihiko Takemoto tohru miyoshi-akiyama Tomoko Sumitomo Masanobu Nakata Tadayoshi Ikebe Tomoki Hanada Takahiro Yamaguchi Ryuji Kawahara Rumi Okuno Hitoshi Otsuka Yuko Matsumoto Yuji Terashima Yu Kazawa Noriko Nakanishi Kaoru Uchida Yumi akiyama Kaori Iwabuchi Chikara Nakagawa Kazunari Yamamoto Victor Nizet Shigetada Kawabata Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuitaOsakaJapan Department of Pediatrics University of California at San Diego School of MedicineLa JollaCAUSA Department of Infectious Diseases Research InstituteNational Center for Global Health and MedicineTokyoJapan Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan Department of Bacteriology I National Institute of Infectious DiseasesTokyoJapan Division of Microbiology Osaka Institute of Public HealthOsaka CityOsakaJapan Department of Microbiology Tokyo Metropolitan Institute of Public HealthTokyoJapan Department of Public Health Sciences Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi CityYamaguchiJapan Microbiological Testing and Research Division Yokohama City Institute of Public HealthYokohamaKanagawaJapan Department of Microbiology Fukushima Prefectural Institute of Public HealthFukushima CityFukushimaJapan Department of Infectious Diseases Kobe Institute of HealthKobeHyogoJapan Department of Bacteriology Toyama Institute of HealthImizuToyamaJapan Infectious Disease Research Division Hyogo Prefectural Institute of Public Health ScienceKakogawaHyogoJapan Department of Health Science Iwate Prefectural Research Institute for Environmental Sciences and Public HealthMoriokaIwateJapan Division of Microbiology Kyoto City Institute of Health and Environmental SciencesKyoto CityKyotoJapan Niigata City Institute of Public Health and the Environment Niigata CityNiigataJapan Skaggs School of Pharmaceutical Sciences University of California at San DiegoLa JollaCAUSA.

Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains,designated clade 3.In Japan,the features of emm89 S.pyogenes strains,such as clade classification,remains unknown.In this study,we collected emm89 strains isolated from both streptococcal toxic shock syndrome(STSS)(89 STSS isolates)and noninvasive infections(72 non-STSS isolates)in Japan from 2011 to 2019,and conducted wholegenome sequencing and comparative analysis,which resulted in classification of a large majority into clade 3 regardless of disease severity.In addition,invasive disease-associated factors were found among emm89 strains,including mutations of control of virulence sensor,and absence of the hylP1 gene encoding hyaluronidase.These findings provide new insights into genetic features of emm89 strains.

关键词： clade 3 emm89 streptococcal toxic shock syndrome Streptococcus pyogenes

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Optical grade (Gd_(0.95-x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) ceramics with near-zero optical loss: Effects of Lu^(3+) doping on structural feature, microstructure evolution, and far-red luminescence

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Journal of Advanced Ceramics 2024年第1期13卷 113-123页

作者： Zhigang Sun Ji-Guang Li Huiyu Qian Yoshio Sakka tohru SSuzuki Bin Lu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Research Center for Electronic and Optical Materials National Institute for Materials ScienceIbaraki 305-0044Japan Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China

A chemical co-precipitation strategy was employed to synthesize a series of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12)(x=0.1−0.95)powder phosphors,followed by vacuum sintering to achieve transparent garnet ceramic phosphors.The density functional theory indicated Lu_(3)Al_(5)O_(12) was formed in priority compared with Gd_(3)Al_(5)O_(12) during solid-phase reaction.Upon high-temperature sintering,the Lu^(3+)substitution for Gd^(3+)suppressed point mass diffusion leading to a smaller grain size.The in-line transmittances of bulk specimens with x=0.1,0.3,0.5,0.7,and 0.95 nm were~83.5%,80.1%,68.8%,73.7%,and 82.2%at 710 nm(Eu^(3+)emission center),respectively,among which the sample of x=0.1 exhibited the optical grade with near-zero optical loss in agreement with the defect-free single crystal(~100%of the theoretical transmittance).The resulting particle and ceramic materials both presented characteristic Eu^(3+)emission arising from 5D0→7FJ(J=1−4)transition,where the dominant far-red emission at~710 nm arising from ^(5)D_(0)→^(7)F_(4) transition overlapped with the absorption of phytochrome(PFR).The photoluminescence excitation and photoluminescence intensities of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) powders and ceramics generally increased at a higher Gd^(3+)/Lu^(3+)ratio.Lu^(3+)dopants delayed the fluorescence lifetime while the bulk samples had shorter lifetime compared to the particle counterparts.The transparent(Gd_(0.85)Lu_(0.1)Eu_(0.05))3Al_(5)O_(12) ceramic phosphor exhibited good thermal stability with a high thermal quenching temperature above 533 K.The designed ceramic phosphor-converted light-emitting diode had a saturation injection current of 435 mA and a current-dependent color rendering index.More importantly,our report marked the developmental stage of transparent ceramic materials towards zero optical loss.

关键词： transparent ceramics garnet phosphors light-emitting diode(LED) optical properties Gibbs free energy

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Usefulness of Newly Devised Clomiphene Citrate Administration Method Compared with the Conventional Method in Ovulation and Pregnancy

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 637-649页

作者： Makoto Kawamura Misaki akiyama Remi Nakajima Eri Satoi Yoko Ogaki Rieko Kanda Department of Obstetrics and Gynecology Kohseichuo General Hospital Tokyo Japan

Objective: Since not all women wish to conceive a child through aggressive treatment, we investigated the usefulness of modified repeated intracyclic clomiphene citrate (CC) therapy (repeated CC therapy) as a newly devised administration method. Methods: We evaluated the effects of CC administration on menstrual cycle length and retrospectively compared ovulation and pregnancy in 220 women who received CC at our hospital. Patients in the conventional method group received 50 mg per day for five days, starting on the fifth day of menstruation (withdrawal bleeding). Groups with and without menstrual cycle shortening after conventional CC administration were compared. The repeated CC therapy group was also compared with the non-shortened group. Repeated CC therapy was administered for the first five days as in the conventional method, and a second five-day repeat treatment was administered after an interval of five to seven days. Pregnancy rates, including indirect pregnancies, were evaluated by three different methods. Results: Ovulation and pregnancy rates were significantly better in the shortened group than in the non-shortened group (P < 0.001 and P = 0.010, respectively). Even in the non-shortened group, ovulation and pregnancy rates including indirect pregnancies were significantly improved when ovulation was observed with repeated CC therapy (P < 0.001 and P = 0.022, respectively). Conclusions: For patients whose menstrual cycle was not improved or shortened, repeated CC therapy as the newly devised CC administration method is useful as the next step after the conventional CC administration method.

关键词： Clomiphene Citrate Infertility Menstrual Cycle Ovulation Induction

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日本学校撤并的多主体决策参与研究——基于理性选择制度主义视角

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比较教育研究 2024年第2期46卷 74-82,102页

作者：三好大树高益民北京师范大学国际与比较教育研究院北京100875

基础教育阶段的学校撤并是许多国家存在的共同现象。学校撤并涉及各方利益,不同主体对相关决策的参与方式和参与程度极大地影响着学校撤并的效果。日本有过强行推动学校撤并引起官民严重冲突的历史,这为研究学校撤并的多主体决策参与问... 详细信息

基础教育阶段的学校撤并是许多国家存在的共同现象。学校撤并涉及各方利益,不同主体对相关决策的参与方式和参与程度极大地影响着学校撤并的效果。日本有过强行推动学校撤并引起官民严重冲突的历史,这为研究学校撤并的多主体决策参与问题提供了重要的样本。基于理性选择制度主义的视角分析日本学校撤并的决策过程,发现各行动者的偏好差异和利益冲突、权力分配的不均衡以及决策监管机制的缺失等导致决策效率较低、家长和社区居民对决策的公平参与缺乏保障、决策的程序化和形式化明显、政策适应存在较多不确定性因素等问题。尽管存在上述问题且经历了不少挫折,但日本的学校撤并决策还是逐渐从政府独断走向了政府主导下的民主协商。

关键词：学校撤并教育政策决策参与理性选择制度主义

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Kink-band formation in directionally solidified Mg/Mg_(2)Yb and Mg/Mg_(2)Ca eutectic alloys with Mg/Laves-phase lamellar microstructure

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Journal of Magnesium and Alloys 2022年第2期10卷 530-538页

作者： Koji Hagihara Kosuke miyoshi Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1YamadaokaSuitaOsaka 565-0871Japan Department of Adaptive Machine Systems Graduate School of EngineeringOsaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Department of Physical Science and Engineering Nagoya Institute of TechnologyNagoya 466-8555Japan

For the development of high-strength Mg alloys,active use of Laves phases such as C14-type Mg_(2)Yb and Mg_(2)Ca is strongly expected.However,the brittleness of the Laves phases is the biggest obstacle to it.We first found that kink-band formation can be induced in directionally solidified Mg/Mg_(2)Yb and Mg/Mg_(2)Ca eutectic lamellar alloys when a stress is applied parallel to the lamellar interface,leading to a high yield stress accompanied with ductility.That is,microstructural control can induce a new deformation mode that is not activated in the constituent phases,thereby inducing ductility.It was clarified that the geometric relationship between the operative slip plane in the constituent phases and the lamellar interface,and the microstructural features that provide kink-band nucleation sites are important factors for controlling kink-band formation.The obtained results show a possibility to open the new door for the development of novel high-strength structural material using the kink bands.

关键词： Deformation kink band Lamellar microstructure Laves phase Magnesium alloys Mechanical properties

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Comparative evaluation of acute phase proteins by C-reactive protein(CRP)and serum amyloid A(SAA)in nonhuman primates and feline carnivores

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Animal Diseases 2022年第4期2卷 258-268页

作者： tohru Kimura Laboratory Animal Science Joint Faculty of Veterinary MedicineYamaguchi University1677-1YoshidaYamaguchi-cityYamaguchi 753-8515Japan

The feasibility of a commercially available assay for C-reactive protein(CRP,CRP for humans:hCRP,and CRP for dogs:vCRP)and a trial reagent of serum amyloid A(SAA,vSAA for animals)were applied to the measurement of acute phase proteins in zoo animals,particularly in nonhuman primates and feline carnivores was evaluate.Results showed that hCRP and vSAA methods were applicable to measure CRP and SAA in Haplorhini.There was a highly signifcant correlation between both parameters with remarkably high correlation coefcient.A higher proportion of Bonnet macaques in Haplorhini,and the linear regression with good correlation between hCRP and vSAA levels were observed.Reference values in healthy Bonnet macaques were hCRP(46.86±30.97 nmol/L)and vSAA(9.06±1.95μg/mL).Although Ring-tailed lemur,which belonging to Strepsirrhini,showed low vSAA concentrations(reference values:1.08±0.47μg/mL),vSAA in patients was apparently elevated.The vCRP and vSAA methods were applicable to measurements of CRP and SAA in feline carnivores for highly signifcant correlation between both parameters.Theses two methods were also been deteded in lions,tigers and cheetahs.vSAA assays can be applied to measure SAA levels in other carnivores and herbivores.In conclusion,vSAA systems have potential utility as diagnostic tools for health screening and prediction in zoo animals.

关键词： Acute phase proteins C-reactive protein Feline carnivores Nonhuman primates Serum amyloid A Zoo animal

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Efficacy of transanal drainage tube in preventing anastomotic leakage after surgery for rectal cancer: A meta-analysis

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1202-1210页

作者： Shiki Fujino Masayoshi Yasui Masayuki Ohue Norikatsu miyoshi Innovative Oncology Research and Regenerative Medicine Osaka International Cancer InstituteOsaka 541-8567Japan Department of Surgery Osaka International Cancer InstituteOsaka 541-8567Japan

BACKGROUND Anastomotic leakage(AL)following rectal cancer surgery is an important cause of mortality and recurrence.Although transanal drainage tubes(TDTs)are expected to reduce the rate of AL,their preventive effects are controversial.AIM To reveal the effect of TDT in patients with symptomatic AL after rectal cancer surgery.METHODS A systematic literature search was performed using the PubMed,Embase,and Cochrane Library databases.We included randomized controlled trials(RCTs)and prospective cohort studies(PCSs)in which patients were assigned to two groups depending on the use or non-use of TDT and in which AL was evaluated.The results of the studies were synthesized using the Mantel-Haenszel randomeffects model,and a two-tailed P value>0.05 was considered statistically significant.RESULTS Three RCTs and two PCSs were included in this study.Symptomatic AL was examined in all 1417 patients(712 with TDT),and TDTs did not reduce the symptomatic AL rate.In a subgroup analysis of 955 patients without a diverting stoma,TDT reduced the symptomatic AL rate(odds ratio=0.50,95%confidence interval:0.29–0.86,P=0.012).CONCLUSION TDT may not reduce AL overall among patients undergoing rectal cancer surgery.However,patients without a diverting stoma may benefit from TDT placement.

关键词： Meta-analysis Drainage Transanal Anastomotic leakage Surgical stomas Rectal cancer

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Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 646-653页

作者： Shintaro akiyama Taku Sakamoto Joshua M Steinberg Yutaka Saito Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaIbaraki 305-8575Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Magnifying endoscopy is a useful technique to differentiate neoplasia from non-neoplastic lesions. Data regarding the clinical utility of magnifying endoscopy for neoplasia in patients with inflammatory bowel disease(IBD) has been emerging.While Kudo’s pit pattern types Ⅲ-Ⅴ are findings suggestive of neoplasia in non-IBD patients, these pit patterns are predictive of IBD-associated neoplasia as well.However, active chronic inflammatory processes, particularly regenerative changes, can mimic neoplastic pit patterns and may affect a meticulous evaluation of pit pattern diagnosis in patients with IBD. The clinical evidence regarding the utility of magnifying endoscopy with narrow band imaging or endocytoscopy has also been evolving in regard to the diagnosis of IBD-associated neoplasia. These advanced endoscopic techniques are promising for multiple reasons;not only for making an accurate diagnosis of neoplasia, but also in determining if endoscopic resection is appropriate for such lesions in patients with IBD. In this review, we discuss the diagnostic accuracy and limitations of magnifying endoscopy in assessing IBD-associated neoplasia and examine the feasibility and outcomes of endoscopic resection for these lesions.

关键词： Magnifying endoscopy Neoplasia Ulcerative colitis Inflammatory bowel disease Endoscopic resection

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Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases

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World Journal of Gastroenterology 2022年第25期28卷 2843-2853页

作者： Shintaro akiyama Soma Fukuda Joshua M Steinberg Hideo Suzuki Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaTsukuba 305-8575IbarakiJapan Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Patients with inflammatory bowel disease(IBD)are more likely to have concurrent immune-mediated inflammatory diseases(IMIDs)than those without IBD.IMIDs have been observed to alter the phenotype and outcomes of IBD in recent studies.Several studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes,and are considered to be at increased risk of requiring biologics and IBD-related surgeries,suggesting that having multiple IMIDs is a poor prognostic factor for IBD.Furthermore,IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes,suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory distributions.In this review,we discuss the pathogenesis,disease phenotypes,and clinical outcomes in IBD patients with concomitant IMIDs.

关键词： Inflammatory bowel disease Phenotypes Outcomes Concurrent immunemediated inflammatory diseases

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Change in elastic properties during room-temperature aging in body-centered cubic Mg-Li and Mg-Li-Al single crystals

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Journal of Materials Science & Technology 2022年第14期109卷 49-53页

作者： Ruxia Liu Shota Higashino Koji Hagihara Lianmeng Zhang tohru Sekino Masakazu Tane SANKEN(The Institute of Scientific and Industrial Research) Osaka University8-1 MihogaokaIbarakiOsaka 567-0047Japan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Graduate School of Engineering Osaka City University3-3-138 SugimotoOsaka558-8585Japan Department of Physical Science and Engineering Nagoya Institute of TechnologyNagoya 466-8555Japan

Biodegradable materials,with many advantages over conventionally used non-biodegradable materials,have received much attention owing to the elimination of the need for a secondary surgery for the removal of implants after implantation.Compared with other biodegradable ceramics and/or polymers,Mg alloys are considered to be the most promising biodegradable orthopedic materials because they feature not only high specific strength and compressive yield strength but also a low Young’s modulus,which is comparable to that of human bones(10-30 GPa)[1,2].

关键词： strength aging alloys

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