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Mesenchymal Stem Cell Allograft Improved Pain Management in Dogs with Osteoarthritis

Journal of Biosciences and Medicines 2023年第11期11卷 181-189页

作者： Jonathan R. T. Lakey Wenyi Guo Michael Alexander Mike K. S. Chan Michelle B. F. Wong todd scott Department of Surgery University of California Irvine Irvine USA Department of Biomedical Engineering University of California Irvine Irvine USA Department of Pancreatic Surgery General Surgery Qilu Hospital of Shandong University Jinan China European Wellness Biomedical Group Edenkoben Germany Baden R&D Laboratories GmbH Sabine Conrad Ferdinand-Laselle-Strasse Edenkoben Germany Crestwood Veterinary Clinic Edmonton Canada

Background: Osteoarthritis is one of the most common bone diseases, triggered by bone destruction stemming from the inflammatory response of chondrocytes. The disease progresses slowly, but halting its progression or finding a cure remains elusive. The treatment of pain associated with osteoarthritis has yielded unsatisfactory results. In recent years, mesenchymal stem cells (MSCs) have emerged as a potential avenue for addressing the condition. In this study, we used MSCs to treat companion dogs with osteoarthritis. Methods: For this study, 26 animals were included in this study to assess the pain and mobility one month after treatment. The pain scores were obtained from owners using a questionnaire based on the Helsinki Chronic Pain Index, and the Liverpool Osteoarthritis in Dogs (LOAD) Owner questionnaire to assess the mobility of the dogs from stem cell infusion. Results: Questionnaires were administered to dog owners before and one month after treatment, and we found that dogs treated with MSCS experienced an 81.2% ± 6.8% reduction in pain and a 77.9% ± 10.1% increase in mobility, whereas most of the dogs in the untreated control group experienced disease progression. Conclusions: The transplantation of stem cells into companion pets is a promising and expanding opportunity for pet owners with aging and arthritic dogs. MSCs may play an important role in the treatment of OA without complications in companion pets.

关键词： Stem Cell Therapy Canine Pain Osteoarthritis Mesenchymal Stem Cell

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智能家庭视频监控的技术挑战及解决之道

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中国公共安全(市场版) 2007年第8期 126-127页

作者： todd scott Altera消费、汽车及广播事业部

家庭监控正逐步从报警能力有限的模拟技术过渡到压缩数字IP传送技术,其分析和监视能力几乎不受任何限制。家庭监控的需求多种多样,包括简单的安防以及儿童和保姆的全面监控等。考虑到多种视频输入的QOS(服务质量)要求,基于IP的家庭监控... 详细信息

家庭监控正逐步从报警能力有限的模拟技术过渡到压缩数字IP传送技术,其分析和监视能力几乎不受任何限制。家庭监控的需求多种多样,包括简单的安防以及儿童和保姆的全面监控等。考虑到多种视频输入的QOS(服务质量)要求,基于IP的家庭监控系统趋向于采用专门的互联网络,但最终会采用大众化的家庭网络技术。系统可以通过

关键词：家庭监控系统视频监控摄像头解决之道

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实现灵活的汽车电子设计

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今日电子 2007年第9期 72-73页

作者： todd scott Axel Zimmermann Tapan Mehta Altera公司

微控制器在汽车和消费类市场上得到了广泛的应用，其主要优势在于能够以相对较低的成本实现系统高度集成。然而，这类产品也有潜在的成本问题。例如，如果元件功能不切合要求，就必须采用外部逻辑、软件或其他集成器件来进行扩展。此外... 详细信息

微控制器在汽车和消费类市场上得到了广泛的应用，其主要优势在于能够以相对较低的成本实现系统高度集成。然而，这类产品也有潜在的成本问题。例如，如果元件功能不切合要求，就必须采用外部逻辑、软件或其他集成器件来进行扩展。此外，随着最终市场需求的迅速变化，微控制器会很快过时。许多具有一定数量专用接口的特殊功能微控制器在经过短期试用后，

关键词：汽车电子设计微控制器成本问题市场需求高度集成集成器件专用接口消费类

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The acceleration of a high-charge electron bunch to 10 GeV in a 10-cm nanoparticle-assisted wakefield accelerator

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Matter and Radiation at Extremes 2024年第1期9卷 15-24页

作者： Constantin Aniculaesei Thanh Ha Samuel Yoffe Lance Labun Stephen Milton Edward McCary Michael M.Spinks Hernan J.Quevedo Ou Z.Labun Ritwik Sain Andrea Hannasch Rafal Zgadzaj Isabella Pagano Jose A.Franco-Altamirano Martin L.Ringuette Erhart Gaul scott V.Luedtke Ganesh Tiwari Bernhard Ersfeld Enrico Brunetti Hartmut Ruhl todd Ditmire Sandra Bruce Michael E.Donovan Michael C.Downer Dino A.Jaroszynski Bjorn Manuel Hegelich University of Texas at Austin AustinTexas 78712USA SUPA Department of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Systems Inc.AustinTexas 78701USA Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Brookhaven National Laboratory UptonNew York 11973USA Ludwig-Maximilians-Universität MunichGermany

An intense laser pulse focused onto a plasma can excite nonlinear plasma *** appropriate conditions,electrons from the background plasma are trapped in the plasma wave and accelerated to ultra-relativistic *** scheme is called a laser wakefield *** this work,we present results from a laser wakefield acceleration experiment using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the *** find that a 10-cm-long,nanoparticle-assisted laser wakefield accelerator can generate 340 pC,10±1.86 GeV electron bunches with a 3.4 GeV rms convolved energy spread and a 0.9 mrad rms *** can also produce bunches with lower energies in the 4–6 GeV range.

关键词： acceleration nanoparticle charge

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Acute liver failure secondary to acute antibody mediated rejection after compatible liver transplant: A case report

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World Journal of Hepatology 2022年第1期14卷 287-294页

作者： todd J Robinson James B Hendele Idoia Gimferrer Nicolae Leca scott W Biggins Jorge D Reyes Lena Sibulesky Department of Surgery Virginia MasonSeattleWA 98101United States Department of Surgery University of Washington Medical CenterSeattleWA 98195United States Bloodworks Northwest SeattleWA 98104United States Department of Nephrology University of Washington Medical CenterSeattleWA 98195United States Department of Gastroenterology and Hepatology University of Washington Medical CenterSeattleWA 98195United States

BACKGROUND The liver has traditionally been regarded as resistant to antibody-mediated rejection(AMR).AMR in liver transplants is a field in its infancy compared to kidney and lung *** our case we present a patient with alpha-1-antitrypsin disease who underwent ABO compatible liver transplant complicated by acute liver failure(ALF)with evidence of antibody mediated rejection on allograft biopsy and elevated serum donor-specific antibodies(DSA).This case highlights the need for further investigations and heightened awareness for timely *** SUMMARY A 56 year-old woman with alpha-1-antitrypsin disease underwent ABO compatible liver transplant from a deceased *** recipient MELD at the time of transplant was *** flow cytometric crossmatches were noted to be positive for T and B *** patient had an uneventful recovery *** on postoperative day 5 the patient developed fevers,elevated liver function tests,distributive shock,renal failure,and hepatic *** went into ALF with evidence of antibody mediated rejection with portal inflammation,bile duct injury,endothelitis,and extensive centrizonal necrosis,and C4d staining on allograft biopsy and elevated *** various interventions including plasmapheresis and immunomodulating therapy,she continued to *** was relisted and successfully underwent liver *** This very rare case highlights AMR as the cause of ALF following liver transplant requiring retransplantation.

关键词： Liver transplant Acute antibody mediated rejection Acute liver failure Donor specific antibody Liver rejection Case report

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The History Highway : A 21st-century Guide to Internet Resources 4th

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丛书名： Gale Virtual Reference Library

2006年

作者： Dennis A. Trinkle Dorothy Auchter scott A. Merriman todd E. Larson

ISBN: (纸本)9780765616302;9780765616319;9780765617941;9781315289595;9781315289601

Save yourself and your students hours of research time. Now extensively revised and expanded,''The History Highway''is widely recognized as the one essential tool for students, teachers and researchers seeking a reliable guide to history sites on the web.''The History Highway''offers the broadest, most current coverage of the astonishing amount of historical information available on the Internet: provides detailed, easy-to-use, and up-to-date information on more than 3000 web sites; covers U.S. and World history and all sub-fields; features ten new chapters, with coverage of futurism, environmental history, immigration history, and Mediterranean and Middle Eastern history; all sites have been thoroughly checked by specialists in the relevant field of history; the best sites in each field are clearly identified; hard cover and paperback editions include a CD of the entire contents with live links to sites; and e-book version with live links to sites is in preparation.

关键词： History--Computer network resources Internet History--Research--Methodology History--Computer-assisted instruction

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Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 577-586,I0001页

作者： Ariella M.Altman scott Kizy Schelomo Marmor Jane Y.C.Hui todd M.Tuttle Eric H.Jensen Jason W.Denbo Department of Surgery University of MinnesotaMinneapolisMNUSA Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFLUSA

Background:Intrahepatic cholangiocarcinoma(ICC)is rare with limited evidence-based *** retrospective study evaluates the use of chemotherapy in patients with resected ***:The Surveillance Epidemiology and End Results(SEER)program database was used to identify patients with resected *** were stratified by date of diagnosis(2000-2004,2005-2009,2010-2014),T,and N *** logistic regression models identified predictors of chemotherapy ***-Meier and Cox proportional hazard models were used to identify survival ***:One thousand and two hundred twenty-three patients met inclusion *** utilization increased over time(33%to 41%,P≤0.05).Chemotherapy use increased in lymph node(LN)positive patients[32%to 60%in 2010-2014;(P≤0.05)and T3/T4 disease(40%to 60%in 2010-2014;P≤0.01)],but not in patients with LN negative or T1/T2 *** positivity was associated with utilization of chemotherapy in 2005-2009 and *** survival increased from 32 to 41 months(P≤0.05).In LN positive patients,chemotherapy was associated with a decreased hazard ratio of death(P≤0.05)and T3/T4 disease was associated with an increased hazard ratio of death(P≤0.05).Conclusions:Adjuvant chemotherapy use in ICC has *** LN positive or patients with T3/T4 tumors are receiving chemotherapy,which may explain the improvement in overall survival.

关键词： Cholangiocarcinoma adjuvant chemotherapy survival lymph node(LN) surgical procedures

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Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 296-303页

作者： scott Kizy Ariella M.Altman Keith M.Wirth Schelomo Marmor Jane Y.C.Hui todd M.Tuttle Emil Lou Khalid Amin Jason W.Denbo Eric H.Jensen Division of Surgical Oncology Department of SurgeryUniversity of MinnesotaMinneapolisMNUSA Division of Hematology and Oncology Department of Internal MedicineUniversity of MinnesotaMinneapolisMNUSA Department of Laboratory Medicine and Pathology University of MinnesotaMinneapolisMNUSA

Background:The utility of neoadjuvant treatment for resectable pancreas cancer is yet to be determined,but has commonly included *** evaluated outcomes in patients with radiographically resectable pancreatic adenocarcinoma treated with neoadjuvant chemotherapy without ***:A retrospective review of patients in our institutional pancreatic cancer registry was performed,which identified 36 patients who received neoadjuvant chemotherapy alone for resectable pancreatic adenocarcinoma between 2012 and ***:Median age at diagnosis was 66.3 *** regimens included gemcitabine(n=17),gemcitabine/nab-paclitaxel(n=8),or 5-FU/leucovorin/irinotecan/oxaliplatin(FOLFIRINOX)(n=11).Surgical resection was performed in 69%of patients(n=25),with an R0 resection rate of 92%(n=23 patients).During chemotherapy,distant disease became apparent in 19%of patients(n=7),while no patients had evidence of local *** rates were similar between chemotherapy regimens(single agent=59%,multiple agent=79%).Median overall survival for all patients who received neoadjuvant chemotherapy was 30.3 and 34.4 months for those who underwent surgical *** was no difference in median survival for patients treated with gemcitabine(31.3 months)or multi-agent chemotherapy(29.7 months).Conclusions:A short course of neoadjuvant chemotherapy without chemoradiation may improve patient selection prior to surgical resection for pancreas ***,local disease progression did not limit surgical resection in this small series.

关键词： Pancreatic adenocarcinoma chemotherapy survival neoadjuvant chemotherapy resection

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Environmental Assessment of Halogen-Free Printed Circuit Boards,A Design for Environment (DfE) Project with the High Density Packaging User Group (HDPUG)

Environmental Assessment of Halogen-Free Printed Circuit Boa...

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2007中国科协年会

作者： scott O’Connell Allen Whitley Ruben Bergman todd Brady John Burkitt Steve Ching Arthur Fong Dell HDPUG Intel HP IBM

Rostrictions on the use of halogenated flame retardant materials in IT products are baing considered due to environmental ***,little information exists involving trio potential environmental impacts of halogen-free materials which are being devoloped as alternatives to traditional brominated flame *** primary driver cited for use of halogen-free materials is to eliminato the potential for dioxin/furan formation during incineration at end of life,however the environmontal footprint of a material is not solely defined by end of life *** impacts occur throughout the life cycle of a material,from development and manufacture,through product use and finally at end of life. The results of this study include an environmental assessment of seven halogen-free flame retardants and one high-volume haloganated flama retardant,tetrabromobisphenol *** flame retardant material was evaluated on the basis of the toxicity of the raw material,potential environmental impacts during use and end of life and incineration and/or degradation *** on the available literature data,a relative ranking was applied to compare the strengths and weaknesses of each flame retardant *** research is recommended to develop a more comprehensive environmental profile for both halogenated and halogen-free flame retardant matarials.

关键词： halogen-free flame retardants printed circuit board

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Addition of Thiourea Host Monomer to Polymer Flocculants to Improve Selectivity of Phosphate Sorption

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Journal of Agricultural Chemistry and Environment 2020年第3期9卷 147-158页

作者： Timothy S. Goebel Kevin J. McInnes scott A. Senseman Robert J. Lascano Alex M. Cullen Timothy J. Fuhrer Sarah Pickle Netochi O. Adeolokun todd A. Davis USDA Wind Erosion and Water Conservation Unit Lubbock TX USA Department of Soil and Crop Sciences Texas A & M University College Station TX USA Department of Plant Sciences University of Tennessee Knoxville TN USA Department of Chemistry United States Air Force Academy USAF Academy Colorado Springs CO USA Department of Chemistry Radford University Radford VA USA Department of Chemistry Idaho State University Pocatello ID USA

Inorganic phosphate is a common nutrient that is applied as a fertilizer to both agricultural fields as well as urban settings such as private yards, public parks and other urban landscaping. While phosphate typically binds tightly to soil, movement of phosphate off of application sites can occur through soil erosion. The soil and its bound phosphate can then end up in surface waters such as rivers and lakes. Phosphate found in surface water bodies exists both as bound to the suspended clay as well as that free in solution. Elevated phosphate concentration in surface waters can lead to algal blooms and eutrophication. While the phosphate bound to clay in suspension in surface water bodies can be removed by commercially available polymer flocculants, the phosphate that is free in solution is more challenging as it is usually found in low concentrations and other anionic salts are generally present in higher concentrations. To remove phosphate from contaminated water systems, where other anions exist at higher concentrations, it is favorable to have a method of removal that is selective for phosphate. As a proof of principle, thiourea derivatized polymer flocculants were examined for the selective removal of phosphate in the presence of competing anions. The polymer flocculants exhibited selectivity for phosphate through hydrogen bonding and were effective at removing up to 43% of phosphate from simulated wastewater. Computational studies and 1H NMR were used to investigate the selectivity of the thiourea monomer for phosphate over competing anions such as chloride and sulfate.

关键词： Molecular Recognition Thiourea Polymers Flocculants Phosphate

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