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住宅灰尘中的多环芳烃:变异性来源

环境与职业医学 2013年第8期30卷 613-613页

作者： todd p.whitehead Catherine Metayer Myrto petreas Monique Does patricia A.Buffler Stephen M.Rappaport

[背景]人们对于使用住宅灰尘评估人类环境污染物暴露感兴趣。[目的]探讨住宅灰尘中多环芳香烃（pAHs）变异性来源的特征，并为计划采用住宅灰尘评估pAHs暴露的研究者提供指导。[方法]从北加州儿童白血病研究的293户家庭的两轮采样（2001... 详细信息

[背景]人们对于使用住宅灰尘评估人类环境污染物暴露感兴趣。[目的]探讨住宅灰尘中多环芳香烃（pAHs）变异性来源的特征，并为计划采用住宅灰尘评估pAHs暴露的研究者提供指导。[方法]从北加州儿童白血病研究的293户家庭的两轮采样（2001--2007年和2010年期间）中，使用家用吸尘器重复收集灰尘样本，并采用气相色谱一质谱法测量12种pAHs。采用随机和混合效应模型将每种pAH实测方差分为4种成分，并找出变异性的来源。[结果]灰尘中各种pAHs的中值浓度介于10～190ng／g。对于每种pAH，总方差分解为区域变异性（1％～9％）、家庭之间的区域内变异性（24％-48％）、随着时间推移的家庭内变异性（41％～57％）以及样本内分析变异性（2％～33％）opAH灰尘水平的区域差异与周围空气中pAH浓度估值相关。家庭之间的区域内差异与住宅施工日期和居民吸烟习惯相关。某些pAHs随着时间呈下降的趋势，解释了一小部分家庭内的变异性。然而，混合效应模型未能解释大部分家庭内的变异性。当灰尘样品采集时间间隔至少6年时，两轮采样之间家庭内的差异最大。[结论]上述研究结果表明，在研究pAH的健康影响时，采用住宅灰尘对pAH暴露进行回顾性评估是可行的。

关键词：环境暴露住宅灰尘多环芳烃

Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension

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Chronic Diseases and Translational Medicine 2024年第2期10卷 102-117页

作者： Nicholas R.powell Tyler Shugg Jacob Leighty Matthew Martin Rolf p.Kreutz Michael T.Eadon Dongbing Lai Tao Lu todd C.Skaar Division of Clinical pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of pharmacology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Medical and Molecular Genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive *** previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay *** AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT *** independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related *** We used in silico,in vitro,in vivo,and retrospective models to test this *** In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIp results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT ***,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression ***-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>***,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with *** We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White *** studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>*** like this will help clinicians move beyond the use of race as a surrogate for genotype.

关键词： angiotensinogen genetic and genomic medicine hypertension rs699

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Whose Bone

小学生时代（大嘴英语） 2024年第6期 34-35页

作者： Susan todd(图) 不详

对疼痛线索的晚期注视偏向预测慢性疼痛的维持:来自眼动的证据

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心理学报 2024年第1期56卷 44-60页

作者：杨周朱嘉雯苏琳熊明洁 todd Jackson 西南大学心理学部认知与教育部重点实验室西南大学医院重庆400715 澳门大学心理学院中国澳门999078

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研... 详细信息

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研究发现,点探测视觉任务中,慢性疼痛患者在前3个时间窗上(0~500 ms、500~1000 ms、1000~1500 ms)对疼痛线索的注视偏向显著高于对中性线索的注视偏向,但在第四个时间窗上(1500~2000ms)不存在差异;融入真实疼痛刺激的视觉任务中,慢性疼痛患者在4个时间窗上对疼痛线索的注视偏向均显著高于对中性线索的注视偏向。分层标准多元回归模型和机器学习回归模型均发现,慢性疼痛患者在两个任务中对疼痛线索的晚期注视偏向(1000~1500ms、1500~2000ms两个时间窗),均可以独立预测6个月后慢性疼痛强度和功能损伤的维持。研究结果表明,尽管慢性疼痛患者对疼痛线索从注意早期就表现出注视偏向,但是只有晚期的注视偏向能够预测慢性疼痛的维持。

关键词：慢性疼痛疼痛强度功能损伤注视偏向眼动追踪

家庭中杀虫剂浓度的时间变异性和对流行病学研究中衰减偏倚的启示

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环境与职业医学 2013年第8期30卷 647-647页

作者： Nicole C.Deziel Mary H.Ward Erin M.Bell todd p.whitehead Robert B.Gunier Melissa C.Friesen John R.Nuckols

[背景]已证实住宅杀虫剂暴露与成人和儿童的不良健康结局相关。高质量的暴露评估是确认这些关联的关键。以往的流行病学研究采用一次测量地毯灰尘中杀虫剂浓度来描述个体长期暴露的平均值。如果浓度随着时间的推移而变化，那么这种方法... 详细信息

[背景]已证实住宅杀虫剂暴露与成人和儿童的不良健康结局相关。高质量的暴露评估是确认这些关联的关键。以往的流行病学研究采用一次测量地毯灰尘中杀虫剂浓度来描述个体长期暴露的平均值。如果浓度随着时间的推移而变化，那么这种方法会导致对暴露明显的错误分类，削弱对风险的估计。[目的]评估地毯灰尘样本中杀虫剂浓度的可重复性和流行病学研究中依赖于一个样本的潜在衰减偏倚。[方法]在2003-2005年期间，从加州Fresno县的21个家庭中，重复收集地毯灰尘样本（中位数=3，范围1～7）。使用气相色谱-质谱法分析灰尘中的13种杀虫剂；采用混合效应模型估计家庭之间和家庭内的方差。计算每一种杀虫剂的组内相关系数（ICC），并估计收集单次灰尘样品的假设病例对照研究衰减回归系数。[结果]ICC的中位数为0．73（范围0．37—0．95），表明大多数杀虫剂家庭之间的变异性高于家庭内部的变异性。对于13种化合物中进行评估的7种，与使用单一灰尘样本相关的预期衰减偏倚估计为≤30％。[结论]对于研究的几种杀虫剂，使用一个灰尘样本代表约为2年的暴露期，其比值比不会大幅衰减。还需要进一步研究，以确定上述研究结果是否可以代表更长的暴露时间并且适用于其他杀虫剂。

关键词：灰尘环境暴露杀虫剂信度

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南京天印山医院

建筑实践 2024年第4期 152-153页

作者：曹伟孙承磊吉英雷 todd pilgreen Roman Wittmer 舒帆东南大学建筑设计研究院有限公司晋思建筑设计事务所

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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah p Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of population and public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a predictive Tool for Spontaneous preterm Birth

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov todd Rosen Jennifer Hill Meena Khandelwal Victors Kurtenoks Brendan Francy Noune Sarvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obstetrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (spTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 24p>0/7p> - 28p>6/7p> gestational weeks. spTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kpa/mm compared to the term group’s 1.63 ± 0.65 kpa/mm with a p-value of 1.1 × 10p>−p>p>4p>. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

关键词： Cervical Elasticity Spontaneous preterm Birth Tactile Ultrasound probe

始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar定年的证据

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地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andrew todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIRO Energy 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Environment The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar定年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近EW向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar定年分析揭示,随着样品粒级减小,高温2M1型伊利石含量相对低温1M/1Md型伊利石含量逐渐减少,其K-Ar年龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar年龄是由碎屑2M1型和自生1M/1Md型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1M/1Md型伊利石的年龄为(42.6±9.4)Ma,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar定年始新世中期