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气功缓解物理治疗师职业倦怠的初步研究(英文)

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中西医结合学报 2012年第11期10卷 1233-1239页

作者： Joāo Pedro Saganha Christoph Doenitz tobias greten Thomas Efferth Henry J. greten Institute of Biomedical Sciences University of Porto German Society of Traditional Chinese Medicine Heidelberg School of Chinese Medicine Department of Pharmaceutical Biology Institute of Pharmacy and Biochemistry University of Mainz

目的:本研究探讨物理治疗师发生职业倦怠的普遍性,了解气功疗法是否可以有效地缓解这类情况,并为今后更深入的研究提供初步的数据。方法:物理治疗师们在试验前先完成一份人口调查问卷以及职业倦怠问卷,然后选择那些在最重要的量表维度... 详细信息

目的:本研究探讨物理治疗师发生职业倦怠的普遍性,了解气功疗法是否可以有效地缓解这类情况,并为今后更深入的研究提供初步的数据。方法:物理治疗师们在试验前先完成一份人口调查问卷以及职业倦怠问卷,然后选择那些在最重要的量表维度中显示职业倦怠水平最高的物理治疗师分为干预组和对照组。8个干预组成员需完成一个由海德堡中医学院研发的特定的气功介入,另外8个对照组成员则被排在等待名单中。在为期3周的治疗或等待后,再一次对两组人员进行职业倦怠问卷调查,并比较前后两次的结果。结果:对106个物理治疗师(36名男性,70名女性)的职业倦怠问卷结果显示,52人(49%)存在情绪疲劳,36人(33.9%)存在自我感觉丧失,33人(31.2%)成就感降低,而在这33人中有4人(3.8%)存在严重的工作倦怠情绪,29人(27.4%)则处于中等程度倦怠。气功治疗干预组的情绪疲劳分量表的平均值从38.0下降到31.4,而对照组的均值从33.9上升到37.9,两组数据差异具有统计学意义(P =0.023)。气功治疗使自我感觉丧失分量表的平均值从10.8降低到6.8,而在对照组中则从7.3上升到10.6,干预组与对照组之间的差异同样具有统计学意义(P =0.013)。关于成就感的分量表,两组数据之间的差异不明显。结论:气功可以有效改善职业倦怠的症状,此类气功是自我控制工作倦怠感的有效途径。每天仅需2次,每次5min的练习就能取得一定的效果。本次试验的结果也为今后进行更大范围的盲法、对照、随访试验设计奠定了基础。

关键词：气功厌倦,职业性物理治疗技术生物反馈试点项目

Quantification of Acupuncture Effects on Peripheral Neuropathy of Unknown and Diabetic Cause by Nerve Conduction Studies

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 312-314页

作者： Sven Schroeder Andrew Remppis tobias greten Frank Brazkiewicz Michael Morcos Henry Johannes greten Hamburg Center of Traditional Chinese Medicine Germany Heidelberg School of Chinese MedicineGermany German Society for TCMGermany Heidelberg School of Chinese Medicine Germany Dpt.of Internal Medicine ⅢUniversity Hospital of HeidelbergGermany German Society for TCMGermany German Society for TCM Germany Heidelberg School of Chinese Medicine Germany Bremen Institute of Traditional Chinese MedicineGermany German Society for TCMGermany Dpt.of Internal Medicine Ⅰ University Hospital of HeidelbergGermany Heidelberg School of Chinese Medicine Germany Instituto di Ciencas Biomedicas Abel SalazarUniversity of PortoDepartment of NeurophysiologyPortugal German Society for TCMGermany

Objective： To evaluate the effect of acupuncture on peripheral neuropathy （PN） as measured by changes in nerve conduction studies （NCS）. Methods： 192 patients with PN were evaluated over a period of 1 year. In 17 patients diabetic neuropathy was found. 3 of these patients received acupuncture therapy according to classical Chinese medicine as defined by the Heidelberg model of TCM and all improved in NCS. Of the 14 non-specifically treated patients, 3 （21.4%） presented with improved NCS and 11 （78.6%） aggravated in NCS （P〈0.03）. An overall of 47 patients met the criteria for PN of undefined aetiology, 21 patients received acupuncture therapy, while 26 patients received no specific treatment. All groups were examined by NCS before treatment and 4 months later. Results： 1） Diabetic neuropathy, in the control-group 3 patients improved and 11 showed an aggravation. Comparison of groups was significantly different. 2） PN, 16 patients （76.2%） in the acupuncture group improved, while only 4 patients in the control group （15.4%） did so. 3 patients in the acupuncture group （14.3%） showed no change and 2 patients an aggravation （9.5%）, whereas in the control group 7 patients showed no change （26.9%） and 15 an aggravation （57.7%）.Comparison of the groups was significantly different. Conclusion： There is a positive effect of acupuncture on PN, as measured by objective parameters （NCS）.

关键词： Acupuncture Therapy Diabetic Neuropathies Nerve Conduction

气功对学习横笛儿童焦虑和心理应激功能的影响(英文)

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中西医结合学报 2012年第8期10卷 858-865页

作者： Claudia Maria Sousa Mario Gonalves Jorge Machado Thomas Efferth tobias greten Petra Froeschen Henry J. greten Institute of Biomedical Sciences University of Porto German Society of Traditional Chinese Medicine Heidelberg School of Chinese Medicine Department of Pharmaceutical Biology Institute of Pharmacy and Biochemistry University of Mainz

目的:基于病例治疗,对气功疗效是否可以用生理测量指标和心理评分量化这一命题进行研究。方法:研究设计为前瞻性干预对照研究。气功组纳入8名儿童,接受为期7周的"白球"气功训练,每周2次,每次30min。对照组纳入8名儿童不接受气功训练。... 详细信息

目的:基于病例治疗,对气功疗效是否可以用生理测量指标和心理评分量化这一命题进行研究。方法:研究设计为前瞻性干预对照研究。气功组纳入8名儿童,接受为期7周的"白球"气功训练,每周2次,每次30min。对照组纳入8名儿童不接受气功训练。使用针对儿童的"抑郁、焦虑和压力量表"衡量焦虑的主观感受。此外,在研究开始和结束时分别测量两组儿童的唾液中皮质醇水平、心率变化、血压、斜方肌肌电图、反应时间等指标。结果:与对照组比较,气功组在心率指标方面显著降低。虽然在其他指标方面两组之间无显著差异,但是气功组在唾液中皮质醇水平、斜方肌肌电图及血压等指标方面的效应量更大。在焦虑主观感受、唾液中皮质醇水平和心率指标方面,气功组相对较低。结论:"白球"气功可以显著降低学习乐器表演的儿童的心率。基于本研究8/8的样本量,气功也有减轻焦虑和降低血压的作用。对于今后将要开展的量化气功疗效的研究,可以增大样本量,研究其他焦虑感增加的环境下年轻人的情况,设置合理的对照干预措施,解决设盲的问题,测量其他可能会受到气功治疗影响的指标,以及比较气功与其他可以降低焦虑的方法的疗效。

关键词：气功中医学说焦虑应激音乐可行性研究

Immunobiology and immunotherapy of HCC:spotlight on innate and innate-like immune cells

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Cellular & Molecular Immunology 2021年第1期18卷 112-127页

作者： Benjamin Ruf Bernd Heinrich Tim F.greten Gastrointestinal Malignancy Section Thoracic and Gastrointestinal Malignancies BranchCentre for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA NCI CCR Liver Cancer Program National Institutes of HealthBethesdaMD 20892USA

Immune-based therapies such as immune checkpoint inhibitors have revolutionized the systemic treatment of various cancer *** therapeutic application of monoclonal antibodies targeting inhibitory pathways such as programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)and CTLA-4 to cells of the adaptive immune system has recently been shown to generate meaningful improvement in the clinical outcome of hepatocellular carcinoma(HCC).Nevertheless,current immunotherapeutic approaches induce durable responses in only a subset of HCC *** immunologic mechanisms such as chronic inflammation due to chronic viral hepatitis or alcoholic and nonalcoholic fatty liver disease play a crucial role in the initiation,development,and progression of HCC,it is important to understand the underlying mechanisms shaping the unique tumor microenvironment of liver *** liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial,viral,and fungal antigens through the gut-liver ***,we summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target *** also discuss current immunotherapeutic strategies in HCC and outline recent advances in our understanding of how the therapeutic potential of these agents might be enhanced.

关键词： HCC immunotherapy innate immunity tumor microenvironment

Self-medication with nutritional supplements and herbal over-the-counter products

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Natural Products and Bioprospecting 2011年第2期1卷 62-70页

作者： Tolga EICHHORN Henry Johannes greten Thomas EFFERTH Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityStaudinger Weg 555128 MainzGermany Heidelberg School of Chinese Medicine Karlsruher Straße 1269126 HeidelbergGermanyand Biomedical Sciences Institute Abel SalazarUniversity of PortoPortugal

In recent years,the popularity increased for nutritional supplements and herbal *** drugs,but not herbal therapies are paid by health *** are sold over-the-counter(OTC)on the patients’own ***,there are potential risks of self-medication,*** self-diagnosis,severe adverse reactions,dangerous drug interactions,risk of addiction *** are often used by patients at their own discretion without knowledge of and control by their *** users are at risk of *** medications taken by older patients increase the risk for adverse drug reactions,drug-drug interactions,and compliance problems for this age group(polypharmacy).Herbals should be discontinued prior to operations to avoid interactions with anesthetics or *** preparations may also be carcinogenic or interfere with cancer *** women use various OTC ***,in many cases,it is unclear whether their use is safe for mother or ***-medication with herbals is also largely distributed among anxious and depressive patients,and patients with other conditions and *** popularity of herbal products has also brought concerns on quality,efficacy and *** of botanical misidentification,contaminations with heavy metals,pesticides,radioactivity,organic solvents,microbials as well as adulteration with chemical drugs necessitate the establishment of international quality control *** effects have been reported for more than 300 plant species,and some commonly used herbs have been demonstrated to interact with Western *** care professionals have a critical responsibility assessing the self-care ability of their *** are available for pharmacists with information on action,side effects and toxicities as well as herbdrug *** is a need for established guidelines regarding the correct use of nutritional supplements and herbal OTC pre

关键词： botanicals contamination complementary and alternative medicine drug interactions geriatric gynecology insomnia hepatotoxicity menopause nephrotoxicity over-the-counter pain phase I/II enzymes pharmacognosy pharmacovigilance phyto-chemicals phytotherapy phytovigilance quality control

Effectiveness of Acupuncture on Pain, Physical Function and Health-Related Quality of Life in Patients with Rheumatoid Arthritis: A Systematic Review of Quantitative Evidence

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Chinese Journal of Integrative Medicine 2019年第9期25卷 704-709页

作者： Susana Seca Diana Miranda Daniela Cardoso Bernice Nogueira Henry J.greten Antonio Cabrita Manuel Alves Rodrigues Faculty of Medicine University of CoimbraInstitute of Science Biomedicine Abel Salazar University of Porto Porto PortugalHeidelberg School of Chinese Medicine Heidelberg Germany Institute of Science Biomedicine Abel Salazar University of Porto Porto Portugal Health Sciences Research Unit:Nursing (UICISA: E) Nursing School of Coimbra (ESEnfC) Portugal Centre for Evidenee Based Practice: A Joanna Briggs Institute Centre of Excellence Coimbra Portugal School of Health Sciences Macao Polytechnic Institute Macao SAR China Institute of Science Biomedicine Abel Salazar University of PortoHeidelberg School of Chinese Medicine Heidelberg Germany Faculty of Medicine University of Coimbra Portugal Health Sciences Research Unit: Nursing (UICISA:E) Nursing School of Coimbra (ESEnfC)Portugal Centre for Evidence Based Practice: A Joanna Briggs Institute Centre of Excellence Portugal

Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). Methods: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials(RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included. Primary outcomes included pain, physical function and HRQoL. Secondary outcomes included morning stiffness, functional impairment, number of tender and swollen joints and serum concentrations of inflamatory markers. Methodological quality was assessed by three independent reviewers using the standardized critical appraisal instrument from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. Results: Twenty-two studies met the inclusion criteria. Of those, 9 studies were excluded after assessment of their methodological quality. The remaining 13 original RCTs included 974 patients. Ten of these studies published in China, showed favorable statistical significant effects of acupuncture in relieving symptoms of RA compared with controls. Conclusions: Evidence suggests that acupuncture interventions may have a positive effect in pain relief, physical function and HRQo L in RA patients. However, due to the heterogeneity and methodologic limitations of the studies included in this systematic review, evidence is not strong enough to produce a best practice guideline.

关键词： acupuncture rheumatoid arthritis quality of life pain physical function randomized clinical trial

Animal plant warfare and secondary metabolite evolution

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Natural Products and Bioprospecting 2013年第1期3卷 1-7页

作者： Steffen WÖLL Sun Hee KIM Henry Johannes greten Thomas EFFERTH Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg-UniversityMainzGermany Institute of Biomedical Sciences(ICBAS) University of PortoPortugal

The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of *** recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and *** a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal *** evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest *** a result of this selective pressure,animals developed special enzymes,*** P450 monooxigenases(CYP450)that metabolize xenobiotic *** a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as *** these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been *** evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays.

关键词： natural products phytochemicals liver metabolism cytochrome P450 monooxigenase ABC-transporter herbivore

Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第20期12卷 3275-3282页

作者： Lars A Ormandy Anatol Frber tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F greten Department of Gastroenterology Hepatology and Endocrinology Hannover Medical SchoolGermany Departments of Visceral and Transplantation Surgery Hannover Medical School Germany

AIM： To analyze the phenotype and function of dendritic cells （DC） from patients with hepatocellular carcinoma （HCC） in order to understand their role in this disease. METHODS： Myeloid dendritic cells were enumerated in peripheral blood of HCC patients. CD80, CD83, CD86 and HLA-DR expression on naive and stimulated myeloid dendritic cells from peripheral blood were analyzed. Myeloid dendritic cells were isolated from peripheral blood and their function was tested. Phagocytosis was analyzed using FITC-dextran beads, peptide specific stimulation, the capacity to stimulate allogeneic T cells and secretion of cytokines upon poly dZ：dC was tested. RESULTS： Myeloid dendritic cells were reduced in patients with HCC. No differences in CD80, CD83, CD86 and HLA-DR expression were found on naive and stimulated myeloid dendritic cells from HCC patients and healthy controls. Normal phagocytosis or stimulation of peptide specific T cells was observed in contrast to an impaired allo-stimulatory capacity and a reduced IL-12 secretion. CONCLUSION： Impaired IL-12 production of mDCs in patients could lead to an impaired stimulatory capacity of naive T cells suggesting that IL-12 directed therapies may enhance tumor specific immune responses in HCC patients.

关键词： Myeloid DC Hepatocellular carcinoma CD80 CD83 CD86

What is the Role of Chinese Medical Theory in Modern Scientific Research

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 259-260页

作者： Henry Johannes greten ICBAS Porto UniversityPortoPortugal Heidelberg School of Chinese Medicine and German Society for TCMHeidelbergGermany

Defining the classical Chinese diagnosis such as by the Heidelberg model of TCM has shown that outcome of studies is largely dependent on classical diagnostic criteria. The quality of future studies in TCM will largely depend on a variety of factors, such as （1） the classical Chinese diagnosis as an inclusion criterion, （2） objectively measurable parameters as the main criterion of outcome, （3） double blinding of controls. A common understanding of the diagnosis and functional criteria of TCM is therefore necessary, as well as a common understanding of the functional terminology and rationally accessible theory. This underlines the necessity of classical Chinese medical theory for modem scientific research, its proper definition and application in studies.

关键词： Traditional Medicine, Chinese Acuouncture-Moxibustion: Methods