Animal plant warfare and secondary metabolite evolution
动物植物战和次生代谢产物的演化作者机构：Department of Pharmaceutical BiologyInstitute of Pharmacy and BiochemistryJohannes Gutenberg-UniversityMainzGermany Institute of Biomedical Sciences(ICBAS)University of PortoPortugal
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2013年第3卷第1期
页 面：1-7页
学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 071001[理学-植物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学]
主 题：natural products phytochemicals liver metabolism cytochrome P450 monooxigenase ABC-transporter herbivore
摘 要：The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of *** recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and *** a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal *** evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest *** a result of this selective pressure,animals developed special enzymes,*** P450 monooxigenases(CYP450)that metabolize xenobiotic *** a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as *** these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been *** evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays.
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