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Incisional Negative Pressure Wound Therapy in the Prevention of Surgical Site Infection after Vascular Surgery with Inguinal Incisions: Rationale and Design of a Randomized Controlled Trial (INVIPS-Trial)

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Surgical Science 2015年第12期6卷 562-571页

作者： Julien Hasselmann tobias kühme Jonas Bjork Stefan Acosta Vascular Center Skane University HospitalMalmoSweden Division of Occupational and Environmental Medicine Lund UniversityLundSweden

Background/Aims: Inguinal incisions are a common route of access in vascular surgery. Due to anatomical challenges and a diverse bacterial flora in this area, surgical site infections (SSI) represent a common, debilitating and sometimes life-threatening complication. The INVIPS-Trial evaluates the role of Negative Pressure Wound Therapy (NPWT) on closed inguinal incisions in elective vascular surgery to prevent SSI and other wound complications. Methods: This randomized controlled trial (RCT) registered at *** (Identifier: NCT01913132) compares the effects of a NPWT dressing (PICO, Smith & Nephew, Uk) and the center’s standard wound dressing (Vitri Pad, ViTri Medical, Sweden) on postoperative wound complications, especially SSI. The study includes two distinct vascular procedures with different SSI risk profiles: endovascular aortic repair (EVAR) and open surgical approaches involving the common femoral artery (OPEN). Results: Four hundred ninety-five groin incisions in both treatment arms are anticipated to be included in the EVAR group and 147 inguinal incisions in both treatment arms in the OPEN group. Since a large percentage of inguinal vascular procedures in both groups but especially in the EVAR group are performed bilaterally, many patients can serve as their own control by randomly receiving NPWT on one and the standard dressing on the contralateral inguinal incision. Conclusions: This ongoing RCT attempts to elucidate the potential benefit of NPWT on closed inguinal incisions after different vascular procedures. Outcome and conclusions of this trial could have implications on postoperative wound care of patients in both vascular surgery and other surgical specialties.

关键词： Incisional Negative Pressure Wound Therapy Vascular Surgery Inguinal Incisions Surgical Site Infection Randomized Controlled Trial Research Design

Modularization of adhesion G protein-coupled receptor(aGPCR)structure:how alternative splicing regulates synaptogenesis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1793-1795页

作者： tobias Langenhan Rudolf Schönheimer Institute of Biochemistry Division of General BiochemistryMedical FacultyLeipzig UniversityLeipzigGermany Comprehensive Cancer Center Central Germany(CCCG) Leipzig UniversityLeipzigGermany Institute of Biology Faculty of Life SciencesLeipzig UniversityLeipzigGermany

A recent report has uncovered a fascinating aspect of how neurons utilize alternative splicing of transcripts of an adhesion G protein-coupled receptor(aGPCR)gene to serve specific functions in the life of a synapse.1 The work provides significant insight into the ability of cells to support distinct biochemical and physiological operations through post-transcriptional processing of genetic information that is encoded in a single aGPCR locus.

关键词： GPCR utilize operations

Extension of Flow Behaviour and Damage Models for Cast Iron Alloys with Strain Rate Effect

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 297-310页

作者： Chuang Liu Dongzhi Sun Xianfeng Zhang Florence Andrieux tobias Gersterc School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Fraunhofer Institute for Mechanics of Materials(IWM) 79108 FreiburgGermany Fraunhofer Institute for High Speed Dynamics Ernst-Mach-Institute(EMI)79104 FreiburgGermany

Cast iron alloys with low production cost and quite good mechanical properties are widely used in the automotive *** study the mechanical behavior of a typical ductile cast iron(GJS-450)with nodular graphite,uni-axial quasi-static and dynamic tensile tests at strain rates of 10^(-4),1,10,100,and 250 s^(-1)were carried *** order to investigate the influence of stress state on the deformation and fracture parameters,specimens with various geometries were used in the *** strain curves and fracture strains of the GJS-450 alloy in the strain rate range of 10^(-4)to 250 s^(-1)were obtained.A strain rate-dependent plastic flow model was proposed to describe the mechanical behavior in the corresponding strain-rate *** available damage model was extended to take the strain rate into account and calibrated based on the analysis of local fracture *** with the proposed plastic flow model and the damage model were conducted to observe the deformation and fracture *** results show that the strain rate has obviously nonlinear effects on the yield stress and fracture strain of GJS-450 *** predictions with the proposed plastic flow and damage models at various strain rates agree well with the experimental results,which illustrates that the rate-dependent plastic flow and damage models can be used to describe the mechanical behavior of cast iron alloys at elevated strain *** proposed plastic flow and damage models can be used to describe the deformation and fracture analysis of materials with similar properties.

关键词： Dynamic behavior of materials Strain rate dependency Damage model Voce model Cast iron

Transfer learning from synthetic data for open-circuit voltage curve reconstruction and state of health estimation of lithium-ion batteries from partial charging segments

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Energy and AI 2024年第3期17卷 80-97页

作者： tobias Hofmann Jacob Hamar Bastian Mager Simon Erhard Jan Philipp Schmidt Chair of Systems Engineering for Electrical Energy Storage University of BayreuthWeiherstraße 26Bayreuth95448BavariaGermany BMW Group Petuelring 130Munich80809BavariaGermany

Data-driven models for battery state estimation require extensive experimental training data,which may not be available or suitable for specific tasks like open-circuit voltage(OCV)reconstruction and subsequent state of health(SOH)*** study addresses this issue by developing a transfer-learning-based OCV reconstruction model using a temporal convolutional long short-term memory(TCN-LSTM)network trained on synthetic data from an automotive nickel cobalt aluminium oxide(NCA)cell generated through a mechanistic model *** data consists of voltage curves at constant temperature,C-rates between C/30 to 1C,and a SOH-range from 70%to 100%.The model is refined via Bayesian optimization and then applied to four use cases with reduced experimental nickel manganese cobalt oxide(NMC)cell training data for higher use *** TL models’performances are compared with models trained solely on experimental data,focusing on different C-rates and voltage *** results demonstrate that the OCV reconstruction mean absolute error(MAE)within the average battery electric vehicle(BEV)home charging window(30%to 85%state of charge(SOC))is less than 22 mV for the first three use cases across all *** SOH estimated from the reconstructed OCV exhibits an mean absolute percentage error(MAPE)below 2.2%for these *** study further investigates the impact of the source domain on TL by incorporating two additional synthetic datasets,a lithium iron phosphate(LFP)cell and an entirely artificial,non-existing,cell,showing that solely the shifting and scaling of gradient changes in the charging curve suffice to transfer knowledge,even between different cell chemistries.A key limitation with respect to extrapolation capability is identified and evidenced in our fourth use case,where the absence of such comprehensive data hindered the TL process.

关键词： Lithium-ion battery State of health estimation Transfer learning OCV curve Partial charging Synthetic data

Comparison of Air Pollution−Mortality Associations Using Observed Particulate Matter Concentrations and Reanalysis Data in 33 Spanish Cities

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Environment & Health 2024年第3期2卷 161-169页

作者： Dominic Roye Carmen Íñiguez Aurelio tobias Climate Research Foundation 28003 MadridSpainSpanish Consortium for Research on Epidemiology and Public Health(CIBERESP)28029 MadridSpain Institute of Environmental Assessment and Water Research(IDAEA) Spanish Council for Scientific Research(CSIC)08034 BarcelonaSpain

Air pollution poses a health hazard in all ***,complete data on ambient particulate matter(PM)concentrations are not available in all world *** data is already a valuable source of exposure data in epidemiological studies examining the relationship between temperature and ***,the performance of reanalysis data in assessing the short-term health effects of particulate air pollution remains *** assessed the performance of CAMS reanalysis(EAC4)data from the European Centre for Medium-Range Weather Forecasts,compared with daily PM concentrations from field monitoring stations,to estimate short-term exposure to PM with an aerodynamic diameter less than 10μm(PM_(10))on daily mortality in 33 Spanish provincial capital cities using a two-stage time series regression *** shape of the PM_(10)distribution varied substantially between PM observations and CAMS global reanalysis of atmospheric composition(EAC4)reanalysis data,with correlation ranging from 0.21 to *** pooled mortality risk for a 10μg/m^(3)increase in PM_(10)showed similar estimates using PM concentrations{relative risks(RR)=1.007,95%confidence intervals(95%CI)=[1.002,1.011]}and EAC4 reanalysis data(RR=1.011,95%CI=[1.006,1.015]).However,the city-specific PM_(10)beta coefficients estimated using PM concentrations and EAC4 reanalysis data showed a low correlation(r=0.22).The use of reanalysis data should be approached with caution when assessing the association between particulate matter air pollution and health outcomes,particularly in cities with small populations.

关键词： Air pollution particulate matter PM_(10) reanalysis EAC4 mortality Spain time series regression

Hyper spectral resolution stimulated Raman spectroscopy with amplified fs pulse bursts

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Light(Science & Applications) 2024年第3期13卷 566-576页

作者： Hongtao Hu tobias Flöry Vinzenz Stummer Audrius Pugzlys Markus Zeiler Xinhua Xie Aleksei Zheltikov Andrius Baltuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFEL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Quantum Science and Engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a novel approach for Stimulated Raman Scattering(SRS)spectroscopy in which a hyper spectral resolution and high-speed spectral acquisition are achieved by employing amplified offset-phase controlled fs-pulse *** investigate the method by solving the coupled non-linear Schrödinger equations and validate it by numerically characterizing SRS in molecular nitrogen as a model *** spectral resolution of the method is found to be determined by the inverse product of the number of pulses in the burst and the intraburst pulse *** SRS spectrum is obtained through a motion-free scanning of the offset phase that results in a sweep of the Raman-shift *** to high spectral resolution and fast motion-free scanning the technique is beneficial for a number SRS-based applications such as gas sensing and chemical analysis.

关键词： compound spectral resolution

Two-dimensional atomically thin Pt layers on MXenes: The role of electronic effects during catalytic dehydrogenation of ethane and propane

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Nano Research 2024年第3期17卷 1251-1258页

作者： Zhe Li tobias k.Misicko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao Ma Jeffrey T.Miller Daniela S.Mainardi Collin D.Wick Zhenhua Zeng Yang Xiao Yue Wu Department of Chemical and Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Institute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA Davidson School of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for Materials Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and Science Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 MXenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical *** compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and *** unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is *** is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst *** metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance MXene-supported metallic catalysts.

关键词： MXene catalysis alkane dehydrogenation nanolayers

The Structure of Gravity Funnels and Stability Considerations of Matter in SI Units

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 71-81页

作者： tobias Bartusch Bartusch Plasma and Vacuum Kissing Germany

This article describes an extension of the theory of vortices to electromagnetic types with a start point from known fluid systems. From this, properties of gravity-generating objects (particles and black holes) can be derived, which can also describe their possible interior. This also leads to questions about stability, which are then addressed and ultimately lead to considerations of black holes and their possible internal structure. The results fit into the observable areas and can also be directly verified because they were analytically calculated in SI units.

关键词： Black Hole Dark Matter Electromagnetic Gravity Singularity Vortex

A shoe-box-sized 3D laser nanoprinter based on two-step absorption

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Light(Advanced Manufacturing) 2024年第2期5卷 115-122页

作者： tobias Messer Michael Hippe Jingya(Lilyn)Gao Martin Wegener Institute of Applied Physics(APH) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Nanotechnology(INT) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany

State-of-the-art commercially available 3D laser micro-and nanoprinters using polymeric photoresists based on two-or multi-photon absorption rely on high-power pico-or femtosecond lasers,leading to fairly large and expensive ***,we have introduced photoresists based on two-step absorption instead of two-photon absorption,allowing for the use of small and inexpensive continuous-wave 405 nm wavelength GaN semiconductor laser diodes with light-output powers below 1 ***,using the identical photoresist system and similar laser diodes,we report on the design,construction,and characterization of a 3D laser nanoprinter that fits into a shoe *** shoe box contains all optical components,namely the mounted laser,the collimation-and beam-shaping optics,a miniature MEMS xy-scanner,a tube lens,the focusing microscope objective lens(NA=1.4,100×magnification),a piezo slip-stick z-stage,the sample holder,a camera monitoring system,LED sample illumination,as well as the miniaturized control electronics employing a *** present a gallery of example 3D structures printed with this *** achieve about 100 nm lateral spatial resolution and focus scan speeds of about 1 mm/***,our shoe-box-sized system can be made orders of magnitude less expensive than today’s commercial systems.

关键词： Two-step absorption Direct laser writing 3D laser nanoprinters Micro-electro-mechanical-systems scanner 3D nanostructures