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三羧酸循环在嗜铬细胞瘤和副神经节瘤中的相关研究进展

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中华内分泌代谢杂志 2018年第5期34卷 423-425页

作者：齐季瑛苏颋为上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病临床医学中心上海市内分泌代谢病研究所200025

在嗜铬细胞瘤和副神经节瘤（统称为PPGL）中，与三羧酸循环相关的基因发生突变，会导致三羧酸循环中间代谢产物水平紊乱，通过激活缺氧诱导因子（HIF）可引发假性缺氧应答，还会导致表观遗传变异、阻碍细胞分化和凋亡，共同促进PPGL发... 详细信息

在嗜铬细胞瘤和副神经节瘤（统称为PPGL）中，与三羧酸循环相关的基因发生突变，会导致三羧酸循环中间代谢产物水平紊乱，通过激活缺氧诱导因子（HIF）可引发假性缺氧应答，还会导致表观遗传变异、阻碍细胞分化和凋亡，共同促进PPGL发生和发展。本文综述了目前三羧酸循环在PPGL发生机制中的基础研究进展以及相关检测方法的应用。

关键词：嗜铬细胞瘤和副神经节瘤易感基因假性缺氧应答

Arterial stimulation with simultaneous venous sampling for localizing insulinomas

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Journal of Interventional Medicine 2018年第1期1卷 28-31页

作者： Zhiyuan Wu tingwei su Daming Wu Xiaoyi Ding Zhongmin Wang Wei Huang Ziyin Wang Qin Liu Hua Zhang Department of Interventional Radiology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine Department of Endocrinology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine the Department of Radiology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine

Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 males and 14 females(median age, 48.5y; range, 28–62y) with pathologically proven insulinomas were included in this study. Selective angiographies were performed with the superior mesenteric artery(SMA), gastroduodenal artery(GDA), proximal splenic artery, and midsplenic artery in all individuals. Then ASVS procedures were followed after angiographies for these arteries. Clinical characteristics of the patient and the tumor number, location, and size were recorded. The accuracy of preoperative localization of insulinomas was tested. Results: A total of 22 tumors were identified by histopathological diagnosis. The mean size of the tumor was 1.40±0.60 cm. Five tumors were in the head/neck region and 17 in the body/tail region. ASVS accurately localized 17/20(85%) cases with only biochemical data and 19/20(95%) cases with biochemical data and angiography images. Variant pancreatic arterial anatomy was revealed in 2 false cases with inferior pancreatic artery replaced by the superior mesenteric artery. Conclusion: ASVS was highly accurate in localizing insulinomas and should be performed in most of the patients with suspected insulinomas before the operation.

关键词： insulinomas arterial stimulation with simultaneous venous sampling localization diagnosis

Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Data from 52 cases from one institute over an eight-year period

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Neural Regeneration Research 2011年第28期6卷 2203-2210页

作者： Changyan Fan Xiuhua Shi Qingfang sun Liuguan Bian Weiguo Zhao Jiankang Shen Hua Zhang tingwei su Weiqing Wang Xiaoying Li Guang Ning Liang Kong Lingling Hu Department of Neurology Wuxi No. 3 People＇s Hospital Wuxi 241043 Jiangsu Province China Department of Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Endocrine and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

The present study analyzed data from 108 Cushing＇s disease patients, who underwent transsphenoidal surgery in one hospital between January 2003 and April 2010, to investigate the performance value of bilateral inferior petrosal sinus sampling （BIPSS）. Of the 108 patients 52 underwent BIPSS prior to surgery and 56 did not. Results showed that BIPSS accuracy for the diagnosis of Cushing＇s disease was 86.5% （45/52）, and accuracy for adenoma lateralization during surgery was 76.9% （40/52）. In addition, early remission rate was significantly greater compared to patients without BIPSS. Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing＇s disease and helped to predict adenoma lateralization.

关键词： bilateral inferior petrosal sinus Cushing's disease Cushing's syndrome pituitary adenoma transsphenoidal surgery

死刑案件法律援助律师准入标准的中美比较研究

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湖南警察学院学报 2023年第6期35卷 100-111页

作者：苏亭玮北京大学北京100871

2021年出台的《中华人民共和国法律援助法》首次规定了死刑案件法律援助律师的准入标准,为保障死刑案件法律援助的质量提供了重要的法律蓝本。然而,由于有效辩护理念缺位,程序职权主义色彩过浓,死刑控制方式单一,《中华人民共和国法律... 详细信息

2021年出台的《中华人民共和国法律援助法》首次规定了死刑案件法律援助律师的准入标准,为保障死刑案件法律援助的质量提供了重要的法律蓝本。然而,由于有效辩护理念缺位,程序职权主义色彩过浓,死刑控制方式单一,《中华人民共和国法律援助法》忽视了对法律援助律师辩护能力的规定。美国法的经验表明,法律援助律师的辩护能力是评价死刑案件法律援助律师是否适格的重要内容。为进一步完善我国死刑案件法律援助律师的准入标准,需要在立法层面细化准入条件、建立培训机制;激活程序性制裁,将一审审理程序中律师的辩护质量纳入二审的审查范围,并在辩护律师未能提供适格辩护时提供救济;完善死刑复核程序,引入诉讼主体参与诉讼程序,改造死刑复核程序的行政化构造。

关键词：法律援助准入标准有效辩护

Significance of Adrenocorticotropin Stimulation Test in determining the subtypes of primary aldosteronism

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Significance of Adrenocorticotropin Stimulation Test in dete...

Changes and influencing factors of parathyroid hormone in primary aldosteronism

中华医学会第十三次全国内分泌学学术会议

作者： shuwei Wang Yiran Jiang Cui Zhang tingwei su Weiwei Zhou Lei Jiang Wei Zhu Guang Ning Weiqing Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Second Medical University

Objective To evaluate the diagnostic accuracy of ACTH stimulation tests under 1-mg dexamethasone suppression(DST)in determining the subtypes of primary aldosteronism(PA).Patients and methods Ninety-nine patients with PA all confirmed by saline infusion test were included in the study,of which 35 patients were diagnosed as idiopathic hyperaldosteronism(IHA),35 as aldosterone-producing

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Changes and influencing factors of parathyroid hormone in pr...

顽固性低钠血症伴垂体肿瘤——不适当抗利尿激素分泌综合征一例

中华医学会第十二次全国内分泌学学术会议

作者： Cui Zhang Yiran Jiang tingwei su weiwei Zhou wei Zhu Wei Wei Xu Zhong Yanan Cao Bin Cui Guang Ning Weiqing Wang Department of Endocrine and Metabolic Diseases Ruijin HospitalShanghai Jiaotong University School of Medicine

Objective Primary aldosterone(PA) accompanied with an elevated serum parathyroid hormone(PTH) level,but if PTH level elevated in all subtypes of PA and what are main factors effect serum PTH level are *** study is to ...

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中华内分泌代谢杂志 2016年第12期32卷 1023-1026页

作者：苏颋为洪洁刘建民王卫庆上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病研究所上海市内分泌代谢病临床医学中心200025

57岁女性患者，因为垂体肿瘤手术后顽固性低钠血症人院评估，患者在应激剂量的糖皮质激素替代下，依旧存在明显的低钠血症。通过对患者血尿渗透压以及患者限制饮水后的各项临床指标的分析，发现患者限水500ml／d后血钠与尿酸水平逐渐升... 详细信息

57岁女性患者，因为垂体肿瘤手术后顽固性低钠血症人院评估，患者在应激剂量的糖皮质激素替代下，依旧存在明显的低钠血症。通过对患者血尿渗透压以及患者限制饮水后的各项临床指标的分析，发现患者限水500ml／d后血钠与尿酸水平逐渐升高，血压逐渐下降至正常，即使停止氢化可的松替代治疗依旧可以维持正常血钠水平。提示患者诊断为不适当抗利尿激素分泌综合征。患者接受垂体手术以及放疗，最终患者血钠水平在没有限水的情况下维持于正常范围。

关键词：不适当抗利尿激素分泌综合征低钠血症垂体肿瘤

右侧颊部红肿、疼痛2周——库欣综合征伴面部感染一例

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中华内分泌代谢杂志 2016年第3期32卷 245-247页

作者：苏颋为洪洁高一鸣王卫庆宁光上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病研究所上海市内分泌代谢病临床医学中心200025

61岁女性患者，因右侧面部红肿痛2周就诊。诊断为非促肾上腺皮质激素依赖性库欣综合征，右侧肾上腺肿瘤，右侧面部感染。经过抗感染、切开引流以及酮康唑治疗，患者临床表现得到控制。在药物治疗16个月后，患者接受右侧肾上腺肿瘤切除... 详细信息

61岁女性患者，因右侧面部红肿痛2周就诊。诊断为非促肾上腺皮质激素依赖性库欣综合征，右侧肾上腺肿瘤，右侧面部感染。经过抗感染、切开引流以及酮康唑治疗，患者临床表现得到控制。在药物治疗16个月后，患者接受右侧肾上腺肿瘤切除术获得治愈。病例提示在库欣综合征存在严重感染时，通过药物治疗降低患者皮质醇水平可能是较好的选择。

关键词：库欣综合征感染并发症

螺内酯单药治疗及低剂量螺内酯联合治疗特发性醛固酮增多症的有效性及安全性

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中华内分泌代谢杂志 2018年第6期34卷 479-484页

作者：蒋怡然张翠姜蕾苏颋为周薇薇王卫庆上海交通大学医学院附属瑞金医院内分泌代谢病科、上海市内分泌代谢病研究所、上海市内分泌代谢病临床医学中心 200025

目的比较螺内酯单药治疗及小剂量螺内酯联合治疗特发性醛固酮增多症（特醛症）的有效性及安全性。方法本研究为前瞻性、随机对照研究，经2周洗脱期后，48例特醛症随机分为螺内酯单药治疗及联合治疗组，观察16周血压达标率（血压〈140/90... 详细信息

目的比较螺内酯单药治疗及小剂量螺内酯联合治疗特发性醛固酮增多症（特醛症）的有效性及安全性。方法本研究为前瞻性、随机对照研究，经2周洗脱期后，48例特醛症随机分为螺内酯单药治疗及联合治疗组，观察16周血压达标率（血压〈140/90 mmHg, 1 mmHg＝0.133 kPa）及不良反应（男性乳房发育、肾功能不全及高钾血症）发生率。结果治疗16周，单药治疗组血压达标率为70.8%（17/24），联合治疗组血压达标率为95.8%（23/24），2组差异有统计学意义（P〈0.05）。2组治疗期间均无高钾血症发生。单药治疗组2例出现肾功能不全，5例出现男性乳房发育；而联合治疗组无肾功能不全及男性乳腺发育。结论小剂量螺内酯联合治疗在有效控制血压、血钾情况下，不增加肾功能不全及男性乳房发育等不良反应，可作为特醛症新一代治疗方案。

关键词：特发性醛固酮增多症螺内酯男性乳腺发育单药治疗联合治疗