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Journal of Forestry Research 2023年第3期34卷 677-691页

作者： Xiaoming Yang Qi Xu Linlin Le tingting zhou Wanwen Yu Guibin Wang Fang-Fang Fu Fuliang Cao Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037People’s Republic of China

Gingko biloba accumulates high levels of secondary metabolites of pharmaceutical *** calli develop a typical browning that reduces its regenerative capacity and thus its *** elucidate the browning mechanism,histological,transcriptomic,and metabolic alterations were compared between green and browning calli derived from immature ginkgo *** observations revealed that browning calli had a more loosely arranged cell structure and accumulated more tannins than in green *** metabolic and transcriptomic analyses showed that phenylpropanoid metabolism was specifi-cally activated in the browning calli,and 428 diff erentially expressed genes and 63 diff erentially abundant metabolites,including 12 fl avonoid compounds,were identifi ed in the browning calli compared to the green ***,the expression of fl avonol synthase(FLS)and UDP-glucuronosyl-transferase(UGT)genes involved in the fl avonoid pathway was more than tenfold higher in browning calli than in green calli,thus promoting biosynthesis of fl avonol,which serves as a substrate to form glycosylated fl *** glycosides constituted the major coloring component of the browning calli and may act in response to multiple stress conditions to delay cell death caused by *** results revealed the cellular and biochemical changes in browning callus cells that accompanied changes in expression of browning-related genes,providing a scientifi c basis for improving ginkgo tissue culturability.

关键词： Ginkgo Callus browning Histology Transcriptome Metabolite Flavonoid biosynthesis

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LBR基因低表达与甲状腺癌的相关性研究

现代实用医学 2024年第3期36卷 294-297,F0003页

作者：周婷婷翁一如叶恭杰宁波市医疗中心李惠利医院宁波315040

目的探讨LBR基因低表达与甲状腺癌的相关性。方法本研究利用TCGA大数据分析,探究LBR在甲状腺癌中的表达,并且寻找在不同亚型中的表达差异;通过甲基化、免疫浸润分析、免疫荧光和免疫组化等方法探讨LBR基因低表达在甲状腺癌发生及发展中... 详细信息

目的探讨LBR基因低表达与甲状腺癌的相关性。方法本研究利用TCGA大数据分析,探究LBR在甲状腺癌中的表达,并且寻找在不同亚型中的表达差异;通过甲基化、免疫浸润分析、免疫荧光和免疫组化等方法探讨LBR基因低表达在甲状腺癌发生及发展中的作用。结果本研究发现LBR在甲状腺癌中低表达,且在不同亚型中存在表达差异(P<0.05);ROC曲线分析显示LBR在甲状腺癌中有良好的诊断效能;通过甲基化分析发现LBR表达与启动子区两个甲基化位点均呈负相关(均P<0.05),免疫浸润分析发现LBR表达与嗜酸性粒细胞、辅助型T细胞及中央记忆型T细胞浸润均呈正相关(均P<0.05);此外,研究发现LBR与TP53存在共表达和共定位,提示LBR的抑癌作用或与TP53有关。结论LBR基因的低表达可能会促进甲状腺癌的发生及发展。

关键词：甲状腺癌 LBR基因低表达

Total syntheses of hyperaspidinols A and B enabled by a bioinspired diastereoselective cascade sequence

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Chinese Chemical Letters 2022年第2期33卷 885-889页

作者： Anquan Zheng tingting zhou Sasa Wang Wenge Zhang Xiuxiang Lu Huiyu Chen Haibo Tan Key Laboratory of Plant Resources Conservation and Sustainable Utilization Key Laboratory of South China Agricultural Plant Molecular AnalysisGuangdong Provincial Key Laboratory of Applied BotanySouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Guangxi Key Laboratory of Chemistry and Engineering of Forest Products Guangxi University for NationalitiesNanning 530006China University of Chinese Academy of Sciences Beijing 100049China

A bioinspired acid-triggered hemiacetalization/dehydration/[3 + 3]-type cycloaddition cascade process was disclosed, diastereoselectively furnishing furo[2,3-b]chromene skeleton under mild conditions. The viability of this approach was demonstrated by syntheses of a series of furo[2,3-b]chromene and pyrano[2,3-b]chromene derivatives. The successful total syntheses of two lignan-phloroglucinol hybrids,hyperaspidinols A and B, exemplified the synthetic utility of our biomimetic methodology.

关键词： Total synthesis Bioinspried Diastereoselective Cascade reaction Hyperaspidinol

Eu^(3+)-Bi^(3+)Codoping Double Perovskites for Single-Component White-Light-Emitting Diodes

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Energy Material Advances 2023年第1期4卷 175-184页

作者： Tianyuan Wang Donglei zhou Zhongzheng Yu tingting zhou Rui Sun Yuqi Wang Xiaomei Sun Yue Wang Yongzhi Shao Hongwei Song State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun130012China Cavendish Laboratory University of CambridgeCambridgeCB30HEUK

Double perovskites(DPs)with Cs_(2)AgInCl_(6) composition,as one of the lead-free perovskites,have been in the spotlight owing to their intriguing optical properties,namely,self-trapped exciton(STE)emission and dopant-induced ***,the current DPs still face the challenge of low photoluminescence efficiency and cannot be applied in ***,we synthesize the Bi^(3+)and Eu^(3+)codoped Cs_(2)AgInCl_(6) DPs,which displays enhanced STE and Eu^(3+)ions characteristic *** results indicate that the Eu^(3+)ions mainly substitute the In sites and can increase the radiative recombination rate and exciton binding energy of STEs,which is discovered that Eu^(3+)ions can promote the localization of STEs by breaking the inversion symmetry of the Cs_(2)AgInCl_(6) *** existence of Bi^(3+)ions decreases the excitation(absorption)energy,provides a new absorption channel,and increases the energy transfer rate to Eu^(3+)*** adjusting the Bi^(3+)and Eu^(3+)concentrations,a maximum photoluminescence quantum yield of 80.1%is obtained in 6%Eu^(3+)and 0.5%Bi^(3+)codoped Cs_(2)AgInCl_(6) ***,the high-quality single-component white-light-emitting diodes based on Bi^(3+)and Eu^(3+)codoped Cs_(2)AgInCl_(6) DPs and a 410-nm commercial ultraviolet chip are fabricated with the optimum color rendering index of 89,the optimal luminous efficiency of 88.1 lm/W,and a half-lifetime of 1,493 *** work puts forward an effective lanthanide and transition metals codoping strategy to design single-component white-light emitter,taking a big step forward for the application lead-free DPs.

关键词： perovskite doping rendering

以内生动力为导向的医学微生物学实验课程思政探索

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大学教育 2024年第1期 122-125页

作者：周婷婷彭云飞王越李冰艳南京医科大学康达学院江苏连云港222000 连云港市急救中心江苏连云港222000

文章深挖医学微生物学实验课程中的思政元素,以内生动力为导向,探索医学微生物学实验课程教学与思政教育有效融合的途径。在实验教学过程中,笔者从激发情感动力、树立正确挫折观、坚持守正创新、厚植爱国情怀四个方面开展思政教育,激发... 详细信息

文章深挖医学微生物学实验课程中的思政元素,以内生动力为导向,探索医学微生物学实验课程教学与思政教育有效融合的途径。在实验教学过程中,笔者从激发情感动力、树立正确挫折观、坚持守正创新、厚植爱国情怀四个方面开展思政教育,激发学生内在学习动力,以期实现知识传授、能力培养和素质教育相融合的教育目标,落实好立德树人根本任务。

关键词：内生动力医学微生物学实验课程思政立德树人

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老年营养风险指数联合肌少症指数预测腹膜透析患者预后的价值

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肾脏病与透析肾移植杂志 2024年第2期33卷 108-113页

作者：张志宏周婷婷成水芹余乐俞雨生东部战区总医院、国家肾脏疾病临床医学研究中心南京210016

目的:分析老年营养风险指数(GNRI)联合肌少症指数(SI)判断维持性腹膜透析(PD)患者预后的价值。方法:本文为单中心回顾性研究,基线截取2020年7月至2021年6月于国家肾脏疾病临床医学研究中心规律透析≥1年PD患者。利用体质量与血液生化指... 详细信息

目的:分析老年营养风险指数(GNRI)联合肌少症指数(SI)判断维持性腹膜透析(PD)患者预后的价值。方法:本文为单中心回顾性研究,基线截取2020年7月至2021年6月于国家肾脏疾病临床医学研究中心规律透析≥1年PD患者。利用体质量与血液生化指标分别计算GNRI和SI。经胸心脏超声测量左心室舒张末期内径(LVEDd)、后壁厚度(PWT)、室间隔厚度(IVST)。计算左心室质量(LVM)和左心室质量指数(LVMI)。完善螺旋CT和腹部侧位X线片检测,获得冠状动脉钙化评分(CACS)与腹主动脉钙化评分(AACS)。纳入对象随访至2023年7月,以全因死亡或PD技术失败定义复合事件。利用受试者曲线曲线下面积(AUC)比较GNRI联合SI判断预后价值。结果:296例PD患者年龄51.2±15.2岁,其中男性141例(47.6%),日间不卧床腹膜透析(DAPD)247例(83.4%),透析龄60.5±32.7月,总尿素清除指数(Kt/V)1.79±0.62,血清白蛋白水平37.4±4.1 g/L,GNRI 92.6±7.7,SI 0.77±0.22。单因素分析显示,GNRI(r=-0.26,P<0.01)和SI(r=-0.20,P=0.01)水平分别与CACS呈显著负相关,但与LVMI相关性均无统计学意义。随访发生复合事件196例(66.2%),其中死亡29例,转血液透析167例。多因素Logistic回归分析显示,标准蛋白分解率(nPCR)、LVMI及SI均是发生复合事件独立预测因素。AUC显示,GNRI与SI预测复合事件能力差异有统计学意义(AUC 0.70 vs 0.77,P<0.01),两者联合预测能力进一步提高(AUC 0.81,与两者比较均P<0.01)。结论:GNRI与SI均与PD患者冠状动脉钙化风险相关,SI是发生不良事件独立预测因素,两者联合预测不良事件能力显著提高。

关键词：腹膜透析老年营养风险指数肌少症指数

UI layers merger: merging UI layers via visual learning and boundary prior

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Frontiers of Information Technology & Electronic Engineering 2023年第3期24卷 373-387页

作者： Yunnong CHEN Yankun ZHEN Chuning SHI Jiazhi LI Liuqing CHEN Zejian LI Lingyun SUN tingting zhou Yanfang CHANG School of Software Technology Zhejiang UniversityHangzhou 310027China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Alibaba-Zhejiang University Joint Research Institute of Frontier Technologies Hangzhou 310027China Alibaba Group Hangzhou 311121China Zhejiang-Singapore Innovation and AI Joint Research Lab Hangzhou 310027China

With the fast-growing graphical user interface(GUI)development workload in the Internet industry,some work attempted to generate maintainable front-end code from GUI *** can be more suitable for using user interface(UI)design drafts that contain UI ***,fragmented layers inevitably appear in the UI design drafts,which greatly reduces the quality of the generated *** of the existing automated GUI techniques detects and merges the fragmented layers to improve the accessibility of generated *** this paper,we propose UI layers merger(UILM),a vision-based method that can automatically detect and merge fragmented layers into UI *** UILM contains the merging area detector(MAD)and a layer merging *** MAD incorporates the boundary prior knowledge to accurately detect the boundaries of UI ***,the layer merging algorithm can search for the associated layers within the components’boundaries and merge them into a *** present a dynamic data augmentation approach to boost the performance of *** also construct a large-scale UI dataset for training the MAD and testing the performance of *** results show that the proposed method outperforms the best baseline regarding merging area detection and achieves decent layer merging accuracy.A user study on a real application also confirms the effectiveness of our UILM.

关键词： User interface(UI)to code UI design lint UI layer merging Object detection

Isoflavones’effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats

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Journal of Pharmaceutical Analysis 2020年第6期10卷 571-580页

作者： Ruirui Chang Jialin Liu Yusha Luo Taohong Huang Qiang Li Jun Wen Weidong Chen tingting zhou School of Pharmacy Second Military Medical UniversityShanghai200433China School of Pharmacy Anhui University of Chinese MedicineHefei230031China Shimadzu China Co.LTD. Shanghai200233China d Shanghai Key Laboratory for Pharmaceutical Metabolite Research School of PharmacySecond Military Medical UniversityShanghai200433China

Gardeniae Fructus(GF)and Semen Sojae Praeparatum(SSP)are both medicine food homologies and widely used in Chinese clinical prescriptions *** research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats,which were administered with isolfavones from SSP for 7,14,21 and 28 consecutive days.A validated LC-MS/MS method was developed for determining shanzhiside,genipin-1-gentiobioside,geniposide and their metabolite genipin in rat *** samples were pretreated by solid-phase extraction using paeoniflorin as the internal *** chromatographic separation was performed on a Waters Atlantis T3(4.6 mm×150 mm,3 mm)column using a gradient mobile phase consisting of acetonitril and water(containing 0.06%acetic acid).The mass detection was under the multiple reaction monitoring(MRM)mode via polarity switching between negative and positive ionization *** calibration curves exhibited good linearity(r>0.997)for all *** lower limit of quantitation was in the range of 1 e10 ng/m *** intra-day and inter-day precisions(RSD)at three different levels were both less than 12.2%and the accuracies(RE)ranged fromà10.1%to 16.4%.The extraction recovery of them ranged from 53.8%to 99.7%.Pharmacokinetic results indicated the bioavailability of three iridoid glycosides and the metabolite,genipin in normal rats was higher than that in rats exposed to *** the longer time of administration of isoflavones,plasma concentrations of iridoids decreased,while genipin sulfate,the phase II metabolite of genposide and genipin-1-gentiobioside,appeared the rising *** pharmacokinetic profiles of main iridoids from GF were altered by isoflavones.

关键词： Iridoids Gardeniae fructus Isoflavones Rat Pharmacokinetics LC-MS/MS

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叶黄素合成关键基因及小麦生物强化研究展望

分子植物育种 2024年第13期22卷 4377-4383页

作者：庄文锋黎飞飞赵恒周婷婷刘超孔令让李安飞杨猛山东农业大学农学院作物生物学国家重点实验室泰安271018 山东省农业科学院作物研究所济南250100 山东省鲁粮集团有限公司济南250100

全球超过22亿人具有视力障碍,人们的视力健康面临着新的威胁。叶黄素是构成视网膜的黄斑色素,能够滤过蓝光,增强免疫力,是最有效、最有潜力的维护视力的物质。中国北方的人们主要以面食为主,叶黄素小麦能够让人们在吃主食的同时摄入叶黄... 详细信息

全球超过22亿人具有视力障碍,人们的视力健康面临着新的威胁。叶黄素是构成视网膜的黄斑色素,能够滤过蓝光,增强免疫力,是最有效、最有潜力的维护视力的物质。中国北方的人们主要以面食为主,叶黄素小麦能够让人们在吃主食的同时摄入叶黄素,免去单独补充保健品的昂贵费用,而且生物强化也是解决人类微量元素短缺问题的重要手段,所以选育富含叶黄素的小麦品种和提高小麦中叶黄素的含量显得尤为重要。本综述回顾了叶黄素的发现、结构以及功能,综述了叶黄素的测定方法、合成关键酶和基因及叶黄素小麦的选育,探讨了小麦叶黄素生物强化存在的问题及发展趋势,为今后叶黄素小麦产业发展提供参考,助力农业高质量发展。

关键词：小麦叶黄素生物强化

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河北省邢台市百泉泉域水资源供需平衡分析

水科学与工程技术 2024年第1期 1-3页

作者：陈平魏强王步新任春磊周婷婷河北省水利水电勘测设计研究院集团有限公司天津300220

为保证邢台市百泉泉域持续复涌,通过分析研究区域现状供、需水量情况,并预测该区域总需水量、地表水供水量、地下水供水量、非常规水和外调水量相关指标,定量分析水资源供需平衡。结果得出,上游水库的供水量可进一步置换泉域内生活、工... 详细信息

为保证邢台市百泉泉域持续复涌,通过分析研究区域现状供、需水量情况,并预测该区域总需水量、地表水供水量、地下水供水量、非常规水和外调水量相关指标,定量分析水资源供需平衡。结果得出,上游水库的供水量可进一步置换泉域内生活、工业、农业用水及补充下游河道生态用水,各县(市、区)地下水开采量仍较高,而地表水实际利用量相对与地表水可供水量仍较低。建议该区域减少地下水开采量,科学合理分配利用地表水。

关键词：百泉泉域水资源供需平衡分析