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Influence of severe neck angulation on hemodynamic and clinical outcomes following endovascular aneurysm repair:a hemodynamic analysis and a retrospective cohort study

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Chinese Medical Journal 2022年第21期135卷 2577-2584页

作者： Yang Liu Ming Qing Jichun Zhao Bin Huang Yi Yang tinghui zheng Ding Yuan Department of Vascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Applied Mechanics Sichuan UniversityChengduSichuan 610065China

Background: For patients with severe neck angulation (SNA), hemodynamic and clinical outcomes following endovascular aneurysm repair (EVAR) are still unclear. This study aimed to explore the influence of SNA on hemodynamic and clinical outcomes following ***: This study included a hemodynamic analysis and a retrospective cohort study from West China Hospital of Sichuan University between January 2011 and December 2020. The Cox regression model, inverse probability of treatment weighting (IPTW) analysis, sensitivity analysis, and subgroup analysis were applied. Primary outcome was type IA endoleak (T1AEL).Results: In this hemodynamic analysis, nine non-severe neck angulation (nSNA) and 16 SNA idealized models were constructed. We found a significant difference in drag force between SNA and nSNA models (7.016 ± 2.579 Nvs. 4.283 ± 1.460 N,P = 0.008), and proximal neck angles were significantly associated with the magnitude of drag force (F = 0.082 ×α-0.006 ×β + 2.818, α: 95% confidence interval [CI] 0.070-0.094;P = 0.001;β: 95% CI -0.019 to 0.007;P = 0.319). In our cohort study, 514 nSNA patients (71.5 ± 8.5 years;459 males) and 208 SNA patients (72.5 ± 7.8 years;135 males) were included, with a median follow-up duration of 34 months (16-63 months). All baseline characteristics were well balanced after IPTW matching. We found that SNA was associated with a significant risk of adverse limb event (hazard ratio [HR] 2.18, 95% CI 1.09-3.12), yet was not associated with T1AEL, overall survival, or reintervention. In patients without proximal or distal additional procedures (DAP), subgroup analyses suggested a significant risk of T1AEL (Proximal: HR 5.25, 95% CI 1.51-18.23;Distal: HR 5.07, 95% CI 1.60-16.07) and adverse limb event (Proximal: HR 2.27, 95% CI 1.01-5.07;Distal: HR 2.91, 95% CI 1.30-6.54) in SNA patients. However, no noticeable difference was observed in patients with proximal or ***: SNA has a critical influence on hemodynamic and clinical

关键词： Severe neck angulation Endovascular aneurysm repair Abdominal aortic aneurysm Treatment outcome Hemodynamics

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Thrombotic risk stratification of coronary aneurysms in Kawasaki disease patients:the study of morphology and hemodynamics

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Chinese Medical Journal 2022年第18期135卷 2253-2255页

作者： Haoyao Cao tinghui zheng Da Li Jing Liu Zhan Liu Liqing Peng Department of Applied Mechanics Sichuan UniversityChengduSichuan 610065China Sichuan University Yibin Park/Yibin Institute of Industrial Technology YibinSichuan 644000China Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:Coronary artery aneurysms(CAAs),one of the complications of Kawasaki disease(KD),can cause myocardial ischemia,infarction,and even sudden death.[1]Accurate thrombotic risk stratification in KD patients w... 详细信息

关键词： patients aneurysm coronary

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Design and mechanical properties testing of a new cross-helical popliteal artery stent

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Medicine in Novel Technology and Devices 2021年第3期11卷 210-216页

作者： Yuanxing Dai Hongrui Hu Jiarong Wang Ding Yuan tinghui zheng Department of Applied Mechanics Sichuan UniversityChengdu610065China Department Vascular Surgery of West China Hospital Sichuan UniversityChengdu610041China

The popliteal artery has complex deformations such as axial shortening,bending,squeezing and twisting,as well as specific positions across the knee *** to now there is a high incidence of in-stent restenosis(ISR)after the stent treatment of the popliteal *** paper aimed to design a new type of popliteal artery stent–crosshelical *** meet its deformation *** finite element analysis(FEA)method was used to test the mechanical properties of six stents with different winding height ratios of axial shortening,bending,plate extrusion,and torsional *** results showed that the stents performance was affected by the ratio of winding height,the larger the winding height ratio,the worse the compliance,the worse the axial compressibility,but the better the radial *** when the stent is torsional,the greater the winding height ratio is,the greater the stress *** additon,the maximum stress was also related to the direction of torsion deformation,and the stress when the helix has the same direction with the torsion direction of the stent are was greater than that when the helix direction and torsion direction are ***,when the winding height ratio is 3:5,the performance of the stent is better,not only has better flexibility,its radial force,axial compression,and torsional deformation are *** is concluded that the new cross-helical stent can adapt to the special deformation of popliteal artery and has good mechanical properties.

关键词： Popliteal artery Stent design Finite element analysis helical stent

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Effect of grain boundary diffusion of terbium on mode of mechanical fracture of sintered NdFeB magnets

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Journal of Rare Earths 2024年第4期42卷 696-704页

作者： Zexin Lu tinghui Wang Jianjun Jiang Bizhang zheng Lijing Yang Xingqi He Anli Lin Shengzhi Dong Zhenlun Song CAS Key Laboratory of Magnetic Materials and Devices Zhejiang Province Key Laboratory of Magnetic Materials and Application TechnologyNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China Faculty of Mechanical Engineering and Mechanics Ningbo UniversityNingbo315211China Ningbo Xinqi Precision Magnetism Steel Co. Ltd..Ningbo315156China Center for Advanced Measurement Science National Institute of MetrologyBeijing102200China Division of Functional Materials Central Iron&Steel Research InstituteBeijing100081China

Grain boundary diffusion process(GBDP)is a widely used method of increasing the coercivity of sintered NdFeB *** this study,the effects of the GBDP on the bending strength and microhardness of sintered NdFeB magnets and the fracture mode were *** show that the bending strength of magnets is reduced by pickling and heat treatment and greatly recove rs after heavy rare earth element(Tb)grain boundary *** pickling and the heat treatment cause a slight decrease in *** with the recovery of the bending strength,the hardness decreases after the *** fracture mode of bended magnets changes from intergranular to *** study helps in further improving the mechanical and magnetic properties of sintered NdFeB magnets.

关键词： Sintered NdFeB magnets Grain boundary diffusionprocess Bending strength Heavy rare earth element Coercivity

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Analysis of aortic wall stress and morphology in patients with type B aortic dissection

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Medicine in Novel Technology and Devices 2021年第3期11卷 176-181页

作者： Hongrui Hu Zhan Liu Guoxin Chen Ding Yuan tinghui zheng Department of Applied Mechanics Sichuan UniversityChengdu610065China Department Vascular Surgery of West China Hospital Sichuan UniversityChengdu610041China

Risk assessment is critical in preventing aortic dissection(AD).This study aims to evaluate the wall stress(WS)distribution,especially at the locations of proximal tears in patient-specific type-B aortic dissection(TBAD)to explore the pathogenesis of *** addition,the shape of the aortas were assessed and associated with TBAD *** this paper,30 three-dimensional models were reconstructed based on patient-specific CT angiography images,and finite element analysis(FEA)was used to analyze the admission blood *** addition,the anatomic variables including the head vessel angles,the aorta diameters,curvatures and torturosity ware *** occurred at either local high WS or low WS region,and these acute TBAD patients can be classified into three groups based on the location of initial intimal *** addition,the WS values at tear sites of each group showed significant difference(P<0.001).Moreover,the angles of the left subclavian and brachiocephalic arteries were statistical different among three *** wall stress or decreased wall strength both contribute to the pathogenesis of aortic *** addition,abnormal head vessel angles may be monitored as an important risk factor for aortic dissection,and its specific features may further help to determine the potential tear location.

关键词： Aortic dissection Finite element analysis Tear localization Aortic morphology

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A computational fluid study on hemodynamics in visceral arteries in a complicated type B aortic dissection after thoracic endovascular repair

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Medicine in Novel Technology and Devices 2021年第1期9卷 45-51页

作者： Kaihong Wang Da Li Ding Yuan Jichun Zhao tinghui zheng Yubo Fan Department of Applied Mechanics Sichuan UniversityChengduSichuan610065China Department Vascular Surgery of West China Hospital Sichuan UniversitySichuanChengdu610041China Beijing Advanced Innovation Center of Biomedical Engineering Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China

Objective:To report a numerical research on the effect of a renal artery arising from false lumen(FL)on the treatment outcome of thoracic endovascular repair(TEVAR)for complicated type B aortic dissection(TBAD).Methods:The original patient-specific model with the right renal artery(RRA)partially supplied by the FL(TFM)was reconstructed from its postoperative computed tomography *** additional models were reconstructed by artificially modifying the RRA either fully arising from the FL(CFM)or true lumen(CTM).Computational fluid dynamics(CFD)simulations were ***:First,for all the models,the flow splits to all the visceral arteries were much less than those of a healthy ***,the flow split to RRA in the CFM and in CTM was the least and largest ***,in TFM,the pressure gradient between the true lumen(TL)and FL was negative at the proximal FL and the entire FL was full of active blood *** the contrast,in CTM and CFM,the pressure differences between the two lumens remained positive and little flow was present in ***,both TL and proximal FL of this particular patient expanded and the diameters of all visceral arteries decreased at one-year ***:Compared to a healthy aorta,a renal artery arising from FL following TEVAR would result in severe visceral ischemia including RA and superior mesenteric artery(SMA).In addition,our numerical simulation of the postoperative hemodynamics of this particular patient perfectly matched with its TL remodeling,FL expansion and contraction of the visceral arteries at one-year follow-up,and a patient-specific CFD simulation may be adopted to obtain information on visceral perfusion after endovascular repair for TBAD patients.

关键词： Aortic dissection Thoracic endovascular repair False lumen Visceral ischemia Computational fluid dynamics

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Influence of aortic branch arteries on the hemodynamics of patient-specific type B aortic dissection following TEVAR

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Medicine in Novel Technology and Devices 2019年第4期4卷 31-37页

作者： Yi Jiang Yue Qiu Da Li Ding Yuan tinghui zheng Liqing Peng Department of Applied Mechanics Sichuan UniversityChengdu610041China Department of Vascular Surgery West China HospitalSichuan UniversityChengdu610041China

Objective:Because of the difficulty in obtaining patient specific flow data,branch arteries are often neglected in the flow simulations of a patient-specific type B aortic dissection(AD)following thoracic endovascular repair(TEVAR).This study aims to investigate the influence of the aortic branch arteries on the hemodynamics and physical flow phenomena commonly associated with aortic modeling of an AD after ***:The three-dimensional geometry of a type B AD following TEVAR was generated from a high-quality CT *** were performed with all branch arteries,without the four visceral arteries of the abdominal aorta(FVAoAA),and without the upper three branches of the aortic arch(UTBoAA).Results:The removal of the UTBoAA has marginal effect on the flow patterns and hemodynamic parameters in the false lumen(FL);however,regardless of whether there are aorta branches supplied to the FL or not,the omission of FVAoAA will result in a wrong prediction of the flow direction at tears and flow volume to the ***:The omission of aorta branch arteries has great impact on the hemodynamic prediction including flow field and wall shear stress related parameters in a type B AD after TEVAR,which may induce misleading estimates of the potential thrombus in the *** is strongly recommended to keep aorta branches in the computational model to predict the post-operative hemodynamic performance in a type B AD following TEVAR.

关键词： Computational fluid dynamics Aortic dissection Wall shear stress Branch arteries

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Hemodynamics in renal arteries with partial coverage after endovascular aneurysm repair affected by renal orientations

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Medicine in Novel Technology and Devices 2023年第2期18卷 81-90页

作者： Jun Wen Xinhui Liu Jianguo Lei Jiarong Wang Xiyang Chen tinghui zheng Ding Yuan School of Computer Science and Technology Southwest University of Science and TechnologyMianyang621010China Institute of Civil Engineering and Architecture Southwest University of Science and TechnologyMianyang621010China Department of Vascular Surgery West China HospitalSichuan UniversityChengdu610041China Department of Applied Mechanics Sichuan UniversityChengdu610000China

Endovascular aortic repair(EVAR)has been increasingly used to treat abdominal aortic aneurysm(AAA)due to its lower mortality and shorter recovery ***,the complications caused by renal artery coverage remained a major *** this study,three types of renal orientation and five types of partial renal coverage degree were adopted to numerically investigate the flow pattern,wall shear stress distribution,and blood perfusion during a cardiac *** results show that as for the mild partial coverage(=<30%),the renal artery with a downward orientation suffered fewer unfavorable wall shear stress(WSS)distribution and more blood *** should be noted that the renal artery with horizontal orientation suffered more unfavorable WSS *** terms of severe coverage(≥50%),all of the renal arteries displayed highly disturbed wall shear distribution,resulting in a significant reduction in blood perfusion It was interesting to note that the artery with an upward orientation had a smaller rate of reduction in blood *** can be concluded that as for the mild renal coverage after EVAR,renal arteries with downward orientation may have the advantage of reducing the possibility of renal occlusion,while renal arteries with horizontal orientation may increase the unfavorable wall shear *** the other hand,as for serious coverage(≥50%),high risk of renal ischemia remains the main concern for all types of renal arteries due to highly disturbed wall shear distribution would significantly increase regardless of renal orientation.

关键词： Hemodynamics Orientation Follow-up Numerical simulation Renal artery

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串列双圆柱尾迹流的数值分析

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西南交通大学学报 2008年第6期43卷 747-750,798页

作者：郑庭辉费宝玲杨骏六 Tang S K 四川大学建筑与环境学院四川成都610065 香港理工大学屋宇建筑设备系中国香港Hong Hom

为避免流体流动引起共振,采用有限体积法,对串列双圆柱尾迹流进行了数值分析,探讨了斯特劳哈尔数(Strouhal数)随圆柱间距比和雷诺数变化的规律.研究表明:在不同流场形态下,斯特劳哈尔数随圆柱间距比的变化规律不同;斯特劳哈尔数随雷诺... 详细信息

为避免流体流动引起共振,采用有限体积法,对串列双圆柱尾迹流进行了数值分析,探讨了斯特劳哈尔数(Strouhal数)随圆柱间距比和雷诺数变化的规律.研究表明:在不同流场形态下,斯特劳哈尔数随圆柱间距比的变化规律不同;斯特劳哈尔数随雷诺数的增大而增大,但增大幅度与流场形态有关.

关键词：圆柱绕流斯特劳哈尔数(Strouhal数) 涡脱落

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Influence of morphology and hemodynamics on thrombosis in kawasaki disease patients

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Medicine in Novel Technology and Devices 2023年第2期18卷 91-101页

作者： Haoyao Cao Zhuxiang Xiong Zhan Liu Yan Li Huaxia Pu Jing Liu Liqing Peng tinghui zheng Department of Mechanics Sichuan UniversityChengdu610065China Sichuan University Yibin Park Yibin Institute of Industrial TechnologyYibin644000China Department of Radiology West China HospitalSichuan UniversityChengdu610041China Med-X Center for Informatics Sichuan UniversityChengdu610041China

Kawasaki Disease(KD)patients with co-occurrent coronary artery aneurysms(CAAs)are prone to *** study explores the thrombotic influence of morphology and hemodynamics in KD patients with ***-specific computed tomography angiogram images of 9 patients were used to rebuild coronary models(including 23 aneurysms;10 in thrombosed group,and 13 in non-thrombosed group)and perform computational simulations to obtain the hemodynamic *** thrombosed and non-thrombosed groups were compared in terms of six parameters,namely,the maximum diameter(D_(max)),aspect ratio(R_(l/d)),shape,time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and relative residence time(RRT).The results showed that:(1)In thrombosed aneurysms,there were several vortex structures(eddy zone),of which the position changed continuously in a cardiac *** non-thrombosed aneurysms,the streamlines showed a large streaming zone.(2)Abnormal hemodynamic areas of aneurysms with thrombosis tended to appear in the same region(especially the proximal and near myocardial side of aneurysms).(3)In the non-thrombosed group,there was a correlation between the morphological and hemodynamic *** thrombosed aneurysms,the flow pulsatility has a significant impact on the flow *** thrombosed coronary aneurysms exhibited more risk factors and the co-location of hemodynamic abnormalities was consistent with the position of thrombosis.A score of risk factors could provide the thrombotic information of coronary aneurysms,which might be helpful for long-term clinical management of KD patients.

关键词： Coronary artery aneurysms Kawasaki disease Thrombotic risk stratification Morphology Hemodynamics

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