Influence of morphology and hemodynamics on thrombosis in kawasaki disease patients
作者机构：Department of MechanicsSichuan UniversityChengdu610065China Sichuan University Yibin ParkYibin Institute of Industrial TechnologyYibin644000China Department of RadiologyWest China HospitalSichuan UniversityChengdu610041China Med-X Center for InformaticsSichuan UniversityChengdu610041China
出 版 物：《Medicine in Novel Technology and Devices》 (医学中新技术与新装备（英文）)
年 卷 期：2023年第18卷第2期
页 面：91-101页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China the Key Research&Development Project of Science and Technology of Sichuan Province[2021YFS0142] 1⋅3⋅5 project for disciplines of excellence,West China Hospital,Sichuan University[ZYGD18013]
主 题：Coronary artery aneurysms Kawasaki disease Thrombotic risk stratification Morphology Hemodynamics
摘 要：Kawasaki Disease(KD)patients with co-occurrent coronary artery aneurysms(CAAs)are prone to *** study explores the thrombotic influence of morphology and hemodynamics in KD patients with ***-specific computed tomography angiogram images of 9 patients were used to rebuild coronary models(including 23 aneurysms;10 in thrombosed group,and 13 in non-thrombosed group)and perform computational simulations to obtain the hemodynamic *** thrombosed and non-thrombosed groups were compared in terms of six parameters,namely,the maximum diameter(D_(max)),aspect ratio(R_(l/d)),shape,time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and relative residence time(RRT).The results showed that:(1)In thrombosed aneurysms,there were several vortex structures(eddy zone),of which the position changed continuously in a cardiac *** non-thrombosed aneurysms,the streamlines showed a large streaming zone.(2)Abnormal hemodynamic areas of aneurysms with thrombosis tended to appear in the same region(especially the proximal and near myocardial side of aneurysms).(3)In the non-thrombosed group,there was a correlation between the morphological and hemodynamic *** thrombosed aneurysms,the flow pulsatility has a significant impact on the flow *** thrombosed coronary aneurysms exhibited more risk factors and the co-location of hemodynamic abnormalities was consistent with the position of thrombosis.A score of risk factors could provide the thrombotic information of coronary aneurysms,which might be helpful for long-term clinical management of KD patients.
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