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An underdamped and delayed tri-stable model-based stochastic resonance

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Chinese Physics B 2024年第1期33卷 280-286页

作者：靳艳飞王昊天张婷婷 Department of Mechanics Beijing Institute of TechnologyBeijing 100081China

Stochastic resonance(SR) is investigated in an underdamped tri-stable potential system driven by Gaussian colored noise and a periodic excitation, where both displacement and velocity time-delayed states feedback are considered. It is challenging to study SR in a second-order delayed multi-stable system analytically. In this paper, the improved energy envelope stochastic average method is developed to derive the analytical expressions of stationary probability density(SPD)and spectral amplification. The effects of noise intensity, damping coefficient, and time delay on SR are analyzed. The results show that the shapes of joint SPD can be adjusted to the desired structure by choosing the time delay and feedback gains. For fixed time delay, the SR peak is increased for negative displacement or velocity feedback gain. Meanwhile, the SR peak is decreased while the optimal noise intensity increases with increasing correlation time of noise. The Monte Carlo simulations(MCS) confirm the effectiveness of the theoretical results.

关键词： stochastic resonance underdamped tri-stable system spectral amplification time-delayed feedback

Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta‑hydroxylase deficiency

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World Journal of Pediatrics 2024年第4期20卷 422-433页

作者： Wen‑Li Lu Xiao‑Yu Ma Jiao zhang Jun‑Qi Wang ting‑ting zhang Lei Ye Yuan Xiao Zhi‑Ya Dong Wei Wang Shou‑Yue Sun Chuan‑Yin Li Rong‑Gui Hu Guang Ning Li‑Dan zhang Department of Pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin 2nd RdHuangpu DistrictShanghai 200025China Department of Pediatric Genetic and Metabolic Endocrinology West China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadSichuan 610041China Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Cancer Center School of MedicineShanghai Tenth People’s HospitalTongji UniversityYanchang Zhong Lu 301St RdJing’an DistrictShanghai 200031China

Background The clinical manifestations of nonclassical 11beta-hydroxylase deficiency are very similar to those of nonclassical 21-hydroxylase *** this study,we investigated the relationship between the clinical and molecular features of congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency and reviewed the related literature,which are expected to provide assistance for the clinical diagnosis and analysis of congenital adrenal *** Clinical data for 10 Chinese patients diagnosed with congenital adrenal hyperplasia in our hospital from 2018 to 2022 were retrospectively *** examined the effects of gene mutations on protease activity and constructed threedimensional structure prediction models of *** We describe 10 patients with 11beta-hydroxylase gene mutations(n=5,46,XY;n=5,46,XX),with 10 novel mutations were *** patients received treatment at an early stage,with an average age of 2.08±1.66 years,whereas male patients received treatment significantly later,at an average age of 9.77±3.62 *** most common CYP11B1 pathogenic variant in the Chinese population was found to be c.1360C>*** mutations lead to spatial conformational changes that affect protein *** Our study found that there was no significant correlation between each specific mutation and the severity of clinical *** patients with the same gene pathogenic variant may have mild or severe clinical *** correlation between genotype and phenotype needs further ***-dimensional protein simulations may provide additional support for the physiopathological mechanism of genetic mutations.

关键词： 11β-hydroxylase deficiency CYP11B1 Enzymatic activity Phenotype-genotype correlation Threedimensional protein simulations

Pathological process of liver sinusoidal endothelial cells in liver diseases

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World Journal of Gastroenterology 2017年第43期23卷 7666-7677页

作者： yao ni juan-mei li ming-kun liu ting-ting zhang dong-ping wang wen-hui zhou ling-zi hu wen-liang lv Department of Infection Guang’anmen HospitalChina Academy of Chinese Medical Sciences

Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and cirrhosis involve excess production of extracellular matrix,which is closely related to liver sinusoidal endothelial cells(LSECs). Damaged LSECs can synthesize transforming growth factor-beta and platelet-derived growth factor,which activate hepatic stellate cells and facilitate the synthesis of extracellular matrix. Herein,we highlight the angiogenic cytokines of LSECs related to liver fibrosis and cirrhosis at different stages and focus on the formation and development of liver fibrosis and cirrhosis. Inhibition of LSEC angiogenesis and antiangiogenic therapy are described in detail. Targeting LSECs has high therapeutic potential for liver diseases. Further understanding of the mechanism of action will provide stronger evidence for the development of anti-LSEC drugs and new directions for diagnosis and treatment of liver diseases.

关键词： Sinusoidal endothelial cells Hepatitis Fibrosis Cirrhosis Liver disease

Synergistic effects of three traditional herbs green tea,mulberry leaf and corn silk on glucose uptake level of L6 myoblasts and the hypoglycemic mechanism

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Traditional Medicine Research 2024年第7期9卷 1-12页

作者： Jing-Na Zhou Ming-Yue Li ting-ting zhang Jing-Yang Lu Min zhang Peng-Wei Zhuang Hai-Xia Chen Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China. School of Food Science and Bioengineering Tianjin Agricultural UniversityTianjin 300384China. State Key Laboratory of Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China. Haihe Laboratory of Modern Chinese Medicine Chinese Materia Medica CollegeTianjin University of Traditional Chinese MedicineTianjin 301617China.

Background:Green tea,mulberry leaf and corn silk are traditional herbs used in the prevention and treatment of diabetes in China for a long time,but their synergistic hypoglycemic effects and mechanisms remain ***:The effective components of green tea,mulberry leaf and corn silk were extracted and *** design of experiments was used to study the influences of different combinations on the cell viability and glucose uptake level of L6 myoblasts,so as to determine the optimal synergistic hypoglycemic *** possible hypoglycemic mechanism of the optimal synergistic combination was explored by cytotoxicity assay,glucose uptake assay,and western ***:Three polyphenol enrichment fractions of the herbs,30%ethanol elution fraction of green tea(GT),50%ethanol elution fraction of mulberry leaf(ML)and 60%ethanol elution fraction of corn silk(CS)were *** antioxidant activities of GT-30%,ML-50%and CS-60%were superior to those of crude extracts,and showed strong potential inα-amylase andα-glucosidase inhibition *** optimal synergistic combination of crude extracts G7(crude extract of green tea:crude extract of mulberry leaf:crude extract of corn silk=1:5:3),polyphenol enrichment fractions R3(GT-30%:ML-50%:CS-60%=1:7:1)and monomers X2(epigallocatechin gallate:morusin:formononetin=3:1:2)were selected,respectively.G7,R3,and X2 showed promoting effects on the cell viability and glucose uptake of L6 myoblasts within the detected concentration *** addition,G7,R3,and X2 could increase the expression levels of p-PI3K/PI3K and p-Akt/Akt in L6 myoblasts,and promote the translocation of Glut4,but G7 and R3 showed more significant ***:The synergistic hypoglycemic effects of green tea,mulberry leaf and corn silk had the characteristics of multiple-components and multiple-targets with p-PI3K/PI3K,p-Akt/Akt and the translocation of Glut4 signal pathways *** three traditional herbs might have the potential

关键词： green tea mulberry leaf corn silk synergistic effect type 2 diabetes mellitus mechanism

An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in

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Neuroscience Bulletin 2023年第5期39卷 793-807页

作者： ting-ting zhang Su-Shan Guo Hui-Ying Wang Qi Jing Xin Yi Zi-Han Hu Xin-Ren Yu Tian-Le Xu Ming-Gang Liu Xuan Zhao Department of Anesthesiology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghai 200025China Center for Brain Science of Shanghai Children's Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China

Itch is an unpleasant sensation that provokes the desire to *** acute itch serves as a protec-tive system to warn the body of external irritating agents,chronic itch is a debilitating but poorly-treated clinical dis-ease leading to repetitive scratching and skin ***-ever,the neural mechanisms underlying the pathophysiol-ogy of chronic itch remain ***,we identified a cell type-dependent role of the anterior cingulate cortex(ACC)in controlling chronic itch-related excessive scratch-ing behaviors in ***,we delineated a neural circuit originating from excitatory neurons of the ACC to the ventral tegmental area(VTA)that was critically involved in chronic ***,we demonstrate that the ACC→VTA circuit also selectively modulated histaminergic acute ***,the ACC neurons were shown to predomi-nantly innervate the non-dopaminergic neurons of the *** together,our findings uncover a cortex-midbrain cir-cuit for chronic itch-evoked scratching behaviors and shed novel insights on therapeutic intervention.

关键词： sAnterior cingulate cortex Chronic itch Ventral tegmental area-Chemogenetics Neural circuit

Genetic structure,gene flow pattern,and association analysis of superior germplasm resources in domesticated upland cotton(Gossypium hirsutum L.)

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Plant Diversity 2020年第3期42卷 189-197页

作者： ting-ting zhang Na-Yao zhang Wei Li Xiao-Jian Zhou Xiao-Yu Pei Yan-Gai Liu Zhong-Ying Ren Kun-Lun He Wen-Sheng zhang Ke-Hai Zhou Fei zhang Xiong-Feng Ma Dai-Gang Yang Zhong-Hu Li Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationCollege of Life SciencesNorthwest UniversityXi'an710069China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyang455000China

Gene flow patterns and the genetic structure of domesticated crops like cotton are not well ***,marker-assisted breeding of cotton has lagged far behind that of other major crops because the loci associated with cotton traits such as fiber yield and quality have scarcely been *** this study,we used 19 microsatellites to first determine the population genetic structure and patterns of gene flow of superior germplasm resources in upland *** then used association analysis to identify which markers were associated with 15 agronomic traits(including ten yield and five fiber quality traits).The results showed that the upland cotton accessions have low levels of genetic diversity(polymorphism information content=0.427),although extensive gene flow occurred among different ecological and geographic *** clustering analysis indicated that the cotton resources used in this study did not belong to obvious geographic populations,which may be the consequence of a single source of domestication followed by frequent genetic introgression mediated by human transference.A total of 82 maker-trait associations were examined in association analysis and the related ratios for phenotypic variations ranged from 3.04% to 47.14%.Interestingly,nine SSR markers were detected in more than one environmental *** addition,14 SSR markers were co-associated with two or more different *** was noteworthy that NAU4860 and NAU5077 markers detected at least in two environments were simultaneously associated with three fiber quality traits(uniformity index,specific breaking strength and micronaire value).In conclusion,these findings provide new insights into the population structure and genetic exchange pattern of cultivated cotton *** quantitative trait loci of domesticated cotton identified will also be very useful for improvement of yield and fiber quality of cotton in molecular breeding programs.

关键词： Domestication cotton Fiber quality traits Genetic exchange Microsatellite markers Yield

Epitaxial growth and transport properties of compressively-strained Ba_(2)IrO_(4) films

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Chinese Physics B 2021年第8期30卷 492-495页

作者： Yun-Qi Zhao Heng zhang Xiang-Bin Cai Wei Guo Dian-Xiang Ji ting-ting zhang Zheng-Bin Gu Jian Zhou Ye Zhu Yue-Feng Nie National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of Physics The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Applied Physics Research Institute for Smart EnergyThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Ba_(2)IrO_(4) is a sister compound of the widely investigated Sr_(2)IrO_(4) and has no IrO_(6) octahedral rotation nor net canted antiferromagnetic moment,thus it acts as a system more similar to the high-T_(c) *** this work,we synthesize the Ba_(2)IrO_(4) epitaxial films by reactive molecular beam epitaxy and study their crystalline structure and transport properties under biaxial compressive *** resolution scanning transmission electron microscopy and x-ray diffraction confirm the high quality of films with partial strain *** compressive epitaxial strain,the Ba_(2)IrO_(4) exhibits the strain-driven enhancement of the conductivity,consistent with the band gap narrowing and the stronger hybridization of Ir-t_(2g) and O-2p orbitals predicted in the first-principles calculations.

关键词： molecular beam epitaxy iridate oxides epitaxial strain transport properties

Pre-existing orthorhombic embryos-induced hexagonal-orthorhombic martensitic transformation in MnNiSi_(1-x)(CoNiGe)_x alloy

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Chinese Physics B 2024年第4期33卷 691-699页

作者：张婷婷龚元元鲁子骞徐锋 MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

The thermal-elastic martensitic transformation from high-temperature Ni_(2)In-type hexagonal structure to low-temperature TiNiSi-type orthorhombic structure has been widely studied in MnMX(M=Ni or Co,and X=Ge or Si)***,the answer to how the orthorhombic martensite nucleates and grows within the hexagonal parent is still *** this work,the hexagonal-orthorhombic martensitic transformation in a Co and Ge co-substituted MnNiSi is *** can find some orthorhombic laths embedded in the hexagonal parent at a temperature above the martensitic transformation start temperature(M_(s)).With the the sample cooing to M_(s),the laths turn broader,indicating that the martensitic transformation starts from these pre-existing orthorhombic *** observation suggests that these pre-existing orthorhombic laths do not originate from the hexagonal-orthorhombic martensitic transformation because of the difference between atomic occupations of doping elements in the hexagonal parent and those in the preexisting orthorhombic *** phenomenological crystallographic theory and experimental investigations prove that the pre-existing orthorhombic lath and generated orthorhombic martensite have the same crystallography relationship to the hexagonal ***,the orthorhombic martensite can take these pre-existing laths as embryos and grow *** work implies that the martensitic transformation in MnNiSi_(1-x)(CoNiGe)_(x) alloy is initiated by orthorhombic embryos.

关键词： martensitic transformation MnMX alloy orthorhombic embryo crystallography relationship

Distribution and Risk Factors of Disability Attributed to Personality Disorders： A National Cross-sectional Survey in China

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Chinese Medical Journal 2016年第15期129卷 1765-1771页

作者： ting-ting zhang Yue-Qin Huang Zhao-Rui Liu Hong-Guang Chen Department of Social Psychiatry and Behavioral Medicine Peking University Sixth Hospital (Institute of Mental Health) National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing 100191 China

Background： Personality disorders can lead to some disability. However, little is known about the disability prevalence and function impairments. This study aimed to describe the disability prevalence attributed to personality disorders, its distribution, impairments of daily activities and social functions, and risk factors in China. Methods： Using a descriptive and analytic epidemiological method, data from the Second China National Sample Survey on Disability in 2006 were analyzed. The disability prevalence attributed to personality disorders, its distribution in different people and regions, and risk factors were statistically calculated. Results： Respondents included 1,909,205 adults. The disability prevalence rate attributed to personality disorders in China was 5.9/100,000. The disability rate attributed to personality disorders of males was higher than that of females （P 0.012）, while the rate of the unemployed was higher than that of the employed （P 〈 0.001 ）. Furthermore, the rates of unmarried/divorced/widowed people and the illiterate population were higher than those of married and educated people （P 〈 0.001 ）. Regarding the severity of disability attributable to personality disorders, mild disability accounted for a majority or 60% of the respondents. The data showed that disability mainly impaired respondents＇ ability to engage in daily activities, get along with people, and participate in social situations. According to the case-control study, marriage, employment, and higher education were protective factors of disability. Conclusions： The prevalence of disability attributed to personality disorders is low in China and always leads to mild disability. The distribution of disability attributed to personality disorders also varies in the Chinese population.

关键词： Disability Prevalence Epidemiology Mental Disability Personality Disorders