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Image Steganalysis System optimization Based on Boundary Samples

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Journal of Harbin Institute of Technology(New Series) 2014年第6期21卷 57-62页

作者： Li-Na Wang Min-Jie Wang ting-ting zhu Qing Dou Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education Wuhan University School of Computer Wuhan University

In the image steganalysis,the training samples often determine the performance of the model when the features and classification are in the same *** the existing research on steganalysis lacks the in-depth study of the classifier's training method which may deeply influence the detection *** paper provides an optimization of universal steganalysis based on the boundary samples classification concerning about image *** paper proposes a strategy of selecting boundary samples in steganalysis and divides the training samples into good samples,poor samples and boundary samples three categories and then chose the optimal threshold to get boundary samples through *** experimental results show the effectiveness of boundary sample,which dramatically improve detection capability especially for the low embedding rate Stego-image.

关键词： image steganalysis digital forensics support vector machine(SVM) boundary samples

Massive Preparation of Coumarone-indene Resin-based Hyper-crosslinked Polymers for Gas Adsorption

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Chinese Journal of Polymer Science 2018年第10期36卷 1168-1174页

作者： Ke Tian ting-ting zhu Ping Lan Zheng-Chen Wu Wei Hu Fei-Fei Xie Lei Li College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen University Material and Textile College Jiaxing University

Hyper-crosslinked polymers （HCPs） are promising materials for gas capture and storage because of their low cost and easy preparation. In this work, we report the massive preparation of coumarone-indene resin-based hyper-crosslinked polymers via one-step Friedel-Crafts alkylation. Low-cost coumarone-indene resin serves as the new building block and chloroform is employed as both solvent and external crosslinker. A maximum surface area of 966 m2·g-1 is achieved, which is comparable with that of previously-reported coal tar-based porous organic polymers. Most importantly, a large number of heteroatoms including inherent oxygen atoms and introduced chlorine atoms in obtianed HCPs further enhance the interaction between specific sorbate molecule and adsorbent. Therefore, optimal structural and chemical property endow the new coumarone-indene resin-based HCPs with decent gas storage capacity （14.60 wt% at 273 K and 0.1 MPa for CO2; 1.18 wt% at 77.3 K and 0.1 MPa for H2）. These results demonstrate that new HCPs are potential candidates for applications in CO2 and H2 capture.

关键词： Coumarone-indene resin Friedel-Crafts alkylation Gas adsorption Microporous organic polymers

Anti-glomerular basement membrane disease with IgA nephropathy: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3916-3922页

作者： Chuan Guo Ming Ye Shen Li ting-ting zhu Xiang-Rong Rao Department of Nephrology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Anti-glomerular basement membrane(GBM)disease is a rare autoimmune disease manifesting as acute progressive nephritis syndrome with or without varying degrees of pulmonary ***-GBM disease coexisting with Immunoglobulin A(IgA)nephropathy is rarer and has different clinical manifestations and prognoses than simple anti-GBM *** describe a case of coexistence of these two *** SUMMARY A 49-year-old man with hematuria and proteinuria accompanied by a slight elevation of serum creatinine was admitted to our *** pathological results of renal biopsy and the elevated serum anti-GBM antibody titer supported a diagnosis of anti-GBM disease combined with IgA *** treatment with corticosteroids and cyclophosphamide,the patient's serum creatinine was relatively stable,and the hematuria and proteinuria moderately improved in the subsequent six *** Anti-GBM disease coexisting with IgA nephropathy is *** clinical manifestations and prognosis are better than those of simple anti-GBM *** this case,the patient's condition was improved and his renal function remained relatively stable with corticosteroid and cyclophosphamide *** detection methods to identify whether the crescents in this case were derived from anti-GBM disease or IgA nephropathy are worthy of further exploration.

关键词： Anti-glomerular basement membrane disease IgA nephropathy Cyclophosphamide Case report

Fabrication of mesoporous lignin-based biosorbent from rice straw and its application for heavy-metal-ion removal

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Journal of Environmental Sciences 2017年第3期29卷 132-140页

作者： Fang Xu ting-ting zhu qing-quan Rao Sheng-Wen Shui Wen-Wei Li Hong-Bo He Ri-Sheng Yao School of Medical Engineering Hefei University of TechnologyHefei 230009China CAS Key Laboratory of Urban Pollutant Conuersion Department of ChemistryUniversity of Science&Technology of ChinaHefei 230026China Environmental Monitoring Center of Taizhou Taizhou 31800China

Lignocellulosic biomass offers the most abundant renewable resource in replacing traditional fossil resources. However, it is still a major challenge to directly convert the lignin component into value-added materials. The availability of plentiful hydroxyl groups in lignin macromolecules and its unique three-dimensional structure make it an ideal precursor for mesoporous biosorbents. In this work, we reported an environmentally friendly and economically feasible method for the fabrication of mesoporous lignin-based biosorbent （MLBB） from lignocellulosic biomass through a SOB micro-thermal-explosion process, as a byproduct of microcrystalline cellulose. BET analysis reveal the average pore-size distribution of 5.50 nm, the average pore value of 0.35 cm3/g, and the specific surface area of 186 m2/g. The physicochemical properties of MLBB were studied by fourier transform infrared spectroscopy （FTIR）, attenuated-total-reflection fourier transform infrared spectroscopy （ATR-FTIR）, X-ray photoelectron spectroscopy （XPS）, and element analysis. These results showed that there are large amounts of sutfonic functional groups existing on the surface of this biosorbent. Pb（II） was used as a model heavy-metal-ion to demonstrate the technical feasibility for heavy-metal-ion removal. Considering that lignocellulosic biomass is a naturally abundant and renewable resource and SO3 micro-thermal-explosion is a proven technique, this biosorbent can be easily produced at large scale and become a sustainable and reliable resource for wastewater treatment.

关键词： Lignocellulosic biomassMesoporous biosorbentRice strawLigninSulfur trioxideMicro-thermal-explosion

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Current Medical Science 2021年第2期41卷 390-397页

作者： Yue-ying PAN Shu-chang ZHOU Yu-jin WANG ting-ting zhu Dan PENG Han-xiong GUAN Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The features and treatment of 98 Chinese patients with immunoglobulin G4 (IgG4)-related disease (IgG4-RD) referred to a single tertiary referring centre were reviewed. Patientsdiagnosed with IgG4-RD according to the comprehensive diagnostic criteria (CDC) were includedin the retrospective study from May 2012 to March 2019. We collcted data on clinical, laboratory,imaging, histological features and treatment. Totally, 98 patients with IgG4-RD were *** common clinical manifestations included abdominal pain, salivary gland swelling andlymphadenopathy. 51% of the patients had multiple organs involvement. Lymph nodes, pancreasand salivary glands were most commonly involved. Four rare sites including ulna, cerebellum,scalp, and mammary gland were found. The serum IgG4 level was increased by 85.7%. The serumIgG4 level was positively correlated with the number of involved organs, IgG and IgG4/IgG. LowC3 and C4 levels were observed in 37.5% and 12.2% patients respectively, and all patients withkidney involvement had hypocomplementemia. A total of 54 patients underwent tissue biopsies,and 55.6%, 31.5% and 11.1% cases were diagnosed as definite, probable and possible IgG4-RD,respectively. Eighty-eight patients received glucocorticoids (GCs) therapy. Five patients underwentradical surgery to remove the lesion. 73% of them presented a complete or partial remission. IgG4-RD is a systemic fibroinflammatory disease with involvement of multiple organs throughout thebody including some rare sites. Most IgG4-RD patients had increased serum IgG4 levels andpatients with kidney involvement showed bypocomplementermia. GCs therapy is effective. Moreresearch is needed to provide a more reliable basis for the diagnosis and treatment of patients.

关键词： immunoglobulin G4-related disease clinical features Immunoglobulin G4 hypocomplementemia glucocorticoid

The impact of^(60)Co-γirradiation on the chemical constituents of Chuanxiong Rhizoma

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Traditional Medicine Research 2024年第1期9卷 23-32页

作者： ting-ting zhu Wei-Shan Qiu Rui Gu Shi-Hong Zhong School of Pharmacy Southwest Minzu UniversityChengdu 610041China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China

Background:In order to clarify the inmpat ofγirradiation on the chemical composition of traditional Chinese medicine,this paper carefully choosed Chuanxiong Rhizoma to carry on a demonstration ***:Through a meticulous assessment,a comprehensive comparison was made between the irradiated and unirradiated Chuanxiong Rhizoma *** property characteristics were investigated by colorimeter and electronic *** changes in chemical structures and contents was analyzed by fourier infrared spectroscopy,high performance liquid chromatography and *** a quest to uncover the presence of any new radiolysis products,cutting-edge techniques like ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry and gas chromatography-mass spectrometry were ***,the difference of antioxidant activity were ***:The irradiation doses within 12 kGy had no significant effects on the content of the main chemical components,characteristics and in vitro antioxidant activity of Chuanxiong Rhizoma,while changes in some functional groups and degradation of some volatile oil components containing olefins need further ***:This study indicates that^(60)Co-γirradiation is a stable method for sterilization of Chuanxiong ***’s also provide a reference for the establishment of irradiation standards for Chuanxiong Rhizoma and other aromatic medicinal plants.

关键词： ^(60)Co-γirradiation Chuanxiong Rhizoma chemical component comprehensive evaluation

Autocrine IL-8 Contributes to Propionibacterium Acnes-induced Proliferation and Differentiation of HaCaT Cells via AKT/FOXO1/Autophagy

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Current Medical Science 2024年第5期44卷 1058-1065页

作者： Xiu-qin YU Jin-zhu MAO Shu-yun YANG Lu WANG Chang-zhi YANG Lei HUANG Qi-hong QIAN ting-ting zhu Department of Dermatology the First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Dermatology Baoshan People’s Hospital of Yunnan ProvinceBaoshan678000China

Objective Proprionibacterium acnes(***)-induced inflammatory responses,proliferation and differentiation of keratinocytes contribute to the progression of acne vulgaris(AV).*** was found to enhance the production of interleukin-8(IL-8)by *** study aimed to investigate the role of IL-8 in ***-induced proliferation and differentiation of keratinocytes and the underlying *** The ***-stimulated HaCaT cell(a human keratinocyte cell line)model was *** blotting and immunofluorescence were performed to detect the expression of the IL-8 receptors C-X-C motif chemokine receptor 1(CXCR1)and C-X-C motif chemokine receptor 2(CXCR2)on HaCaT *** counting kit-8(CCK-8)assay,5-ethynyl-20-deoxyuridine(EdU)assay and Western blotting were performed to examine the effects of IL-8/CXCR2 axis on the proliferation and differentiation of HaCaT cells treated with ***,the IL-8 neutralizing antibody,the CXCR2 antagonist(SB225002),or the CXCR1/CXCR2 antagonist(G31P).Western blotting,nuclear and cytoplasmic separation,CCK-8 assay,and EdU assay were employed to determine the downstream pathway of CXCR2 after ***-stimulated HaCaT cells were treated with the CXCR2 antagonist,the protein kinase B(AKT)antagonist(AZD5363),or the constitutively active forkhead box O1(FOXO1)***,autophagy markers were measured in HaCaT cells following the transfection of the FOXO1 mutant or treatment with the autophagy inhibitor 3-methyladenine(3-MA).Results The expression levels of CXCR1 and CXCR2 were significantly increased on the membrane of HaCaT cells following *** *** IL-8/CXCR2 axis predominantly promoted the proliferation and differentiation of ***-induced HaCaT cells by activating AKT/FOXO1/autophagy *** brief,IL-8 bound to its receptor CXCR2 on the membrane of keratinocytes to activate the AKT/FOXO1 ***,phosphorylated FOXO1 facilitated autophagy to promote the proliferation and diffe

关键词： acne vulgaris Proprionibacterium acnes keratinocyte interleukin-8 C-X-C motif chemokine receptor 2 protein kinase B forkhead box O1 autophagy

Glycine-conjugated porphyrin fluorescent probe with iRGD for live cell imaging

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Chinese Chemical Letters 2017年第4期28卷 777-781页

作者： Qian Zhang Xue Dong Kun-Peng Wang ting-ting zhu Feng-Nan Sun Shu-Xian Meng Ya-Qing Feng School of Chemical Engineering and Technology Tianfin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 200072 China

A porphyrin modified by glycine has been synthesized and developed as a near-infrared（NIR）fluorescence probe to detect ***＇ longwavelength emission at ~650 nm can efficiently avoid the spectral crosstalk with Spontaneous fluorescence in the visible light region.A disulfide-based cyclic RGD peptide named iRGD c（CRGDKGPDC）,a tumor homing peptide,harbors a cryptic C-end Rule（CendR） motif that is responsible for neuropilin-1（NRP-1） binding and for triggering extravasation and tumor penetration of the peptide to improve the imaging sensitivity and therapeutic *** used N hydroxy succinimide as an activator to introduce the glycine methyl ester to detect *** got a porphyrin modified by *** affinity between probe and tumor cell entered GLC-82 cells（human glandular lung cancer cell line） can be observed by Confocal *** toxicity of probe has been identified by MTT *** summary has been gotten that the porphyrins were nontoxic to GLC-82 cells and glycine modified porphyrin has a good affinity with GLC-82 cells under the iRGD function by our experiment.

关键词： Fluorescence probe iRGD Glycine Porphyrin Near-infrared

Application of Low Tube Voltage, Low-concentration Contrast Agent Using a 320-row CT in Coronary CT Angiography: Evaluation of Image Quality, Radiation Dose and Iodine Intake

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Current Medical Science 2020年第1期40卷 178-183页

作者： Yue-ying PAN Shu-chang ZHOU Yu-jin WANG Qian LI ting-ting zhu Chun-xia LIU Han-xiong GUAN Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Health Records Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The effect of low voltage and low concentration contrast agent on image quality of coronary CT angiography,radiation dose and iodine intake was evaluated.A total of 121 patients with body mass index(BMI)0.05).The radiation doses in groups A,B,C and D were 2.6±1.4,3.6±1.&4.9±3.5 and 4.9±2.8 mSv,*** radiation dose in group A was significantly less than that in the rest three groups(P<0.05).The iodine intakes in groups A,B,C and D were 14.9±1.5,15.0±1.5,17.7±2.0

关键词： tube voltage contrast agent coronary CT angiography radiation dose iodine intake