检索结果-南通市图书馆

Prediction of sepsis within 24 hours at the triage stage in emergency departments using machine learning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2024年第5期15卷 379-385页

作者： jingyuan Xie jiandong Gao Mutian Yang ting Zhang Yecheng Liu Yutong Chen Zetong Liu Qimin Mei Zhimao Li Huadong Zhu ji Wu Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Center for Big Data and Clinical Research Institute for Precision MedicineTsinghua UniversityBeijing 100084China Institute of Medical Technology Peking University Health Science CenterBeijing 100091China Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Health Care Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

BACKGROUND:Sepsis is one of the main causes of mortality in intensive care units(ICUs).Early prediction is critical for reducing *** approximately 36%of sepsis occur within 24 h after emergency department(ED)admission in Medical Information Mart for Intensive Care(MIMIC-IV),a prediction system for the ED triage stage would be *** methods such as the quick Sequential Organ Failure Assessment(qSOFA)are more suitable for screening than for prediction in the ED,and we aimed to fi nd a light-weight,convenient prediction method through machine ***:We accessed the MIMIC-IV for sepsis patient data in the *** dataset comprised demographic information,vital signs,and synthetic *** Gradient Boosting(XGBoost)was used to predict the risk of developing sepsis within 24 h after ED ***,SHapley Additive exPlanations(SHAP)was employed to provide a comprehensive interpretation of the model's *** percent of the patients were randomly selected as the testing set,while the remaining patients were used for training with 10-fold ***:For 10-fold cross-validation on 14,957 samples,we reached an accuracy of 84.1%±0.3%and an area under the receiver operating characteristic(ROC)curve of 0.92±*** model achieved similar performance on the testing set of 1,662 *** values showed that the fi ve most important features were acuity,arrival transportation,age,shock index,and respiratory ***:Machine learning models such as XGBoost may be used for sepsis prediction using only a small amount of data conveniently collected in the ED triage *** may help reduce workload in the ED and warn medical workers against the risk of sepsis in advance.

关键词： Sepsis Machine learning Emergency department Triage Informatics

Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He jia-Bin Cai Xuan Wu Yin-Bing Tang jin-Yan Wang Jun-Qin Mao ji-Jun Chen Li-Feng Zhang Zhong-Hai Guan jie-Ni Xiong Wan-Xin Peng jin-Hu Wang ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

A tunable ionic covalent organic framework platform for efficient CO_(2) catalytic conversion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第1期18卷 25-36页

作者： ting Li ji Xiong Minghui Chen Quan Shi Xiangyu Li Yu jiang Yaqing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Guangdong Laboratory of Chemistry and Fine Chemical Industry jieyang Center Jieyang 522000China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

The cycloaddition reaction between epoxides and CO_(2) is an effective method to utilize CO_(2) *** organic frameworks(COFs)provide a promising platform for the catalytic CO_(2) transformations on account of their remarkable chemical and physical ***,a family of novel vinylene-linked ionic COFs named TE-COFs(TTE-COF,TME-COF,TPE-COF,TBE-COF)has been facilely synthesized from N-ethyl2,4,6-trimethylpyridinium bromide and a series of triphenyl aromatic aldehydes involving different numbers of nitrogen atoms in the central aromatic *** resulting catalyst TTE-COF with excellent adsorption capacity(45.6 cm3·g^(-1),273 K)exhibited outstanding catalytic performance,remarkable recyclability and great substrate ***,it was also observed that the introduction of nitrogen atom in the precursor led to a great improvement in the crystallinity and CO_(2) adsorption capacity of TE-COFs,thus resulting to a progressively improved catalytic *** work not only illustrated the influence of monomer nitrogen content on the crystallinity and CO_(2) adsorption capacity of TE-COFs but also provided a green heterogeneous candidate for catalyzing the cycloaddition between CO_(2) and epoxides,which shed a light on improving the catalytic performance of the CO_(2) cycloaddition reaction by designing the covalent organic frameworks structures.

关键词： CO_(2)cycloaddition nreaction covalent organic frameworks cyclic carbonate vinylene-linked synergetic effects

Impact of Low-temperature Storage on Volatile Flavor Compounds in Prepared Pork Products

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Biotechnology 2024年第4期13卷 70-75,81页

作者： Xiulian WANG jiamin ZHANG ting BAI Wei WANG Kaihong YANG Lili ji College of Food and Bioengineering Chengdu UniversityChengdu 610106China Meat Processing Key Laboratory of Sichuan Province Chengdu UniversityChengdu 610106China Chengdu Hope Food Co. Ltd.Chengdu 610000China

[Objectives]This study was conducted to explore the dynamic changes of volatile flavor compounds in prepared pork during storage at different low-temperature conditions.[Methods]Prepared pork was stored at 4,-4 and-18℃.The volatile flavor compounds of prepared pork were determined by solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)at days 0,7,14,21 and 28,and relative odor activity value(OAV),principal component analysis(PCA)and cluster analysis(CA)were combined to analyze changes in volatile flavor compounds of prepared pork during storage.[Results]The total number of volatile flavor compounds gradually decreased with the prolongation of the storage period,and OAV analysis identified 22 key flavor compounds(OAV≥1).The results of PCA and CA showed that 2-methyl-1-butanol,1-octen-3-ol,linalool,cineole,hexanal and nonanal were the main key flavor components,and the degree of flavor degradation was low under both superchilling and freezing *** 28 days of storage,the alcohol content in the chilling group was significantly higher than other two groups,and the overall content of volatile flavor compounds was also significantly higher than other two groups,indicating that the-4℃chilling storage was more favorable for maintaining the overall flavor of prepared pork.[Conclusions]This study provides a theoretical basis for finding a better storage method for prepared meat products.

关键词： Low-temperature storage Prepared pork Volatile flavor component Principal component analysis Cluster analysis

不同力学激励形式探索La基非晶合金微观结构非均匀性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理学报 2024年第4期73卷 224-234页

作者：张剑郝奇张浪渟乔吉超西北工业大学力学与土木建筑学院西安710072

非晶合金力学行为与其微观结构非均匀性之间本征关联,是固体力学研究领域至今未能很好解决的重要科学问题之一.单一力学激励形式并不能有效地描述非晶合金微观结构非均匀性,特别是结构与动力学的关联.如何探索非晶合金结构信息,须将诸... 详细信息

非晶合金力学行为与其微观结构非均匀性之间本征关联,是固体力学研究领域至今未能很好解决的重要科学问题之一.单一力学激励形式并不能有效地描述非晶合金微观结构非均匀性,特别是结构与动力学的关联.如何探索非晶合金结构信息,须将诸多因素综合,在不同力学激励下研究非晶合金微观结构非均匀性与变形机理.本研究以La_(62)Cu_(12)Ni_(12)Al_(14)非晶合金为模型体系,利用动态力学分析仪研究非晶合金动态弛豫行为.基于准点缺陷模型,对模型合金体系α弛豫和β弛豫进行了分离.借助于拉伸应变率跳实验,探索非晶合金高温流变行为.确定非晶合金塑性流变过程中弹性、滞弹性以及塑性变形的贡献.本研究从非晶合金动态力学弛豫行为和宏观塑性流变行为出发,尝试揭示微观非均匀性对非晶合金在不同激励形式中缺陷的激活、扩展和融合的物理本质.

关键词：非晶合金微观结构非均匀性动力学弛豫高温变形准点缺陷模型

多模态MRI在终末期肾病合并认知障碍中的研究进展

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

磁共振成像 2024年第1期15卷 229-234页

作者：陆婷鲁际三峡大学第一临床医学院宜昌443000 湖北省宜昌市中心人民医院放射科宜昌443000

认知障碍在终末期肾病(end-stage renal disease, ESRD)患者中非常普遍,这种障碍涉及一系列认知领域,包括注意力、记忆力和执行力等,严重降低了患者的生活质量。然而这种神经认知缺陷的确切机制尚不清楚,因此在早期阶段检测和管理这种... 详细信息

认知障碍在终末期肾病(end-stage renal disease, ESRD)患者中非常普遍,这种障碍涉及一系列认知领域,包括注意力、记忆力和执行力等,严重降低了患者的生活质量。然而这种神经认知缺陷的确切机制尚不清楚,因此在早期阶段检测和管理这种认知障碍具有很大的挑战性。近年来多模态磁共振成像在这一领域取得了诸多成果,并有望选择出指导早期筛查及诊断慢性肾脏疾病(chronic kidney disease, CKD)患者认知缺陷的影像学生物标志物。本文将简要阐述多种MRI新兴技术及人工智能在ESRD合并认知障碍患者中的研究进展,尝试揭示ESRD患者脑结构、功能、灌注、代谢及神经血管耦合与认知功能障碍之间的联系,帮助临床了解ESRD患者大脑缺陷的潜在神经元机制,有利于合并认知障碍ESRD患者的早期诊断、治疗及随访。

关键词：终末期肾病认知障碍磁共振成像多模态脑功能成像血液透析脑损伤

Clinical comprehensive treatment protocol for managing diabetic foot ulcers:A retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第17期12卷 2976-2982页

作者： Yan-Bin Wang Yan Lv Guang-Yu Li ji-ting Zheng Qing-Xin jiang Ran Wei Department of Vascular Surgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina First Department of General Surgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of *** current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications.A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with *** hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing,reduced amputation rates,and improved overall patient outcomes compared to standard treatment *** To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment *** This retrospective study included 62 patients with DFUs,enrolled between January 2022 and January 2024,randomly assigned to the experimental(n=32)or control(n=30)*** experimental group received a comprehensive treatment comprising blood circulation improvement,debridement,vacuum sealing drainage,recombinant human epidermal growth factor and anti-inflammatory dressing,and skin *** control group received standard treatment,which included wound cleaning and dressing,antibiotics administration,and surgical debridement or amputation,if *** taken to reduce the white blood cell count,number of dressing changes,wound healing rate and time,and amputation rate were *** The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate,wound healing time,and amputation ***,the comprehensive treatment protocol was safe and well tolerated by the *** Comprehensive treatment for DFUs is more effective than standard treatment,promoting granulation tissue growth,shortening hospitalization time,reducing pain and amputation rate,improving wound healing,and enhancing quality of life.

关键词： Diabetic foot ulcers Comprehensive treatment protocol Clinical study White blood cell count Wound healing Amputation rate

Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第6期12卷 1274-1282页

作者： ting ZENG QI SHEN YUAN CAO jiAN-YU GUAN MENG-ZHE LIAN jiN-jiAN HAN LEI HOU jiAN LU XIN-XIN PENG MIN LI WEI-YUE LIU jiN-CAI WU YONG WANG JUAN YIN ji-GANG REN HAI-FENG jiANG QIANG ZHANG CHENG-ZHI PENG jiAN-WEI PAN Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

荷电可调性碳化聚合物点的合成、性能及其对槲皮素的响应研究

在线全文

学校读者我要写书评

暂无评论

光谱学与光谱分析 2024年第9期44卷 2523-2530页

作者：翁文婷季泉彤王亚庭陈桦杰陈少云泉州师范学院化工与材料学院制药工程系福建泉州362000

以海藻酸钠(SA)为碳源,引入邻苯二胺(oPDA)为助剂,采用一步水热合成法制备新型的氮掺杂碳化聚合物点SA-oPDA CPDs。该CPDs溶液在352nm波长激发下,于462nm处有蓝绿色荧光发射信号,stokes shift可达到110nm,并显示出良好的光稳定性和激发... 详细信息

以海藻酸钠(SA)为碳源,引入邻苯二胺(oPDA)为助剂,采用一步水热合成法制备新型的氮掺杂碳化聚合物点SA-oPDA CPDs。该CPDs溶液在352nm波长激发下,于462nm处有蓝绿色荧光发射信号,stokes shift可达到110nm,并显示出良好的光稳定性和激发波长不依赖性,荧光量子产率为16.9%。碳化聚合物点保留有海藻酸钠聚合链的特征,通过静电吸附组装技术,与壳聚糖形成复合发光薄膜,具有发光器件可应用潜力。该碳点水溶液对pH值极具敏感性,随着溶液环境由酸性变化到碱性,荧光强度增加的同时伴随着荧光发射峰位置从465nm蓝移突变至425nm,相应碳点的表面荷电状态由正电荷变化为负电荷。结构和形貌表征,在高温碳化过程中,该碳点内部形成碳化发光中心,外层表面共存来源于邻苯二胺和海藻酸钠的胺基和羧基。在溶液环境中,碳点的带电状态随溶液pH值的变化而变化,出现类似两性电解质的荷电性质,并在pH 6~7存在等电点。这可能是由于碳点表面羧基的解离和胺基的质子化的共同作用,并导致溶液表现出发光可调性。CPDs在pH 6.80的溶液环境下与铅离子结合后,溶液发射的荧光从蓝色变化为蓝绿色,可实现对一定浓度铅离子的明显可视化响应。研究表明还原性的药物对该碳点荧光信号有明显的猝灭效应。槲皮素对碳点的荧光猝灭程度在7.9×10^(-6)~7.7×10^(-5)mol·L^(-1)浓度范围内,可呈现方程为I0/I=0.8788+1.6897×10^(-6)cQue的线性响应,相关系数r^(2)=0.9748,检出限LOD=1.7×10^(-6)mol·L^(-1)。

关键词：碳化聚合物点荷电可调性槲皮素响应发光薄膜