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物理学报 2002年第9期51卷 2034-2037页

作者：王大威刘婷婷杨宏蒋红兵龚旗煌北京大学物理系

讨论了气体介质的非均匀性对飞秒激光高次谐波产生过程的可能影响 .计算结果表明 ,采用喷阀技术所提供的气体介质的密度梯度和气体原子运动速度的影响很小 ,不会产生实验上可观测的效果 .

关键词：非均匀性高次谐波气体介质各向异性飞秒激光喷阀技术密度梯度激光传播非线性光学

Preoperative serum lipid profile and outcome in nonmetastatic colorectal cancer

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Chronic Diseases and Translational Medicine 2016年第4期2卷 -页

作者： ting-ting hong Di Shen Xiao-Ping Chen Xiao-hong Wu Dong Hua Department of Medical 0ncology Affiliated Hospital of Jiangnan University and Wuxi 4th People's Hospital Wuxi Jiangsu 214062 China

Objective: A large portion of non-metastatic colorectal cancers (non-mCRCs) recur after curative surgery. In addition to the traditional tumor-related factors, host-related factors are also required to accurately predict prognosis. A few studies have shown an association between the serum lipid profile and the survival and treatment response of patients with colorectal cancer. Methods: We retrospectively evaluated the prognostic significance of the preoperative serum lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] in patients with non-mCRC treated with curative surgery. The Spearman rank correlation test was used to analyze associations between lipid levels and categorical variables. Lipid levels were modeled as four equal-sized quartiles based on the distribution among the whole cohort. Kaplan-Meier curves were used to estimate survival probabilities, and the log-rank test was used to detect differences between them. Multivariate fractional polynomial (MFP) analysis was used to model any non-linear effects and avoid categorization. To evaluate the added prognostic value of lipids, the predictive power of two models (with and without lipids as covariates) was compared by using Harrell's C-statistic and the Akaike information criterion (AIC). Results: A total of 266 patients with non-mCRC were enrolled in the present study. Spearman rank correlation test showed that TG levels inversely correlated with N stage (r ? ?0.20, P ? 0.00) and Tumor-Node-Metastasis (TNM) stage (r ? ?0.19, P ? 0.00). HDL-C levels positively correlated with perineural invasion (PNI) (r ? 0.15, P ? 0.02), and LDL-C levels inversely correlated with lymphovascular invasion (LVI) (r ? ?0.12, P ? 0.04). None of the four lipids predicted overall survival (OS) in univariate or multivariate analyses adjusted for age, gender, T stage, N stage, TNM stage, histological grade, tumor deposits,

关键词： Serum lipids Colorectal cancer Overall survival Prognostic model

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Experimental studies on antipyretic,analgesic and antibacterial effects of GK 001,a poly-prescription of traditional chinese medicine

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沈阳药科大学学报 2008年第S1期25卷 105-105页

作者： JIANG Su-yun,ZhANG ting-ting,DING hong-yu(Dalian Institute for Drug Control,Dalian 116021,China)

Objective To study the anti-inflammatory effect of a poly-prescription of traditional Chinese medicine *** *** effect on pain in mice:The pain was induced by i.p.0.2 ml of 0.6% HAc per mouse 1 h post dosing *** writhing numbers of mice were recorded in 10 minutes and the inhibitory rate of pain was calculated compared with the control *** effect In single dose experiment 15 healthy rabbits weighing 1.7-2.8 kg with body temperature(BT)measured in the experiment day meeting to the requirements were selected for the experiment and divided into 5 groups(3 in each group),which were dosed orally with GK001 and 1 h later followed by *** of 40 EU bacterial endotoxin standard·***,the BT of rabbits was measured every 30 min during 1-3 h after *** difference between the highest BT post-dose and the average BT pre-dose was *** multi-dose experiment rabbits were selected and grouped as well as received *** in the same way as above,but were administered with GK001 for consecutive 5 *** *** antibacterial activities of GK001 on Bacillus Pumilus,Bacillus Subtilis and Micrococcus Luteus were measured in vitro at concentrations of 0.125-1.0 g·*** *** GK001 showed a significant and dose-dependent pain-suppressant effect,with inhibitory rate being 45.2%,31.2% and 20.8% at high,medium and low dose,respectively(P<0.05).*** single and multiple administration of GK001 had no effect on rabbit pyrogen response caused by ***001 had bacteriostatic effects on the aforementioned 3 bacteria significantly and in dose-dependent *** GK001 has analgesic and in vitro antibacterial but no antipyretic effects.

关键词： GK001 antipyretic analgesic bacteriostasis

脑卒中合并吞咽功能障碍的老年病人序贯肠内营养支持治疗的研究

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肠外与肠内营养 2016年第5期23卷 293-296页

作者：范隽韵单廷葛婷婷康宏伟南京医科大学附属无锡第二医院康复医学科江苏无锡214002 南京医科大学附属无锡第二医院普通外科江苏无锡214002

目的:探讨序贯肠内营养(EN)支持治疗在脑卒中合并吞咽功能障碍老年病人治疗中的应用和临床效果。方法:将62例急性缺血性脑卒中合并吞咽功能障碍的老年病人随机分为研究组和对照组。研究组(n=32)病人给予短肽型EN制剂,逐步过渡至整蛋白... 详细信息

目的:探讨序贯肠内营养(EN)支持治疗在脑卒中合并吞咽功能障碍老年病人治疗中的应用和临床效果。方法:将62例急性缺血性脑卒中合并吞咽功能障碍的老年病人随机分为研究组和对照组。研究组(n=32)病人给予短肽型EN制剂,逐步过渡至整蛋白型EN制剂的序贯EN治疗方案。对照组(n=30)病人直接给予整蛋白型EN制剂。观察两组病人入组第1和第14天的营养指标、免疫功能指标和神经功能缺损评分(NIHSS)的变化以及并发症的发生情况。结果:入组第14天,两组病人的营养指标、免疫功能指标和NIHSS评分均较第1天明显下降(P0.05)。研究组病人总并发症的发生率少于对照组(P<0.05)。结论:序贯EN支持治疗能减轻脑卒中合并吞咽功能障碍的老年病人营养不良发展程度和免疫功能下降程度,促进神经功能恢复,降低并发症发生的风险。

关键词：脑卒中吞咽功能障碍序贯肠内营养

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考虑信息熵模型的道路交通安全态势模型

数学的实践与认识 2016年第20期46卷 193-198页

作者：高婷婷王武宏周艳龙北京理工大学交通工程研究所北京100081 天津职业技术师范大学汽车与交通学院天津300222

分析道路交通事故统计中的交通事故数、死亡人数和受伤人数,并且将这三种统计数据和某地区的机动车辆数和机动车驾驶人数相结合,分别得到万车交通事故数和万人死亡人数和万人受伤人数,建立信息熵模型(information entropy model)对以上... 详细信息

分析道路交通事故统计中的交通事故数、死亡人数和受伤人数,并且将这三种统计数据和某地区的机动车辆数和机动车驾驶人数相结合,分别得到万车交通事故数和万人死亡人数和万人受伤人数,建立信息熵模型(information entropy model)对以上数据进行分析研究,从而得出评价交通安全程度的指标.这种方法突破了以往仅停留在万车死亡人数的指标上,且以往的研究方法还需采用专家评价法或德尔菲等定性评价方法,此评价方法对道路交通安全的分析更客观.最后以北京和天津近三年的交通事故统计数据为案例进行分析,研究结果表明:2012年至2014年间北京道路交通安全评价指标主要以交通事故起数认定所在年的道路交通安全状况,天津道路交通安全评价指标主以交通事故造成的受伤人数认定所在年的道路交通安全状况,且北京三个指标的G_i均高于天津,因此北京交通安全水平要低于天津.

关键词：交通工程安全分析信息熵模型道路交通态势模型

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

The cGAS-Sting-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou ting Li Wei Zhang Jian Wu Hui hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 Sting type I interferon

Bioinspired Ultrasensitive Flexible Strain Sensors for Real-Time Wireless Detection of Liquid Leakage

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Zhou, Weilong Du, Yu Chen, Yingying Zhang, Congyuan Ning, Xiaowei Xie, Heng Wu, ting Hu, Jinlian Qu, Jinping Huazhong Univ Sci & Technol Sch Chem & Chem Engn Key Lab Mat Chem Energy Convers & Storage Minist EducHubei Key Lab Mat Chem & Serv Failure Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Hubei Engn Res Ctr Biomat & Med Protect Mat Sch Chem & Chem Engn Wuhan 430074 Peoples R China Wuhan Inst Technol Sch Mat Sci & Engn Wuhan 430205 Peoples R China City Univ hong Kong Dept Biomed Engn Hong Kong 999077 Peoples R China

Micro-extrusion compression molding and surface modification were proposed for the mass fabrication of a superhydrophobic thermoplastic polyurethane sensor (TCGS).Inspired by scorpions, TCGS features Archimedean spiral crack arrays and micropores, achieving 218.13 sensitivity at 2% strain, a 4300% increase, and over 5000 usage cycles of *** robust superhydrophobicity of TCGS improves sensitivity and stability for detecting small-scale liquid leakage, allowing precise monitoring across various sizes and compositions while providing early warnings in various scenarios. Liquid leakage of pipeline networks not only results in considerable resource wastage but also leads to environmental pollution and ecological imbalance. In response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) has been developed using a combination of micro-extrusion compression molding and surface modification for real-time wireless detection of liquid leakage. The TCGS utilizes the synergistic effects of Archimedean spiral crack arrays and micropores, which are inspired by the remarkable sensory capabilities of scorpions. This design achieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability by withstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability in detecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositions while issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenarios in everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effective solution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

太湖中大银鱼、太湖新银鱼和寡齿新银鱼群体的遗传结构

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水产学报 1999年第3期22卷 254-260页

作者：夏德全曹萤吴婷婷杨弘中国水产科学研究院淡水渔业研究中心!无锡214081

利用ＲＡＰＤ技术对太湖中的大银鱼、太湖新银鱼、寡齿新银鱼的遗传结构进行了研究。共在太湖中的６个采样片采到大银鱼和太湖新银鱼样品，在两个采样片得到了寡齿新银鱼的样品。结果表明，太湖中不同水域的三种银鱼没有明显的遗传差... 详细信息

利用ＲＡＰＤ技术对太湖中的大银鱼、太湖新银鱼、寡齿新银鱼的遗传结构进行了研究。共在太湖中的６个采样片采到大银鱼和太湖新银鱼样品，在两个采样片得到了寡齿新银鱼的样品。结果表明，太湖中不同水域的三种银鱼没有明显的遗传差异。三种银鱼中，大银鱼的遗传相似性指数显示最大，太湖新银鱼的次之，寡齿新银鱼的最小，说明大银鱼的遗传变异性最小，寡齿新银鱼的最大，太湖新银鱼的遗传变异性界于两者之间。

关键词：大银鱼太湖新银鱼寡齿新银鱼遗传结构太湖